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Expert consensus on radiotherapy combined with immunotherapy for esophageal cancer(2024 edition)

radiation Medicine and Protection 2024年第2期5卷 59-67页

作者： Professional Committee of radiation Oncology china Anti-Cancer Association Branch of radiation Oncology Chinese Medical Association Branch of radiation Oncology TreatmentPhysician Chinese Medical Doctor Association Qingsong Pang Jun Wang Zhouguang Hui Wencheng Zhang 不详 Tianjin Medical University Cancer Institute&Hospital Tianjin 300060China the Fourth Hospital of Hebei Medical University Shijiazhuang 050011China National Cancer Center National Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin Medical University Cancer Hospital China

Radiotherapy represents an essential treatment approach for esophageal *** recent years,immunotherapy combined with chemotherapy has become the first-line standard treatment for patients with advanced esophageal *** phase III studies on immunotherapy combined with radiotherapy for locally advanced esophageal cancer are currently *** evidence-based medical data are urgently needed to support the integration of immunotherapy and chemoradiotherapy as a new treatment strategy for patients with locally advanced esophageal *** consensus,formulated based on the latest study results,in-depth research,and thorough discussions,provides a comprehensive set of *** document extensively covers treatment strategies and evaluation methods for radiotherapy combined with immunotherapy across patients with operable esophageal cancer,inoperable locally advanced esophageal cancer,and advanced esophageal ***,common complications and radiation-related issues associated with radiotherapy combined with immunotherapy are discussed,serving as clinical *** expert group comprised members from the Professional Committee of radiation Oncology,china Anti-Cancer Association,the Branch of radiation Oncology,Chinese Medical Association,and the Branch of radiation Oncology Treatment Physician,Chinese Medical Doctor Association.

关键词： Esophageal squamous cell carcinoma Esophageal adenocarcinoma Immunotherapy Chemoradiotherapy Radiotherapy Expert consensus

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Exotic structure of the third excited state in^(21)Na

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Chinese Science Bulletin 2005年第23期50卷 2677-2680页

作者： LI Xihan1,2,3. LIANG Yujie1,2,3. DENG Fuguo1,2,3. LIU Zuhua1,4 & ZHOU Hongyu1,2,3.1. Key Laboratory of Beam Technology and Material Modification of Minister of Education, Beijing Normal University, Beijing 100875, china 2. Institute of Low Energy Nuclear Physics, and Department of Material Science and Engineering, Beijing Normal University, Beijing 100875, china 3. Beijing radiation Center, Beijing 100875, china 4. china Institute of Atomic Energy, Beijing 102413. china Key Laboratory of Beam Technology and Material Modification of Minister of Education Beijing Normal University Beijing 100875 China Institute of Low Energy Nuclear Physics and Department of Material Science and Engineering Beijing Normal University Beijing 100875 China Beijing radiation Center Beijing 100875 China china Institute of Atomic Energy Beijing 102413 China

The probability of the last proton being out of the binding potential, P and the root-mean-square (rms) ra- dius (1/2= of the third excited state in 21Na are calcu- lated by means of asymptotic normalization coefficient (ANC) method with the experimental date existing. The results are P=54.73. and 1/2=5.28 fm respectively. The P value and the contribution of the asymptotic part to the 1/2 are compared with those of several other low energy states in 21Na. It is found that the valence particle in the third excited state has an obvious larger P than those of other states. The density distribution of the valence proton in this state is also compared with the nucleons in the nuclear core 20Ne, and a far extended tail can be seen clearly. These results show that the third ex- cited state in 21Na is a proton halo state.

关键词：钠第三激发态外部结构有效半径密度分布渐近标准化系数

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Human hepatopoietin augmenter of liver regeneration──A hepatotrophic factor for liver regeneration, and its potential antihepatitis effect in vivo

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Chinese Science Bulletin 1998年第12期43卷 1026-1031页

作者： YANG Xiaoming 1, WANG Aimin 2, ZHOU Ping 3. XIE Ling 1, WANG Qingming 1, WU Zuze 1 and HE Fuchu 1 1. Institute of radiation Medicine, Beijing 100850, china 2. No. 252 Hospital of PLA, Baoding 071000, china 3. General Hospital of the Air Institute of radiation Medicine Beijing China No. 252 Hospital of PLA Baoding China General Hospital of the Air Force of PLA Beijing China

The effect of human hapatopoietin i.e. augmenter of liver regeneration (hALR) was determined on hepatocyte DNA synthesis, and on CCl 4-induced hepatitis in animal in vitro and in vivo. It is found that ALR could directly stimulate DNA synthesis of hepatocytes in primary culture in a dose-dependent manner. In 3.% hepatectomied rats, significant DNA synthesis occurred in control rats ; even so, exogenous hALR gene encoding protein increased DNA synthesis of regeneration liver by 2.3.fold compared with control rats. A lower dose of CCl 4 was administrated in rats and the effect of ALR on DNA synthesis of regenerating liver 48 h after CCl 4 administration was analyzed. Few Budr-labeled hepatocytes were visible in control rats. However, exogenous hALR markedly increased the number of labeled cells in a dose-dependent manner. Statistical analysis showed that 10 or 40 μg·kg -1 ALR protein stimulated DNA synthesis by 1.7 and 4.8 fold respectively. In addition to enhancing cell growth, adiministration of hALR achieved a significant improvement in reversing the lethality of rat hepatic failure when compared with that of control group; the elevation of cytosolic enzymes was dramatically suppressed by exogenous hALR in CCl 4-treated mice in vivo and in vitro; histologically, hepatocytes around the central vein were necrotic, and the degree of hepatocyte necrosis in control mice was more prominent than that in the mice given 40 μg·kg-1 hALR 48 h after CCl 4 administration. We also noted that hALR had a strong antihepatitis effect in vitro which was determined with primary cultured rat hepatocytes. These findings suggest that hALR protects the integrity of hepatocytes against severe hepatitis, and indicate that ALR may be an important regulator of liver regeneration and play a major role in liver injury repair. It proves ALR adminstration to be a useful treatment to accelerate liver regeneration and to prevent the onset of hepatitis or intrahepatic cholestasis induced by toxin.

关键词： liver regeneration hepatopoietin DNA synthesis hepatitis.

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STUDY OF Ag DIFFUSION INTO Cu SINGLE CRYSTALS BY RUTHERFORD BACKSCATTERING SPECTROMETRY

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Acta Metallurgica Sinica(English Letters) 2003年第5期16卷 332-334页

作者： R.Wang 1) Key Laboratory of Beam Technology and Materials Modification, Ministry of Education, Beijing 100875, china2) Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, china3. Beijing radiation Center, Beijing 100875, china Key Laboratory of Beam Technology and Materials Modification Ministry of Education Beijing 100875China Institute of Low Energy Nuclear Physics Beijing Normal University Beijing 100875 China Beijing radiation Center Beijing 100875 China

4.0Me V 7Li++ RBS was used for investigations of thermal diffusion of Ag in Cu single crystals. The annealing of samples was carried out in vacuum in the temperature range from 498K to 613.. The element depth concentration profiles transformed from RBS spectra indicate that the diffusion of Ag into Cu is a typical volume diffusion. The Arrhenius parameters corresponding to the diffusion were obtained.

关键词： Ag diffusion single crystal

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Synthesis of vertically aligned carbon nanotube arrays on silicon substrates

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Science china(Technological Sciences) 2004年第5期47卷 616-624页

作者： ZHENG Ruiting1, CHENG Guoan1, PENG Yibin1, 2, ZHAO Yong1, 3. LIU Huaping1 & LIANG Changlin1 1. Key Laboratory of radiation Beam Technology and Materials Modification of Ministry of Education, Department of Materials Science and Engineering, Beijing Normal University, Beijing 100875, china 2. School of Science, Civil Aviation University of china, Tianjin 3.03.0, china 3. Department of Physics, Nanchang University, Nanchang 3.0047, china Correspondence should be addressed to Zheng Ruiting 1. Key Laboratory of radiation Beam Technology and Materials Modification of Ministry of Education Department of Materials Science and Engineering Beijing Normal University 100875 Beijing China 2. School of Science Civil Aviation University of China 300300 Tianjin China 3. Department of Physics Nanchang University 330047 Nanchang China

The growth of well-aligned carbon nanotube (CNT) arrays using a heat chemical vapor deposition system on silicon substrates is reported. The growth properties of CNT arrays are studied as a function of synthesis conditions. It is found that 750°C and 10 nm Fe film are suitable conditions for the growth of well-aligned CNT arrays. CNT arrays with a uniform diameter, thick tube wall and firm cohesion to the Si substrate can be grown for C2H2 concentration of 27%. Based on the experiment, the processes of improving the alignment of CNT arrays and cohesion between CNT arrays and Si substrates are discussed.

关键词： carbon nanotubes, vertically aligned, silicon substrate, chemical vapor deposition.

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Collision dynamics of He@C_(60)+He@C_(60) at low energies

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Science china(Physics,Mechanics & Astronomy) 2008年第7期51卷 765-772页

作者： ZHAO Qiang1,2, ZHANG FengShou1,2,3.& ZHOU HongYu1,2 1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education, Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, china 2 Beijing radiation Center, Beijing 100875, china 3.Center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 73.000, china 1. Key Laboratory of Beam Technology and Material Modification of Ministry of Education Institute of Low Energy Nuclear Physics Beijing Normal University Beijing 100875 China 2. Beijing radiation Center Beijing 100875 China 3. Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou 730000 China

A semi-empirical molecular dynamics model is developed. The central collisions of C60+C60 and He@C60+He@C60 at different incident energies are investigated based on this model. It is found that the dimer structures have been produced at proper incident energies and these fullerene dimers could be formed by a self-assembly of C60 fullerene and He@C60. The He atom has a significant effect at higher incident energy and this embedded He atom can enhance the stability of the dimer structure.

关键词： C60 He@C60 collision molecular dynamics

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Formation of complexes of Rubisco-Rubisco activase from La^3., Ce^3. treatment spinach

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Science china Chemistry 2005年第1期48卷 67-74页

作者： HONG Fashui1, LIU Chao1, ZHENG Lei1, WANG Xuefeng1, WU Kang1, SONG Weiping1, Lü Shipeng1, TAO Ye2 & ZHAO Guiwen3.1. College of Life Sciences, Suzhou Universty, Suzhou 215006, china 2. Synchrotron radiation Laboratory, Institute of High Energy Physics, The Chinese Academy of Science, Beijing 10003., china 3. Chemical Department, University of Science and Technology of china, Hefei 23.026, china 1. College of Life Sciences Suzhou Universty 215006 Suzhou China 2. Synchrotron radiation Laboratory Institute of High Energy Physics The Chinese Academy of Science 100039 Beijing China 3. Chemical Department University of Science and Technology of China 230026 Hefei China

The complex of Rubisco and Rubisco activase from LaCl3., CeCl3. treated spinach in vivo is induced. SDS-PAGE result shows that the purified proteins from LaCl3., CeCl3. treated spinach have not only large and small subunits (55 kD, 14.4 kD) of Rubisco, but also two large subunits of 45 kD and 41 kD near the large subunits of Rubisco. Native-PAGE shows that the purified proteins from LaCl3., CeCl3. treated spinach have not only a band of Rubisco (560 kD), but also a band of about 1100 kD, about twice distant from Rubisco, which might be a complex of Rubisco and Rubisco activase. The purified enzyme activities from LaCl3., CeCl3.treated spinach are 1.8 and 2.8 times that of the control,the intensities of absorption and fluorescence are sig- nificantly higher than that of the purified Rubisco from the control, and the total sulfhydryl groups and available sulfhydryl groups are 3.—3. –SH per mol enzyme, 14—25 –SH per mol enzyme more than those of the purified Rubisco from the control, respectively. The CD spectra show that the secondary structure of the purified enzyme from LaCl3., CeCl3.-treated spinach is very dif- ferent from the control. The enzyme activities from LaCl3., CeCl3. treated spinach in vivo are 1.5 and 1.9 times those of the control.

关键词： La3., Ce3., spinach, Rubisco, complex of Rubisco and Rubisco acitivase, spectral characteristics.

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Complete multiple round quantum dense coding with quantum logical network

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Chinese Science Bulletin 2007年第9期52卷 1162-1165页

作者： LI ChunYan1,2,LI XiHan1,2,DENG FuGuo1,2,3.ZHOU Ping1,2 & ZHOU HongYu1,2,3.1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education,Beijing Normal University,Beijing 100875,china 2 Institute of Low Energy Nuclear Physics,and Department of Material Science and Engineering,Beijing Normal University,Beijing 100875,china 3.Beijing radiation Center,Beijing 100875,china Key Laboratory of Beam Technology and Material Modification of Ministry ofEducation Beijing Normal University Beijing 100875 China

We present a complete multiple round quantum dense coding scheme for improving the source ca-pacity of that introduced recently by Zhang et al. The receiver resorts to two qubits for storing the four local unitary ope... 详细信息

关键词：量子通信多重量子紧凑编码量子逻辑网络量子纠缠

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radiation Effect of Neutrons in a Reactor on Polyurethane

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 966-968页

作者：黄玮 Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics

The radiation effect of neutrons in a reactor on polyurethane was *** gases produced by irradiated samples were analyzed by gas chromatography,and the dynamic mechanical and compression properties of the samples were also *** positron annihilation lifetime of irradiated samples was measured at room temperature in *** experimental results indicate that gas chromatography is a powerful tool to quantitatively analyze the gas products from neutron-irradiated polyurethane and characterizes the chemical changes in the *** the changes in microstructure determined from the PAL correlate well with the measurements of the mechanical properties by dynamic mechanical analysis（DMA）.

关键词： neutrons in a reactor polyurethane radiation effect

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Simulation of energy and water balance in Soil-Vegetation-Atmosphere Transfer system in the mountain area of Heihe River Basin at Hexi Corridor of northwest china

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Science china Earth Sciences 2005年第4期48卷 538-548页

作者： KANG Ersi1, CHENG Guodong1, , SONG Kechao1, JIN Bowen1, , LIU Xiande3.2 3.& WANG Jinye3.1. Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 73.000, china 2. State Key Laboratory of Frozen Soil Engineering, Chinese Academy of Sciences, Lanzhou 73.000, china 3. Academy of Water Resources Conservation Forest of Qilian Mountains, Gansu Province, Zhangye 73.000, china 1. Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences 730000 Lanzhou China 2. State Key Laboratory of Frozen nSoil Engineering Chinese Academy of Sciences 730000 Lanzhou China 3. Academy of Water Resources Conservation Forest of Qilian Mountains 734000 Gansu Province Zhangye China

In the mountain area of inland Heihe River Basin at Hexi Corridor of northwest china during the vegetation growing season from May to September, the Simultaneous Heat and Water (SHAW) model of Soil-Vegetation-Atmosphere Transfer (SVAT) system is applied to simulating and studying energy and water balance of the soil-residue-plant canopy layers in the Picea crassifolia forest and the grassland by the forest at the shaded slope and the grassland at the sun-facing slope. The simulation of energy balance indicates that net radiation of the grass- land at the sun-facing slope is more than that of the Picea crassifolia forest and the grassland by the forest at the shaded slope. The energy outgoing components are the first latent heat and next sensible heat from the grassland both at the shaded slope and the sun-facing slope, but those at the former are less. The energy outgoing components are the first sensible heat and next latent heat from the Picea crassifolia forest. The composition and distribution of energy in the soil-residue-plant canopy layers in the Picea crassifolia forest and the grassland by the forest at the shaded slope make the soil layer receive less energy, which therefore, especially the forest possesses the energy conditions for soil water conservation. The simulation of water balance indicates that the water loss of the grassland at the sun-facing slope is mainly caused by soil evaporation, while evapotranspiration of the Picea crassifolia forest and the grassland by the forest at the shaded slope is less than that of the grassland at the sun-facing slope. Half of the evapotranspiration of the Picea crassifolia forest and the grassland by the forest at the shaded slope is consumed by transpiration. After precipitation, the soil water storage is increased much more for the Picea crassifolia forest and also more for the grassland by the forest at the shaded slope. Therefore the shaded slope vegetation, especially the forest is favorable for soil water s

关键词： inland rivers, mountain vegetation zone, Soil-Vegetation-Atmosphere Transfer (SVAT) system, energyand water balance, simulation.

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