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Ecological Economy 2022年第4期18卷 261-273页

作者： LIU Ya-jun paula NOVO The University of Leeds Leeds LS29JTUK

This study evaluates the ecosystem service value of Qingdao Luhaifeng Sea Ranch artificial reef area through the established meta-analysis value transfer model,and the results show that the total value will be 150 million yuan in *** to the regression results of the meta-analysis,the types of ecosystem services,the types of pasture sediment,the population density of the pasture area,and the economic level all have a significant impact on the wetland *** model in this paper passes the validity test,and the conclusions are the same as many current empirical *** shows that the benefit transfer method meta-analysis can save assessment labor,time and capital,and the decision-makers can make judgments ***-analysis is an effective and fast ex ante evaluation *** reliability of the value transfer method of meta-analysis largely depends on the quantity and quality of existing studies and the establishment of mathematical *** is necessary to expand the number of literature ***,the current evaluation method of ecosystem services in China has just started,so the government needs to encourage research institutions to evaluate the value of ecosystem services to provide more effective and abundant research literature.

关键词： sea ranching artificial reef ecosystem services benefit transfer meta-analysis

Distinguishing normal brain aging from the development of Alzheimer＇s disease：inflammation,insulin signaling and cognition

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Neural Regeneration Research 2018年第10期13卷 1719-1730页

作者： Paul Denver paula L.McClean Greater Los Angeles Veterans Affairs Healthcare System West Los Angeles Medical Center and Department of NeurologyUniversity of CaliforniaLos AngelesCAUSA Centre for Molecular Biosciences University of UlsterColeraine Northern Ireland UK Northern Ireland Centre for Stratified Medicine ClinicalTranslational and Research Innovation Centre (C-TRIC)University of UlsterDerry/Londonderry Northern Ireland UK

As populations age, prevalence of Alzheimer＇s disease（AD） is rising. Over 100 years of research has provided valuable insights into the pathophysiology of the disease, for which age is the principal risk factor. However, in recent years, a multitude of clinical trial failures has led to pharmaceutical corporations becoming more and more unwilling to support drug development in AD. It is possible that dependence on the amyloid cascade hypothesis as a guide for preclinical research and drug discovery is part of the problem. Accumulating evidence suggests that amyloid plaques and tau tangles are evident in non-demented individuals and that reducing or clearing these lesions does not always result in clinical improvement. Normal aging is associated with pathologies and cognitive decline that are similar to those observed in AD, making differentiation of AD-related cognitive decline and neuropathology challenging. In this mini-review, we discuss the difficulties with discerning normal, age-related cognitive decline with that related to AD. We also discuss some neuropathological features of AD and aging, including amyloid and tau pathology, synapse loss, inflammation and insulin signaling in the brain, with a view to highlighting cognitive or neuropathological markers that distinguish AD from normal aging. It is hoped that this review will help to bolster future preclinical research and support the development of clinical tools and therapeutics for AD.

关键词： Alzheimer's disease aging inflammation cognitive function spatial learning insulin signaling synapses cytokines

Recruitment of Minorities into Nursing, Best Practices: A Scoping Review

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Open Journal of Nursing 2022年第10期12卷 683-701页

作者： paula R. Klemm Hason Jafrey School of Nursing University of Delaware Newark Delaware USA Christiana Care Health System Newark Delaware USA

The recruitment and retention of minorities into nursing is a pressing need given the evolving racial makeup of the U.S. A scoping review of the literature was conducted to identify and map evidence of the best practices and timing for recruitment and retention of minorities in nursing. This review utilized methods described by Asksey and O’Malley. PubMed, CINAHL, SCOPUS, Cochrane, Web of Science, and ProQuest were searched from 2000 to 2022. Data were extracted from 20 full text papers published in English in the U.S. Recruitment usually begins in middle or high school, but several authors recommended beginning as early as elementary school to establish positive views of nursing. Retention methods included multi-pronged approaches tailored by the academic institutions. Most received federal funding. Financial aid is key to the success for many minority nursing students, but must be aligned with other supports (e.g., academic, social, mentoring) in recruitment and retention efforts. Partnerships with local elementary, middle, and high schools, hospitals, community agencies and centers, businesses, and minority groups are necessary. Future research that measures outcomes of early recruitment of minorities and their choice of nursing as a career is needed. Recruitment and retention efforts should include information on potential sources of funding prior to student enrollment. More information is needed on recruitment and retention programs that are successful without funding and those that remain robust after funding ends.

关键词： Recruitment and Retention African American Nursing

Analysis of the Most Likely Regions of Stability of an NCS and Design of the Corresponding Event-driven Controller

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International Journal of Automation and computing 2018年第1期15卷 39-51页

作者： Ana paula Batista Fabio Goncalves Jota Centre for Intelligent Energy Research Federal Centre of Technological Education of Minas Gerais Belo Horizonte Brazil Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil

In this paper, some issues related to design and analysis of real networked control systems （NCS） under the focus of the most likely region of stability are addressed. Such a system is cumbersome due to its inherent variable time delays, ranging from microseconds to hours. To show the influence of such huge variations in the control performance, a laboratory-scale luminosity system has been setup using the Internet as part of the control loop with dominant time constant in the order of milliseconds. Proportional and integral （PI） control strategies with and without explicit compensation for the time-delay variations were implemented using an event-driven controller. Using the well-known Monte Carlo method and subsequent analyses of time responses, it has been possible to identify the most likely region of stability. Some experimental results show the influence of the statistical parameters of the delays on the determination of the most likely regions of stability of the NCS and how these can be used in assessment and redesign of the control system. The experiments show that much larger delays than one sample period can be supported by real NCSs without becoming unstable.

关键词： Networked control systems real NCS delay compensation most likely regions of stability delay statistics.

Kindlin-1 drives early steps of breast cancer metastasis

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Cancer Communications 2022年第10期42卷 1036-1040页

作者： Florian Bonin Aurélie Chiche Zakia Tariq paula Azorin Sébastien Nola Rosette Lidereau Keltouma Driouch Genetics Department Institut CurieParis 75005France Cell Biology and Cancer Department/Unit 144 Institut Curie/Centre National de Recherche ScientifiqueParis 75005France Department of Developmental&Stem Cell Biology/Unit 3738 Institut Pasteur/Centre National de Recherche ScientifiqueParis 75015France Membrane Traffic in Health And Brain Disease/Unit 1266 Institute of Psychiatry and Neuroscience of Paris/Institut National de la Santéet de la Recherche MédicaleUniversitéde ParisParis 75014France

Dear Editor,Kindlin-1 plays a major role in the activation of integrins[1].Kindlin-1 is often overexpressed in ***-1 overexpression has been associated with a higher propensity of breast cancer patients to metastasize to the lungs[2,3].Furthermore,Kindlin-1 depletion in mouse models was found to inhibit tumor growth and lung metastasis[3,4].However,the underlying mechanisms remain poorly explored.

关键词： metastasis Kindlin breast

Brazilian adolescents’lifestyle in the COVID‑19 pandemic:a mixed‑methods study

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World Journal of Pediatrics 2022年第8期18卷 553-557页

作者： Caroline Lima Fonseca Carolina Ferreira Peterle Bruna Hinnah Borges Martins de Freitas Maria Aparecida Munhoz Gaíva paula Manuela Jorge Diogo Juliano Bortolini Federal University of Mato Grosso 2367 Fernando Corrêa da Costa AvBoa EsperançaCuiabáMT 78060-900Brazil Lisbon College of Nursing LisbonPortugal

The COVID-19 pandemic has forced the health authorities and governments worldwide to engage in a battle against the disease,adopting several mitigation strategies[1].Since then,the world population has been afected by various changes in its *** imposed by the COVID-19 pandemic are believed to have had an impact on adolescents'lifestyle(LS)[2].The LS is determined by discernible behavior patterns that can trigger efects on adolescents'health and is related to countless aspects that refect attitudes,values and life opportunities[3].Therefore,LS can be observed from the habits,behaviors and activities performed by people in their daily lives[4].

关键词： has routine COV

Quality of life,depression and anxiety in potential living liver donors for pediatric recipients:A retrospective single center experience

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World Journal of Hepatology 2022年第10期14卷 1899-1906页

作者： paula K Reine Flavia Feier Eduardo Antunes da Fonseca Rosely G Hernandes Joao Seda-Neto Department of Psychology Hospital Sirio-LibanesSao Paulo 01308901Brazil Department ofLiver Transplantation Santa Casa de Porto AlegrePorto Alegre 90020090Brazil Department of Liver Transplantation Hospital Sirio-LibanesSao Paulo 01308901Brazil

BACKGROUND Living donor liver transplantation is a safe alternative for patients on a liver transplant *** evaluation goes beyond physical variables to include social,emotional,and ethical *** role of pre-donation sociopsychological evaluation of the donor candidate is as important to the success of the procedure as is the medical *** implies recovery from the operation and pro-mpt engagement in pre-transplant professional and social activities,without leading to psychological or physical *** profiling of potential living liver donors(PLLD)and evaluation of quality of life(QOL)can influence *** To evaluate the socio-demographics and psychological aspects(QOL,depression,and anxiety)of PLLD for pediatric liver transplantation in a cohort of 250 *** This was a retrospective cohort study of 250 PLLD who underwent psychological pre-donation evaluation between 2015 and *** the recipients were *** Beck anxiety inventory,Beck depression inventory,and 36-item short-form health survey(SF-36)scores were used to evaluate anxiety(Beck anxiety inventory),depression(Beck depression inventory),and QOL,*** A total of 250 PLLD were *** of them were women(54.4%),and the mean age was 29.2±7.2 years.A total of 120(48.8%)PLLD were employed at the time of evaluation for donation;however,most had low income(57%earned<2 times the minimum wage).A total of 110 patients(44%)did not finish the donation process,and 247 PLLD answered a questionnaire to evaluate depression,anxiety,and QOL(SF-36).Prevalence of depression was of 5.2%and anxiety 3.6%.Although most of the PLLD were optimistic regarding the donation process and never had doubts about becoming a donor,some traces of ambivalence were observed:46%of the respondents said they would feel relieved if a deceased donor became *** PLLD had a low prevalence of anxiety and *** foundation for effective and sa

关键词： Liver transplantation Children Outcomes Living donation

How Learning from Trauma Benefits the Obstetric Population?Damage Control Surgery

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Maternal-Fetal Medicine 2023年第4期5卷 248-252页

作者： María Fernanda Escobar Vidarte Daniela Nasner Albaro José Nieto-Calvache María paula Echavarría Javier Andrés Carvajal Department of Obstetrics and Gynecology High Complexity Obstetric UnitFundación Valle del LiliCali 760032Colombia Department of Obstetrics and Gynecology School of MedicineUniversidad IcesiCali 760032Colombia Clinical Research Center Fundación Valle del LiliCali 760032Colombia

The recent implementation of trauma-validated damage control strategies in severe postpartum hemorrhage proves the importance of interdisciplinary management in the obstetric *** hemorrhage control techniques and damage control surgery are clear examples of how learning from trauma can benefit the obstetric ***,most obstetric programs do not include training in this type of ***,it has been shown that these interventions are useful in the management of severe postpartum *** aim of this article is to introduce the application of damage control surgery principles in the management of massive obstetric *** propose to include appropriate training and the implementation of damage control surgery in obstetric management *** prompt application of damage control principles can be considered in patients with persistent hemodynamic instability despite control of the source of bleeding.

关键词： Postpartum hemorrhage Damage control Obstetric hemorrhage Critical care Maternal mortality

Objective tinnitus secondary to palatal tremor:Two case reports and brief literature review

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Journal of Otology 2022年第2期17卷 107-110页

作者： Raúl Mellidez Acosta Miguel Saro-Buendía Lidia Torres García Maria Antonia Marcos Pena Carlos De paula Vernetta Hospital Universitarii Politecnic LaFe Institutode Investigacion Sanitaria LaFeUniversity of ValenciaSpain

Objective tinnitus is defined as a type of tinnitus perceived by both the patient and external *** paper presents two cases of objective tinnitus related to palatal tremor,along with a literature *** tremor is a condition characterized by soft palate involuntary *** types of palatal tremor have been described:symptomatic palatal tremor and essential palatal tremor,with different clinical *** workup is based on medical history and physical examination,including direct oropharynx exploration and cavum visualization through *** MRI is mandatory in all *** a secondary origin is suspected,additional lab tests should be performed based on clinical ***-line treatment is botulinum toxin injection into the levator veli palatini and tensor veli palatini muscles,with velopharyngeal insufficiency being its main adverse *** medications have not been shown to be effective.

关键词： Objetive tinnitus Palatal tremor Botox injection

Urban development and industrialization impacts on semiaquatic bugs diversity: A case study in eastern Amazonian streams

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Water Biology and Security 2022年第4期1卷 43-50页

作者： Erlane Jose Cunha Gabriel Martins Cruz Ana paula Justino Faria John Nascimento De Oliveira Leandro Juen Programa de Pos-graduaçao em Ecologia Universidade Federal do Para e Embrapa Amazonia OrientalRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-graduaçao em Zoologia Universidade Federal do Para/Museu Paraense Emílio GoeldiRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Laboratorio de Ecologia e Conservaçao Universidade Federal do Para/Rua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-Graduaçao em Agricultura e Ambiente Laboratorio de Ciencias Ambientais e BiodiversidadeUniversidade Estadual do MaranhaoSao LuísBrazil Hydro Alunorte Rodovia PA–481km 12Distrito de MurucupiCEP68447-000BarcarenaParaBrazil

Landscape changes have caused the decline of biodiversity and affected the integrity of aquatic *** this study,we assessed the influence of industrialization associated with urban development on aquatic environments and the biodiversity of semiaquatic bugs(Gerromorpha)at different scales(water quality,habitat,and landscape).Using the simple buffer method,we evaluated nine streams assessing water quality variables,habitat structure,and linear features(radius¼300 m,length¼600 m)for the percentage of land use and land *** results found that species composition of Gerromorpha was mainly affected by primary forest cover,habitat integrity,leaves substrate,and water temperature(29%explanation),and the species richness was mostly influenced by the habitat integrity index(HII)and phosphorus *** model that best explained the variation in species richness showed a positive relationship with phosphorus concentrations and HII(43%variation).Therefore,our results show that those human activities are the main factors altering aquatic biodiversity from local to regional ***,the retention of riparian forests–even in urban and industrialized areas–can maintain the diversity of semiaquatic insect species by providing suitable environments for the habitat,feeding,and reproductive requirements of these aquatic ***,our results also show that the management of riparian vegetation in urban areas and industrial complexes promotes aquatic biodiversity conservation in regions under development in the Amazon.

关键词： Aquatic insects Biodiversity conservation Gerromorpha Stream conservation Land use