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A BODIPY analogue from the tautomerization of sodium 3.oxide BODIPY

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Chinese Chemical Letters 2015年第6期26卷 631-635页

作者： Peng-Zhong Chen Hai-Rong Zheng Li-Ya Niu Yu-Zhe Chen Li-Zhu Wu Chen-ho tung Qing-Zheng Yang Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences University of the Chinese Academy of Sciences College of Chemistry Beijing Normal University

The introduction of hydroxy group to the 3. or 5-position of 4,4-difluoro-4-bora-3.Aa-diazaindacene （BODIPY） results in unexpected tautomerization to BDPONa with interesting structural and photophysical properties. The core of BDPONa is an anion with sodium cation as counter-ion. BDPONa displays strong fluorescence in organic solvents.

关键词： Bodipy Substitution reaction Tautomerization Sodium salt

Monofunctionalized pillar [5] arene-based stable [1] pseudorotaxane

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Chinese Chemical Letters 2015年第7期26卷 843-846页

作者： Cai-Li Sun Jiang-Fei Xu Yu-Zhe Chen Li-Ya Niu Li-Zhu Wu Chen-ho tung Qing-Zheng Yang Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences College of Chemistry Beijing Normal University University of the Chinese Academy of Sciences

We reported a new monofunctionalized pillar[5]arene bearing imidazolium moiety that formed stable [1]pseudorotaxane even at high concentration （100 mmol/L） in chloroform. The self-assembly was detailed investigated by multiple methods, including varying concentration 1H NMR, 2D COSY NMR, 2D NOESY NMR, viscosity measurements, 2D DOSY NMR, and HR-ESI-MS analysis. [llRotaxane was obtained efficiently through photo thiol-ene reaction which further confirmed the formation of [l]pseudorotaxane.

关键词： PillarareneSelf-assembly[ 1 ]pseudorotaxanesThinl-ene reaction

Efficacy of Vaccine Protection Against COVID-19 Virus Infection in Patients with Chronic Liver Diseases

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 718-735页

作者： Carmen Ka Man Cheung Kimmy Wan tung Law Alvin Wing Hin Law Man Fai Law Rita ho Sunny Hei Wong Department of Medicine and Therapeutics Prince of Wales HospitalHong KongChina West Island School Hong KongChina Department of Medicine North District HospitalHong KongChina Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChinaLee Kong Chian School of MedicineNanyang Technological UniversitySingapore

The outbreak of coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Vaccination against coronavirus disease 2019 is a use-ful weapon to combat the virus. Patients with chronic liver diseases (CLDs), including compensated or decompensated liver cirrhosis and noncirrhotic diseases, have a decreased immunologic response to coronavirus disease 2019 vaccines. At the same time, they have increased mortality if infected. Current data show a reduction in mortality when patients with chronic liver diseases are vaccinated. A suboptimal vac-cine response has been observed in liver transplant recipi-ents, especially those receiving immunosuppressive therapy, so an early booster dose is recommended to achieve a better protective effect. Currently, there are no clinical data com-paring the protective efficacy of different vaccines in patients with chronic liver diseases. Patient preference, availability of the vaccine in the country or area, and adverse effect profiles are factors to consider when choosing a vaccine. There have been reports of immune-mediated hepatitis after coronavi-rus disease 2019 vaccination, and clinicians should be aware of that potential side effect. Most patients who developed hepatitis after vaccination responded well to treatment with prednisolone, but an alternative type of vaccine should be considered for subsequent booster doses. Further prospec-tive studies are required to investigate the duration of immu-nity and protection against different viral variants in patients with chronic liver diseases or liver transplant recipients, as well as the effect of heterologous vaccination.

关键词： COVID-19 SARS-CoV-2 Chronic liver disease Liver transplanta-tion Vaccine mRNA.

Special Issue Dedicated to the Memory of Professor Enze Min

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Chinese Journal of Chemistry 2017年第5期35卷 519-519页

作者： Chen-ho tung Mingyuan He Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Shanghai Key Laboratory of Green Chemistry andChemical ProcessesEast China Normal UniversityShanghai 200062 China

This special issue is dedicated to the memory of the late Professor Enze Min at Research Institute of Petroleum Processing,Sinopec.

关键词： SPECIAL issues of periodicals

Photocatalytic Dehydrogenative and Hydrogen-Evolution Cross-Couplig Reactions

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Photocatalytic Dehydrogenative and Hydrogen-Evolution Cross-...

Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era

中国化学会第十二届全国物理有机化学学术会议

作者： Chen-ho tung Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences

＜正＞Catalyzed oxidative cross-couplings have emerged as a powerful tool for constructing carbon-carbon（C-C）linkage directly from two simple carbon-hydrogen（C-H）bonds and for building carbon-heteroatom（C-X）link...

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世界胃肠病学杂志:英文版 2023年第33期29卷 4942-4961页

作者： Joyce Wing Yan Mak Alvin Wing Hin Law Kimmy Wan tung Law Rita ho Carmen Ka Man Cheung Man Fai Law Department of Medicine and Therapeutics Prince of Wales HospitalHong Kong 852China West Island School Hong Kong 852China Department of Medicine North District HospitalHong Kong 852China

Hepatitis due to hepatitis B virus(HBV)reactivation can be serious and potentially fatal,but is *** reactivation is most commonly reported in patients receiving chemotherapy,especially rituximab-containing therapy for hematological malignancies and those receiving stem cell *** with inactive and even resolved HBV infection still have persistence of HBV genomes in the *** expression of these silent genomes is controlled by the immune *** or ablation of immune cells,most importantly B cells,may lead to reactivation of seemingly resolved HBV ***,all patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core *** found to be positive for HBsAg should be given prophylactic antiviral *** patients with resolved HBV infection,there are two *** first is pre-emptive therapy guided by serial HBV DNA monitoring,and treatment with antiviral therapy as soon as HBV DNA becomes *** second approach is prophy-lactic antiviral therapy,particularly for patients receiving high-risk therapy,especially anti-CD20 monoclonal antibody or hematopoietic stem cell *** and tenofovir are the preferred antiviral *** new effective therapies for hematological malignancies have been introduced in the past decade,for example,chimeric antigen receptor(CAR)-T cell therapy,novel monoclonal antibodies,bispecific antibody drug conjugates,and small molecule inhibitors,which may be associated with HBV *** there is limited evidence to guide the optimal preventive measures,we recommend antivi-ral prophylaxis in HBsAg-positive patients receiving novel treatments,including Bruton’s tyrosine kinase inhibitors,B-cell lymphoma 2 inhibitors,and CAR-T cell *** studies are needed to determine the risk o

关键词： Hepatitis B Hematologic neoplasms Chimeric antigen receptor-T cell therapy Monoclonal antibodies Bruton’s tyrosine kinase inhibitors Antiviral agents

Facile one-pot synthesis of a novel all-carbon stair containing dimerized pentalene core from alkyne

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Chinese Chemical Letters 2022年第4期33卷 2047-2051页

作者： Hui Zhao Rakesh Kumar Gupta Wei Zhang Jiong Jia Qun Yu Zhiyong Gao Guilin Zhuang Dacheng Li Xingpo Wang Chen ho tung Di Sun Key Laboratory of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringState Key Laboratory of Crystal MaterialsShandong UniversityJi’nan 250100China College of Chemical Engineering and Materials Science Zhejiang University of TechnologyHangzhou 310032China School of Chemistry and Chemical Engineering Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Normal UniversityXinxiang 453007China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology and School of Chemistry and Chemical EngineeringLiaocheng UniversityLiaocheng 252000China

The construction of all-carbon molecule frameworks remains challenging. Herein, we report a facile and efficient one-pot synthesis of a novel all-carbon stair containing dimerized pentalene core using inexpensive cyclopropyl alkyne catalyzed by in situ generated Cu(I) from the comproportionation reaction of Cu(II) salt and Cu powder under mild reaction conditions. The reaction proceeds via sequential acetylenic coupling, followed by cyclization and [2 + 2] cycloaddition to directly produce pentalene dimer, which is difficult to access by other established methods. Different mechanistic paths were studied for the pentalene formation using density functional theory, suggesting that the reaction also proceeds through acetylenic coupling followed by cyclization and [2 + 2] cycloaddition. Based on the activation energy barriers, Path 1 has the rate-determining step of 3..63.kcal/mol, which is the most thermodynamically preferred one among the four paths.

关键词： One-pot synthesis Penatlene dimerization Comproportionation reaction Crystal structure Theoretical calculations

Anionic passivation layer-assisted trapping of an icosahedral Ag_(13.kernel in a truncated tetrahedral Ag_(89)nanocluster

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Science China Chemistry 2021年第9期64卷 1482-1486页

作者： Yan-Min Su Bao-Qian Ji Zhi Wang Shan-Shan Zhang Lei Feng Zhi-Yong Gao Yun-Wu Li Chen-ho tung Di Sun Lan-Sun Zheng Key Lab of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringState Key Laboratory of Crystal MaterialsShandong UniversityJinan250100China School of Chemistry and Chemical Engineering Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Normal UniversityXinxiang453007China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical EngineeringLiaocheng UniversityLiaocheng252000China State Key Laboratory for Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China

Isolating reductive silver kernel from shell is a challenging task but is quite important to understand the embryonic form during the formation of silver *** intercalation of suitable anionic species may be of benefit for passivating then capturing such highly active ***,we successfully isolated a novel silver thiolate nanocluster[Ag_(13.@Ag_(76)S_(16)(Cyh S)_(42)(p-NH_(2)-Ph As O_(3.)_(4)]^(3.)(SD/Ag89 a,Cyh SH=cyclohexanethiol)that contains a well-isolated icosahedral Ag_(13. kernel passivated by four Ag S_(4)^(7-) tetrahedra and four p-NH_(2) Ph As O_(3.^(2-) piercing from outer Ag_(72) *** note,this Ag_(13. kernel is the largest isolable subvalent silver kernel beneath the silver shell with extremely legible core-shell boundary ever before and represents a precise embryonic model formed in the reducing Ag(I)to Ag(0)followed by aggregating to large silver *** reductive role of DMF and the introduction of anionic passivation layer(APL)synergistically modulate the reduction kinetics,facilitating the capture of ultrasmall subvalent silver ***/Ag89 a emits in near infrared(NIR)region(λ_(em)=800 nm)at low *** synthetic strategy shown in this work opens up new opportunities for precisely capturing and recognizing diverse reductive silver kernels in different systems.

关键词： silver cluster anionic passivation layer X-ray structure luminescence

Aggregation-Enabled Intermolecular Photo[2+2]cycloaddition of Aryl Terminal Olefins by Visible-Light Catalysis

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CCS Chemistry 2020年第1期2卷 582-588页

作者： Zan Liu Chao Zhou Tao Lei Xiao-Lei Nan Bin Chen Chen-ho tung Li-Zhu Wu Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryThe Chinese Academy of SciencesBeijing 100190(China) School of Future Technology University of Chinese Academy of SciencesBeijing 100049(China)

Photo[2+2]cycloaddition of olefins is a sought-after tool for making cyclobutanes,which are the building blocks for a wide range of biologically active molecules and natural ***,the formation of cyclobutane derivatives from aryl terminal olefins is problematic due to their high redox potential,and high energy in the excited state,making visible-light-absorbing photocatalyst difficult to realize either electron or energy transfer to olefins during the photocyclic addition ***,we report,for the first time,the aggregationinduced photo[2+2]cycloaddition of two olefins by visible-light catalysis in homogeneous *** array of control experiments and spectroscopic analyses reveal that the terminal olefins tend to aggregate to form excimers/exciplexes,which possess much lower energy than their monomeric forms,and enables triplet energy transfer from excited Ir(ppy)3.to supramolecular self-assembly feasible,leading to homo and cross[2+2]photodimerization of the olefins to fabricate cyclobutanes at ambient conditions in good to excellent yields.

关键词： aggregation aryl terminal olefin cyclobutane photocatalysis energy transfer