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Journal of Earth Science and Engineering 2013年第11期3卷 764-775页

作者： lar Uriah Tsuwang Kenneth Gusikit Rhoda Mangs Ayuba Department of Geology University of Jos Jos P.M.B. 2084 Nigeria

Code blue applications as an indicator of clinical quality

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Journal of Acute Disease 2020年第1期9卷 14-19页

作者： Mehmet Süleyman Sabaz Nagihan Sabaz Gokhan Sertcakacilar Sinan Asar Department of Intensive Care Unit Bakirkoy Dr Sadi Konuk Training and Research HospitalIstanbulTurkey Faculty of Health Sciences Division of Nursing Department of Pediatric Nursing Marmara UniversityIstanbulTurkey Department of Anaesthesia and Reanimation Bakirkoy Dr Sadi Konuk Training and Research HospitalIstanbulTurkey

Objective:To investigate the code blue application at a training and research hospital in ***:The code blue declaration forms and the hospital database with 238 complete records between January 2016 and July 2017 were *** form involved individual characteristics,the reason for issuing the code blue call,the unit and block where the code was given,time and location related properties such as working time and arrival duration,properties regarding the intervention process such as its type,duration or *** 24-hour and 30-day long survival data of the patients to whom cardiopulmonary resuscitation was implemented were obtained from the hospital database,or from their *** influencing factors of arrival duration were ***:The median duration of arrival was 2.14(2.00-3.02)*** blue applications were performed more frequently in Departments of General Surgery,Internal Medicine,Orthopaedics,and Cardiology *** of the code blue calls were due to cardiac arrest;the other half was due to shortness of breath or respiratory distress,syncope,and respiratory ***-out-of four code blue calls were treated with orotracheal intubation and cardiopulmonary resuscitation,or only orotracheal intubation or only medical treatment;one-fourth of the calls were not ***,72.36%of the code blue calls patients were intervened;69.35%of them were made both orotracheal intubation and cardiopulmonary resuscitation,and 20.5%of them were made only orotracheal intubation and 10.55%of them made only medical *** was found that giving the code blue day or night had no effect on the time to reach the area where the code was ***,it was found that giving the code blue within daytime or night shift had no effect on the time to reach the area where the code was given.(P>0.05).The survival rates were 39.1%within the first 24 h and 18.1%within the first 30 ***:Applications of code blue should be anal

关键词： Code blue Cardiopulmonary resuscitation Heart arrest Respiratory arrest Paging system

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银行视觉概念

设计 2014年第1期27卷 59-59页

作者： Yvette Emre ?a?lar

土耳其设计师EMRE？A？lar应邀为HALKBANK做了一套视觉系统的概念设计，包括修订品牌标识和新产品。主色调为不同深度的蓝色、灰色及白色，并有橘色点缀其中，所涉及的产品包括办公桌、座椅、灯具等办公家具上。这个系统将应用于土耳其... 详细信息

土耳其设计师EMRE？A？lar应邀为HALKBANK做了一套视觉系统的概念设计，包括修订品牌标识和新产品。主色调为不同深度的蓝色、灰色及白色，并有橘色点缀其中，所涉及的产品包括办公桌、座椅、灯具等办公家具上。这个系统将应用于土耳其乔鲁姆（？ORUM）的OSMANCIK分行。

关键词：视觉系统银行概念设计品牌标识办公家具土耳其设计师主色调

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fabien Chantegreil Florian Nachon Xavier Brazzolotto Anna Skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia Binda Francisco López-Muoz Stanislav Gobec JoséMarco-Contelles University of Ljubljana Faculty of PharmacyLjubljana 1000Slovenia Laboratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of Biology and Biotechnology University of PaviaPavia 27100Italy Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal Anatomy and Preclinical Sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of Biochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of Translational Neurobiology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain Biotechnology and Vegetal Biology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hMAO-A/B)for the therapy of neurodegenerative *** identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available *** 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h MAO-B(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding,which was further studied by enzyme *** 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19.

关键词： Quinolylnitrone Butyrylcholinesterase Monoamine oxidase B Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task Novel object recognition

多病种言语性幻听症状影像遗传学特征及治疗靶点模式识别的研究概况

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中华诊断学电子杂志 2019年第2期7卷 73-77页

作者：马晓燕 Frank lar■i 李猛 Walter Martin 林小东陈策刘莎徐勇禚传君 Steffen Gais 天津市精神卫生研究中心天津市安定医院 300222 Psychology of University of Lie'ge Psychiatry and Psychotherapy University Tübingentübingen72076 温州第七人民医院精神科 325000 山西医科大学第一医院精神科太原030001 Institute of Medical Psychology and Behavioral Neurobiology University Tübingentübingen72076

言语性幻听(AVHs)特指在确无外界现实声音刺激的条件下,患者体验到有针对自己的"真实"声音存在,多数"声音"给患者带来精神痛苦,是高致残致死性精神症状之一;并且AVHs可出现于多种精神障碍患者中,极易导致疾病的误诊误治。因此,探寻AVHs... 详细信息

言语性幻听(AVHs)特指在确无外界现实声音刺激的条件下,患者体验到有针对自己的"真实"声音存在,多数"声音"给患者带来精神痛苦,是高致残致死性精神症状之一;并且AVHs可出现于多种精神障碍患者中,极易导致疾病的误诊误治。因此,探寻AVHs的病理特征和精准治疗靶点已经成为当前亟需解决的问题。采用基于高通量测序的基因组学技术和基于脑影像的脑连接组学技术,探索分裂症、双相障碍、单纯抑郁、边缘型人格障碍和具有AVHs症状的健康者等6类患者AVHs症状的影像遗传学特征;并采用模式识别技术,基于上述特征,建立不同病种AVHs早期定性诊断和疗效预测体系将有助于言语性幻听的机制研究。笔者从内源性遗传特征-内表型特征(脑环路/脑网络)-表型特征(临床表现)3个角度揭示不同病种AVHs共性及特异性影像遗传学特征,以确定不同AVHs的精准治疗靶点,对建立早期诊疗预测模型、提高早期治愈率具有重要的科学意义。

关键词：言语性幻听影像遗传学脑环路精神障碍

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有握力时尺骨移位改变

中国临床解剖学杂志 2003年第4期21卷 F003-F003页

作者： M.Snmez U.T.Tura lar F.Ta■ V.Sabancio■ullari 李鉴轶傅群武

尺骨移位与腕功能障碍间的原因关系已经清楚。握拳旋前导致桡骨近侧端绕尺骨移位能够显著增加尺骨改变。研究目的是调查有握力情况下尺骨移位的变化度。对 4 1名 1 9～ 2 5岁的男性志愿者进行研究。对所有实验对象进行腕部后前位标准位... 详细信息

尺骨移位与腕功能障碍间的原因关系已经清楚。握拳旋前导致桡骨近侧端绕尺骨移位能够显著增加尺骨改变。研究目的是调查有握力情况下尺骨移位的变化度。对 4 1名 1 9～ 2 5岁的男性志愿者进行研究。对所有实验对象进行腕部后前位标准位摄X线片后 ,进行后前中性位X线摄片。然后要求实验对象以最大力握住假手握力计进行后前标准位X线摄片。垂直测量尺骨移位变化。平均最大握力为 38.1kg(范围 :2 6 .6 - 47.9kg)。无加力 (中性位 )和加力情况下尺骨平均移位分别为 ( 0 .0 6± 0 .2 1 )mmand ( 1 .87± 0 .2 3)mm。两组间的尺骨移位差异有统计学意义 (P

关键词：尺骨移位握力 X线摄片正常范围

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小鼠Lin28基因的克隆及原核表达

中国实验动物学报 2011年第6期19卷 456-460页

作者：宁方勇王春生张秋婷安星兰朴善花安铁洙东北林业大学生命科学学院哈尔滨150040 东北农业大学动物科技学院哈尔滨150030

目的探讨获取小鼠Lin28蛋白的方法。方法提取8.5 d ICR小鼠胚胎mRNA后反转录为cDNA序列,用一对两端引入特定酶切位点(NcoⅠ及XhoⅠ)引物,从该cDNA中扩增出Lin28基因编码区序列;将获得的Lin28基因编码区序列克隆到pMD18-T载体上。对质... 详细信息

目的探讨获取小鼠Lin28蛋白的方法。方法提取8.5 d ICR小鼠胚胎mRNA后反转录为cDNA序列,用一对两端引入特定酶切位点(NcoⅠ及XhoⅠ)引物,从该cDNA中扩增出Lin28基因编码区序列;将获得的Lin28基因编码区序列克隆到pMD18-T载体上。对质粒双酶切回收其中Lin28基因片段,与pET-30a(+)载体相连接并转化Rosetta(DE3)型大肠杆菌,用IPTG诱导表达,最后采用SDS-PAGE对表达结果进行分析。结果对所克隆的Lin28蛋白编码区的DNA序列分析表明,Lin28 CDS区包括终止密码子在内为630 bp,与参照DNA(NM_145833)相比同源性为99.37%,与参照氨基酸序列相比同源性为100%;在IPTG诱导下pET-30a(+)-Lin28重组质粒可表达与预期相符的约为27.5×103的蛋白质。结论利用克隆的小鼠Lin28基因,采用原核表达方法,成功获得小鼠Lin28蛋白,为进一步开展以重组蛋白诱导体细胞重编程研究奠定基础。

关键词： ICR小鼠 Lin28 克隆原核表达

The amazing potential of fungi:50 ways we can exploit fungi industrially

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Fungal Diversity 2019年第4期97卷 1-136页

作者： Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.PaPaeA.Mae TaengChiang Mai 50150Thailand Aix Marseille Université INRAUMR1163 BBF13288 Marseille Cedex 09France Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Center of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Center of Chemical Innovation for Sustainability Mae Fah Luang UniversityTasudMuangChiang Rai 57100Thailand Center of Excellence in Microbial Diversity and Sustainable Utilization Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Institute of Fungal Research School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Department Microbial Drugs Helmholtz Centre for Infection Researchand German Centre for Infection Research(DZIF)partner site Hannover-BraunschweigInhoffenstrasse 738124 BrunswickGermany Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOH 43210USA Department of Chemistry University of Science and TechnologyBannuKhyber PakhtunkhwaPakistan Department of Crop Physiology University of Agricultural SciencesGKVKBengaluruKarnataka 560065India Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai Univers

Fungi are an understudied,biotechnologically valuable group of *** to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival *** unique attributes of fungi thus herald great promise for their application in biotechnology and ***,fungi can be grown with relative ease,making production at scale *** search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel *** manuscript reviews fifty ways in which fungi can potentially be utilized as *** provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable *** also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential *** have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential.

关键词： Biocontrol Biodiversity Biotechnology Food Fungi Mushrooms

氨氯地平和阿托伐他汀对高血压大鼠血浆及心肌血管紧张肽Ⅱ的影响

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中国新药与临床杂志 2009年第3期28卷 191-195页

作者：鲁静朝崔炜张海林刘德敏杨晓红张冀东刘凡谢瑞芹都军河北医科大学第二医院心内科、河北省心脑血管病研究所河北石家庄050000 河北医科大学药理学教研室河北石家庄050017

目的观察氨氯地平、阿托伐他汀单药和联合用药对自发性高血压大鼠(SHR)循环及心肌血管紧张肽Ⅱ(AngⅡ)的影响,探讨联合用药改善左室肥厚的机制。方法8只雄性Wistar-Kyoto大鼠(WKY大鼠)作为正常血压WKY对照组;雄性SHR32只,随机分为4组,每... 详细信息

目的观察氨氯地平、阿托伐他汀单药和联合用药对自发性高血压大鼠(SHR)循环及心肌血管紧张肽Ⅱ(AngⅡ)的影响,探讨联合用药改善左室肥厚的机制。方法8只雄性Wistar-Kyoto大鼠(WKY大鼠)作为正常血压WKY对照组;雄性SHR32只,随机分为4组,每组8只,即SHR对照组、氨氯地平组(10mg·kg-1·d-1)、阿托伐他汀组(10mg·kg-1·d-1)、联合用药组(氨氯地平10mg·kg-1·d-1及阿托伐他汀10mg·kg-1·d-1)。灌胃给药12wk后,应用形态测量学测定左室质量指数(LVMI),经胸超声心动图测定心室壁厚度、左室重量(LVW)及心脏舒张功能,应用放射免疫法测定大鼠血浆及心肌AngⅡ含量,ELASA法测定血浆BNP含量。结果阿托伐他汀抑制了氨氯地平诱发的循环AngⅡ含量增高[(418±s117)ng·L-1vs(872±128)ng·L-1,P<0.01],降低了心肌AngⅡ含量(P<0.01)。氨氯地平、阿托伐他汀单药及联合用药均明显降低LVMI、血浆BNP含量(均P<0.01),逆转了左室肥厚,这一作用在联合用药时尤为明显(P<0.01)。氨氯地平及阿托伐他汀联合用药明显缩短了SHR的等容舒张时间(IVRT)[(29±4)msvs(40±5)ms,P<0.01]。结论氨氯地平和阿托伐他汀联合用药对高血压左室肥厚及舒张功能的改善具有协同效应,其机制可能与联合用药降低循环及心肌AngⅡ含量有关。

关键词：氨氯地平阿托伐他汀高血压血管紧张肽Ⅱ

目视化纳米探针检测宫颈癌组织HPV16E6基因的研究

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生物技术 2004年第5期14卷 19-20页

作者：李轶杰张富春马彩玲王艳萍王业富王宾新疆大学生命科学与技术学院分子生物学重点实验室武汉大学生命科学学院湖北武汉430072

目的 :建立目视化纳米探针检测宫颈癌组织HPV16E6基因的方法 ,为临床降低HPV感染者宫颈癌的发病率提供技术支持。方法 :采用固定于硅烷化片基上的捕获探针 ,特异性结合单链人乳头瘤病毒 16型新疆株E6基因 (HPV16E6 )扩增片断 ,再与互补... 详细信息

目的 :建立目视化纳米探针检测宫颈癌组织HPV16E6基因的方法 ,为临床降低HPV感染者宫颈癌的发病率提供技术支持。方法 :采用固定于硅烷化片基上的捕获探针 ,特异性结合单链人乳头瘤病毒 16型新疆株E6基因 (HPV16E6 )扩增片断 ,再与互补的纳米金颗粒标记的探针结合 ,通过银染加强显色。结果 :初步建立了金标银染法快速检测HPV16E6DNA的技术。结论 :金标银染法灵敏 ,可以快速特异地检测出各类宫颈组织中人乳头瘤病毒的感染 ,为进一步应用于临床检测降低新疆维吾尔妇女宫颈癌的发病率奠定了基础。

关键词：人乳头瘤病毒目视化检测金标银染法定量PCR