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Effects of salvianolic acid B on in vitro growth inhibition and apoptosis induction of retinoblastoma cells

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 272-276页

作者： Xing-An Liu Department of Radiotherapy, People’s Hospital of zhengzhou, zhengzhou 450003. Henan Province, china Department of Radiotherapy People's Hospital of Zhengzhou Zhengzhou 450003 Henan Province China.

AIM: To observe the effects of salvianolic add B (SalB) on in vitro growth inhibition and apoptosis induction of retinoblastoma HXO-RB4. cells. METHODS: The effects of SalB on the HXO-RB4. cells proliferation in vitro were observed by MTT colorimetric method. The morphological changes of apoptosis before and after the treatment of SalB were observed by Hoechst 33258 fluorescent staining method. Apoptosis rate and cell cycle changes of HXO-RB4. cells were detected by flow cytometer at 4. hours after treated by SalB. The expression changes of Caspase-3 protein in HXO-RB4. cells were detected by Western Blot. RESULTS: SalB significantly inhibited the growth of HXO-RB4. cells, while the inhibition was in a concentration-and time-dependent manner. The results of fluorescent staining method indicated that HXO-RB4. cells showed significant phenomenon of apoptosis including karyorrhexis, fragmentation and the formation of apoptotic bodies, etc. after 24. 4. and 72 hours co-culturing of SalB and HXO-RB4. cells. The results of flow cytometer showed that the apoptosis rate and the proportion of cells in S phase were gradually increased at 4. hours and 72 hours after treated by different concentrations of SalB. Western Blot strip showed that the expression of Caspase-3 protein in HXO-RB4. cells was gradually increased with the increase of the concentration of SalB. CONCLUSION: SalB can significantly affect on HXO-RB4. cells growth inhibition and apoptosis induction which may be achieved through the up-regulation of Caspase-3 expression and the induction of cell cycle arrest.

关键词： salvianolic acid B HXO-RB4. cell apoptosis Caspase-3 protein

Baseline design of the KunLun Turbulence Profiler instrument

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Astronomical Techniques and Instruments 2024年第4期1卷 218-226页

作者： Xiaohui Guo Yi Hu Jing Li Xu Yang zhengzhou Yan School of Physics&Astronomy China West Normal UniversityNanchong 637002China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China

Adaptive optics systems are the most powerful tools to counteract the image blurring caused by atmospheric turbulence,allowing ground-based telescopes to capture high-resolution images.A critical parameter influencing adaptive optics system performance is the atmospheric refractive index structure constant,C_(n)^(2),which characterizes the intensity of atmospheric optical turbulence as a function of *** its simplicity,the lunar scintillometer is the preferred method for detecting atmospheric turbulence in challenging environments like Dome A in Antarctica,where sites are still in the developmental stages and local environmental conditions are extremely ***,optimizing the performance of such instruments requires carefully determining the baseline configuration of photon sensors according to each site's specific optical turbulence profile *** study uses a Monte Carlo method to identify the optimal configuration for the KunLun Turbulence Profiler(KLTP),an instrument comparable to the lunar scintillometer,developed for use at Dome *** conducted using the obtained optimal baseline configuration recovered three different model optical turbulence profiles,demonstrating the effectiveness of our method in obtaining an optimal baseline *** approach can be easily applied to baseline design for similar turbulence profilers at other sites.

关键词： KunLun Turbulence Profiler Monte Carlo Simulation Turbulence profile

Risk analysis model for landslide mass of high slope in dam area

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Science china(Technological Sciences) 2008年第S2期51卷 25-31页

作者： GU ChongShi1,2,HE XianFeng3,4.WU ZhongRu1,2 & SU HuaiZhi1,2 1 College of Water Conservancy and Hydropower Engineering,Hohai University,Nanjing 210098,china 2 National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety,Nanjing 210098,china 3 Yellow River Institute of Hydraulic Research,zhengzhou {4.china 4.Embankment Security Defect Prevention and Control Engineering Research Center of MWR,zhengzhou {4.china College of Water Conservancy and Hydropower Engineering Hohai University Nanjing China National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Nanjing China Yellow River Institute of Hydraulic Research Zhengzhou China Embankment Security Defect Prevention and Control Engineering Research Center of MWR Zhengzhou China

In order to identify the threat of reservoir bank landslide to dam safety and reduce the risk of dam failure,impact factors of the landslide are *** concept of landslide risk degree is put forward to measure the threat of landslide to dam *** monotony of the landslide risk assessment function which changes with different affecting factors is analyzed *** on gene automatic programming,a data mining model of the landslide risk assessment function is constructed combined with impact factors of reservoir bank landslide on dam *** the assessment function of landslide risk has been excavated and established according to practical project information,which provides a valuable reference for analyzing the impact of landslide on dam risk.

关键词： landslide dam failure risk landslide risk

Study on the changes of water cycle and its impacts in the source region of the Yellow River

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Science china(Technological Sciences) 2004年第z1期47卷 142-151页

作者： ZHANG Shifeng1, JIA Shaofeng1, LIU Changming1, CAO Wenbing2, HAO Fanghua3, LIU Jiuyu4.& YAN Huayun5 1. Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, china 2. china University of Geosciences, Beijing 100083, china 3. Beijing Normal University, Beijing 100875, china 4. Bureau of Hydrology of Yellow River Conservancy Commission,{4. 5. Bureau of Hydrology and Water Resource Investigation of Qinghai Province, Xining 810001, china Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China

The water cycle in the source region of the Yellow River underwent great changes in the 1990s. The major features of the changes are as follows: the gauged runoff declined significantly while the precipitation increased slightly, and the runoff process was more concentrated on the flood season. Water balance analyses indicate that the pondage was kept in the status of negative equilibrium, causing eco-environmental problems. The runoff decrement is due to evaporation increment in this region. Studies show that the runoff process in this region is closely related to that of the other hydrological stations in the upper reaches. When the runoff declines in the source regions, the amount of water also declines in the whole upper reaches of the Yellow River, affecting the balance between water demand and supply. Meanwhile changes will take place in the water cycle of the river course system when the eco-environment deteriorates. The trend of water cycle change in the source region is that the runoff will keep declining with the increment of evaporation caused by temperature rise in the northwest of china in the 21st century. But the hydraulic engineering in the source region will help to mitigate the deterioration of local eco-environment system, though the impacts to the lower reaches of this project may not be the case.

关键词： source region of the Yellow River, water cycle, evaporation, negative equilibrium.

Response of flood discharging capacity to the deterioration of the lower Yellow River

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Science china(Technological Sciences) 2004年第z1期47卷 152-160页

作者： LI Wenxue1, LI Yong2, YAO Wenyi2, SU Yunqi2 & ZHANG Xiaohua2 1. Yellow River Engineering Consulting Co. Ltd., zhengzhou 450003. china 2. Yellow River Institute of Hydraulic Research, zhengzhou 450003. china Yellow River Institute of Hydraulic Research

Based on the clarifications of the deterioration characteristics of the lower Yellow River (LYR), the influence of river deterioration on flood discharging capacity is studied through theoretical derivation and analysis of field data. This study indicates that response of flood discharging capacity to river deterioration is nonlinear. Sediment depositions in the main channel cause the reductions of dominant discharge and thus the increase of initial flood stage. Reductions in the channel width result in the increases of the rising rate of flood stage and the decrease of flood discharging capacity.

关键词： flood discharging capacity, boundary condition, deterioration, sediment, the lower Yellow River.

Soil erosion and sediment transport in the gullied Loess Plateau:Scale effects and their mechanisms

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Science china(Technological Sciences) 2009年第5期52卷 1283-1292页

作者： LI TieJian1,WANG GuangQian1,XUE Hai2,3 & WANG Kai4.1 State Key Laboratory of Hydroscience and Engineering,Tsinghua University,Beijing 100084.china 2 Yellow River Engineering Consulting Co.,Ltd.,zhengzhou {4.china 3 North china Institute of Water Conservancy and Hydropower,zhengzhou 4.0008,china 4.china Institute of Water Resources and Hydropower Research,Beijing 100038,china State Key Laboratory of Hydroscience and Engineering Tsinghua University china Institute of Water Resources and Hydropower Research

Scale effects exist in the whole process of rainfall-3-runoff-3-soil erosion-3-sediment transport in river basins. The differences of hydrographs and sediment graphs in different positions in a river basin are treated as basic scale effects, which are more complex in the gullied Loess Plateau, a region notorious for high intensity soil erosion and hyper-concentrated sediment-laden flow. The up-scaling method of direct extrapolation that maintains dynamical mechanism effective in large scale application was chosen as the methodology of this paper. Firstly, scale effects of hydrographs and sediment graphs were analyzed by using field data, and key sub-processes and their mechanisms contributing to scale effects were clearly defined. Then, the Digital Yellow River Model that integrates sub-models for the subprocesses was used with high resolution to simulate rainfall-3-runoff-3-soil erosion-3-sediment transport response in Chabagou watershed, and the distributed results representing scale effects were obtained. Finally, analysis on the simulation results was carried out. It was shown that gravitational erosion and hyper-concentrated flow contribute most to the spatial variation of hydrographs and sediment graphs in the spatial scale. Different spatial scale distributions and superposition of different sub-processes are the mechanisms of scale effects.

关键词： scale effect soil erosion hyper-concentrated sediment-laden flow the Loess Plateau

Dam risk assistant analysis system design

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Science china(Technological Sciences) 2008年第S2期51卷 101-109页

作者： HE XianFeng1,2,3,GU ChongShi3,4.WU ZhongRu3,4.& SU HuaiZhi3,4.1 Yellow River Institute of Hydraulic Research,zhengzhou {4.china 2 Embankment Security Defect Prevention and Control Engineering Research Center of MWR,zhengzhou 4.000,china 3 College of Water Resources and Hydropower Engineering,Hohai University,Nanjing 210098,china 4.National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety,Hohai University,Nanjing 210098,china Yellow River Institute of Hydraulic Research Zhengzhou China Embankment Security Defect Prevention and Control Engineering Research Center of MWR Zhengzhou China College of Water Resources and Hydropower Engineering Hohai University Nanjing China National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Hohai University Nanjing China

In order to reduce the labor intensity and task difficulty of dam risk analysis and to meet the actual requirement of dam risk analysis,it is necessary to establish a dam risk assistant analysis *** program structure and the implementation ways of the dam risk assistant analysis system are analyzed,and a procedural framework with "three-tier and multi-database" structure and "level structure" is *** concept of dam risk assessment system modular development is proposed and the coupled mode of function module and data is ***,the dam risk assistant analysis system is developed using Delphi visual programming language.

关键词： dam risk risk analysis assistant analysis system

Combined adjustment project of national astronomical geodetic networks and 2000' national GPS control network

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Progress in Natural Science:Materials International 2005年第5期15卷 435-441页

作者： YANG Yuanxi1*, ZHA Ming2, SONG Lijie3, WEI Ziqing1, WANG Zhouping2, OUYANG Guichong2, XU Bilin2, WU Xiaoping3 and WANG Junqin4.1. Xi'an Research Institute of Surveying and Mapping, Xi'an 710054. china 2. Xi'an Informational and Technical Center of Surveying and Mapping, Xi'an 710054. china 3. zhengzhou Institute of Surveying and Mapping, zhengzhou 4.0052, china 4. The First Surveying Team of Tianjin, Tianjin 30014., china) Xian Research Institute of Surveying and Mapping Xi''an 710054 China Xi''an Informational and Technical Center of Surveying and Mapping Xi''an 710054 China zhengzhou Institute of Surveying and Mapping Zhengzhou 450052 China

The combined adjustment project of the nationwide astronomical geodetic networks and 2000' national GPS control network involve 4.519 terrestrial observational stations and 2666 GPS observational stations. In the terrestrial network, 25107 stations are height fixed and 234.2 stations are in three dimensions. 4.0793 terrestrial observations and 183668 unknowns are involved in the adjustment. The three-dimensional observational models for the adjustment have been established. The crustal deformation influences and corrections are researched. Fast methods of solving partitioned adjustment for super large-scale geodetic network have been studied. The standard deviations of three-dimensional coordinates for all stations are evaluated. As a result of the combined adjustment, a unified national geodetic network with nearly 50000 stations is established, the high accurate three-dimensional geocentric coordinates are obtained. The standard deviation for geoid is averagely 0.2 m, for vertical deflection is about 1.5″, for the horizontal position is about 0.12 m, for the geodetic height is about 0.14.m, and for the three-dimensional position is averagely 0.3 m.

关键词： astronomical geodetic network GPS network combined adjustment datum geocentric coordinates.

REGULATION OF FLOW AND SEDIMENT LOAD IN THE YELLOW RIVER

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International Journal of Sediment Research 2007年第2期22卷 103-113页

作者： Wenxue LI1, Jixiang LIU1 and Zhanwei WAN2Yellow River Engineering Consulting Co. Ltd., zhengzhou 450003. china,Yellow River Engineering Consulting Co. Ltd., zhengzhou 450003. china Yellow River Engn Consulting Co Ltd Zhengzhou 450003 Peoples R China

Small runoff, large sediment load, and incompatible relationship of flow and sediment load are very important characteristics of the Yellow River. They are also the crux of the most prominent problems of the Yellow River. To solve these problems, the regimes of flow and sediment load have to be improved by increasing water, reducing sediment load, and by using reservoirs to regulate flow and sediment load. The results of experiments for regulating the flow and sediment load in the last three years by the Xiaolangdi Reservoir have indicated that this measure is a realistic and effective way to mitigate the prominent problems in flood control of the Lower Yellow River at present and in the near future. However, the regulation system is still imperfect. It is advisable to speed up the pace of research and construction of the system for regulating flow and sediment load.

关键词： The Yellow River Regulation of flow and sediment load The Xiaolangdi Reservoir Experiment Channel deterioration