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Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de amorim Miguel soares Conceição Rodrigo Menezes Jales Patrick Nunes Pereira Luis Otávio Sarian Glauco Baiocchi Sophie derchain Agnaldo Lopes da Silva Filho department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

In Silico and in Vitro Analysis of Pyrazolone derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of Biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene soares Silva Tiago soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa amorim Leonardo Alves Miceli Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

Ecological study of gastric cancer in Brazil:Geographic and time trend analysis

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World Journal of Gastroenterology 2014年第17期20卷 5036-5044页

作者： César Augusto amorim Jéssica Pronestino Moreira Luisa Rial Antonio José Carneiro Homero soares Foga?a Celeste Elia Ronir Raggio Luiz Heitor Siffert Pereira de Souza Servi?o de Gastroenterologia Departamento de Clínica MédicaHospital UniversitárioUniversidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Instituto de Epidemiologia e Saúde Coletiva Universidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil

AIM: To investigate the geographic distributions and time trends of gastric cancer (GC) incidence and mortality in Brazil.

关键词： Gastric cancer Ecological study Hospitalization Lethality rate

Isolation of Filamentous Fungi from the Caatinga Region and Production of Amylolytic Enzymes of Great Industrial Interest

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Journal of Biosciences and Medicines 2020年第11期8卷 152-164页

作者： Ingrid Cristina soares amorim Gessica Oliveira Marinho Tarcisio Michael Ferreira soares de Oliveira Juan Pedro Bretas Roa Arlete Barbosa dos Reis David Lee Nelson Thiago Machado Pasin Vivian Machado Benassi Instituto de Ciência e Tecnologia Universidade Federal dos Vales dos Jequitinhonha e Mucuri Campus JK Diamantina Brasil Programa de Pós-Graduaç &atilde o em Biocombustíveis Universidade Federal dos Vales dos Jequitinhonha e Mucuri Campus JK Diamantina Brasil departamento de Bioquímica e Imunologia Faculdade de Medicina de Ribeir&atilde o Preto Universidade de S&atilde o Paulo Ribeir&atilde o Preto Brasil

The industrial importance and the high cost of the commercial amylase require the study of microorganisms that produce these enzymes. For this reason, the objective of this work was to isolate filamentous fungi from a region of the caatinga and evaluate their potential for the production of amylase. Four soil samples were collected from a deactivated dump located in the city of Diamantina, MG, in a region of the caatinga. The analysis of amylolytic production in a submerged medium at the ideal temperature of each microorganism was performed using the saccharification method, and the reducing sugars formed were quantified by DNS. Fourteen filamentous fungi were isolated, which had different morphological aspects. Regarding amylase production, a mean activity of 0.477 U·mL-1 was obtained with the isolates I 1.2.1 and I 4.4.1. These results bring important information regarding the biodiversity of the caatinga, in addition to the isolation of microorganisms that can be used as biological machinery to obtain metabolites with high biotechnological and industrial potential.

关键词： Amylolytic Enzyme Bioprospecting Filamentous Fungi Industrial Interest

Homocysteine and Cardiovascular Risk Factors in Overweight or Obese Children and Adolescents

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Health 2015年第3期7卷 381-389页

作者： Adriana amorim de Farias Leal Monica Oliveira da Silva Simoes Alessandra Teixeira Carla Campos Muniz Medeiros Astrid Camelo Palmeira Gabriella Menezes Almeida de Castro Mayara Larrys Gomes de Assis Maísa soares de Oliveira Graduate Program in Public Health State University of ParaibaCampina GrandeBrazil department of Pharmacy State University of ParaibaCampina GrandeBrazil department of Nursing State University of ParaibaCampina GrandeBrazil Scientific Initiation Program State University of ParaibaCampina GrandeBrazil

Introduction: Among the extrinsic factors, homocysteine (Hy) stands out, which is an intermediate amino acid of the intracellular metabolism of methionine involved in the process of cellular oxidation, which promotes the installation of atheromatous plaques and, therefore, is considered as an emerging cardiovascular risk factor. Objective: To evaluate the plasma homocysteine levels (Hy) in overweight or obese children and adolescents and their relation with cardiovascular risk factors. Methods: A cross-sectional study was conducted from July 2011 to May 2012 with overweight or obesity children and adolescents aged 2 to 18 years followed at the Center for Childhood Obesity (IOC), Campina Grande-PB. A structured form was used to record demographic, socioeconomic and clinics variables and the patients underwent laboratory tests to define their lipid and glucose profiles and measurement of plasma Hy levels. Results: The study evaluated a total of 165 children and adolescents with mean age of 12.5 (±2.5) years;the majority were female (57.0%). Regarding the lipid profile, there was more individuals with low HDL cholesterol (88.5%). Plasma Hy levels were high in 24.2% of the sample. The mean Hy levels ranged from 4.3 to 18.9 μmol/L, being higher in males, obese adolescents and also in patients with high insulin levels and resistance. Conclusions: The results shown in this study emphasize the importance of detecting and controlling the plasma Hy levels as an independent cardiovascular risk factor, and the need for further studies to evaluate the clinical and biological factors related to alterations in its metabolism.

关键词： Homocysteine Cardiovascular Diseases Child Adolescent Obesity

Variables Associated with Cirrhosis Diagnosis in Patients with Chronic Hepatitis C: A Case-Control Study

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Health 2015年第12期7卷 1634-1641页

作者： Gilmar amorim de Sousa Iris do Céu Clara Costa Dyego Leandro Bezerra de Souza Fabia Barbosa de Andrade Lívia Medeiros soares Celani Ranna Santos Pessoa Marlon César de Souza Filho Daniel Fernandes Mello de Oliveira Luana Lopes de Medeiros Lucila Samara Dantas de Oliveira Maria Flávia Monteiro The Integrated department of Medicine Federal University of Rio Grande do Norte UFRN Natal Brazil The Post-Graduate Program in Collective Health of UFRN Natal Brazil Gastroenterology Program of the University Hospital Onofre Lopes/UFRN Natal Brazil The Medical School of UFRN Natal Brazil

The diagnosis of liver cirrhosis in patients with chronic hepatitis C has not always been easy, since the gold standard method is the liver biopsy, which is an invasive procedure with interobserver accuracy problems and there have been reports of complications including records of deaths due to hemoperitoneum. Cirrhosis changes the prognosis of the subject with hepatitis C and requires a different clinical management. This study aimed to identify clinical and laboratory variables associated with the diagnosis of cirrhosis in the ultrasonography of patients infected with hepatitis C. In a case-control study, we evaluated 70 cirrhotic patients with chronic hepatitis C compared to a control group of 70 non-cirrhotic people with positive HCV. The results showed, through logistic regression analysis, that the variables blood donor and professional athlete, adjusted for alcohol consumption, showed OR 0.24 and 0.18, with p values of 0.044 and 0.035, respectively. We conclude that the diagnosis of cirrhosis in patients with chronic hepatitis C remains challenging, but the patients with the condition of blood donor or professional athlete prove to be less likely to cirrhosis in ultrasonography in the initial consultation.

关键词： Cirrhosis Biomakers Fibrosis Hepatitis C Virus Clinical Diagnosis Biopsy Non-Invasive Methods Scores Ultrasonography

The Phytochemical Profile and Photoprotective Potential of Bark and Leaves of Erythrina velutina Willd.—A Medicinal Species from the Caatinga Region of Brazil

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Journal of Biosciences and Medicines 2023年第12期11卷 325-342页

作者： Bruno de Almeida Andrade Allan Jonathan Chernichiarro Corrêa Ana Klarissa soares Gomes Patrícia Maria da Silva Neri Cruz Aline Michaele de Saint-George Albuquerque Cheron Valerium Thijan Nobre de Almeidae Castro Décio Henrique Araújo Salvadôr de Mello Cláudia Sampaio de Andrade Lima Ricardo Yara Elba Lúcia Cavalcanti de amorim department of Pharmaceutical Sciences Federal University of Pernambuco Recife Brazil Pharmacy Course Mauricio de Nassau University Center Recife Brazil department of Biophysics Federal University of Pernambuco Recife Brazil departament of Biomedical Engineering Federal University of Pernambuco Recife Brazil

The use of medicinal plants as therapeutic and economic resources has been on the rise in recent years. In Brazil, however, increasing doubt is being cast on the quality of these products, owing to the prevalence of adulteration and fraud. Solar radiation can cause serious damage to human skin, as a result, mostly, of ultraviolet light, which is a cause of skin cancer. Photoprotective substances are capable of absorbing, reflecting, or refracting ultraviolet radiation and thus protecting skin from exposure to sunlight. The present study aimed to characterize samples and examine the phytochemical profile and photoprotective potential of bark and leaves of Erythrina velutina Willd. The samples underwent five extraction methods using 80% ethanol. The phenolic content was measured using spectrophotometry. Antioxidant activity was examined using the DPPH and the photoprotective properties of the plant extracts were assessed using the method developed by Mansur. There was a quantitative difference in some groups of metabolites, with higher levels of tannin in the bark and of flavonoids in the leaves. The latter showed greater DPPH free radical scavenging capacity than the bark, although higher levels of SPF were obtained from the bark, with no statistically significant differences between methods. The results indicate that Erythrina velutina Willd. has potential as a photoprotector.

关键词： Phytochemical Caatinga Phytochemistry Sun Protection Factor (SPF)

Characterization of Virulence Factors in Enteroaggregative and Atypical Enteropathogenic Escherichia coli Strains Isolated from Children with Diarrhea

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Advances in Infectious Diseases 2012年第4期2卷 135-142页

作者： Thiago Azevedo Feitosa Ferro Francyelle Costa Moraes Andreia Meneses da Silva Claude Porcy Leandro amorim soares Cristina Andrade Monteiro Nyla Thyara Melo Lobao Francisco Amazonas Assis de Mello Valério Monteiro-Neto Patrícia de Maria Silva Figueiredo Research Group of Endemic and Parasitic Diseases CEUMA UniversitySao LuisBrazil Federal Institute of Maranhao Sao LuisBrazil Health and Biological Sciences Center Federal University of MaranhaoSao LuísBrazil

Enteroaggregative (EAEC) and atypical enteropathogenic (EPEC) Escherichia coli are important bacterial etiologic agents causing diarrhea among children. The aim of the present study was to examine the impact of virulence factors predisposes to diarrhea. In this study some virulence properties were examined on 11 EAEC and 8 EPEC strains identified by Polymerase Chain Reaction (PCR), isolated from stool samples of children were analyzed genotypically and phenoltypically for the prevalence of virulence factors. The most frequently detected factor was resistance to serum (94%), followed by curli fimbriae (78%), biofilm production (73%), and gene coding for Extended-Spectrum Beta-Lactamase (ESBL) (68%). EPEC isolates showed at least three of the evaluated properties, while EAEC isolates showed at least two. The prevalence of these virulence factors between the two strains showed no statistical difference. This study showed the heterogeneity of the virulence profile of the isolates of EAEC and atypical EPEC strains and suggests that this diversity may influence in the disease severity.

关键词： E.coli Diarrhea Virulence Factors

Oncologic Outcomes of Breast Cancer Patients Treated with Oncoplastic Surgery

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Journal of Cancer Therapy 2013年第1期4卷 331-337页

作者： Leda Marques Ribeiro Daniela Francescato Veiga Ivanildo Archangelo-Junior Fabiola soares Moreira Campos Renata Bites amorim Mirian Fatima Brasil Engelman Yara Juliano Lydia Masako Ferreira Division of Mastology Department of GynecologyUniversidade do Vale do SapucaiPouso AlegreBrazil Division of Plastic Surgery Department of SurgeryUniversidade do Vale do SapucaiPouso AlegreBrazil Division of Plastic Surgery Department of SurgeryUniversidade Federal de Sao PauloSao PauloBrazil department of Pathology Universidade do Vale do SapucaiPouso AlegreBrazil department of Bioestatistics Universidade do Vale do SapucaiPouso AlegreBrazil.

Background: The impact of breast appearance after breast cancer surgical treatment on patients’ quality of life led to the development of the oncoplastic approach. However, studies reporting oncologic results associated with this treatment strategy are scarce. This cross-sectional study was designed to assess oncologic outcomes among patients who underwent oncoplastic surgery. Methods: A total of 190 breast cancer patients who underwent breast-conserving surgery were enrolled. Fifty of them underwent oncoplastic surgery and 140 had none breast reconstruction procedure (control group). All surgeries were performed by the same surgical team. Results: Groups were similar with regard to staging, histological type, grade of the tumor, presence of intraductal component, hormone receptors and nodal commitment. Patients in oncoplastic surgery group had larger tumors (ρ = 0.001) and more lymphovascular invasion (ρ = 0.047). Further, a higher proportion of them underwent chemotherapy (ρ = 0.030). Follow-up time of control group was longer (ρ = 0.05), and these patients also had a longer relapse-free survival time (ρ = 0.001). Local recurrence rate was 5.8% (11/190) and it was significantly greater in the oncoplastic surgery group (8/11, ρ = 0.001). Time to local recurrence after surgery was longer in oncoplastic surgery group (ρ = 0.002). Overall, patients in oncoplastic surgery group were younger (ρ = 0.001), but at the time of local recurrence, patients in oncoplastic surgery group were older than those in control group (ρ = 0.0002). Conclusions: Among the studied patients, local recurrence rate was greater in those who underwent oncoplastic surgery.

关键词： Breast Cancer Mastectomy Segmental Breast Reconstruction Local Neoplasm Recurrence