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Permeability Estimation of Shale Oil Reservoir with Laboratory-derived Data: A Case Study of the Chang 7 Member in Ordos Basin

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Applied Geophysics 2024年第3期21卷 440-455,616页

作者： Zhang lin Gao Li Ba Jing Zhang Meng-bo JoséM.Carcione Liu Wei-Hua School of Earth Sciences and Engineering Hohai UniversityNanjingJiangsu211000 Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an Shanxi710018 National Institute of Oceanography and Applied Geophysics(OGS) SgonicoTrieste 34010 Sinopec Geophysical Research Institute NanjingJiangsu211103

The shale oil reservoir within the Yanchang Formations of Ordos Basin harbors substantial oil and gas resources and has recently emerged as the primary focus of unconventional oil and gas exploration and *** to its complex pore and throat structure,pronounced heterogeneity,and tight reservoir characteristics,the techniques for conventional oil and gas exploration and production face challenges in comprehensive implementation,also indicating that as a vital parameter for evaluating the physical properties of a reservoir,permeability cannot be effectively *** study selects 21 tight sandstone samples from the Q area within the shale oil formations of Ordos *** systematically conduct the experiments to measure porosity,permeability,ultrasonic wave velocities,and resistivity at varying confining *** reveal that these measurements exhibit nonlinear changes in response to effective *** using these experimental data and effective medium model,empirical relationships between P-and S-wave velocities,permeability and resistivity and effective pressure are established at logging and seismic ***,relationships between P-wave impedance and permeability,and resistivity and permeability are determined.A comparison between the predicted permeability and logging data demonstrates that the impedance–permeability relationship yields better results in contrast to those of resistivity–permeability *** relationships are further applied to the seismic interpretation of shale oil reservoir in the target layer,enabling the permeability profile predictions based on inverse P-wave *** predicted results are evaluated with actual production data,revealing a better agreement between predicted results and logging data and productivity.

关键词： shale oil reservoir P-wave impedance resistivity permeability rock physics experiment

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Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang Ya-li lin Yin-yan Gao Jin-lu Song Lang Qin ling-qi Li Wen-qi Liu Claire C.W.Zhong Mary Y.Jiang Chen Mao Xiao-bo Yang Vincent C.H.Chung Irene X.Y.Wu Jockey Club School of Public Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on CHM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 13.8 RCTs were *** binary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23.95%CI:[1.07,1.3.]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03.1.3.]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23.95%CI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23.95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.3.

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

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三联冶炼+挤压制备的GH4710合金棒材热变形行为及热加工图

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稀有金属材料与工程 2024年第9期53卷 2555-2564页

作者：陈由红兰博孙兴林莺莺中国航发北京航空材料研究院北京100095

采用真空感应(VIM)+电渣重熔(ESR)+真空自耗(VAR)三联冶炼制备的GH4710合金铸锭经挤压获得棒材。在Gleeble-1500试验机上开展等温压缩实验,研究了三联铸锭挤压态GH4710合金在温度1050~1150℃,应变速率0.01~5 s^(-1)条件下的热变形行为... 详细信息

采用真空感应(VIM)+电渣重熔(ESR)+真空自耗(VAR)三联冶炼制备的GH4710合金铸锭经挤压获得棒材。在Gleeble-1500试验机上开展等温压缩实验,研究了三联铸锭挤压态GH4710合金在温度1050~1150℃,应变速率0.01~5 s^(-1)条件下的热变形行为。结果表明,应力-应变曲线具有明显的动态再结晶特征,且应力随着变形温度的升高和应变速率的降低而明显减小。基于应力应变曲线,建立了合金动态再结晶临界应变模型,同时建立了考虑应变影响的Arrhenius本构模型来精确描述合金应力、应变速率和温度的依赖关系。最后以动态材料模型为基础构建了合金热加工图,结合显微组织分析,明确了合金流变失稳特征为不均匀显微组织,确定了合金最佳锻造工艺参数范围为1050℃≤T≤1100℃、0.01 s^(-1)≤ε≤0.1 s^(-1)。

关键词： GH4710合金挤压三联冶炼工艺热加工图

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Biosynthetic pathway of prescription cucurbitacin IIa and high-level production of key triterpenoid intermediates in engineered yeast and tobacco

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Plant Communications 2024年第6期5卷 154-172页

作者： Geng Chen Zhaokuan Guo Yanyu Shu Yan Zhao Lei Qiu Shaofeng Duan Yuan lin Simei He Xiaobo Li Xiaolin Feng Guisheng Xiang bo Nian Yina Wang Zhiyuan Li Chongkang Yang Yang Shi Yingchun Lu Guanze Liu Shengchao Yang Guanghui Zhang Bing Hao State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan The Key Laboratory of Medicinal Plant Biology of Yunnan ProvinceNational&Local Joint Engineering Research Center on Germplasms Innovation&Utilization of Chinese Medicinal Materials in Southwest ChinaYunnan Agricultural UniversityKunming 650201China Yunnan Characteristic Plant Extraction Laboratory KunmingYunnan 650106China

Cucurbitacin IIa is a triterpenoid isolated exclusively from Hemsleya plants and a non-steroidal anti-inflammatory drug that functions as the main ingredient of prescription Hemslecin capsules and tablets in *** biology provides new strategies for production of such valuable cucurbitacins at a large scale;however,the biosynthetic pathway of cucurbitacin IIa has been unknown,and the heterologous production of cucurbitacins in galactose medium has been expensive and low *** this study,we characterized the functions of genes encoding two squalene epoxidases(HcSE1-2),six oxidosqualene cyclases(HcOSC1-6),two CYP450s(HcCYP87D20 and HcCYP81Q59),and an acyltransferase(HcAT1)in cucurbitacin IIa biosynthesis by heterologous expression in Saccharomyces cerevisiae and Nicotiana *** achieved high-level production of the key cucurbitacin precursor 11-carbonyl-20b-hydroxy-Cuol from glucose in yeast via modular engineering of the mevalonate pathway and optimization of P450 expression *** resulting yields of 46.41 mg/l 11-carbonyl-20b-hydroxy-Cuol and 126.47 mg/l total cucurbitacin triterpenoids in shake flasks are the highest yields yet reported from engineered ***,production of 11-carbonyl-20b-hydroxy-Cuol by transient gene expression in tobacco resulted in yields of 1.28 mg/g dry weight in *** work reveals the key genes involved in biosynthesis of prescription cucurbitacin IIa and demonstrates that engineered yeast cultivated with glucose can produce high yields of key triterpenoid *** describe a low-cost and highly efficient platform for rapid screening of candidate genes and high-yield production of pharmacological triterpenoids.

关键词： cucurbitacin IIa oxidosqualene cyclase OSC 11-carbonyl-20b-hydroxy-Cuol Saccharomyces cerevisiae Nicotiana benthamiana Hemsleya chinensis

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Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng lin-Zhu Lu Qian-Qian Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang bo Zou Hong-Ping Long Qing Zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

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海口市臭氧浓度统计预报模型的构建与效果评估

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环境科学 2024年第5期45卷 2516-2524页

作者：符传博林建兴唐家翔丹利海南省气象科学研究所海口570203 海南省南海气象防灾减灾重点实验室海口570203 海南省气象台海口570203 中国科学院大气物理研究所东亚区域气候‐环境重点实验室北京100029

主要利用2015~2020年海口市臭氧(O_(3.)浓度资料和ERA5再分析资料,基于污染物浓度控制方程挑选出海口市O_(3.-8h浓度(日最大8 h滑动平均)的15个关键预报因子,构建了多元线性回归模型(MLR)、支持向量机模型(SVM)和BP神经网络模型(BPNN),... 详细信息

主要利用2015~2020年海口市臭氧(O_(3.)浓度资料和ERA5再分析资料,基于污染物浓度控制方程挑选出海口市O_(3.-8h浓度(日最大8 h滑动平均)的15个关键预报因子,构建了多元线性回归模型(MLR)、支持向量机模型(SVM)和BP神经网络模型(BPNN),并对2021年海口市O_(3.-8h浓度进行预测和效果检验.结果表明,O_(3.-8h浓度与关键预报因子的相关系数绝对值主要分布在0.2~0.507之间,其中1000 hPa的相对湿度(RH1000)和风向(WD1000),875 hPa的经向风(v875)的相关系数绝对值超过了0.4,具有较好的指示作用.3.预报模型基本能预报出海口市O_(3.-8h浓度冬半年偏高,夏半年偏低的变化趋势,其中BPNN模型的标准误差(RMSE)数值最小(22.29μg·m^(−3.).实测值与3.统计模型预报值的相关系数从大到小排列为:0.73.(BPNN)>0.724(SVM)>0.591(MLR),均通过了99.9%的信度检验.O_(3.-8h浓度等级预报的结果检验表明,3.预报模型的TS评分均随着O_(3.-8h浓度等级的上升而下降,而漏报率(PO)和空报率(NH)随着O_(3.-8h浓度等级的上升而上升.SVM和BPNN模型在3.等级预报中TS评分均略高于MLR模型,特别是在轻度污染等级,TS评分还维持在70%以上,具有较好的预报性能.

关键词：臭氧(O_(3.) 多元线性回归支持向量机 BP神经网络预报评估海口市

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光热转换材料在相变储能领域的研究进展

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精细化工 2024年第2期41卷 315-329页

作者：李紫琪林琳张健王卿平徐博张强北华大学吉林省木质材料科学与工程重点实验室吉林吉林132013 北华大学理学院吉林吉林132013 燕山大学先进锻压成形技术与科学教育部重点实验室河北秦皇岛066004

相变储能是热储能的一种,即利用相变材料的储热特性来储存或释放热量,达到调控温度的效果。但相变材料往往不具备光吸收能力,不能及时收集太阳光,导致其光热转换效率较低。将相变材料与光热转换材料复合,可在增强吸光能力的同时将获得... 详细信息

相变储能是热储能的一种,即利用相变材料的储热特性来储存或释放热量,达到调控温度的效果。但相变材料往往不具备光吸收能力,不能及时收集太阳光,导致其光热转换效率较低。将相变材料与光热转换材料复合,可在增强吸光能力的同时将获得的能量存储在相变材料中,赋予复合相变材料高光热转换能力。该文对光热转换材料进行了分类,介绍了其光热转换机理、对紫外光-可见光-近红外光的吸收能力以及在相变领域的应用。此外,还阐述了光热复合相变材料的复合策略,包括浸渍法、溶胶-凝胶法、涂层法和改性微胶囊法,分析表明,不同复合策略下制备的光热复合相变材料的光吸收能力、导热系数、光热转换效率几乎都得到了提高。因此,将光热转换材料拓展到相变储能领域,将进一步优化太阳能资源。

关键词：相变材料光热转换材料光热复合相变材料复合策略光热转换效率

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一年施与两年连施生物炭对稻田土壤磷素稳定性及有效性的影响

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生态与农村环境学报 2024年第10期40卷 1337-1347页

作者：高博涵马长林王艳玲南京信息工程大学应用气象学院江苏南京210044

以酸性水稻土为研究对象,通过水稻盆栽试验,分析了在不施加生物炭(CK)、只施加一年生物炭(B1)和连续两年施加生物炭(B2)处理下,不同生育期稻田土壤全磷(TP)、活性磷(P_(SOL)、P_(M3.)、中稳态磷(Pi_(OH)、Po_(OH)、P_(HCl))、高稳态磷(P... 详细信息

以酸性水稻土为研究对象,通过水稻盆栽试验,分析了在不施加生物炭(CK)、只施加一年生物炭(B1)和连续两年施加生物炭(B2)处理下,不同生育期稻田土壤全磷(TP)、活性磷(P_(SOL)、P_(M3.)、中稳态磷(Pi_(OH)、Po_(OH)、P_(HCl))、高稳态磷(P_(CL)、P_(OCL))含量及占比的动态变化差异,讨论了稻田土壤遗存磷指数(LGC)、磷饱和度(DPS)、磷吸附容量(SOR)对生物炭添加施用的响应特征。结果表明,与CK相比,B1处理的土壤活性磷含量在分蘖期显著降低、成熟期显著增加,中稳态磷含量在分蘖期显著增加,高稳态磷含量各时期均无显著变化。B2土壤活性磷含量在抽穗期和成熟期均显著增加,中稳态磷含量在分蘖期和成熟期显著增加,高稳态磷含量无显著变化,但占比在抽穗期与成熟期分别显著降低18.8%和27.8%。B1和B2处理LGC和DPS均显著增加,且B1处理土壤SOR在抽穗期显著增加。因此,生物炭添加显著增加了稻田土壤活性磷和中稳态磷的含量与占比,降低了植物利用率较低的高稳态磷的占比,说明生物炭施加增加了稻田土壤遗存磷和生物有效磷含量。研究结果明确了稻秆生物炭施用后稻田土壤磷的稳定性及有效性的变化特征,为稻田土壤磷素管理提供了合理化建议。

关键词：生物炭稻田土壤磷组分磷流失风险

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基于量子力学的PT对称无铁芯变压器机理提出及研究进展

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中国电机工程学报 2024年第18期44卷 7479-7490,I0028页

作者：张波赖立林靖扬杨伦华南理工大学电力学院广东省广州市510641

正如光纤替代铜线成为信息传输媒介,这一变革引领了互联网的出现,改变了世界。无铁芯变压器(coreless transformer,CLT)若能替代有铁芯变压器,必将改变电能的传输技术甚至方式,引发能源领域新的一场技术变革。文中在世界上首次基于量子... 详细信息

正如光纤替代铜线成为信息传输媒介,这一变革引领了互联网的出现,改变了世界。无铁芯变压器(coreless transformer,CLT)若能替代有铁芯变压器,必将改变电能的传输技术甚至方式,引发能源领域新的一场技术变革。文中在世界上首次基于量子力学理论的宇称时间对称原理(parity-time symmetry,PT对称)实现了高效、高性能的CLT。文中首先论述CLT的研究现状及基于PT对称原理提出PT对称CLT思想的来源;进而,介绍所提出的SS型和SP型PT对称CLT的机理和工作特性,并与有铁芯变压器进行对比;然后,介绍所推广出的两种广义PT对称CLT;最后,总结PT对称CLT的优势及尚需解决的问题。文中的研究表明,PT对称CLT不仅可以达到有铁芯变压器相同的运行特性,且可以实现单位功率因数运行,有望将在中、小功率的高频电能变换中首先得到应用。

关键词：量子力学宇称-时间对称无铁芯变压器高性能高效率

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Correction to“Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence of primary liver cancer”

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4298-4299页

作者： Yu-Jie Shu bo Lao Ying-Yang Qiu Department of Gastroenterology Yinzhou District Second HospitalNingbo 315199Zhejiang ProvinceChina Yong Loo lin School of Medicine National University of SingaporeSingapore 119077Singapore

Correction to“Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer”in World J Gastrointest Oncol 2024;16:23.5-23.9,published by Shu YJ,L... 详细信息

关键词： Correction Ferroptosis Lipid peroxidation Primary liver cancer Lipid metabolism

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