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Prediction of Tumor Outcome Based on Gene Expression Data

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Wuhan University Journal of Natural Sciences 2004年第2期9卷 177-182页

作者： Liu Juan 1,2, Hitoshi Iba 3.1. School of Computer, Wuhan University, Wuhan 43.072, Hubei, China 2. State Key Laboratory of Software Engineering, Wuhan 43.072, Hubei, China 3. Department of Frontier Informatics, University of Tokyo, Tokyo 113.8656, Japan Wuhan University School of Computer Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) University of Tokyo Department of Frontier Informatics Tokyo Japan (GRID:grid.26999.3d) (ISNI:***)

Gene expression microarray data can be used to classify tumor types. We proposed a new procedure to classify human tumor samples based on microarray gene expressions by using a hybrid supervised learning method called MOEA+WV (Multi-Objective Evolutionary Algorithm+Weighted Voting). MOEA is used to search for a relatively few subsets of informative genes from the high-dimensional gene space, and WV is used as a classification tool. This new method has been applied to predicate the subtypes of lymphoma and outcomes of medulloblastoma. The results are relatively accurate and meaningful compared to those from other methods. Key words bioinformatics - tumor classification - Pareto optimization - MOEA CLC number Q 786 - TP 181 Foundation item: Supported by the National Natural Science Foundation of China (603.1009), the Foundation of Young Scholars of Ministry of Education of China (150118) and Chenguang Project of Wuhan City (211121009).Biography: Liu Juan (1970-), female, Associate Professor, Postdoctoral, research direction: bioinformatics, data mining, machine learning.

关键词： bioinformatics tumor classification Pareto optimization MOEA

Discovery of immune related factors in Fenneropenaeus chinensis by annotation of ESTs

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Progress in Natural Science:Materials International 2004年第1期14卷 48-55页

作者： SHEN Yaoqing 1,2 , XIANG Jianhai 1*, WANG Bing 1,2 , LI Fuhua 1 and TONG Wei 3.1. Experimental Marine Biology Laboratory, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071,China 2. Graduate School of the Chinese Academy of Sciences, Beijing 10003., China 3. Genomics & Bioinformatics Institute, Chinese Academy of Sciences, Beijing 1013.0, China) Chinese Acad Sci Inst Oceanol Expt Marine Biol Lab Qingdao 266071 Peoples R China Chinese Acad Sci Grad Sch Beijing 100039 Peoples R China Chinese Acad Sci Geonom & Bioinformat Inst Beijing 101300 Peoples R China

A total of 10446 expressed sequence tags (ESTs) are obtained by a large scale sequencing of a cDNA library from cephalothorax of adult Fenneropenaeus chinensis . An EST analysis platform was built up based on local computers and bioinformatic techniques were used to annotate these ESTs in order to promptly find possible functional genes, especially for immune related factors. About 4% of the ESTs show similarity to the coding sequences of such factors, including lectin, serine protease, serpin, lysozyme, etc. These ESTs provide a partial profile of the immune system in F. chinensis and useful information for further study on these genes.

关键词： Fenneropenaeus chinensis bioinformatics ESTs immune factors

一道闪电的传说巴塞罗那Relámpago住宅

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室内设计与装修 2024年第6期 99-103页

作者： h3.建筑事务所秋落 h3.建筑事务所

总部位于巴塞罗那的年轻建筑事务所h3.建筑事务所推出了Relámpago住宅,这是他们最为特别和不同寻常的住宅项目之一。在巴塞罗那郊区圣胡斯特德斯韦恩的传统加泰罗尼亚农舍内,对一座面积55m2的谦逊老谷仓进行翻新,打造出一个色彩丰富的... 详细信息

总部位于巴塞罗那的年轻建筑事务所h3.建筑事务所推出了Relámpago住宅,这是他们最为特别和不同寻常的住宅项目之一。在巴塞罗那郊区圣胡斯特德斯韦恩的传统加泰罗尼亚农舍内,对一座面积55m2的谦逊老谷仓进行翻新,打造出一个色彩丰富的独特空间,向访客诉说着自己难忘的故事。项目的灵感源自业主的愿望,这是一位热爱创意和艺术的历史学家。设计师以多年前一道闪电穿越古老农舍的传说为出发点,力图在功能性和大胆设计中展现这一灵感,以激发客户的艺术兴趣。

关键词：建筑事务所巴塞罗那住宅项目艺术兴趣加泰罗尼亚 Rel 闪电

Deposition features of Ni on self-assembled microtubule template from biolipid by electroless method

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Science China Chemistry 2004年第3期47卷 228-234页

作者： FU Yubin1,2, ZHANG Lide1, ZHENG Jiyong2, FU Shangang3.& ZHU Mingwei3.1. Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 23.03., China 2. Luoyang Ship Material Research Institute, Luoyang 47103., China 3. College of Life Science, Henan Normal University, Xinxiang 453.02, China 1. Institute of Solid State Physics Chinese Academy of Sciences 230031 Hefei China 2. Luoyang Ship Material Research Institute 471039 Luoyang China 3. College of Life Science Henan Normal University 453002 Xinxiang China

Diacetylenic glycero-phosphatidylcholine is a chiral molecule with amphiphilic property, and it can self-assembly into a lipid microtubular structure. The lipid microtubule is a stable structure formed by tightly wound helical ribbons, and the ribbon-wrapping patterns have a significant effect on their chemical deposition on the microtubules. The deposition of colloidal Pd catalyst occurs mainly on the helical edge of the wound helical ribbons to form helical deposition lines of colloidal Pd particles in the interior and exterior of the lipid microtubules, resulting in an uneven chemical deposition of Ni on the microtubules. Catalyzed by as-deposited colloidal Pd, metallized Ni microtubules are characterized by a helical form, which may be in relation to inner stress due to the thickness difference or the different deposition processes. The observation of microtom shows that metallized tubules have a hollow structure. Some metallized tubules have a kind of coaxial double layer structure observed in the direct experiment evidence, indicating that metallization can occur in the inner and outer surface of the lipid tubules. Both lipid microtubules and metallized microtubules can be used as vehicles for encapsulating biological active molecules to control their release and to develop micro-components in biological and mechanical systems. Keywords molecular self-assembly - lipid microtubules - helical pattern - site-specific deposition - electroless metallization

关键词： molecular self-assembly, lipid microtubules, helical pattern, site-specific deposition, electroless metallization.

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转角的邂逅巴塞罗那Tiberi酒吧

室内设计与装修 2024年第6期 104-107页

作者： h3.建筑事务所西溪 h3.建筑事务所

h3.建筑事务所是巴塞罗那一家年轻的设计公司,而同样位于巴塞罗那的Ti&beri俱乐部则以客制化的餐饮服务为人们所熟知。为了重新定义本地传统酒吧的体验,Tiberi俱乐部联手h3.建筑事务所的3.创始人Adri,Orriols、JoanGener和MiquelRuiz,... 详细信息

h3.建筑事务所是巴塞罗那一家年轻的设计公司,而同样位于巴塞罗那的Ti&beri俱乐部则以客制化的餐饮服务为人们所熟知。为了重新定义本地传统酒吧的体验,Tiberi俱乐部联手h3.建筑事务所的3.创始人Adri,Orriols、JoanGener和MiquelRuiz,共同打造了Tiberi酒吧。这是该俱乐部的第一家实体店,并已于2023.初夏开业。Tiber酒吧位于充满活力的PobleSec街区的一个转角处,面积82m^(2)。这个地区以多元的文化特色为亮点,吸引着众多的年轻人。设计师将这个空间打造成一个“宾至如归的酒吧”,完美诠释了Tiberi俱乐部的本质:试图通过提供独特的餐饮体验,来促进陌生人之间的交流和联系。

关键词：建筑事务所巴塞罗那餐饮服务俱乐部实体店酒吧陌生人客制化

Critical slope gradient for compulsory abandonment of farmland on the hilly Loess Plateau

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Chinese Science Bulletin 1998年第5期43卷 409-412页

作者： TANG Keli+1, ZHANG Keli 1,2 and LEI Aling 1,3.1. Institute of Soil and Water Conservation, Chinese Academy of Sciences, Yangling 712100, China 2. Department of Hydraulic Engineering, Tsinghua University, Beijing 100084, China 3. Water Resources C Institute of Soil and Water Conservation Chinese Academy of Sciences Yangling China Department of Hydraulic Engineering Tsinghua University Beijing China Water Resources Conservation Bureau of Yangtze River Ministry of Water Resources Wuhan China

Scientific evidence for the upper limit of farmland is proposed. Shallow gully erosion is one of erosion types distributed extensively on sloping farmland in the hilly regions of the Loess Plateau. Field observation and aerial photos interpretation, as well as laboratory experiments show that the shallow gully erosion occurring on the steeper farmland in the hilly regions of the Loess Plateau is an important factor leading to intensive erosion on slope, because of its extensive distribution and intensive runoff collection. The data on the formation, development and distribution of shallow gullies on sloping farmland indicate that critical slope gradient for shallow gully initiation ranges from 15 to 20 degrees with an average of 18.2 degrees. Therefore, it is suggested that critical slope gradient for compulsory abandonment of farmland on the hilly Loess Plateau should be kept within the critical slope gradient for shallow gully initiation to prevent shallow gully formation in order to control soil loss more effectively. But as the first step, the cultivation on the slopes with slope larger than 25 degrees where the maximum erosion occurs should be strictly forbidden.

关键词： hilly region of Loess Plateau upper limitation for farmland shallow gully erosion erosion dynamic.

Gene flow from transgenic oilseed rape (Brassica napus L.) to cruciferous weeds under mentor pollen inducement

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Progress in Natural Science:Materials International 2007年第11期17卷 1284-1289页

作者： Zhao Xiangxiang1,2, Luo Yuming1, Lu Weiping2, Qi Cunkou3. Pu Huiming3.and Wang Youping2(1. Biotechnology Key Laboratory of Eco-agriculture in Hongze Lake Region, Jiangsu Province, Huaiyin Normal College, Huai'an 223.01, China 2. Jiangsu Provincial Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou 225009, China 3. Institute of Industrial Crops, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China) Biotechnology Key Laboratory of Eco-agriculture in Hongze Lake Region Jiangsu Province Huaiyin Normal College Huai'an 223001 China Jiangsu Provincial Key Laboratory of Crop Genetics and Physiology Yangzhou University Yangzhou 225009 China Institute of Industrial Crops Jiangsu Academy of Agricultural Sciences Nanjing 210014 China

The alien gene flow between genetically modified glyphosate-resistant rapeseed variety Q3.(Brassica napus L.) and four cruciferous weeds was studied under mentor pollen inducement. The results showed that when Thlaspi arvense L., Capsella bursa-pastoris (L.) Medic, Cardamine hirsuta L. and Rorippa palustris (L.) Besser were pollinated with mentor pollen, the mixed Q3.and the weed, pollen grains aggregated largely and germinated quickly, and the numbers of pollen tubes penetrating into the style and the ovary were greatly increased as compared with corresponding self-pollination groups. Twenty four to forty eight hours after pollination, several pollen tubes were observed to penetrate into the ovule via micropyle in each mentor combination. However, when the mentor progenies were analyzed by PCR, all of them showed negative for the Q3.herbicide-resistant gene. Collectively, these results indicated that crossing between T. arvense, C. bursa-pastoris, C. hirsuta, R. palustris (as female) and Q3.(as male) was highly incompatible and the herbicide-resistant gene could not flow from Q3.to these four weeds.

关键词： herbicide-resistant rapeseed cruciferous weeds mentor pollination aniline blue fluorescence gene flow

Geochemical simulation of the formation of brine and salt minerals based on Pitzer model in Caka Salt Lake

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Science China Earth Sciences 2004年第8期47卷 720-726页

作者： LIU Xingqi1, CAI Keqin2 & YU Shengsong3.1. Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China 2. China University of Geosciences, Beijing 100083. China 3. Institute of Salt Lakes, Chinese Academy of Sciences, Xining 810008, China 1. Nanjing Institute of Geography and Limnology Chinese Academy of Sciences 210008 Nanjing China 2. China University of Geosciences 100083 Beijing China 3. Institute of Salt Lakes Chinese Academy of Sciences 810008 Xining China

The geochemical simulation of the formation of brine and salt minerals based on Pitzer model was made in Caka Salt Lake. The evolution of the mixed surface-water and the mineral sequences were calculated and compared with the hydrochemical compositions of the brine and the salt minerals of the deposit in Caka Salt Lake. The results show that the formation temperature of the lake is between 0°C and 5°C, which is well identical with other studies. The mixing of salt-karst water with the surface waters, neglected by the former researchers, is very important to the formation of the lake, indicating that the initial waters resulting in the formation of the lake are multi-source. It is the first time to use Pitzer model in China for making geochemical simulation of the formation and evolution of inland salt lake and satisfactory results have been achieved.

关键词： Pitzer model,Caka Salt Lake,geochemical simulation,salt-karst water.

Effects of Y211 phase contents on the critical current density J_c and microstructural analysis in YBCO bulk superconductors

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Rare Metals 2002年第4期21卷 282-288页

作者： SHA Jianjun, YU Gang, and YU JinnanChina Institute of Atomic Energy, P. O. Box 275-51, Beijing 102413, China China Institute of Atomic Energy P.O. Box 275-51 北京 102413

YBCO bulk superconductors were prepared by the solid state reaction andtop-seed-melt-textured growth (TSMTG) process. By using the AC susceptibility measurement, thecritical transition temperature T_c of samples is 91.5 K for the highest value, and the transitionwidth ΔT_c is less than 1 K. The highest magnetization critical current densities J_c achieved 10~6A/cm^2 under 5 T at 10 K and 1.3.X10^4 A/cm^2 under 2 T at 70 K (H//c), respectively. The resultscombining the SEM observation indicate that doping of Y211 particles is more effective in improvingthe growth quality of melt-textured YBCO superconductor and in reducing the micro-cracks ofspecimens. Doping of Y_2O_3.powder forms the rod-shaped Y211 particles, but doping of Y211 particlesdirectly to matrix materials forms the spherical Y211 particles mainly. Combining themicrostructures with J_c measurements shows that the interfaces are most important on flux bundlepinning, in which the gradient of free energy is larger than that of other place between the Y211particles and the Y123.matrix materials.

关键词： quasi-single domain melt-textured Y211 particles critical current density magnetic flux pinning