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Stressful living in lower-quality habitats?Body mass,feeding behavior and physiological stress levels in wild wood mouse populations

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Integrative Zoology 2019年第1期14卷 114-126页

作者： álvaro navarro-castilla Isabel BARJA Department of Biology Unit of ZoologyFaculty of SciencesAutonomous University of MadridSpain

Wild populations are continuously subjected to changes in environmental factors that pose different *** condition and hormones have been commonly used as health indicators due to their potential correlation with *** the present study,we analyzed whether habitats of different quality influenced body mass,food intake and physiological stress levels in wild wood mice(Apodemus sylvaticus).Field work was seasonally carried out in Holm oak woods and pine forests in central Spain.A total of 93 wood mice from 4 different populations(2 per habitat type)were *** each captured individual we noted body mass and food intake,measured as the amount of bait remaining in each *** physiological stress levels were measured non-inva-sively in collected fresh feces by quantifying fecal corticosterone metabolites(FCM)with a 5a-pregnane-3ß,11ß,21-triol-20-one enzyme *** mice abundances decreased from spring to summer,were higher in Holm oak woods than in pine forests and also resulted in different age-class distribution between both *** inhabiting pine forests showed a lower body mass and increased food intake,probably because of the comparatively lower food quality and availability in this ***,these individuals showed increased physiological stress levels,likely due to the lower quality habitat in relation to both food and vegetation cover ***,besides affecting local wood mouse abundance,our study underscores the effect of habitat quality on body mass,food intake and the endocrine stress *** the wood mouse’s piv-otal position in ecosystems,these results could help in the understanding of environmental traits hampering the viability of wild populations.

关键词： Apodemus sylvaticus body condition corticosterone environmental factors fecal corticosterone metabolites feeding behavior

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia Jiménez-Díaz Juan D.navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Foraging, feeding, and physiological stress responses of wild wood mice to increased illumination and common genet cues

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Current Zoology 2018年第4期64卷 409-417页

作者： Alvaro navarro-castilla Isabel BARJA Mario DíAZ Department of Biology Faculty of Sciences Universidad Autónoma de Madrid C/Darwin 2 Campus Universitario de Cantolanco Madrid 28049 Spain Department of Biogeography and Global Change Museo Nacional de Ciencias Naturales CSIC Madrid 28006 Spain

In nature, animals are exposed to a broad range of threats imposed by predators, which may strongly influence the ecology of prey species directly or indirectly by affecting their behavior via fear of predation. Here, we studied wood mice Apodemus sylvaticus behavioral and physiological responses to simulated predation risk. Risk avoidance was analyzed by live trapping with control traps and traps treated with feces of common genet Genetta genetta （direct cue of risk） under new moon nights and following by simulated full moon conditions （indirect cue）. The time devoted to foraging behavior and capture time were analyzed by video recording mice activity around traps. Food intake was calculated based on the amount of bait remaining in each trap. Fecal cortico- sterone metabolites （FCMs） were measured by enzyme-immunoassay as indicators of physio- logical stress responses. Fewer wood mice were captured during full moon, yet only non-breeding adult males clearly avoided common genet odor. Mice were captured sooner at night during the simulated full moon conditions and later in predator-treated traps. Foraging activity was lower when individuals faced predator＇s feces, but neither food intake nor FCM levels were affected by predation risk cues. Direct and indirect cues of predation risk selectively affected wood mice behavior, although behavioral responses seem to be modulated by different costs-benefit balances related to the individual＇s perception of risk. The lack of physiological responses to predation risk cues suggests that wood mice did not perceive them as reliable stressors or the response was too small or transient to be measured by FCM.

关键词： common genet fecal predator cues feeding foraging moonlight predator avoidance

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Dynamics of mediterranean pine forests reforested after fires

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Journal of Forestry Research 2023年第2期34卷 345-354页

作者： Álvaro Enríquez-de-Salamanca Departamento de Biodiversidad Ecología y EvoluciónFacultad de Ciencias BiológicasUniversidad Complutense de MadridMadridSpain Draba Ingeniería y Consultoría Medioambiental San Lorenzo de El EscorialSpain

Forest fires are frequent under a Mediterranean climate and have shaped the landscape of the region but are currently altered by human action and climate *** have historically conditioned the presence of pine forests,depending on severity and forest *** of Mediterranean pine forests is not always successful,and a transition to shrublands or stands of resprouting species can occur,even after *** study analyses vegetation changes in two Mediterranean pine forests after severe fires and both *** pines had difficulty to regenerate,even despite post-fire *** problem is the difficulty of young seedlings to survive,possibly due to increased summer *** are greater in pine species at the limit of their ecological tolerance:Pinus pinea had a much better recovery success while *** and *** virtually *** pinaster had intermediate results but recovery was generally poor.A transition has taken place in many burnt areas to scrubland or to thickets of the resprouting Quercus rotundifolia,although it is not possible to know whether they will evolve into forests or remain in a sub climatic *** species may increase fire severity but facilitates post-fire ***-fire recovery difficulties are closely linked to issues of natural *** could initiate the disappearance of pine forests,but even in the absence of fire they may disappear in the long-term due to the lack of *** is needed to increase the resilience of these forests,ensuring natural regeneration,and incorporating resprouting species in the understorey.

关键词： Mediterranean region Pine forests Post-fi re recovery Vegetation dynamics Wildfi re transitions

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Natural variation of ncHLAII molecules:challenges and perspectives

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Cellular & Molecular Immunology 2022年第12期19卷 1432-1434页

作者： MiguelÁlvaro-Benito Protein Biochemistry Institute for BiochemistryFreie Universität BerlinBerlinGermany

Identifying causal genetic variants for a given phenotype improves diagnosis and provides insights for designing ***,defining the link and/or contribution to a phenotype of rare variants or those with an indirect cont... 详细信息

关键词： diagnosis insight designing

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Changes in air pollution during COVID-19 lockdown in Spain:A multi-city study

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Journal of Environmental Sciences 2021年第3期33卷 16-26页

作者： Álvaro Briz-Redón Carolina Belenguer-Sapiña Ángel Serrano-Aroca Statistics Office City Council of Valenciac/Arquebisbe Mayoral246002 ValenciaValenciaSpain Department of Analytical Chemistry Faculty of ChemistryUniversity of Valenciac/Doctor Moliner 5046100 BurjassotValenciaSpain Centro de Investigación Traslacional San Alberto Magno Universidad Católica de Valencia San Vicente Mártirc/Guillem de Castro 9446001 ValenciaValenciaSpain

The COVID-19 pandemic has escalated into one of the largest crises of the 21 st *** new SARS-CoV-2 coronavirus,responsible for COVID-19,has spread rapidly all around the *** Spanish Government was forced to declare a nationwide lockdown in view of the rapidly spreading virus and high mortality rate in the *** study investigated the impact of short-term lockdown during the period from March 15th to April 12th 2020 on the atmospheric levels of CO,SO_(2),PM_(10),O_(3),and NO_(2)over 11 representative Spanish *** possible influence of several meteorological factors(temperature,precipitation,wind,sunlight hours,minimum and maximum pressure)on the pollutants'levels were also *** results obtained show that the 4-week lockdown had significant impact on reducing the atmospheric levels of NO_(2)in all cities except for the small city of Santander as well as CO,SO_(2),and PM_(10)in some cities,but resulted in increase of O_(3)level.

关键词： COVID-19 Lockdown Air quality Pollution Meteorology

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Practical Non-Uniform Channelization for Multistandard Base Stations

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ZTE Communications 2011年第4期9卷 15-24页

作者： lvaro Palomo navarro Rudi Villing Ronan J. Farrell Callan Institute Electronic Engineering Department National University of Ireland Maynooth (NUIM) Ireland

A multistandard software-defined radio base station must perform non-uniform channelization of multiplexed frequency bands. Non-uniform channelization accounts for a significant portion of the digital signal processing workload in the base station receiver and can be difficult to realize in a physical implementation. In non-uniform channelization methods based on generalized DFT filter banks, large prototype filter orders are a significant issue for implementation. In this paper, a multistage filter design is applied to two different non-uniform generalized DFT-based channelizers in order to reduce their filter orders. To evaluate the approach, a TETRA and TEDS base station is used. Experimental results show that the new multistage design reduces both the number of coefficients and operations and leads to a more feasible design and practical physical implementation.

关键词： SDR non-uniform channelization base station TETRA

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Elenoside increases intestinal motility

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World Journal of Gastroenterology 2006年第44期12卷 7143-7148页

作者： E navarro SJ Alonso R navarro J Trujillo E Jorge Department of Pharmacology Faculty of Medicine University of La Laguna 38071 La Laguna Apdo. 55 Tenerife Canary Islands Spain Department of Medical and Chirurgical Sciences University of Las Palmas Gran Canaria Canary Islands Spain Centro de Productos Naturales y Agrobiologia CSIC Tenerife Canary Islands Spain

AIM： TO study the effects of elenoside, an arylnaphthalene lignan from Justicia hyssopifolia, on gastrointestinal motility in vivo and in vitro in rats. METHODS： Routine in vivo experimental assessments were catharsis index, water percentage of boluses, intestinal transit, and codeine antagonism. The groups included were vehicle control （propylene glycol-ethanolplant oil-tween 80）, elenoside （i.p. 25 and 50 mg/kg）, cisapride （i.p. 10 mg/kg）, and codeine phosphate （intragastric route, 50 mg/kg）. In v/tro approaches used isolated rat intestinal tissues （duodenum, jejunum, and ileum）. The effects of elenoside at concentrations of 3.2 ×10^4, 6.4 ×10^4 and 1.2 ×10^3 mol/L, and cisapride at 10^6 mol/L were investigated. RESULTS： Elenoside in vivo produced an increase in the catharsis index and water percentage of boluses and in the percentage of distance traveled by a suspension of activated charcoal. Codeine phosphate antagonized the effect of 25 mg/kg of elenoside. In vitro, elenoside in duodenum, jejunum and ileum produced an initial decrease in the contraction force followed by an increase. Elenoslde resulted in decreased intestinal frequency in duodenum, jejunum, and ileum. The in vitro and in vivo effects of elenoside were similar to those produced by cisapride. CONCLUSION： Elenoside is a lignan with an action similar to that of purgative and prokinetics drugs. Elenoside, could be an alternative to cisapride in treatment of gastrointestinal diseases as well as a preventive therapy for the undesirable gastrointestinal effects produced by opioids used for mild to moderate pain.

关键词： Elenoside Gastrointestinal motility, Smail intestine preparation

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Impact of socioeconomic and health-related factors on consumption of homeopathic and natural remedies in Spain in 2006, 2011 and 2017

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Journal of Integrative Medicine 2022年第1期20卷 52-56页

作者： Jose Antonio castilla-Jimena Isabel Ruiz-Perez Jesus Henares-Montiel Andalusian School of Public Health 1801J GranadaSpain Unit of Clinical Management of Preventive Medicine and Public Health and Occupational Medicine Puerto del Mar University Hospital11009 CadizSpain Consortium for Networked Biomedical Research in Epidemiology and Public Health 28029 MadridSpain Institute for Biosanitary Research(ibs.GRANADA) 18012 GranadaSpain

Objective: Complementary and alternative medicine use and type of use may be influenced by sociodemographic and economic determinants through which we could identify characteristics of patients with greater trend to use it. This paper aims to describe the changes in the consumption of homeopathic and natural remedies in Spain for three time points in order to discern changes in rate of consumption, associated factors and whether their use has been affected by a period of economic ***: This study utilized 2006, 2011 and 2017 cross-sectional data from the Spanish National Health Survey, a nationally representative survey of the population aged more than 15 years old and resident in Spain. Independent bivariate and multivariate descriptive analyses for each of the 3 years studied were ***: The rate of consumption of both homeopathic and natural remedies has decreased over the periods studied. In spite of this decrease, the consumer profile appears to remain stable over the three periods. The sociodemographic factors associated with their consumption were being female, being 30–64 years old, being separated/divorced, having higher education qualifications, being employed and belonging to a higher social class. Psychiatric morbidity, chronic health problems such as pain, mental health problems or malignant tumors, and absence of major cardiovascular events were the clinical factors ***: It can be concluded that beyond the economic situation, the use of homeopathic and natural remedies obeys to the needs of the patients related to their state of health and the response they receive from the health system. It may be that women have different needs and expectations of the healthcare system and, given this breach of expectations, seek remedy to alleviate their needs outside the system and conventional medicine.

关键词： Complementary and alternative medicine Homeopathic remedies Natural remedies Economic recession Gender differences

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Overnight at the Crossroads: Abelardo Lafuente's Architectural Legacy for 'The Hong Kong and Shanghai Hotels Ltd.' in Shanghai

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Built Heritage 2019年第3期3卷 21-33页

作者： Álvaro Leonardo Pérez Independent Scholar MadridSpain

The business success of the most important hotel company in Asia in the 20^(th) century,and therefore of its owners,the Kadoorie Family,is intertwined with the life of the only Spanish architect in the city of Huangpu.A long-forgotten story,its discovery reveals the interests,tastes and cultural mix of the multinational community that inhabited the most open city of the *** Lafuente García-Rojo(Madrid 1871-Shanghai 1931)worked uninterruptedly for the‘Hong Kong and Shanghai Hotels Ltd.’(HSH)for ten years since *** that decade,he carried out interior renovations in eight HSH hotels in the cities of Shanghai,Hong Kong and Shameen in *** with that,he worked for many clients and introduced the Spanish neo-Arab style in several buildings which still stand today in the city under unknown *** professional career in China-linked to the HSH-is a case study of the cultural melting pot of the city of *** is nowadays a foot note in Shanghai's architecture history and yet he deserves a chapter of his own,and this article is the first step.

关键词： Abelardo Lafuente Spanish architects in China Shanghai Hong Kong and Shanghai Hotels ballrooms

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