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Highly toxic Aβ begets m.re Aβ

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Neural regeneration research 2024年第9期19卷 1871-1872页

作者： m.rc m.Kemeh Noel d.Lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheim.r’s disease(Ad)is the most common form of dementia-the 7th leading cause of death *** the tissue level,Ad is characterized by the presence of extracellular amyloid plaques that are com.rised prim.rily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of *** genetics of early-onset Ad and longitudinal brain-imaging studies of late-onset Ad indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheim.r death

Clinical validation of the early em.ryo viability assessment system: Analysis for the blastocyst m.rphology and pregnancy outcomes

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Asian pacific Journal of reproduction 2024年第5期13卷 219-227页

作者： vu d Hop An m Cuong Phi T T Anh Nguyen T L Huong Le Hoang Nguyen v Hanh Assisted reproductive Technology Centre Tam Anh General HospitalHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:To determine the relationship between the early em.ryo viability assessment(EEvA)and blastocyst m.rphological parameters and pregnancy ***:This retrospective cohort study was conducted on 291 intracytoplasmic sperm injection cycles including 2522 em.ryos with indications of prolonging em.ryo culture to the blastocyst stage in the Genea em.ryo review incubator,and 511 single vitrified-warmed blastocyst transfer cycles from January 2020 to June *** EEvA system produced an EEvA score from E1(best)to E5(worse)for the potential of blastocyst *** m.rphology was *** association between the EEvA score and each type of blastocyst m.rphology,implantation rate,clinical pregnancy,and ongoing pregnancy were assessed using generalized estimating ***:The inner cell mass A(ICm A),trophectoderm A(TE A),blastocoele expansion degree of 3,4,5,6,7 rates were higher with lower the EEvA *** adjusted odd ratio(aOr)(E5 vs E1)was 0.3 for ICm A,0.174 for TE A and 0.210 for BL3,4,5,6,7(all Pr EEvA scores and im.roved em.ryo *** implantation,clinical pregnancy,and ongoing pregnancy rate were also higher with lower the EEvA *** aOr of E5 vs E1 was 0.245 for implantation,0.185 for clinical pregnancy and 0.200 for ongoing pregnancy rate(Pre were associations between blastocyst m.rphology,pregnancy outcome and EEvA *** good blastocyst m.rphology and pregnancy outcomes are higher with lower the EEvA score.

关键词： Automated em.ryo assessment Blastocyst Early em.ryo viability assessment Genea em.ryo review incubator

Pd-1^(+)and TIm-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates Pd-1 and TIm-3 on T cells

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Oncology research 2024年第10期32卷 1575-1587页

作者： EGOr v.BATOrOv ALISA d.INESHINA TATIANA A.ArISTOvA vErA v.dENISOvA SvETLANA A.SIZIKOvA dArIA S.BATOrOvA GALINA Y.USHAKOvA EKATErINA Y.SHEvELA ELENA r.CHErNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelman Institute of medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia department of Hematology and Bone m.rrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(mm)***,previous studies showed the possibility of Pd-1 and TIm-3 expression on T cells upon stimulation with commonγ-chain family cytokines in vitro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating Pd-1 and TIm-3 checkpoint ***:The expression of Cd25,Cd122,Cd127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activator of transcription-5(pSTAT5)and eomesodermin(EOmES)was comparatively assessed with flow cytometry in Pd-1-and TIm-3-negative and positive T cells before the conditioning and during the first post-transplant month in peripheral blood samples of mm ***:Substantial proportions of Pd-1-and TIm-3-positive T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIm-3+T cells compared to Pd-1+TIm-3−*** proportions of both Pd-1-/TIm-3-negative and positive Cd8+T cells express EOmES,while only moderate frequencies of Cd4+Pd-1+/TIm-3+T cells up-regulate this transcription ***,the surface presence of Cd25 and intranuclear expression of EOmES in Cd4+T cells were mutually exclusive regardless of Pd-1 and TIm-3 *** stimulation with commonγ-chain cytokines up-regulates Pd-1 and TIm-3 during the proliferation of initially Pd-1/TIm-3-negative T cells but fails to expand initially Pd-1+and TIm-3+T cell subsets in ***:Both Pd-1 and TIm-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between Pd-1+and TIm-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to alleviate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) Cd25 Cd122 Eomesodermin(EOmES) Homeostatic proliferation

magnesium oxide(mgO)nanoadsorbents in wastewater treatment:A com.rehensive review

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Journal of magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： H.C.S.Perera v.Gurunanthanan Anoop Singh m.m.m.G.P.G.mantilaka G.das Sandeep Arya department of Physics Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of Science University of PeradeniyaPeradeniyaSri Lanka department of Humanities and Sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India Centre for Global Health research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia department of Physics University of JammuJammu and Kashmir180006India

Wastewater contamination by heavy metals and synthetic dyes presents a significant environmental challenge,necessitating effective and sustainable separation *** review article provides a detailed examination of magnesium oxide(mgO)nanoparticles as an innovative nanoadsorbent for wastewater treatment,with a specific focus on heavy metal and dye *** review com.rehensively explores various aspects of mgO nanoparticles,including their structural characteristics and synthesis *** article delves into the m.rphology and crystallographic arrangement of mgO nanoparticles,offering insights into their structural *** the complexity of adsorption processes,the review identifies and analyzes parameters influencing the adsorption efficiency of mgO nanoparticles,such as temperature,pH,contact time,initial concentration,and co-existing *** interplay between these parameters and the adsorption capability of mgO nanoparticles emphasizes the importance of optimizing operational ***,the review assesses various synthesis methods for mgO nanoparticles,including sol-gel,hydrothermal,precipitation,green synthesis,solvothermal,and template-assisted *** discusses the advantages,limitations,and resulting nanoparticle characteristics of each method,enabling readers to grasp the implications of synthesis processes on adsorption *** com.rehensive review consolidates current insights into the effectiveness of mgO nanoparticles as a potent nanoadsorbent for removing heavy metals and dyes from wastewater covering a wide spectrum of aspects related to mgO ***,there is a need to investigate the use of mgO in the treatment of actual wastewater or river water,in order to leverage its cost-effectiveness and high efficiency for practical water treatment applications in real-time.

关键词： mgO nanoparticles Nanoadsorbent Wastewater treatment Heavy metals dye separation Adsorption Synthesis methods

Accounting for Quadratic and Cubic Invariants in Continuum mechanics–An Overview

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Fluid dynamics & materials Processing 2024年第9期20卷 1925-1939页

作者： Artur v.dmitrenko vladislav m.Ovsyannikov department of Physics National Research Nuclear University(MEPhI)Kashirskoye Shosse 31Moscow115409Russian Federation department of Thermal Engineering and department of Waterways Ports and Hydraulic StructuresRussian University of Transport(MIIT)Obraztsova Street 9Moscow127994Russian Federation

The differential equations of continuum mechanics are the basis of an uncountable variety of phenomena and technological processes in fluid-dynamics and related *** equations contain derivatives of the first order with respect to *** derivation of the equations of continuum mechanics uses the limit transitions of the tendency of the volume increment and the time increment to *** are used to derive the wave *** differential wave equation is second order in ***,increments of volume and increments of time in continuum mechanics should be considered as small but finite quantities for problems of wave *** is important for calculating the generation of sound waves and water hamm.r ***,the Euler continuity equation with finite time increments is of *** finiteness of the time increment makes it possible to take into account the quadratic and cubic invariants of the strain rate *** is a new branch in *** and cubic invariants will be used in differential wave equations of the second and third order in time.

关键词： Quadratic invariant cubic invariant continuity equation generation of periodic waves N.E.Zhukovsky’s hydraulic shock turbulence

In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

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microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stevanović Nataša v.Todorović Aleksandar J.Krmpot m.roslav Živić Svetlana Savić-Šević Steva m.Lević m.rina Stanić dejan Pantelić Brana Jelenković mihailo d.rabasović Institute of Physiology and Biochemistry“Ivan djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological research“Siniša Stanković” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics Belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia University of Belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for multidisciplinary research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the mem.rane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing ***,their plasma mem.rane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell ***,we report the first femtosecond Ir laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was *** release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the *** plasma mem.rane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 *** to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.

关键词： patch recording laser

Praseodymium metal nanorods as a 5-fluorouracil carrier

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Journal of rare Earths 2024年第7期42卷 1328-1336,I0005页

作者： varnitha manikantan Govindaraj Sri varalakshmi Ujma Ashapak Tamboli Archana Sumohan Pillai Aleyamma Alexander Anushka Lucas Bose Allben Akash Israel v.m.v.Enoch Centre for Nanoscience and Genomics Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia department of Applied Chemistry Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia

Interest in metal nanoparticles as nanoscale drug-carrying vehicles has been *** such an aspect,lanthanide metal nanoparticles are particularly ***,we report praseodymium nanoparticles as a novel anticancer therapeutic transporting *** material was made as a composite with the supramolecular host polym.r,poly-β-*** praseodymium nanorods were characterized using standard analytical techniques,including X-ray diffraction(Xrd),X-ray photoelectron spectroscopy(XPS),and thermogravimetric analysis(TGA).In addition,they were imaged using transmission electron *** nanostructures are a long rod-shaped material with 2.0±0.1μm in length and 230±10 nm in *** material shows a saturation magnetization value above 30 emu/g with a coercivity value of 130 *** nanocarrier is freighted with the drug 5-fluorouracil,and the encapsulation efficiency is 76.09%.The drug release is continuous from the nanocarrier(polym.r-containing praseodymium nanoparticles)and proceeds for above 250 *** in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them on mCF-7 and vero(non-cancerous)cell *** cytotoxicity on the cancerous cell lines is observed,whereas the non-cancerous cells are *** IC_(50)values on the cell lines are reported.

关键词： metal nanoparticles Praseodymium Poly-cyclodextrin drug delivery Anticancer activity rare earths

design of a large-scale model for wind tunnel test of a multiadaptive flap concept

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Chinese Journal of Aeronautics 2024年第2期37卷 58-80页

作者： m.rüvvet Sinem SICIm dEm.rCI rosario PECOrA metin Orhan KAYA Aeronautical Engineering department Istanbul Technical UniversityIstanbulTurkey Industrial Engineering department University of Naples Federico IINapoliItaly

The design and application of m.rphing systems are ongoing issues compelling the aviation *** Clean Sky-program.represents the most significant aeronautical research ever launched in Europe on advanced technologies for greening next-generation *** prim.ry purpose of the program is to develop new concepts aimed at decreasing the effects of aviation on the environment,increasing reliability,and promoting eco-friendly *** ambitions are pursued through research on enabling technologies fostering noise and gas emissions reduction,mainly by im.roving aircraft aerodynamic *** the Clean Sky framework,a multimodal m.rphing flap device was designed based on tight industrial requirements and tailored for large civil aircraft *** flap is deployed in one unique setting,and its cross section is m.rphed differently in take-off and landing to get the necessary extra lift for the specific flight ***,during the cruise,the tip of the flap is deflected for load control and induced drag *** manufacturing the first flap prototype,a high-speed(ma=0.3),large-scale test campaign(geometric scale factor 1:3)was deemed necessary to validate the performance im.rovements brought by this novel system at the aircraft *** the other hand,the geometrical scaling of the flap prototype was considered im.racticable due to the unscalability of the embedded mechanisms and actuators for shape ***,a new architecture was conceived for the flap model to comply with the scaled dimensions requirements,withstand the relevant loads expected during the wind tunnel tests and emulate the shape transition capabilities of the true-scale *** strategies were developed to effectively m.rph the model during wind tunnel tests while ensuring the robustness of each m.rphed configuration and maintaining adequate stiffness levels to prevent undesirable deviations from the intended aerodynamic ***,

关键词： m.rphing structures Sm.rt aircraft m.rphing flap Adaptive systems Finger-like ribs Wind tunnel tests Large-scale m.rphing archi-tectures variable camber airfoil

Extracellular vesicles-coupled m.rNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early em.ryo development

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1528-1549页

作者： rosane mazzarella Karina Canon‑Beltran Yulia N.Cajas m.riem Hamdi Encina m.Gonzalez Juliano C.da Silveira Claudia L.v.Leal d.rizos department of Animal reproduction INIA-CSICMadridSpain department of Biochemistry and molecular Biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain department Agrarian Production Technical University of MadridUPMMadridSpain departamento de Ciencias Biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador department of Anatomy and Em.ryology FV-UCMMadridSpain department of veterinary medicine FZEA-USPPirassunungaBrazil

Background Extracellular vesicles(Evs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine em.ryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism.related genes(LmGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early em.ryo development and can determine the success or failure of the pregnancy. Bioactive molecules within Evs in maternal reproductive fluids, such as micro rNAs(m.rNAs), may contribute to this regulatory process as they modulate gene expression through post-transcriptional *** This study evaluated m.rNA cargo in OF-Evs from the early luteal phase and UF-Evs from the mid-luteal phase, coinciding with em.ryo transit within oviduct and uterus in vivo, and its possible influence on LmGs and sign-aling pathways crucial for early em.ryo development. A total of 333 m.rNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed m.rNAs, 19 up-regulated in UF-Evs(bta-m.r-134, bta-m.r-151-3p, bta-m.r-155, bta-m.r-188, bta-m.r-181b, bta-m.r-181d, bta-m.r-224, bta-m.r-23b-3p, bta-m.r-24-3p, bta-m.r-27a-3p, bta-m.r-29a, bta-m.r-324, bta-m.r-326, bta-m.r-345-3p, bta-m.r-410, bta-m.r-652, bta-m.r-677, bta-m.r-873 and bta-m.r-708) and one(bta-m.r-148b) in OF-Evs. These m.rNAs were predicted to modulate several pathways such as Wnt, Hippo, mAPK, and lipid metabolism and degradation. differ-ences in m.rNAs found in OF-Evs from the early luteal phase and UF-Evs from mid-luteal phase may reflect differ-ent environments to meet the changing needs of the em.ryo. Additionally, m.rNAs may be involved, particularly in the uterus, in the regulation of em.ryo lipid metabolism, immune system, and *** Our study su

关键词： Em.ryo-maternal interaction Epigenetic Exosomes mammalian Preimplantation reproductive fluids