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Effects of six months losartan administration on liver fibrosis in chronic hepatitis C patients: A pilot study

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World Journal of Gastroenterology 2005年第48期11卷 7560-7563页

作者： Silvia Sookoian María Alejandra fernández Gustavo Casta(n|~)o Instituto de Investigaciones Médicas A.Lanari Cathedra of Physiopathology Gastroenterology Section

AIM： TO evaluate the safety and efficacy of chronic administration of Iosartan on hepatic fibrosis in chronic hepatitis C patients.METHODS： Fourteen patients with chronic hepatitis C non-responders （n = 10）, with contraindications （n = 2） or lack of compliance （n = 2） to interferon plus ribavirin therapy and liver fibrosis were enrolled. Liver and renal function test, clinical evaluation, and liver biopsies were performed at baseline and after Iosartan administration at a dose of 50 mg/d during the 6 mo. The control group composed of nine patients with the same inclusion criteria and paired liver biopsies （interval 6-14 mo）. Histological activity index （HAI） with fibrosis stage was assessed under blind conditions by means of Ishak＇s score. Subendothelial fibrosis was evaluated by digital image analyses.RESULTS： The changes in the fibrosis stage were significantly different between Iosartan group （decrease of 0.5±1.3） and controls （increase of 0.89±1.27; P〈0.03）. In the treated patients, a decrease in fibrosis stage was observed in 7/14 patients vs 1/9 control patients （P〈0.04）. A decrease in sub-endothelial fibrosis was observed in the Iosartan group. No differences were found in HAI after Iosartan administration. Acute and chronic decreases in systolic arterial pressures （P〈0.05） were observed after the Iosartan administration, without changes in mean arterial pressure or renal function.CONCLUSION： Chronic AT-Ⅱ type 1 receptor （AT1R） blockade may reduce liver fibrosis in patients with chronic hepatitis C.

关键词： Hepatitis C Liver fibrosis Losartan AT1R Chronic liver disease Angiotensin Ⅱ

Comorbidity negatively influences prognosis in patients with extrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2009年第42期15卷 5279-5286页

作者： Mario fernández-Ruiz Juan-Manuel Guerra-Vales Francisco Colina-Ruizdelgado Department of Internal Medicine University Hospital "12 de Octubre"Avenue Córdobas/nUniversidad ComplutenseMadrid 28041Spain Hospital Tumor Registry University Hospital "12 de Octubre"Avenue Córdobas/nUniversidad ComplutenseMadrid 28041Spain

AIM:To study the outcome and prognostic factors in a series of patients with extrahepatic cholangiocarcinoma and determine the impact of comorbidity on ***:A retrospective analysis of 68 patients with extrahepatic cholangiocarcinoma(perihilar,n = 37;distal,n = 31) seen at a single tertiary-care institution during the period 1999-2003 was *** on presentation,management,and outcome were assessed by chart *** confirmation was obtained in 37 cases(54.4%) .Comorbidity was evaluated by using the Charlson comorbidity index(CCI) .RESULTS:Mean age at diagnosis was 73.4 ± 11.5 *** was the most common symptom presented(86.8%) .Median CCI score was 1(range,0 to 4) .Nineteen patients(27.9%) underwent tumor *** biliary drainage was performed in 39 patients(57.4%) ,and 6 patients(8.8%) received only best supportive ***-free margin status(R0) was achieved in 15 cases(78.9% of resection group) .Baseline serum carbohydrate antigen 19-9(CA 19-9) level was revealed to be an independent predictor of surgical treatment(P = 0.026) .Overall median survival was 3.1 ± 0.9 mo,with 1-and 2-year survival rates of 21% and 7%,*** the univariate analysis,tumor resection,CCI score,and serum CA 19-9 levels correlated significantly with *** the multivariate analysis,only resection(HR 0.10;95% CI,0.02-0.51,P = 0.005) and a CCI score ≥ 2(HR 3.36;95% CI,1.0-10.9,P = 0.045) were found to independently predict ***:Tumor resection and comorbidity emerged as significant prognostic variables in extrahepatic *** evaluation instruments should be applied in the clinical management of such patients.

关键词： Charlson index Cholangiocarcinoma Comorbidity Prognosis Survival

Analysis of Line-Edge Roughness Using EUV Scatterometry

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Nanomanufacturing and Metrology 2022年第2期5卷 149-158页

作者： Analía fernández Herrero Frank Scholze Gaoliang Dai Victor Soltwisch Helmholtz-Zentrum Berlin Albert-Einstein Str.1512489BerlinGermany Physikalisch-Technische Bundesanstalt Abbestr.2–1210587BerlinGermany Physikalisch-Technische Bundesanstalt Bundesallee 10038116BraunschweigGermany

Smaller and more complex three-dimensional periodic nanostructures are part of the next generation of integrated electronic ***,decreasing the dimensions of nanostructures increases the effect of line-edge roughness on the performance of the *** methods for characterizing three-dimensional nanostructures are required for process ***,extreme-ultraviolet(EUV)scatterometry is exploited for the analysis of line-edge roughness from periodic *** line with previous observations,differences are observed between line edge and line width *** angular distribution of the diffuse scattering is an interplay of the line shape,the height of the structure,the roughness along the line,and the correlation between the ***,existing theoretical methods for characterizing nanostructures using scatterometry do not cover all these *** are shown here and the demands for future development of theoretical approaches for computing the angular distribution of the scattered X-rays are discussed.

关键词： Line-edge roughness LER LWR EUV scatterometry Debye-Waller factor

New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

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Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： Carlos González-fernández Pau González Francisco Javier Rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

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Liver cirrhosis and sarcopenia:a dreadful combination

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 729-731页

作者： Mohammad Shafi Kuchay JoséIgnacio Martínez-Montoro Camilo Julio Llamoza-Torres JoséCarlos fernández-García Bruno Ramos-molina Division of Endocrinology and Diabetes Medanta The Medicity HospitalGurugramHaryanaIndia Department of Endocrinology and Nutrition Virgen de la Victoria University HospitalInstituto de Investigación Biomédica de Málaga(IBIMA)Faculty of MedicineUniversity of MálagaMálagaSpain Department of Gastroenterology Unit of HepatologyHospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Department of Endocrinology and Nutrition Regional University Hospital of MálagaInstituto de Investigación Biomédica de Málaga(IBIMA)Faculty of MedicineUniversity of MálagaMálagaSpain Obesity and Metabolism Research Laboratory Biomedical Research Institute of Murcia(IMIB)MurciaSpain

Patients with liver cirrhosis,irrespective of etiology,have increased risk of liver-related and all-cause mortality(1).Also,the severity of cirrhosis determines health *** instance,patients with compensated cirrhosis have a nearly five-fold increased risk of death,while those with decompensated cirrhosis have approximately a 10-fold increased risk compared with the general population(1).Furthermore,the median survival time of patients with compensated cirrhosis is 12 years,while it is only 1.8 years in those with decompensated cirrhosis(2).Moreover,the presence of intercurrent conditions,such as sarcopenia(loss of skeletal muscle mass and function)may also compromise the prognosis of patients with cirrhosis(3).

关键词： cirrhosis mortality prognosis

Is physical performance(in mice)increased by Veillonella atypica or decreased by Lactobacillus bulgaricus?

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Journal of Sport and Health Science 2020年第3期9卷 197-200页

作者： Manuel fernández-Sanjurjo Javier fernández Cristina Tomás-Zapico Benjamín fernández-García Claudio J.Villar Felipe Lombó Eduardo Iglesias-Gutiérrez Department of Functional Biology PhysiologyUniversity of OviedoAsturias 33006Spain Health Research Institute of the Principality of Asturias(ISPA) Asturias 33011Spain Department of Functional Biology MicrobiologyUniversity of OviedoOviedo 33006Spain Department of Morphology and Cell Biology AnatomyUniversity of OviedoOviedo 33006Spain

*** Regular exercise induces changes in the overall diversity and in the relative abundance of certain gut microbiota phyla and families in humans1,2 and in animal models.3,4 This relationship has attracted a great deal of interest because it is one of the mechanisms involved in the health benefits of regular exercise3 that could also influence performance.5 A recent publication by Scheiman et al.

关键词： al. performance Regular

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Cenozoic basin evolution of the Central Patagonian Andes:Evidence from geochronology, stratigraphy, and geochemistry

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Geoscience Frontiers 2019年第3期10卷 1139-1165页

作者： A.Encinas A.Folguera R.Riffo P.molina L.fernández Paz V.D.Litvak D.A.Colwyn V.A.Valencia M.Carrasco Departamento de Ciencias de la Tierra Facultad de Ciencias Químicas Universidad de Concepción Instituto de Estudios Andinos Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales Departamento de Ciencias Geológicas CONICET-Universidad de Buenos Aires Instituto de Estudios Andinos Don Pablo Groeber (IDEAN) Department of Geology & Geophysics Yale University School of the Environment Washington State University

The Central Patagonian Andes is a particular segment of the Andean Cordillera that has been subjected to the subduction of two spreading ridges during Eocene and Neogene times. In order to understand the Cenozoic geologic evolution of the Central Patagonian Andes, we carried out geochronologic(U-Pb and^(40)Ar/^(39)Ar), provenance, stratigraphic, sedimentologic, and geochemical studies on the sedimentary and volcanic Cenozoic deposits that crop out in the Meseta Guadal and Chile Chico areas(～47°S). Our data indicate the presence of a nearly complete Cenozoic record, which refutes previous interpretations of a hiatus during the middle Eocene-late Oligocene in the Central Patagonian Andes. Our study suggests that the fluvial strata of the Ligorio Marquez Formation and the flood basalts of the Basaltos Inferiores de la Meseta Chile Chico Formation were deposited in an extensional setting related to the subduction of the Aluk-Farallon spreading ridge during the late Paleocene-Eocene. Geochemical data on volcanic rocks interbedded with fluvial strata of the San Jose Formation suggest that this unit was deposited in an extensional setting during the middle Eocene to late Oligocene. Progressive crustal thinning allowed the transgression of marine waters of Atlantic origin and deposition of the upper Oligocene-lower Miocene Guadal Formation. The fluvial synorogenic strata of the Santa Cruz Formation were deposited as a consequence of an important phase of compressive deformation and Andean uplift during the early-middle Miocene. Finally, alkali flood basalts of the late middle to late Miocene Basaltos Superiores de la Meseta Chile Chico Formation were extruded in the area in response to the suduction of the Chile Ridge under an extensional regime. Our studies indicate that the tectonic evolution of the Central Patagonian Andes is similar to that of the North Patagonian Andes and appears to differ from that of the Southern Patagonian Andes, which is thought to have been the s

关键词： Central Patagonian Andes U-Pb geochronology Ar-Ar geochronology Geochemistry Stratigraphy Sedimentology

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Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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Ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán Matías Mastrangelo Marcelo Nosetto Pablo E.Villagra Ezequiel Balducci Martín Pinazo Roxana P.Eclesia Alejandra Von Wallis Sebastián Villarino Francisco Alaggia Marina González Polo Silvina Manrique Pablo A.Meglioli Julián Rodríguez-Souilla Martín Mónaco Jimena E.Chaves Ariel Medina Ignacio Gasparri Eugenio Alvarez Arnesi María Paula Barral Axel von Müller Norberto M.Pahr Josefina Uribe Echevarria Pedro fernández Marina Morsucci Dardo López Juan Manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La Manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco Laura Cavallero Gualberto Zalazar Guillermo Martínez Pastur Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en Energía No Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección Nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad Nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administración de Parques Nacionales (APN) Parque Nacional Los Alerces Centro de Estudios Ambientales Integrados (CEAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（NDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United Nations Framework Conven-tion on Climate Change（UNFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（REDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest Reference Emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google Earth Engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on Enhanced Vegetation Index（EVI） and land surface temperature（LST） images from Landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity Native forest Climate change mitigation Modelling Resilience

Cumulative effects of volcanic ash on the food preferences of two Orthopteran species

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Insect Science 2017年第4期24卷 640-646页

作者： Valeria fern&ndez-Arhex Maria E. Amadio Octavio A. Bruzzone Instituto Nacional de Tecnologia Agropecuaria Estacion Experimental Agropecuaria-Bariloche CC277 A v Modesta Victoria 4450 (8400) San Carlos de Bariloche Argentina Lab ECO TONO-INIBIOMA Pie. Gutierrez 850 San Carlos de Bariloche Rio Negro Argentina Centro Cientifico Tecnologico - Consejo Nacional de Investigaciones Cientificas y Tocnicas (CCT-CONICET) Patagonia Norte. Av. de los Pioneros 2350 San Carlos de Bariloche Rio Negro Argentina

Inert dusts are an early form of insecticide which is still in use. One of the most common inert dusts is volcanic ash. In order to study the reaction ofrangeland grasshoppers, Dichroplus vittigerum （Acrididae） and a katydid, t]wgilis mendosensis （Phaneropteridae）, to the presence of volcanic ash in their food sources and how this reaction changed as a function of time, we conducted paired preference tests between clean leaves of their pre- ferred host plant and leaves exposed to volcanic ash of different grain size. The behavioral response was measured as the rating on the Thurstonian preference scale of leaves with ash in relation to clean leaves. The results showed that the avoidance of volcanic ash increased as a function of time in both species. Both species studied are occasionally exposed to vol- canic activity, and come from an area in which a volcanic eruption had recently occurred. As their populations did not decrease after the ash fall, we propose that some behavioral responses such as avoidance of places with ash, works as tolerance mechanism to inert dusts exposure.

关键词： Burgilis mendosensis Dichroplus vittigerum inert dust preference test thurstone scale