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Association between Premenstrual Dysphoric Disorder and Systemic Lupus Erythematosus: Exacerbation of Major Depression Symptoms?

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第4期3卷 209-215页

作者： Sílvia Fernanda Lima de Moura Cal Lorena Cal Alonso Amanda Galvao de Almeida Mittermayer Barreto Santiago ângela miranda-scippa Medicine and Human Health Post-Graduation Program Fundacao Bahiana para o Desenvolvimento das CiênciasEscola Bahiana de Medicina e Saúde PúblicaBahiaBrazil Medicine Graduation Program Faculdade de Tecnologia e CiênciasBahiaBrazil Department of Psychiatry and Laboratório Interdisciplinar de Neurociências Clínicas(LiNC) Universidade Federal de Sao PauloSao PauloBrazil Medicine and Human Health Post-Graduation Program Fundacao Bahiana Para o Desenvolvimento das CiênciasEscola Bahiana de Medicina e Saúde PúblicaBahiaBrazil Department of Neuroscience and Mental Health Universida de Federal da BahiaBahiaBrazil

Introduction: Systemic Lupus Erythematosus (SLE) usually presents neuropsychiatric manifestations, such as psychosis, convulsion, mood disorder and chronic headache, with mood disorder being the most prevalent. It is also known that other psychiatric disorders and menstrual cycle disorders are frequent in SLE. The aim of this study was to describe for the first time the frequency of premenstrual dysphoric disorder in patients with SLE diagnosis, and its association with depression and anxiety. Material and Methods: An evaluation was made of 62 (sixty-two) patients with diagnosis of SLE, based on the American College of Rheumatology criteria, who received follow-up care at an ambulatory reference center. The patients were submitted to a sociodemographic evaluation questionnaire, upon which the Mini International Neuropsychiatric Interview (MINI PLUS), Brazilian Version 5.0.0, was used to evaluate the diagnosis. Results: Twenty (32%) patients were found to have premenstrual dysphoric disorder, and there was a statistically significant association with major depression (p = 0.010), but no statistical significance was found with dysthymia (p = 0.063) or anxiety (p = 0.223). Conclusions: The frequency of premenstrual dysphoric disorder (PMDD) in patients with SLE was high, as well as the frequency of major depression in this group. There was an association between these two disorders.

关键词： Systemic Lupus Erythematous Depression Anxiety Premenstrual Dysphoric Disorder Premenstrual Syndrome

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Therapies for Tau-associated neurodegenerative disorders:targeting molecules,synapses,and cells

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Neural Regeneration Research 2023年第12期18卷 2633-2637页

作者： miranda Robbins MRC Laboratory of Molecular Biology Cambridge Biomedical CampusFrancis Crick AveTrumpingtonCambridgeUKUniversity of CambridgeDepartment of ZoologyCambridgeUK

Advances in experimental and computational technologies continue to grow rapidly to provide novel avenues for the treatment of neurodegenerative disorders. Despite this, there remain only a handful of drugs that have shown success in late-stage clinical trials for Tau-associated neurodegenerative disorders. The most commonly prescribed treatments are symptomatic treatments such as cholinesterase inhibitors and N-methyl-D-aspartate receptor blockers that were approved for use in Alzheimer's disease. As diagnostic screening can detect disorders at earlier time points, the field needs pre-symptomatic treatments that can prevent, or significantly delay the progression of these disorders(Koychev et al., 2019). These approaches may be different from late-stage treatments that may help to ameliorate symptoms and slow progression once symptoms have become more advanced should early diagnostic screening fail. This mini-review will highlight five key avenues of academic and industrial research for identifying therapeutic strategies to treat Tau-associated neurodegenerative disorders. These avenues include investigating(1) the broad class of chemicals termed “small molecules”;(2) adaptive immunity through both passive and active antibody treatments;(3) innate immunity with an emphasis on microglial modulation;(4) synaptic compartments with the view that Tau-associated neurodegenerative disorders are synaptopathies. Although this mini-review will focus on Alzheimer's disease due to its prevalence, it will also argue the need to target other tauopathies, as through understanding Alzheimer's disease as a Tau-associated neurodegenerative disorder, we may be able to generalize treatment options. For this reason, added detail linking back specifically to Tau protein as a direct therapeutic target will be added to each topic.

关键词： Alzheimer's disease antibody frontotemporal dementia immunotherapy small molecules synapses tau therapeutics

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On Building Practical Biocomputers for Real-world Applications： Receptacles for Culturing Slime Mould Memristors and Component Standardisation

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Journal of Bionic Engineering 2017年第1期14卷 151-162页

作者： Edward Braund Eduardo Reck miranda Interdisciplinary Centre for Computer Music Research (ICCMR) The House Plymouth University Drake Circus UK PL4 8AA

Our application of bionic engineering is novel： we are interested in developing hybrid hardware-wetware systems for music. This paper introduces receptacles for culturing Physarum polycephalum-based memristors that are highly accessible to the creative practitioner. The myxomycete Physarum polycephalum is an amorphous unicellular organism that has been found to exhibit memristive properties. Such a discovery has potential to allow us to move towards engineering electrical systems that encompass Physarum polycephalum components. To realise this potential, it is necessary to address some of the constraints associated with harnessing living biological entities in systems for real-time application. Within the paper, we present 3D printed receptacles designed to standardise both the production of components and memristive observations. Subsequent testing showed a significant decrease in growth time, increased lifespan, and superior similarity in component-to-component responses. The results indicate that our receptacle design may provide means of implementing hybrid electrical systems for music technology.

关键词： unconventional computing Physarum polycephalum computer music biological computing memristor

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Development of a 3D model for particle-wall collision and induced rotation and its influence on particle trajectories

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Particuology 2024年第11期94卷 211-228页

作者： Cairen miranda John Palmore Jr. Department of Mechanical Engineering Virginia TechBlacksburg24060VAUSA Department of Mechanical Engineering University of WashingtonSeattle98195WAUSA

The present research focuses on improving the prediction of rotating particle *** particle-surface collision models do not accurately predict the particle rebound when taking rotation into *** data,such as the studies by Gorham and Kharaz(2000),Buck,Tang,Heinrich,Deen and Kuipers(2017),and Dong and Moys(2006)show that the Tsuji,Oshima and Morikawa(1985)model is inaccurate due to the incorrect tangential coefficient of restitution ***,Kuipers,Mohd Salleh,Stein,and Seville(2001)introduced a similar model to the work by Tsuji et al.(1985)which includes a tangential coefficient of restitution but is only in two dimensions and does not consider out of plane *** work re-derives the particle collision model from the impulse equations for binary collisions in 3D while considering rotating *** derived equations in this work compares well to experimental particle-surface impact *** implications of this model are seen by investigating erosion due to particle collision in a simple pipe *** is shown that Tsuji et al.(1985)over predicts the *** small differences in particle trajectories between the present model and the Tsuji et al.(1985)model will grow in complex flows with multiple close range particle impacts leading to inaccurate erosion predictions which will negatively impact the design of turbomachinery and pneumatic pipes.

关键词： Particle collisions CFD Rotation Three dimensional

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The endophytic mycobiota of Arabidopsis thaliana

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Fungal Diversity 2013年第3期60卷 71-89页

作者： Elena García Ángela Alonso Gonzalo Platas Soledad Sacristán Centro de Biotecnología y Genómica de Plantas(UPM-INIA)and E.T.S.I.Agrónomos Universidad Politécnica de MadridCampus de MontegancedoAutopista M40(Km.38)28223 Pozuelo de Alarcón MadridSpain Departamento de Biotecnología E.T.S.I.AgrónomosUniversidad Politécnica de MadridAvda.Complutense s/n28040 MadridSpain Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía MEDINA Parque Tecnológico de las Ciencias de la Salud de GranadaAvda del Conocimiento 318100 ArmillaGranadaSpain Instituto de Recursos Naturales y Agrobiología Consejo Superior de Investigaciones CientíficasAvenida Reina Mercedes 1041012 SevillaSpain

Fungal endophytes are receiving increasing attention as resources to improve crop production and ecosystem ***,the biology and ecological significance of these symbionts remains poorly understood,due to a lack of model systems for more efficient *** this work,we have analyzed the culturable endophytic mycobiota associated,in the wild,with leaves and siliques of the model plant *** have studied the effect of biotic and abiotic factors in the frequency of fungal endophytes in plant specimens,and in the species composition of the endophytic *** results indicate that the frequency of Arabidopsis plants hosting endophytes depends on the time of the year and the phenological stage of the plant,and that the probability of endophyte colonization increases as the life cycle of the plant *** diversity of the endophytic assemblages of natural *** populations was high,and precipitation and temperature were the two main factors determining the diversity and species composition of the *** propose *** and its endophytes as a model system for an integral approach to the principles governing the endophytic lifestyle,taking advantage of the molecular tools and the abundant knowledge accessible from the host plant.

关键词： Endophyte Mycobiota Arabidopsis Wild populations Ecology

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The versatility of mesenchymal stem cells:From regenerative medicine to COVID,what is next?

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BIOCELL 2022年第4期46卷 913-922页

作者： THAÍS CASAGRANDE PAIM MÁRCIA ROSÂngela WINK Laboratório de Biologia Celular Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre90050-170Brazil

Mesenchymal stem cells(MSCs)play key roles in regenerative medicine by promoting tissue *** can be isolated from different adult tissues and they are able to differentiate into several *** to their antiinflammatory,angiogenic and immune-modulatory properties,MSCs are suitable for tissue engineering applications and,when associated with biomaterials,their benefits can be ***,recently,MSCs have been studied for new clinical applications,such as in the treatment of patients with *** regenerative potential has been attributed to their secretome,which comprises extracellular matrix,soluble proteins and several elements,including the release of extracellular *** though,in order to explore all their therapeutic potential,it is still necessary to advance in the investigation of their basic cell biology characteristics.

关键词： Mesenchymal stem cells Regenerative medicine Secretome Biomaterials Extracellular vesicles

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Successful Large-scale Renewables Integration in Portugal:Technology and Intelligent Tools

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CSEE Journal of Power and Energy Systems 2017年第1期3卷 7-16页

作者： Vladimiro miranda Faculty of Engineering University of PortoPortugal

Portugal is seen worldwide as a case of success in the large-scale integration of renewables in its power system,especially for wind *** policies and sound management decisions are fundamental,but a sustainable process is not possible without the development of endogenous *** paper summarizes a set of models,both applied by the industry and representing actual technologic advancement,denoting the context of research and innovation in the country that helps to explain such *** arise in reliability assessment for systems with renewables,active and reactive power control,integration of wind farms,storage,electric vehicle integration,wind and solar power forecasting and distribution operation and state estimation taking advantage of smart grid *** all cases,one relevant trait is evident:the pervasive use of computational intelligence tools.

关键词： Autoencoders electric vehicles EPSO evolutionary particle swarm optimization forecasting voltage/var control large-scale integration reliability renewables smart grids solar power state estimation storage wind power

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Preventing brain aging by the artificial enforcement of the unfolded protein response:future directions

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Neural Regeneration Research 2024年第2期19卷 393-394页

作者： Felipe Cabral-miranda Claudio Hetz Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Center for Geroscience Brain Health and MetabolismSantiagoChile、Biomedical Neuroscience InstituteFaculty of MedicineUniversity of ChileSantiagoChile、Program of Cellular and Molecular BiologyInstitute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile、Buck Institute for Research on AgingNovatoCAUSA

As the life expectancy of the world’s population increases,age-related diseases are emerging as one of the greatest problems facing modern *** onset of dementia and neurodegenerative diseases is strictly dependent on aging as a major risk factor and has a profound impact on various aspects of the lives of individuals and their families.

关键词： diseases aging directions

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Monodelphis domestica: a new source of mammalian primary neurons in vitro

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Neural Regeneration Research 2022年第8期17卷 1726-1727页

作者： Jelena Ban miranda Mladinic Laboratory for Molecular Neurobiology Department of BiotechnologyUniversity of RijekaRijekaCroatia

In vi t ro mode ls have tremendously revolutionized cell biology and biomedical research,reducing the need for in vivo experiments,as well as offering the simplified models for easier investigations at molecular and cellular level(for example genetic manipulations,electrophysiological measurements,drug screening etc.).However,the major challenge is to develop long-surviving in vitro preparations of post-mitotic cells such as neurons or *** overcome the problem of neuronal inability to proliferate,the immortalized cell lines derived from neuronal tumors have been *** secondary neuronal cultures are restricted to neuroblastoma-like cells,but their biological relevance is often questionable due to genetic drift and lack of mature,differentiated neuronal phenotypes,which makes primary cultures the better *** central nervous system(CNS)in vitro primary cell cultures are mostly prepared from the late embryonic or early postnatal mice and *** mammalian species have been less used,meaning that inter-species diversity is not sufficiently investigated and that the additional comparative analyses are required to avoid misinterpretations in translating the knowledge to humans(Bonfanti and Peretto,2011).

关键词： overcome offering mostly

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