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Mortality rate after total knee arthroplasty or total hip arthroplasty in patients with a history of liver transplant

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World Journal of Orthopedics 2024年第4期15卷 310-311页

作者： E Carlos rodriguez-Merchan Department of Orthopedic Surgery La Paz University Hospital-IdiPazMadrid 28046Spain

In this editorial I comment on the article by Ahmed et al published in a recent issue of the World J Orthop 2023;14:*** is well known that patients who have undergone a liver transplant(LT)may need to have a total hip arthroplasty(THA)or total knee arthroplasty(TKA)*** et al stated that the mortality rate in these patients was similar to the one of the general ***,there are three articles previously published that found higher mortality in LT patients who experienced THA/TKA than in the general population(individuals without LT).Therefore,in this Editorial I would like to point out that there is controversy in the literature regarding whether LT patients undergoing THA/TKA have higher mortality than the general ***,future research should attempt to resolve this controversy.

关键词： Liver transplant Total knee arthroplasty Total hip arthroplasty Results Mortality

Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice

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World Journal of Gastroenterology 2018年第4期24卷 461-474页

作者： Roberto rodriguez-Echevarria Jose Macias-Barragan Marcela Parra-Vargas Judith Rebeca Davila-rodriguez Eduardo Amezcua-Galvez Juan Armendariz-Borunda Institute for Molecular Biology and Gene Therapy-CUCS Department of Molecular Biology and GenomicsUniversity of GuadalajaraGuadalajara 44340Mexico Department of Health Sciences-CUValles University of GuadalajaraGuadalajara 46600Mexico Hospital Civil de Guadalajara Guadalajara 46600Mexico

AIM To study the effect of 18-hydroxy-eicosapentaenoic acid(18-HEPE) and 17-hydroxy-docosahexaenoic acid(17-HDHA) in a murine model of obesity/nonalcoholic fatty liver *** C57 BL/6 mice were fed with standard chow diet(CD) or high-fat, fructose-enriched diet(HFD) for 16 wk. Then, three groups were treated for 14 d with either, diet switch(HFD for CD), 18-HEPE, or 17-HDHA. Weightand fasting glucose were recorded on a weekly basis. Insulin tolerance test was performed at the end of treatment. Histological analysis(HE and Masson's trichrome stain) and determination of serum insulin, glucagon, glucagon-like peptide 1(GLP-1), glucose-dependent insulinotropic polypeptide, adiponectin and resistin were carried out as well as liver proteins by western *** Mice treated with hydroxy-fatty acids 18-HEPE and 17-HDHA displayed no weight loss or improved insulin sensitivity. However, these mice groups showed a significant amelioration on serum GLP-1, adiponectin and resistin levels. Also, a significant reduction on inflammatory infiltrate was observed at both portal and lobular zones. Furthermore, up-regulation of PPARα/γ protein levels was observed in liver tissue and it was associated with decreased levels of NF-κB also determined by western blot analysis. On the other hand, diet switch regimen resulted in a marked improvement in most parameters including: weight loss, increased insulin sensitivity, decreased steatosis, restored levels of insulin, glucagon, leptin, adiponectin and resistin. However, no significant changes were observed regarding inflammatory infiltrate in this last *** 18-HEPE and 17-HDHA differentially exert hepatoprotective effects through up-regulation of nuclear receptors PPARα/γ and amelioration of serum adipokines profile.

关键词： Nonalcoholic fatty liver disease Polyunsaturated fatty acids 18-hydroxy-eicosapentaenoic acid 17-hydroxy-docosahexaenoic acid Obesity

Novel Fast Operating Moving Coil Actuator with Compensation Coil for HVDC Circuit Breakers

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CSEE Journal of Power and Energy Systems 2021年第5期7卷 1041-1050页

作者： Boyuan Yin Xianwu Zeng John F.Eastham Damian Vilchis-rodriguez Xiaoze Pei Department of Electronic&Electrical Engineering.University of Bath.Bath.United Kingdom Department of Mechanical Engineering University of Bath.Bath.United Kingdom. Power and Energy Division School of Electrical and Electronic EngineeringThe University of ManchesterManchester M139PLUnited Kingdom.

DC circuit breakers are major enabling components for multi-terminal HVDC *** key design targets are operating speed and *** paper proposes a novel moving coil actuator using a compensation coil topology to operate mechanical circuit *** topology aims to significantly improve the magnetic field saturation and reduce the system inductance,so that the operating speed is *** possible connection methods for the compensation coils are proposed and analyzed using finite element modeling,ensuing simulation results are compared and *** operating speed of the moving coil actuator with compensation coils is significantly improved compared with the original moving coil *** moving coil actuator with compensation coils can open a distance of 5 mm within 2.8 ms and the peak efficiency is 47%.

关键词： Compensation coil DC circuit breaker HVDC mechanical circuit breaker moving coil actuator

Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing

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Neural Regeneration Research 2022年第8期17卷 1652-1658页

作者： Carmen M.Labandeira Arturo Fraga-Bau David Arias Ron Elena Alvarez-rodriguez Pablo Vicente-Alba Javier Lago-Garma Ana I.rodriguez-Perez Department of Clinical Neurology Hospital Alvaro CunqueiroUniversity Hospital ComplexVigoSpain Laboratory of Cellular and Molecular Neurobiology of Parkinson’s Disease Research Center for Molecular Medicine and Chronic Diseases(CIMUS)IDISUniversity of Santiago de CompostelaSantiago de CompostelaSpain Department of Clinical Oncology University Hospital ComplexOurenseSpain Department of Endocrinology Hospital MeixoeiroUniversity Hospital ComplexVigoSpain Networking Research Center on Neurodegenerative Diseases(CiberNed) MadridSpain

In the last decade,attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system,as insulin in the brain is implicated in neuronal survival,plasticity,oxidative stress and *** mellitus and Parkinson’s disease are both aging-associated diseases that are turning into epidemics *** mellitus and insulin resistance not only increase the possibility of developing Parkinson’s disease but can also determine the prognosis and progression of Parkinsonian ***,there are no available curative or disease modifying treatments for Parkinson’s disease,but the role of insulin and antidiabetic medications in neurodegeneration opens a door to treatment repurposing to fight against Parkinson’s disease,both in diabetic and nondiabetic Parkinsonian ***,it is essential to comprehend how a frequent and treatable disease such as diabetes can influence the progression of neurodegeneration in a challenging disease such as Parkinson’s ***,we review the present evidence on the connection between Parkinson’s disease and diabetes and the consequential implications of the existing antidiabetic molecules in the severity and development of Parkinsonism,with a particular focus on glucagon-like peptide-1 receptor agonists.

关键词： antidiabetic diabetes mellitus dopamine exenatide glucagon-like peptide-1 insulin neurodegeneration neuroinflammation Parkinson’s disease repurposing

Review: Pathogenesis of cholestatic liver diseases

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World Journal of Hepatology 2020年第8期12卷 423-435页

作者： Raquel T Yokoda Eduardo A rodriguez Department of Anatomic and Clinical Pathology Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Department of Gastroenterology Hepatology and NutritionUniversity of UtahSalt Lake CityUT 84132United States

Cholestatic liver diseases(CLD)begin to develop after an impairment of bile flow start to affect the biliary *** actively participate in the liver response to injury and repair and the intensity of this reaction is a determinant factor for the development of *** cholangiopathies may ultimately lead to end-stage liver disease requiring at the end orthotopic liver *** narrative review will discuss cholangiocyte biology and pathogenesis mechanisms involved in four intrahepatic CLD:Primary biliary cholangitis,primary sclerosing cholangitis,cystic fibrosis involving the liver,and polycystic liver disease.

关键词： Cholestasis Cholangitis Epigenomics Immunogenetics Pathogenesis Bile acid

SIMPLE METHOD OF PUNCHING AND RE-LOCATING TISSUES FOR MANUAL CONSTRUCTION OF TISSUE MICROARRAY

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Journal of Shanghai Second Medical University(Foreign Language Edition) 2007年第1期19卷 58-60,F0003页

作者：郑林张帆王莉颜召文姜叙诚 Pierre-tienne Bouchet Department of Pathology School of Medicine Shanghai Jiaotong University Service d'anatomie pathologique Htel-Dieu de Paris France

A series of human tissue samples and cultured cell lines were formalin-fixed and paraffin-embedded. Specimen cylinder （1.2 -1.8ram） were punched by a modified bone marrow biopsy needle and arrayed on a recipient paraffin block. Microscopic analysis on the sections from this tissue microarray （ TMA ） block demonstrated that the spots of tissues and cells were well preserved, and the cultured cell samples were successfully embedded from 5 × 104 to 2 × 105 in number. These TMA sections were also suitable for immunohistochemistry and RNA in situ hybridization.

关键词： tissue microarray immunohistochemistry in situ hybridization

Importance of BRCA mutation for the current treatment of pancreatic cancer beyond maintenance

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World Journal of Gastroenterology 2021年第39期27卷 6515-6521页

作者： Joaquina Martínez-Galán Isabel rodriguez Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain

In this editorial,we comment on pancreatic cancer(PC),one of the most aggressive and lethal *** minimal improvements in survival rates have been achieved over recent *** chemotherapeutic regimens have little impact,and surgical resection remains the only reliable curative *** address current treatment options for these patients,focusing on the usefulness of breast cancer(BRCA)gene mutation as a prognostic biomarker and predictor of response to *** survival outcomes have been reported in patients with PC and mutant BRCA gene treated with first-line platinum-based ***,it appears appropriate to include BRCA gene status among clinical criteria used to select the chemotherapy *** addition,maintenance treatment with poly(ADP-ribose)polymerase inhibitors has been found to improve progression-free survival in patients with PC and mutated BRCA whose disease does not progress after first-line platinum-based *** combination has therefore been proposed as the optimal treatment regimen for these patients.

关键词： Pancreatic cancer Treatment BRCA Mutation Poly(ADP-ribose)polymerase inhibitor Maintenance

Atomic and Close-to-Atomic Scale Manufacturing:A Review on Atomic Layer Removal Methods Using Atomic Force Microscopy

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Nanomanufacturing and Metrology 2020年第3期3卷 167-186页

作者： Paven Thomas Mathew Brian J.rodriguez Fengzhou Fang Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) University College DublinDublin D04V1W8Ireland School of Physics University College DublinBelfieldDublin D04 V1W8Ireland Conway Institute of Biomolecular and Biomedical Research University College DublinBelfield.Dublin D04V1W8Ireland State Key Laboratory of Precision Measuring Technology and Instruments Centre of Micro/Nano Manufacturing TechnologyMNMT.Tianjin UniversityTianjin 300072China

Manufacturing at the atomic scale is the next generation of the industrial *** and close-to-atomic scalemanufacturing(ACSM)helps to achieve *** force microscopy(AFM)is a promising method for this purposesince an instrument to machine at this small scale has not yet been *** the need for increasing the number ofelectronic components inside an integrated circuit chip is emerging in the present-day scenario,methods should be adoptedto reduce the size of connections inside the *** can be achieved using ***,connecting moleculeswith the electrodes and then to the external world is *** must be laid to make this possible for *** layer removal,down to one atom,can be employed for this ***,theoretical works are beingperformed extensively to study the interactions happening at the molecule-electrode junction,and how electronic transportis affected by the functionality and robustness of the *** theoretical studies can be verified experimentally only if nano electrodes are *** is widely used in the semiconductor industry to fabricate electronic ***,carbon-based materials such as highly oriented pyrolytic graphite,gold,and silicon carbide find applications inthe electronic device manufacturing ***,ACSM of these materials should be developed *** paperpresents a review on the state-of-the-art research performed on material removal at the atomic scale by electrochemical andmechanical methods of the mentioned materials using AFM and provides a roadmap to achieve effective mass productionof these devices.

关键词： Atomic force microscopy Atomic-scale manufacturing Molecular scale devices Electrochemistry ACSM ManufacturingⅢ

Effects of corn gluten feed inclusion at graded levels in a corn-soybean diet on the ileal and fecal digestibility of growing pigs

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Journal of Animal Science and Biotechnology 2015年第1期6卷 63-68页

作者： Gerardo Mariscal Landin Tercia Cesaria Reis de Souza Ericka Ramirez rodriguez Centro Nacional de Investigacion en Fisiologia Animal Instituto Nacional de Investigaciones Forestales Agricolas y PecuariasKm 1Carretera a ColonAjuchitlan ColonQueretaro 76280Mexico Facultad de Ciencias Naturales Universidad Autonoma de QueretaroSantiago de QueretaroAv.De las Ciencias s/n Juriquilla 76000QueretaroQueretaroMexico

Background： This study aimed to determine the effect of the inclusion of corn gluten feed （CGF） on the apparent and standardized ileal digestibility of protein and amino acids and the apparent ileal and total tract digestibility of energy in growing pigs. The study was performed using 16 barrows （weight, 45.3 ±4.5 kg） that were fitted with a T cannula at the terminal ileum. There were four treatments： a corn-soybean diet without CGF and three corn-soybean diets containing increasing levels of CGF （65, 130, and 195 g/kg）. Data were analyzed according to a randomized complete block design, four blocks with four pigs each （one pig per treatment）. The trend of the response （linear or quadratic） was determined using orthogonal contrasts, and when a linear effect was determined, a linear equation was obtained. Results： The results showed that the inclusion up to 195 g/kg of CGF in the corn-soybean diet did not diminish the ileal digestibility （apparent and standardized） of protein and amino acids （P 〉 0.05）, except that of phenylalanine, cystine, and proline. A linear decrease （P 〈 0.05） per gram of CGF added to the diet in the apparent and standardized ileal digestibility of phenylalanine （0.011 and 0.015 percentage units, respectively）, cystine （0.048 and 0.043 percentage units, respectively）, and proline （0.045 and 0.047 percentage units, respectively） was noted. Similarly, ileal digestibility of dry matter and energy were adversely affected （reduced by 0.028 and 0.025 percentage units, respectively, per gram of CGF increment in the diet）. A significant （P 〈 0.05） linear reduction in total tract digestibility with increase in CGF amount in the diet was observed for energy （0.027 percentage units）, dry matter （0.027 percentage units）, crude protein （0.020 percentage units）, and neutral detergent fiber （0.041 percentage units） per gram of CGF added to the diet. Conclusion： CGF did not affect the ileal digestibility of protein and most amino acids but reduced the ileal an

关键词： Amino acids Corn gluten feed Energy Ileal digestibility Pigs Total tract digestibility