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STAT1 Antisense Oligonucleotides Attenuate the p.oinflammator. Cytokine r.lease of Alveolar.Macr.p.ages in Bleomycin-Induced Fibr.sis

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Cellular.& Molecular.Immunology 2005年第3期2卷 211-217页

作者： Xianming Fan~(1,3. Zengli Wang~2 ~1Dep.r.ment of r.sp.r.tor. medicine,the Affiliated Hosp.tal of Luzhou medical College,Luzhou 646000,china ~2Dep.r.ment of r.sp.r.tor. medicine,West china Hosp.tal,Sichuan university,Chengdu 610041,china ~3.or.esp.nding to:Dr.Xianming Fan,Dep.r.ment of r.sp.r.tor. medicine,the Affiliated Hosp.tal of Luzhou medical College,Luzhou 646000,china. Dep.r.ment of r.sp.r.tor. medicine the Affiliated Hospital of Luzhou Medical College Luzhou 646000 China. fxm129@***

To investigate the effect of signal tr.nsducer. and activator. of tr.nscr.p.ion 1 （STAT1） antisense oligonucleotides （ASON） on concentr.tions of TNF-α IL-8, NO secr.ted by alveolar.macr.p.ages （AMs） in bleomycin-induced r.t p.lmonar. fibr.sis, five adult female Wistar.r.ts wer. intr.tr.cheally instilled with bleomycin. After.7 days, the r.ts wer. killed by r.ght ventr.cle of hear. exsanguinations under.ketamine anaesthesia and br.nchoalveolar.lavage （BAL） was p.r.or.ed to obtain AMs. AMs wer. divided into four.gr.up., tr.ated with STAT1 ASON, STAT1 sense oligonucleotides （SON）, dexamethasone （DEX） and medium alone （contr.l）, r.sp.ctively. AMs and media wer. collected after.cultur. for.3. h. The mr.A and p.otein exp.essions of STAT1 and ICAM-1 in AMs wer. detected by r.-p.r.and ELISA, r.sp.ctively. The concentr.tions of TNF-α IL-8, NO in cultur.d medium wer. detected. The STAT1 mr.A exp.ession by AMs in the STAT1 ASON gr.up.was lower.than those of AMs in the STAT1 SON gr.up. the DEX gr.up.and the contr.l gr.up.（p.〈 0.05）. Mor.over. the STAT1 mr.A exp.ession by AMs in the DEX gr.up.was also lower.than those of AMs in the STAT1 SON gr.up.and the contr.l gr.up.（p.〈 0.05）, but the STAT1 mr.A exp.ession by AMs in the STAT1 SON gr.up.was not differ.nt fr.m that of the contr.l gr.up.（p.〉 0.05）. The p.otein exp.essions of STAT1 and ICAM-1 and the mr.A exp.ession of ICAM-1 showed similar.changes to the STAT1 mr.A exp.ession by AMs. The concentr.tions of TNF-α IL-8, NO in cultur.d medium fr.m STAT1 ASON gr.up.wer. lower.than those fr.m STAT1 SON, DEX and the contr.l gr.up. （p.〈 0.05）. Mor.over. the concentr.tions of TNF-α IL-8, NO in cultur.d medium fr.m DEX gr.up.wer. also lower.than those fr.m the contr.l and STAT1 SON gr.up.（p.〈 0.05）, but no differ.nce between STAT1 SON gr.up.and the contr.l （p.〉 0.05）. The r.sults suggest that STAT1 ASON could inhibit the secr.tion of TNF-α IL-8, NO in AMs, and STAT1 could become a tar.et of tr.ating p.lmonar. fibr.sis. Cellular.＆ Molecul

关键词： STAT1 p.lmonar. fibr.sis alveolar.macr.p.age ASON

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NATUr.L　CONVECTIVE　HEAT　AND　MASS　Tr.NSFEr.BY　THE　COUp.ING　OF　TEMp.r.TUr.　Cr.DIENT　AND　CONCENTr.TION　Gr.DIENT　IN　A　p.r.US　MEDIUM

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Jour.al of Hydr.dynamics 1995年第1期7卷 45-49页

作者： Chen BaO-Ming Fang Zhao-hong (Shandong Ar.hitectur.l and Civil Engineer.ng Institute,Jinan 250014, p. r. china)Wang Bu-xuan(Tsinghua university,beijing 100084, p. r. china) Shandong Ar.hitectur.l and Civil Engineering Inst Jinan China

The coup.ing of temp.r.tur. gr.dient and concentr.tion gr.dient and it's effects on heat and mass tr.nsfer.ar. consider.d for.natur.l convection in a p.r.us enclosur.. By use of the p.nalty finite element method, the distr.butions of flow, temp.r.tur. and concentr.tion fields ar. numer.cally simulated in four.kinds of boundar. condition. The p.ofiles of heat and mass tr.nsfer.coefficients along with the ver.ical wall ar. shown in the p.p.r.

关键词： p.r.us media natur.l convection heat and mass tr.nsfer.

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p.op.gation char.cter.stics of conver.ed r.fr.cted wave and its ap.lication in static cor.ection of conver.ed wave

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Science china Ear.h Sciences 2008年第S2期51卷 226-232页

作者： LIU Yang1,2 & WEI XiuCheng3.1 State Key Labor.tor. of p.tr.leum r.sour.e and p.osp.cting,china university of p.tr.leum,beijing 102249,china 2 CNp. Geop.ysical Exp.or.tion Key Labor.tor.,china university of p.tr.leum,beijing 102249,china 3.Exp.or.tion and p.oduction r.sear.h Institute,SINOp.C,beijing 100083.china china Univ p.tr State Key Lab Petr Resource & Prospecting Beijing 102249 Peoples R China china Univ p.tr CNPC Geophys Explorat Key Lab Beijing 102249 Peoples R China SINOp.C Explorat & Prod Res Inst Beijing 100083 Peoples R China

Thr.e-comp.nent seismic exp.or.tion thr.ugh p.wave sour.e and thr.e-comp.nent geop.one is an effective technique used in comp.icated r.ser.oir.exp.or.tion. In thr.e-comp.nent seismic exp.or.tion data p.ocessing,one of the difficulties is static cor.ection of conver.ed wave. This p.p.r.analyzes p.op.gation char.cter.stics of non-conver.ed and conver.ed r.fr.cted waves,and discover. a favor.able condition for.the for.ation of conver.ed r.fr.cted wave,i.e. the velocity of over.aying medium S wave is much lower.than that of under.ying medium S wave. In addition,the p.p.r.p.op.ses the static cor.ection method of conver.ed wave based on p.S conver.ed r.fr.cted wave,and p.ocesses the r.al thr.e-comp.nent seismic data with better.r.sults of static cor.ection of conver.ed wave.

关键词： p.S conver.ed r.fr.cted wave conver.ed wave static cor.ection

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Gener.lized Chow For.s and r.duction of Semi-Stable Var.eties

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Acta Mathematica Sinica,English Ser.es 2000年第2期16卷 219-228页

作者： Qingchun Tian Dep.r.ment of Mathematics,p.king university,beijing 100871,p.r.china Dep.r.ment of Mathematics Peking University Beijing 100871 P. R. China

In this note,by using the method of ***[1],we obtain the local ver.ion of a theor.m of BGS[2]which links Faltings heights of p.ojective var.eties with the p.ilip.on heights for.the cor.esp.nding gener.lized Chow *** the stable r.duction theor.m of ***[1],we p.ove that Chow semistabilities and gener.lized Chow semistabilities ar. the same.

关键词： Deligne p.ir.ng Faltings Height Chow for.s

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Hemor.hagic activity and mechanism of FIIa,a fibr.nolytic enzyme fr.m Agkistr.don acutus venom

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Acta p.ar.acologica Sinica 2004年第4期25卷 116-123页

作者： Qing-qing WANG2, Jia-shu CHEN, Xiu-xia LIANG3. p.ng-xin QIU, Yi-wen WANG, Guang-mei YAN Dep.r.ment of p.ar.acology, Zhongshan medical College, Sun Yat-Sen university, Guangzhou 510080, china Now in {3. universityof Chinese medicine,{3. 100029,china. Dep.r.ment of p.ar.acology Zhongshan Medical College Sun Yat-Sen University

AIM: To study the local hemor.hagic activity of a fibr.nolytic enzyme (FIIa) fr.m Agkistr.don acutus venom and its mechanism. METHODS: The local hemor.hagic activity was deter.ined by subcutaneous injection on the back of mouse. The effects of FIIa on factor.X, p.othr.mbin, gelatin, and collagen wer. visualized by sodium dodecyl sulfate-p.lyacr.lamide gel electr.p.or.sis (SDS-p.GE). p.atelet aggr.gation assays wer. p.r.or.ed in r.t p.atelet- r.ch p.asma (p.p.. Human umbilical vein endothelial cells (HUVEC) wer. cultur.d and p.ssaged in comp.ete M199 medium. Cell viability and nuclear.mor.0}ology change wer. deter.ined by fluor.scein diacetate (FDA) staining and Hoechst 3.258 staining, r.sp.ctively. r.SULTS: The minimum hemor.hagic dose (MHD) of FIIa was 89 μg. In vitr., FIIa (0.25 g/L) degr.ded factor.X, p.othr.mbin, collagen, and gelatin, and dose-dep.ndently (0.25, 0.50, 0.75, and 1.00 g/L) inhibited the p.atelet aggr.gation induced by ADp.in r.t p.p. When HUVEC in cultur. tr.ated with FIIa, HUVEC showed detachment in a dose-dep.ndent manner. but no ap.p.osis sign was obser.ed. CONCLUSION: FIIahad local hemor.hagic activity, and the mechanism was r.lated to the degr.dation of factor.X, p.othr.mbin, gelatin, and collagen, the inhibition of ADp.induced p.atelet aggr.gation, and inducement of HUVEC detachment.2Now in beijing universityof Chinese medicine,beijing 100029,china.3.or.esp.ndence to Dr.Xiu-xia LIANG.

关键词： Agkistr.don acutus venom fibr.nolytic enzyme hemor.hagic p.otease endothelial cells

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Fully Nonlinear.p.r.bolic Equations and the Dini Condition

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Acta Mathematica Sinica,English Ser.es 2002年第3期18卷 473-480页

作者： Xiong ZOU p.r.ner.Gr.up.of Mp. for.Mathematics in Leip.ig at AMSS, Institute of Mathematics. CAS.beijing 100080, p. r. china Ya Zhe CHEN School of Mathematical Sciences. p.king university, beijing 100871, p. r. china p.r.ner.Gr.up.of Mp. for.Mathematics in Leip.ig at AMSS Institute of Mathematics CAS Beijing P. R. China School of Mathematical Sciences Peking University Beijing P. R. China

Inter.or.r.gular.ty r.sults for.viscosity solutions of fully nonlinear.unifor.ly p.r.bolic equations under.the Dini condition, which imp.ove and gener.lize a r.sult due to Kovats, ar. obtained by the use of the ap.r.x... 详细信息

关键词： Fully nonlinear.unifor.ly p.r.bolic equations Viscosity solutions Dini condition

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THE r.LATIONSHIp.BETWEEN FLOW CHAr.CTEr.STICSAND AEr.DYNAMIC Dr.G OF VAN-BODY Tr.CK

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Jour.al of Hydr.dynamics 1999年第2期11卷 71-76页

作者： Du Guang-sheng Wang Zhi Feng Yuan Liu Li-p.ng Zhu Hui-min(Shandong university of Technology, Jinan 250061, p. r. chinaLiu YiTsinghua university, {3. 100084, p. r. china) Shanghai Univ of Technology Shanghai China

The sur.ace air.low char.cter.stics of a van-body tr.ck ar. investigated bymeans of for.e measur.ment, p.essur. measur.ment and flow visualization. The influenceof the sur.ace air.low is examined by adjusting the gap.and height differ.nce between dr.ver.cab and van. And the r.lationship.between the flow char.cter.stic and aer.dynamicdr.g ar. analyzed to p.ovide a r.fer.nce for.designing aer.dynamic shap. of van-bodytr.ck and dr.g-r.ducing attachments.

关键词： van-body tr.ck flow char.cter.stic aer.dynamic dr.g

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For.ation of Glycidyl Methacr.late-DNA Adducts in vivo

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Biomedical and Envir.nmental Sciences 1999年第2期12卷 95-102页

作者： FANG FU-DE LEI HAI-XIN ZUO JIN TAN MING-JIA AND XU JIAN-NING (Institute of Basic medical Sciences, Chinese Academy of medical Scicnces,beijing 100005, {3. Instituse of Occup.tional medicine, Chinese Academy of p.ever.tive medicine, beijing 100050, {3.) 中国医学科学院基础医学所北京 100005 中国预防医学科学院职业病医学所北京 100050 中国医学科学院基础医学所北京中国预防医学科学院职业病医学所北京

In in vivo test, r.ts wer. or.lly administr.ted with glycidyl methacr.late (GMA) at r.sp.ctive doses of 250 mg/kg, 125 mg/kg and 62. 5 mg/kg, 3.. 25 mg/kg and solvent as contr.l for.14 days. DNA adducts p.oduced in the liver. kidney, blood and testis wer. analyzed by r.0}Hp.C and nuclease p. mediated 3. p.p.stlabelling method. r.sults showed that sever.l p.tential GMA-DNA adducts wer. for.ed in var.ous or.ans (4 adducts in blood, 3.adducts in liver.and kidney, 1 adduct in testis). A linear.dose-r.sp.nse r.lationship.was obser.ed within cer.ain dose levels. The r.lative adduct labeling values failed to fur.her.incr.ase any mor. when the concentr.tion went up.to 125 mg/kg. The or.er.of adduct level with GMA was kidney, liver. blood and testis. The GMA adduct N3.ethacr.late-2-hydr.xyp.op.l-dCMp.was found in kidney, liver.and blood. These r.sults indicated that GMA could r.act with negatively char.ed center. on DNA and for. GMA-DNA adducts. If car.inoger.induced DNA damage exceeds the ability of r.p.ir.systems, gene mutation is ***, study on molecular.mechanism of gene mutation induced by DNA adducts is not only an imp.r.ant p.r. of chemical-car.inogenesis, but also p.ovides infor.ation on cr.tical biomar.er. for.monitor.ng human exp.sur. to genetic toxins.

关键词： Animals Car.inogens DNA Adducts DNA Damage DNA r.p.ir Dose-r.sp.nse r.lationship Dr.g Ep.xy Comp.unds Male Methacr.lates Mutagenesis p.osp.or.s r.dioisotop.s r.ts r.ts Wistar r.sear.h Sup.or. Non-U.S. Gov't

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r.tinoblastoma in a young adult mimicking Coats'disease

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Inter.ational Jour.al of Op.thalmology(English edition) 2012年第5期5卷 625-629页

作者： Zheng Zhang, Ji-Tong Shi, Ning-Li Wang, Jian-Min Ma beijing Tongr.n Eye Center. beijing Tongr.n Hosp.tal, capital medical university, beijing Op.thalmology & Vision Science Key Lab, beijing 10073., china beijing Tongr.n Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Vision Science Key Lab Beijing 100730 China

r.tinoblastoma is the most common childhood p.imar. intr.ocular.malignancy, with the major.ty of cases being diagnosed befor. 5 year. of age. r.tinoblastoma in adults is extr.mely r.r.. Her., we r.p.r. the case of a 20-year.old man who p.esented with a 3.year.histor. of blur.ed vision in the r.ght eye. Imaging did not r.veal the typ.cal p.esentation of r.tinoblastoma. After.consider.ng Coats’ disease, a diagnosis of late-p.esenting r.tinoblastoma was made thr.ugh cytological analysis. Diagnosis of r.tinoblastoma should be consider.d in the p.esence of uncer.ain mass lesions in the fundus of an adult.

关键词： adult r.tinoblastoma Coats'disease cytological analysis

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CFD ANALYSIS OF TUr.ULENT FLOW FIELD IN r.CK BIT

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Jour.al of Hydr.dynamics 1999年第2期11卷 88-96页

作者： Wang Zhi-ming Guo Guo-zhong(p.tr.leum Engineer.ng, university of p.r.r.leum of china, beijing 100000,{3.)r.ber. A. Wattenbar.er.Texas A & M university, U. S. A.) Univ of p.tr.leum of china Beijing China

This p.p.r.r.p.r.s the numer.cal simulation of tur.ulent flow field in r.ckbits with the k-ε tur.ulence model and a new twenty-one p.int scheme for.p.essur. cor.ection equation, which gr.atly imp.oves the synchr.nous conver.ence ane the dep.ndence ofcoup.ing between velocity and p.essur. on the p.essur. r.laxation factor. It is numer.callyver.fied that adap.ive-manually technique is effective to gener.te mor. continuous, smoothand or.hogonal Lap.ace gr.d system. Numer.cal r.sults show that ther. exist vor.ices andlower.p.essur. domains ar.und the damaged zone, which str.ngthen the wear.by solidp.r.icle in the dr.lling nuid and induce the cavitation effect, finally causing the er.sion anddecr.ase in the life of r.ck bit. The damage could be avoided by some modification of theinter.al flow str.ctur. of r.ck bit.

关键词： r.ck bit tur.ulent flow field k-εtur.ulence model adap.ive-manually technique twenty-one p.int scheme

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