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Integrative Analysis of Transcriptome and Phenolic Compounds Profile Provides Insights into the Quality of Soursop (Annona muricata L.) Fruit

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1717-1732页

作者： Yolotzin Apatzingán Palomino-Hermosillo ángel elpidio díaz-jasso Rosendo Balois-Morales Verónica AlhelíOchoa-Jiménez Pedro Ulises Bautista-Rosales Guillermo Berumen-Varela Unidad de Tecnología de Alimentos-Secretaría de Investigación y Posgrado Universidad Autónoma de Nayarit.Ciudad de la Cultura SNTepic63000NayaritMéxico Programa Académico de Biología Unidad Académica de AgriculturaUniversidad Autónoma de NayaritKm.9.Carretera Tepic-CompostelaXalisco63780NayaritMéxico Estancias Posdoctorales-Consejo Nacional de Humanidades Ciencias y TecnologíasCoordinación de Apoyos a Becarios e InvestigadoresDirección de PosgradoCiudad de México03940México

Soursop(Annona muricata L.)is a tropical fruit highly valued for its uniqueﬂavor,nutritional value,and health-promoting *** ripening process of soursop involves complex changes in gene expression and metabo-lite accumulation,which have been studied using various omics *** analysis has provided insights into the regulation of key genes involved in ripening,while metabolic compound analysis has revealed the presence of numerous bioactive compounds with potential health beneﬁ***,the integration of transcrip-tome and metabolite compound data has not been extensively explored in ***,in this paper,we present a comprehensive analysis of the transcriptome and phenolic compound proﬁles of soursop during *** integration analysis showed that the genes and phenolic compounds were mainly involved in the starch and sucrose metabolism pathways during soursop ***,the phenolic compounds Kaempferol 3-Q-galactoside,Procyanidin C1,Procyanidin trimmer C1,and m-Coumaric,as well as the genes Ubiquitin-like protein 5(UBL5_ARATH),ATP-dependent zinc metalloprotease FTSH8(FTSH8_ORYSJ),Zinc transporter 4(ZIP4_AR-ATH),Thioredoxin-like 3-1(TRL31_ORYSJ),Mitogen-activated protein kinase YOdA(YOdA_ARATH),R-man-delonitrile lyase-like(MGL_ARATH),26s protease regulatory subunit 6A homolog(PRS6_SOLLC),Cytochrome P45072A13(C7A13ARATH),Cytochrome P45084A1(C84A1_ARATH)and Homoserine O-trans-acetylase(MET2-ORYSJ)were correlated and differentially accumulated and expressed,*** study provides new insights into the molecular mechanisms underlying soursop ripening and may contribute to the development of strategies for improving the nutritional quality and shelf life of this important fruit.

关键词： Bioinformatics data integration genes metabolites postharvest storage ripening

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Effect of pesticides on phosphorylation of tau protein,and its influence on Alzheimer’s disease

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世界临床病例杂志 2023年第24期11卷 5628-5642页

作者： Erandis d Torres-Sánchez Genaro G Ortiz Emmanuel Reyes-Uribe Juan H Torres-jasso Joel Salazar-Flores department of Medical and Life Sciences University Center of la CienegaUniversity of GuadalajaraOcotlan 47820JaliscoMexico department of Philosophical and Methodological disciplines and Service of Molecular Biology in Medicine Hospital Civil University of GuadalajaraGuadalajara 44340JaliscoMexico department of Biological Sciences CUCOSTAUniversity of GuadalajaraPuerto Vallarta 48280JaliscoMexico

Alzheimer’s disease(Ad)is a progressive and neurodegenerative illness which results in alterations in cognitive *** is characterized by loss/dysfunction of cholinergic neurons,and formation of amyloid plaques,and formation of neurofibrillary tangles,among other changes,due to hyperphosphorylation of *** to pesticides in humans occurs frequently due to contact with contaminated food,water,or ***,organophosphates,carbamates,pyrethroids and neonicotinoids are associated with the most diagnosed incidents of severe cognitive *** aim of this study was to determine the effects of these pesticides on the phosphorylation of tau protein,and its cognitive implications in the development of *** was found that exposure to pesticides increased the phosphorylation of tau protein at sites Ser198,Ser199,Ser202,Thr205,Ser396 and *** with these chemicals altered the enzymatic activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta,and protein ***,it altered the expression of the microtubule associated protein tau gene,and changed levels of intracellular *** changes affected tau protein phosphorylation and neuroinflammation,and also increased oxidative *** addition,the exposed subjects had poor level of performance in tests that involved evaluation of novelty,as test on verbal,non-verbal,spatial memory,attention,and problem-solving skills.

关键词： Organochlorines Organophosphates Carbamates Pyrethroids Neonicotinoids Tau protein

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Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats

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Neural Regeneration Research 2015年第11期10卷 1819-1824页

作者： Carmen díaz Galindo Beatriz Gómez-González Eva Salinas denisse Calderón-Vallejo Irma Hernández-jasso Eduardo Bautista J Luis Quintanar Laboratory of Neurophysiology Department of Physiology and Pharmacology Universidad Autónoma de Aguascalientes Area of Neuroscience Department of Reproductive Biology CBS Universidad Autónoma Metropolitana Laboratory of Immunology Department of Microbiology Centro de Ciencias Básicas Universidad Autónoma de Aguascalientes

Gonadotropin-releasing hormone（Gn RH） and its synthetic analog leuprolide acetate, a Gn RH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5th week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1st week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury.

关键词： nerve regeneration spinal cord injury leuprolide acetate gonadotropin-releasing hormone neurotrophic factor microglia micturition reflex gait inflammation neural regeneration

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One-oligonucleotide method for constructing vectors for RNA interference

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Acta Pharmacologica Sinica 2005年第12期26卷 1467-1473页

作者： CarlosFabianFLORES-jasso InesVELazQUEZ-QUESAdA LuisVACA CarlosLANdA-SOLIS AndresAGUTIERREZ departamento departamento departamento Unidad Unidad de Biología Celular Instituto de Fisiología Celular Universidad Nacional Autónoma de México Ciudad Universitaria Mexico City 04510 Mexico de Biología Celular Instituto de Fisiología Celular Universidad Nacional Autónoma de México Ciudad Universitaria Mexico City 04510 Mexico de Biología Celular Instituto de Fisiología Celular Universidad Nacional Autónoma de México Ciudad Universitaria Mexico City 04510 Mexico de Terapia Celular Centro National de Rehabilitación Mexico City 14389 México de Terapia Celular Centro National de Rehabilitación Mexico City 14389 México

Aim:To develop an easy,fast,automated,and inexpensive method for construct-ing short-hairpin-RNA cassettes for RNAi ***:Using singleoligonucleotides,a variety of dNA cassettes for RNAi vectors were constructedin only few minutes in an automated *** cassettes,targeting the eGFP,were cloned into plasmids driven by RNA polymerase Ⅲ promoter ***,theplasmids were transfected into HeLa cells that were later infected with a recombi-nant adenovirus encoding the eGFP *** level of eGFP fluorescence wasevaluated by confocal imaging and flow ***:The plasmids con-structed with the dNA cassettes made by the one-oligonucleotide method inhibi-ted eGFP with different potencies,ranging from 55% to 75%.Conclusion:Byusing the method reported here,it is possible to simultaneously construct hun-dreds of different dNA cassettes for RNAi experiments in an inexpensive,auto-mated *** method will facilitate functional genomics studies on mammaliancells.

关键词： RNA interference shRNAs dNA cassette RNAi vector oligonucleotide

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Estimation of rainfall thresholds for shallow landslides in the Sierra Madre Oriental, northeastern Mexico

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Journal of Mountain Science 2020年第7期17卷 1565-1580页

作者： Jorge A.Salinas-jasso Fernando Velasco-Tapia Ignacio Navarro de León Ricardo A.Salinas-jasso Efraín Alva-Nino Facultad de Ciencias de la Tierra Universidad Autónoma de Nuevo LeónEx-Hacienda de Guadalupe km 8.Carr.Linares-Cerro PrietoLinaresN.L.67700México Secretaría de desarrollo Sustentable de Nuevo León Washington #2000Col.ObreraMonterreyN.L.64010México

Landslides induced by prolonged rainfalls are frequent mass movements along the northeastern portion of the Sierra Madre Oriental in Mexico,causing significant damage to *** this work,we have studied the connection between rainfall and landslides in the Santa Rosa Canyon,a catchment located in the northeastern Mexico.A landslide database triggered by major storms and hurricanes that have hit the region over the past 30 years was analyzed.A total of 92 rainfall events in the Santa Rosa Canyon were studied to determine the amount of precipitation needed to trigger shallow *** each event the duration(d,in hours)and the cumulated rainfall event(E,in mm)were determined by using historical rainfall data from weather stations located near the study *** have proposed an Ed threshold for rainfall-induced landslides with durations 0.5dddress the conditions that trigger these events in the study *** analyzing the obtained threshold,it has been established that almost 60 mm of a daily rainfall accumulation is required to trigger shallow landslides in the study *** estimation is consistent with other calculations made for areas close to the Santa Rosa ***,we validated the predictive capability of the threshold with a different set of rainfall data that did not result in landslides performing a straightforward receiver operating characteristic analysis.A good approach was obtained,especially for rainfall events with daily *** could be used as input information in the design of a landslide early warning system for the northeastern Mexico,and replicated for other landslide prone areas in the region.

关键词： Shallow landslides Cumulated rainfall Rainfall thresholds Northeastern Mexico Early warning systems.

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Sustainability of microporous polymers and their applications

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Science China Chemistry 2017年第8期60卷 1033-1055页

作者： Tamara L.Church Alma Berenice jasso-Salcedo Fredrik Bjrnerbck Niklas Hedin department of Materials and Environmental Chemistry Stockholm University

Microporous polymers(MPs) are studied for their intriguing chemistry and physics as well as their potential application in catalytic transformations, gas-separation processes, water purification and so on. Here, we critically review MPs with respect to the sustainability aspects of their synthesis as well as their applications that have sustainable character. Some MPs have been synthesized from monomers derived from biomass resources, but there is certainly a large potential for further *** are also opportunities to improve the sustainability of MP synthesis in terms of the use of solvents, catalysts, and related aspects. The applications of MPs in processes related to sustainability depend upon multiple properties. A rich and flexible chemistry is important to applications as catalysts for, among other useful reactions, the photoreduction of CO_2 and selective oxidation. The(ultra)micropore volume of MPs are crucial in gas-separation applications such as CO_2 capture, and the chemisorption of CO_2 on MP-tethered alkylamines could offer a means to remove that gas from dilute mixtures. When it comes to the storage of H_2 and CH_4 in MPs for onboard use in fuel cell or biogas cars, volumetric capacity is paramount, meaning that the density of the MPs must be considered. Finally, for use in separation and purifications from liquid mixtures(aqueous or hydrocarbon-based), crosslinked MPs are more limited than the solution-processable MPs that can be more easily processed into films and membranes.

关键词： microporous polymers biomass sustainability CO2 capture catalysis H2 storage CH4 storage separation purification

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Viscoelastic Models for Passive Arterial Wall dynamics

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Advances in Applied Mathematics and Mechanics 2009年第2期1卷 151-165页

作者： d.Valdez-jasso H.T.Banks M.A.Haider d.Bia Y.Zocalo R.L.Armentano M.S.Olufsen department of Mathematics and Center for Research in Scientific Computation NC State UniversityCampus Box 8205RaleighNC 27695 departmento de Fisiologia Facultad de MedicinaUniversidad de La RepublicaGeneral Flores 2125PC:11800MontevideoUruguay Facultad de Ingenieria y Ciencias Exactas y Naturales Universidad FavaloroAvda.Belgrano 1723Capital FederalBuenos AiresArgentina

This paper compares two models predicting elastic and viscoelastic properties of large *** compared include a Kelvin(standard linear)model and an extended 2-term exponential linear viscoelastic *** were validated against in-vitro data from the ovine thoracic descending aorta and the carotid *** of blood pressure data were used as an input to predict vessel cross-sectional *** properties were predicted by estimating a set of model parameters that minimize the difference between computed and measured values of the cross-sectional *** model comparison was carried out using generalized analysis of variance type statistical *** the thoracic descending aorta,results suggest that the extended 2-term exponential model does not improve the ability to predict the observed cross-sectional area data,while for the carotid artery the extended model does statistically provide an improved fit to the *** is in agreement with the fact that the aorta displays more complex nonlinear viscoelastic dynamics,while the stiffer carotid artery mainly displays simpler linear viscoelastic dynamics.

关键词： Arterial wall modeling dynamic viscoelastic models inverse problems statistical analysis for model comparison

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ONE ORGANIZATION,MANY OBJECTIVES How The Behring Global Educational Foundation is Changing

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城市漫步（上海版、英文） 2016年第8期 58-59页

作者： CALEB jasso 不详

There are many things that people take for granted-the ease of traveling,the loving embrace of family;perhaps even the ability to see and hear Howevei;there are things that people may not appreciate until they are gone,such as the ability to walk,the ability to learn in a supportive environment and even access to clean drinking water.

关键词： OBJ traveling things

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Aggregation Study of Ag-TiO_(2) Composites

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Materials Sciences and Applications 2011年第12期2卷 1719-1723页

作者： Maria Eugenia Noriega-Trevino Claudia Cristina Quintero-Gonzalez Jose elpidio Morales-Sanchez Jesus Maria Guajardo-Pacheco Martha Eugenia Compean-jasso Facundo Ruiz Science Faculty Universidad Autonoma de San Luis PotosiSan Luis PotosiMexico Mathematics and Physics department Universidad Autonoma de San Luis PotosiSan Luis PotosiMexico Materials Advanced Research Center ChihuahuaMexico Materials Advanced Research Center ApodacaMexico

Most of the toxicity data presented in the literature are obtained in relatively simple media, like distilled water. The literature reported that nanoparticles agglomerate immediately upon being added to cell culture media and if the agglomerates are used directly in antimicrobial studies, the interpretation of the toxicity results tends to be complicated. Six different molar ratios Ag-TiO2 composites were synthesized by a reduction method using two different commercial TiO2 particles as base materials and were used to find the aggregate size in distilled water and Mueller-Hinton Broth, and to obtain the minimum inhibitory concentrations (MIC) against E. coli and E. faecalis. To evaluate the evolution of the Ag-TiO2 particle size (z-average) three dilutions of each of the synthesized composites 100 μg/ml, 250 μg/mL and 500 μg/ml were realized in deionized water and Mueller Hinton broth. It was found that Ag-TiO2 composites increased in size after being diluted in Mueller-Hinton Broth, but once they grew in size, they remained constant for 24 minutes, and after this time, did not affect the MIC for the microorganisms involved.

关键词： Ag-TiO_(2) Composites Nanoparticles Particles Aggregate Size MIC

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Relationship between PON-1 enzymatic activity and risk factors for pesticide poisoning in farmers from the Cienega,Jalisco,Mexico

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BIOCELL 2021年第5期45卷 1241-1250页

作者： HazAEL RAMIRO CEJA-GALVEZ ERANdIS dHENI TORRES-SÁNCHEZ JUAN HERIBERTO TORRES-jasso EMMANUEL REYESURIBE JOEL SALazAR-FLORES department of Medical and Life Sciences University Center of La CienegaUniversity of Guadalajara(CUCI-UdeG)OcotlánCP 47810Mexico department of Biological Sciences University Center of the CoastUniversity of Guadalajara(CUCosta-UdeG)Puerto VallartaCP 48280Mexico

Paraoxonase-1(PON-1)is an enzyme that hydrolyzes organophosphate *** presence of polymorphisms in PON-1(L55M and Q192R)decreases its enzyme activity and increases the risk of central nervous system(CNS)toxicity in occupationally exposed farmers,leading to chronic degenerative diseases and *** studied 103 farmers in the region of Cienega Jalisco,Mexico,which were exposed mainly to organophosphate *** used serum and plasma samples to assay PON-1 activity and perform polymorphism analysis(L55M and Q192R)using qPCR and TaqMan probes,*** both polymorphisms,there was high percentage of heterozygosity(55 LL=0.19,LM=0.75,MM=0.06;192 QQ=0.12,QR=0.72,RR=0.16),while the allelic frequencies were more balanced(L=0.56,M=0.44;Q=0.48,R=0.52).There were no significant differences in enzyme activity of L55M polymorphism genotypes(LL=179.27;LM=192.11;MM=122.11;QQ=135.74;QR=187.90;RR=209;p>0.05).But there was a slight decrease in enzyme activity for the Q192R polymorphism *** genotype and alcohol consumption associated with slight increases in enzyme ***,genotype and tobacco consumption did not have a significant effect on PON-1 activity(μU/mL)(p>0.05).Overall,alcohol and tobacco consumption affected PON-1 enzyme activity(μU/mL)up to 21.1%.The data obtained in this study reveal that PON-1 activity is affected by genetic variants such as Q192R and alcohol *** may influence the susceptibility of populations to organophosphate poisoning.

关键词： Paraoxonase-1 Pesticides Organophosphates Polymorphisms

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