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Data-Driven Direct Adaptive Risk-Sensitive Control of Stochastic Systems

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Journal of Systems Science & Complexity 2024年第4期37卷 1446-1469页

作者： QIAO nan LI Tao School of Mathematical Sciences East China Normal UniversityShanghai 200241China Shanghai Key Laboratory of Pure Mathematics and Mathematical Practice School of Mathematical SciencesEast China Normal UniversityShanghai 200241China

The authors propose a data-driven direct adaptive control law based on the adaptive dynamic programming(ADP) algorithm for continuous-time stochastic linear systems with partially unknown system dynamics and infinite horizon quadratic risk-sensitive *** authors use online data of the system to iteratively solve the generalized algebraic Riccati equation(GARE) and to learn the optimal control law *** the case with measurable system noises,the authors show that the adaptive control law approximates the optimal control law as time goes *** the case with unmeasurable system noises,the authors use the least-square solution calculated only from the measurable data instead of the real solution of the regression equation to iteratively solve the *** authors also study the influences of the intensity of the system noises,the intensity of the exploration noises,the initial iterative matrix,and the sampling period on the convergence of the ADP ***,the authors present two numerical simulation examples to demonstrate the effectiveness of the proposed algorithms.

关键词： Adaptive dynamic programming direct adaptive control generalized algebraic Riccati equation risk-sensitive control

Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia:A case series

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Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang Shi-lin Huang nan-nan Chen Department of Hematology PLA 967th HospitalDalian 116021Liaoning ProvinceChina

Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the successful treatment of patients with relapsed and ATO-resistant *** presentation Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR)when reinduced by ATO;the other five patients progressed to relapse during ATO-based regimens for post-remission *** eight patients received RIF in three doses per day totaling 13. mg/kg(≤3. pills)as induction therapy and achieved HCR at a median time of 46.5 *** received 5 years of post-remission therapy,which consisted of combined chemotherapy followed by *** this period,the patients did not experience renal dysfunction or QT interval *** the last follow-up,three patients survived without relapse,two patients survived with a second or third relapse and third or fourth remission,and the other three patients relapsed for a third or fourth time and *** 5-year overall survival and event-free survival rates were 75.0%(95%confidence interval[CI]:3..5–93.1)and 3..5%(95%CI:5.6–71.7),*** RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

Bending results of graphene origami reinforced doubly curved shell

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Defence Technology（防务技术） 2024年第5期35卷 198-210页

作者： nan Yang Yunhe Zou Mohammad Arefi School of Architecture and Civil Engineering Qiqihar UniversityQiqihar 161006HeilongjiangChina School of Mechanical Engineering Inner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina Inner Mongolia Key Laboratory of Special Service Intelligent Robotics Hohhot 010051Inner MongoliaChina Faculty of Mechanical Engineering Department of Solid MechanicsUniversity of KashanKashan87317-51167Iran

The present work investigates higher order stress,strain and deformation analyses of a shear deformable doubly curved shell manufactures by a Copper(Cu)core reinforced with graphene origami auxetic metamaterial subjected to mechanical and thermal *** effective material properties of the graphene origami auxetic reinforced Cu matrix are developed using micromechanical models cooperate both material properties of graphene and Cu in terms of temperature,volume fraction and folding *** principle of virtual work is used to derive governing equations with accounting thermal *** numerical results are analytically obtained using Navier's technique to investigate impact of significant parameters such as thermal loading,graphene amount,folding degree and directional coordinate on the stress,strain and deformation responses of the *** graphene origami materials may be used in aerospace vehicles and structures and defence technology because of their low weight and high stiffness.A verification study is presented for approving the formulation,solution methodology and numerical results.

关键词： Graphene origami Copper matrix Doubly curved Shear deformable Auxetic metamaterial

An indicator model for assessing community resilience to the COVID-19 pandemic and its validation: A case study in Hong Kong

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Journal of Safety Science and Resilience 2024年第2期5卷 222-234页

作者： nan Liao Muhammad Nawaz Departnent of Geography Faculty Art and Social SciencesSingapore 65166666Singapore

The COVID-19 outbreak had a significant negative impact on the world,and the fifth wave of COVID-19 in Hong Kong brought a considerable shock to Chinese *** is a growing call for more resilient ***,empirical evidence and validation of modeling studies of resilience indicators for urban community responses to the COVID-19 pandemic still need to be *** this study,a resilience assessment indicator model comprising 4 subsystems,7 indicators,and 12 variables was developed to assess the resilience of Hong Kong communities in response to COVID-19(i.e.,Resilience Index).Furthermore,this study utilized regression models such as geographically weighted regression(GWR)and multiscale GWR(MGWR)to validate the resilience model proposed in this study at the model and variable *** the regression model,the Resilience Index and the individual variables in the resilience model are explanatory variables,and the outcomes of the COVID-19 pandemic(confirmed cases,confirmation rate,discharged cases,discharge rate)are dependent *** results showed that:(i)the resilience of Hong Kong communities to the COvID-19 pandemic was not strong in general and showed some clustered spatial distribution characteristics;(i)the validation results at the model level showed that the Resilience Index did not explain the consequences of the COvID-19 pandemic to a high degree;(ii)the validation results at the variable level showed that the MGWR model was the best at identifying the relationships between explanatory variables and the dependent variable;and(iv)compared with the model-level assessment results,the variable-level assessment explained the consequences of the COvID-19 pandemic better than the model level assessment *** above analysis and the spatial distribution maps of the resilience variables can provide empirically based and targeted insights for policymakers.

关键词： Resilience Community resilience CoVID-19pandemic Resilience assessment indicator model Resilience model validation MGWR

Intelligent secure near-field communication

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Science China(Information Sciences) 2024年第9期67卷 340-341页

作者： nan ZHANG Jifa ZHANG Chengwen XING Na DENG nan ZHAO School of Information and Communication Engineering Dalian University of Technology School of Information and Electronics Beijing Institute of Technology

The research and development efforts for the sixth generation(6G) wireless communication are underway to fulfill the growing demands for wireless communications. 6G is expected to become the key enabler for diverse new applications and services [1]. To achieve the excellent performance, 6G will implement extremely large-scale antenna arrays(ELAAs), terahertz [2], and new types of antennas with metamaterials, leading to a paradigm shift for the electromagnetic characteristics.

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Envisioning Water-Resilient Cities Through the Lens of Blue-Green-Grey Solutions

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Engineering 2024年第5期36卷 1-2页

作者： nan-Qi Ren Glen Daigger School of Civil and Environmental Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China Department of Civil and Environmental Engineering University of MichiganAnn ArborMI 48109USA

Cities are dynamic systems,and the urban water systems within them can be evolved to provide water services to both humans and the environment while also enhancing the broader urban *** is done by embracing innovation and technological advancement while focusing on increased service to the human population and the local and broader *** the contemporary era,characterized by the rise of low-carbon and intelligent technologies,the swift pace of socioeconomic expansion highlights the critical need to address issues of urban water security and environmental *** escalating resource and environmental constraints,adopting holistic blue-green-grey strategies becomes imperative for the sustainable governance of urban water *** integrated approach is needed to navigate the intricate challenges of urban water dynamics while fostering enhanced ecological performance and resilience.

关键词： services urban advancement

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双氯芬酸钠迟效制剂的药动学

中国新药与临床杂志 2004年第6期23卷 342-345页

作者：李英谢冬玲周正王高峰高元勋郑州大学第二附属医院河南郑州450003 河南康利医药技术开发公司河南郑州450044 郑州大学癌症研究室河南郑州450052

目的 :以双氯芬酸钠普通肠溶片 (R)为对照 ,比较国产双氯芬酸钠迟效制剂 (T)的相对生物利用度和药动学。方法 :采用双交叉、自身对照的方法 ,将 2 4名受试者分为 2组 ,单剂量组分别口服T和R各 10 0mg ;多剂量组 ,每日分别口服T和R各10 0... 详细信息

目的 :以双氯芬酸钠普通肠溶片 (R)为对照 ,比较国产双氯芬酸钠迟效制剂 (T)的相对生物利用度和药动学。方法 :采用双交叉、自身对照的方法 ,将 2 4名受试者分为 2组 ,单剂量组分别口服T和R各 10 0mg ;多剂量组 ,每日分别口服T和R各10 0mg ,共 4d。结果 :单剂量组T和R的Cmax,Tmax,T1/2 ,MRT ,AUC0～τ分别为 (115 6±s 3. 1)和(3.10± 96 8) μg·L- 1,(3.0± 1.0 )和 (2 .3. 0 .5 )h ,(6 .6± 2 .3.和 (2 .9± 1.5 )h ,(12 .3. 2 .3.和 (4.4±1.0 )h ,(92 3.± 994 )和 (874 5± 12 16 ) μg·h·L- 1,T的F为 (10 7± 12 ) %。多剂量口服T和R的Cav,FI分别为 (3.3. 4 6 ) μg·L- 1和 (3.3. 6 4) μg·L- 1,(2 5 4± 82 ) %和 (40 4± 97) %。结论 :2种制剂口服吸收相似 ,迟效制剂具有峰谷浓度差异小 ,血药浓度波动幅度小等缓释药动学特征。

关键词：双氯芬酸迟效制剂药动学色谱法高压液相

Tailoring microenvironment for efficient CO_(2)electroreduction through nanoconfinement strategy

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nano Research 2024年第9期17卷 7880-7899页

作者： Lulu Chen Minhan Li Jia-nan Zhang Key Laboratory of Advanced Energy Catalytic and Functional Materials Preparation Country College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

The electrocatalytic conversion of CO_(2)to produce fuels and chemicals holds great promise,not only to provide an alternative to fossil feedstocks,but also to use renewable electricity to convert and recycle the greenhouse gas CO_(2)to mitigate climate ***,the selectivity and reaction rates for the conversion of CO_(2)into desirable carbon-based products,especially multicarbon products with high added value,are still insufficient for commercial applications,which is attributed to insufficiently favourable microenvironmental conditions in the vicinity of the *** construction of catalysts/electrodes with confined structures can effectively improve the reaction microenvironment in the vicinity of the electrodes and thus effectively direct the reaction towards the desired *** this review,we firstly introduce the effects of the microenvironment at the electrode-electrolyte interface including local pH,local intermediate concentration,and local cation concentration on CO_(2)reduction reaction(CO_(2)RR)as well as the mechanism of action,and then shed light on the microenvironmental modulation within the confined space,and finally and most importantly,introduce the design strategy of CO_(2)RR catalyst/electrode based on the confinement effect.

关键词： CO_(2)reduction reaction microenvironment confinement effect catalyst design

Microscale shaping and rounding of ridge arrays and star pattern features on nickel mould via electrochemical polishing

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Advances in Manufacturing 2024年第2期12卷 207-226页

作者： Sana Zaki nan Zhang Michael D.Gilchrist School of Mechanical and Materials Engineering University College DublinBelfieldDublin 4Ireland

High quality micro mould tools are critical for ensuring defect-free production of micro injection moulded *** demoulding stage of the micro injection moulding can adversely affect the surface integrity due to friction,adhesion and thermal stresses between the metallic mould and polymeric replicated *** the present work,we propose the use of precision electropolishing(EP)as a shaping and polishing process to control the draft angle and fillet radius of micro features in order to ease *** defects that occur in replicated polymer parts include cracks,burrs and distorted features.A nickel mould having multiple linear ridges and star shape patterns was designed for the present investigation to have characteristic dimensions ranging from 10μm to 150μm and with various aspect ratios to study the effect of electropolishing on modifying the shape of micro features and surface morphology.A transient 2D computational analysis has been conducted to anticipate the effect of shaping on the Ni mould after electrochemical polishing with non-uniform material removal rates,based on the distribution of current *** experimental results indicate that after shaping using EP,the draft angle of star-patterns and linear patterns can be effectively increased by approximately 3.6°,while the fillet radius increases by up to 5.0μ*** controlling the electropolishing process,the surface roughness can be maintained under 50 *** work uses a green and environmental friendly nickel sulfamate electrolyte which can be effective for shaping of nickel micro features without causing any surface deposition.

关键词： Micro feature shaping and electropolishing Micro mould tools Green electrolyte Demoulding micro patterns