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Noise and detectivity limits in organic shortwave infrared photodiodes with low disorder

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npj Flexible Electronics 2020年第1期4卷 58-65页

作者： Zhenghui Wu Ning Li Naresh Eedugurala Jason DAzoulay dong-Seok Leem Tse nga ng Department of Electrical and Computer Engineering University of California San Diego9500 Gilman DriveLa JollaCA 92093-0407USA Department of Electrical and Electronic Engineering Southern University of Science and Technology1088 Xueyuan AvenueShenzhenGuangdong 518023China Center for Optoelectronic Materials and Devices School of Polymer Science and EngineeringUniversity of Southern Mississippi118 College Drive#5050HattiesburgMS 39406USA Samsung Advanced Institute of Technology(SAIT) Samsung ElectronicsCo.Ltd.130 Samsung-roYeongtong-guSuwon-siGyeonggi-do 443-803South Korea

To achieve high detectivity in infrared detectors,it is critical to reduce the device ***,for non-crystalline semiconductors,an essential framework is missing to understand and predict the effects of disorder on the dark *** report presents experimental and modeling studies on the noise current in exemplar organic bulk heterojunction photodiodes,with 10 donor-acceptor combinations spanning wavelength between 800 and 1600 nm.A significant reduction of the noise and higher detectivity were found in devices using non-fullerene acceptors(NFAs)in comparison to those using fullerene *** low noise in NFA blends was attributed to a sharp drop off in the distribution of bandtail states,as revealed by variable-temperature density-of-states *** disorder into account,we developed a general physical model to explain the dependence of thermal noise on the effective bandgap and bandtail *** model provides theoretical targets for the maximum detectivity that can be obtained at different detection wavelengths in inherently disordered infrared photodiodes.

关键词： heterojunction noise donor

Relationship between serum neutrophil gelatinase-associated lipocalin levels and cognitive impairment, anxiety, and depressive symptoms in acute ischemic stroke

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World Journal of Psychiatry 2024年第10期14卷 1467-1473页

作者： You-Quan Gu Xuan Zhou Li-He Yao Qiang Wang Chao-Ning Zhou Zhao-dong Liu Department of Neurology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Neurology The First Clinical Medical College of Lanzhou UniversityLanzhou 730099Gansu ProvinceChina

BACKGROUND Acute ischemic stroke(AIS)is a significant global health issue with increasing incidence owing to aging populations and rising cardiovascular risk *** addition to physical impairments,AIS frequently leads to neuropsychiatric co-mplications,such as cognitive impairment,anxiety,and depressive symptoms,which adversely affect patients’quality of life and *** ge-latinase-associated lipocalin(ngAL)has emerged as a potential biomarker for various conditions,including *** study investigated the association bet-ween serum ngAL levels at admission and neuropsychiatric complications in patients with *** complications in patients with *** Between January 2022 and December 2023,150 patients with AIS were *** ngAL levels were measured at admission using an enzyme-linked immu-nosorbent *** function was assessed using the Mini-Mental State Examination,while anxiety and depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale at *** relationship between serum ngAL levels and cognitive impairment,anxiety,and depressive symptoms was analyzed using multivariate logistic regression,adjusted for potential con-founders of age,sex,body mass index,smoking status,hypertension,diabetes mellitus,dyslipidemia,previous stroke,and stroke *** The mean age of the participants was 65.4±10.2 years,and 58%were *** rates of cognitive impairment,anxiety,and depressive symptoms at discharge were 34.7%,28.0%,and 32.0%,*** ngAL levels were significantly higher in patients with cognitive impairment(median:5.6 ng/mL vs 3.2.ng/mL,Png/mL vs 3.5 ng/mL,P=0.002),and depressive symptoms(median:5.4 ng/mL vs 3.3 ng/mL,PngAL levels at admission were independently associated with cognitive impairment[odds rat

关键词： Neutrophil gelatinase-associated lipocalin Neuropsychiatric complications Biomarker Acute ischemic stroke Cognitive impairment Anxiety Depressive symptoms

气相色谱-三重四极杆质谱测定全血中5种常见兽用麻醉剂

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刑事技术 2024年第2期49卷 135-140页

作者：董林沛任昕昕李佳宜董梅公安部鉴定中心北京100038 岛津企业管理(中国)有限公司北京100020

本文采用程序升温进样技术结合气相色谱-三重四极杆质谱仪建立了全血中的5种常见兽用麻醉剂(替来他明、赛拉唑、氯胺酮、甲苯噻嗪、唑拉西泮)检验方法。以NaCl作为盐析剂、乙腈作为萃取剂,采用盐析辅助液液萃取法作为前处理方法,并使用... 详细信息

本文采用程序升温进样技术结合气相色谱-三重四极杆质谱仪建立了全血中的5种常见兽用麻醉剂(替来他明、赛拉唑、氯胺酮、甲苯噻嗪、唑拉西泮)检验方法。以NaCl作为盐析剂、乙腈作为萃取剂,采用盐析辅助液液萃取法作为前处理方法,并使用小型QuEChERS净化柱对提取液进行净化。提取液采用程序升温进样技术结合气相色谱-三重四极杆质谱仪进行分析,能最大程度去除提取液体系中的乙腈溶剂。采用多反应监测模式进行检测,三组特征离子对进行定性检验,外标法进行定量分析,并对方法进行了确证。结果表明,全血中5种常见兽用麻醉剂检出限为10~20 ng/mL,定量限为20~40 ng/mL。在20~2 000 ng/mL(甲苯噻嗪为40~2 000 ng/mL)范围内表现良好(r>0.998),不同浓度的添加样品回收率为71.61%~119.10%,日内精密度(RSD)为0.34%~14.81%,日间精密度(RSD)为4.03%~14.87%。本文建立的方法前处理简便、稳定性好、灵敏度高,具有广阔的开发前景,可用于实际案件检验。

关键词：兽用麻醉剂气相色谱-三重四极杆质谱程序升温进样盐析辅助液液萃取 QuEChERS技术

乳腺增生患者供血动脉血流参数与促血管新生因子表达及综合治疗疗效的相关性

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中国超声医学杂志 2024年第8期40卷 870-874页

作者：李夏李拓董莹南阳医学高等专科学校第一附属医院超声诊断科南阳医学高等专科学校医学技术系

目的探究乳腺增生患者超声测定乳腺供血动脉血流参数[收缩期峰值流速(PSV)、阻力指数(RI)]与促血管新生因子[血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)]表达及综合治疗疗效的相关性。方法回顾性收集经病理证实的122例乳... 详细信息

目的探究乳腺增生患者超声测定乳腺供血动脉血流参数[收缩期峰值流速(PSV)、阻力指数(RI)]与促血管新生因子[血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)]表达及综合治疗疗效的相关性。方法回顾性收集经病理证实的122例乳腺增生患者临床资料，统计对比不同病理类型、不同疗效乳腺增生患者入院次日(综合治疗前)PSV、RI及VEGF、bFGF水平，观察综合治疗前后指标变化。受试者工作特征(ROC)曲线分析治疗前PSV、RI、VEGF、bFGF对疗效的预测效能；Pearson分析评价治疗前PSV、RI与VEGF、bFGF的相关性。结果混合型与腺瘤样增生患者PSV、RI及血清VEGF、bFGF水平均显著大于囊性增生、小叶增生(P0.05)。乳腺增生患者治疗3个月后PSV、RI、血清VEGF及bFGF水平较治疗前均显著下降(P22例乳腺增生患者中，治疗显效率为83.61%(102/122),不佳率为16.39%(20/122)。治疗显效患者治疗前PSV[(9.75±2.20)cm/s vs.(11.25±2.33)cm/s]、RI(0.49±0.10 vs. 0.60±0.09)、血清VEGF[(206.95±27.07)ng/L vs.(240.58±43.65)ng/L]及bFGF[(42.94±8.13)ng/L vs.(50.00±12.01)ng/L]水平均显著低于不佳患者(P2、0.721、0.676、0.933。乳腺增生患者治疗前PSV与VEGF、bFGF正相关(P<0.001),RI与VEGF、bFGF正相关(P<0.001)。结论乳腺增生患者乳腺供血动脉血流参数与促血管新生因子均呈正相关，检测结果对治疗效果有一定的预测价值，特别是联合检测。

关键词：乳腺增生彩色多普勒超声血流参数促血管新生因子疗效相关性

牙周源性牙周牙髓联合病变病原菌分布及临床特征分析

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中国病原生物学杂志 2024年第10期19卷 1198-1201页

作者：董楠刘霞李强沧州医学高等专科学校基础护理教研室河北沧州061001 沧州市中心医院口腔颌面外科

目的探析牙周源性牙周牙髓病变患者病原菌分布特点及不同病情程度患者龈沟液IL-1β、hs-CRP、LPS水平,为临床研究提供参考依据。方法选取65例牙周源性牙周牙髓联合病变患者为本次研究对象(病变组),同期进行正畸的65例患者为对照组,采... 详细信息

目的探析牙周源性牙周牙髓病变患者病原菌分布特点及不同病情程度患者龈沟液IL-1β、hs-CRP、LPS水平,为临床研究提供参考依据。方法选取65例牙周源性牙周牙髓联合病变患者为本次研究对象(病变组),同期进行正畸的65例患者为对照组,采集患者牙周袋及牙根管标本,采用荧光定量PCR技术检测微生物种类,分析患者病原菌分布情况。按照病情程度将患者分组后,采集患者龈沟液,对比不同分组患者龈沟液IL-1β、hs-CRP、LPS水平。结果 65例病变组病原菌检出率为58.26%(67/115),对照组为15.65%(18/115),两组检出率差异有统计学意义(P2.24%、80.60%、34.33%、25.37%、1.49%、29.85%;对照组患牙弯曲菌属、放线菌属、奈瑟菌属的分布率分别为27.78%、22.22%、72.22%,两组患者各菌属分布率差异有统计学意义(Png/mL、(9.45±2.12.ng/mL、(5.28±1.77)×10^(7)EU/L,中度患者组分别为(8.25±1.90)ng/mL、(12.49±2.90)ng/mL、(7.60±2.22)×10^(7)EU/L,重度患者组分别为(10.27±2.42.ng/mL、(15.20±3.78)ng/mL、(11.24±2.29)×10^(7)EU/L。随着患者病情的加重,患者龈沟液IL-1β、hs-CRP、LPS水平呈上升趋势。结论牙周源性牙周牙髓联合病变患者病原菌检出率显著升高,发病情况与口腔病原菌感染密切相关。患者龈沟液IL-1β、hs-CRP、LPS水平与病情具有相关性,随着病情发展加重而升高。

关键词：牙周源性牙周牙髓联合病变病原菌白细胞介素-1β 超敏C反应蛋白内毒素

Intracellular effects of prodrug-like wortmannin probes

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Chinese Chemical Letters 2019年第1期30卷 67-70页

作者： Shasha Ying Shubo Du Jia dong Bi Xuan ng Chengwu Zhang Lin Li Jingyan Ge Qing Zhua Key Laboratory of Bioorganic Synthesis of Zhejiang Province College of Biotechnology and Bioengineering Zhejiang University of Technology Department of Chemistry National University of Singapore Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University (Nanjing Tech)

Wortmannin, a known inhibitor of phosphoinositide 3-kinases(PI3 Ks), their low selectivity and high toxicity is still problematic and less is known about their effects on PI3 Ks in cellular systems. Hence, we have synthesized a series of multifunctional wortmannin probes with the ability to self-activate, by installing a clickable handle at C11 site, and secondary amine and cancer-targeting moiety at C20 site respectively. MTT assay first confirmed that self-activating probes have better inhibition potency and biotin enhanced their cancer cell uptake. Further experiments showed most of probes can target PI3 K/Akt/mTOR pathway with prolonged turn-over time. Protein profiling and pull-down results were observed that the derivatives not only labelled four PI3 Ks with selectivity, but also engaged in covalent interactions with numerous cellular proteins which could be the major reason of their high toxicity.

关键词： Wortmannin P3IK Activity-based probe profiling Cancer-targeting Self-activating

Application of constructed wetlands for wastewater treatment in tropical and subtropical regions(2000–2013)

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Journal of Environmental Sciences 2015年第4期27卷 30-46页

作者： dong-Qing Zhang K.B.S.N.Jinadasa Richard M.Gersberg Yu Liu Soon Keat Tan Wun Jern ng Advanced Environmental Biotechnology Centre Nanyang Environment & Water Research Institute Nanyang Technological University Department of Civil Engineering University of Peradeniya Graduate School of Public Health San Diego State University

Constructed wetlands（CWs） have been successfully used for treating various wastewaters for decades and have been identified as a sustainable wastewater management option for developing countries. With the goal of promoting sustainable engineered systems that support human well-being but are also compatible with sustaining natural（environmental）systems, the application of CWs has become more relevant. Such application is especially significant for developing countries with tropical climates, which are very conducive to higher biological activity and productivity, resulting in higher treatment efficiencies compared to those in temperate climates. This paper therefore highlights the practice,applications, and research of treatment wetlands under tropical and subtropical conditions since 2000. In the present review, removal of biochemical oxygen demand（BOD） and total suspended solid（TSS） was shown to be very efficient and consistent across all types of treatment wetlands. Hybrid systems appeared more efficient in the removal of total suspended solid（TSS）（91.3%）, chemical oxygen demand（COD）（84.3%）, and nitrogen（i.e.,80.7% for ammonium（NH）4-N, 80.8% for nitrate（NO）3-N, and 75.4% for total nitrogen（TN））as compared to other wetland systems. Vertical subsurface flow（VSSF） CWs removed TSS（84.9%）, BOD（87.6%）, and nitrogen（i.e., 66.2% for NH4-N, 73.3% for NO3-N, and 53.3% for TN）more efficiently than horizontal subsurface flow（HSSF） CWs, while HSSF CWs（69.8%）showed better total phosphorus（TP） removal compared to VSSF CWs（60.1%）. Floating treatment wetlands（FTWs） showed comparable removal efficiencies for BOD（70.7%）,NH4-N（63.6%）, and TP（44.8%） to free water surface（FWS） CW systems.

关键词： Constructed wetlands Treatment Nutrient Removal Tropical

地方政府债务规模对企业资金成本的影响分析--基于美的和TCL的双案例研究

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河南工学院学报 2024年第2期32卷 40-48页

作者：韩冬河南工学院管理学院河南新乡453003 河南工学院现代企业管理研究所河南新乡453003

地方政府通过负债融资推动大规模基建对经济发展具有促进作用,但地方政府债务规模对企业资金成本的提升效应不容忽视。地方政府举债带来的企业融资“挤出”效应提升了企业债权成本和股权成本,这一提升效应具有“门槛”效应,且在不同性... 详细信息

地方政府通过负债融资推动大规模基建对经济发展具有促进作用,但地方政府债务规模对企业资金成本的提升效应不容忽视。地方政府举债带来的企业融资“挤出”效应提升了企业债权成本和股权成本,这一提升效应具有“门槛”效应,且在不同性质企业间表现出明显的异质性。美的和TCL的相关数据印证了这一结论。为保障经济平稳运行、激发市场主体活力,必须认识到地方政府债务规模对企业资金成本的提升作用,并采取多种措施降低企业资金成本,严格控制地方政府债务规模,拓展企业多元化资金渠道。

关键词：地方政府债务规模资金成本股权成本债权成本

Mesh theory of angle modified dual tori double-enveloping toroidal worm drive

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Science China(Technological Sciences) 2010年第7期53卷 1913-1927页

作者： ZHAO YaPing1, SU DaiZhong2, ZHAng Zhao1, WEI WenJun3 & dong XueZhu3 1 College of Machinery and Automation, Wuhan University of Science and Technology, Wuhan 430081, China 2 Advanced Design and Manufacturing Engineering Center, Nottingham Trent University, Nottingham ng1 4BU, UK 3 College of Engineering, China Agricultural University, Beijing 100083, China 1. College of Machinery and Automation Wuhan University of Science and Technology Wuhan 430081 China2. Advanced Design and Manufacturing Engineering Center Nottingham Trent University Nottingham NG1 4BU UK3. College of Engineering China Agricultural University Beijing 100083 China

In this paper, the meshing theory of the angle modified hourglass worm drive is enriched and developed. The ordinary condition of the angle modification is derived and the physical significance of the modification is interpreted. A normal section methodology is proposed for meshing analysis, which can be used to compute the normal distance near a singular meshing point of a conjugate surface couple. By means of the method and after analyzing the normal transversals, it is specified that the worm helicoid, the nominal former contact zone and the new contact zone intersect each other along the locus of singular points of the instantaneous contact lines of an angle-modified worm pair. As a result, it is explained clearly that those three osculate each other but the osculations are different in degree. Moreover, the mechanism of removing the twice-contacted zone from the worm gear tooth surface is clarified and the reason of shortening the worm working length is also elucidated. With the help of the theory described in the present paper and the thorough and systematic research on the relevant meshing characteristics, the angle modified dual tori double-enveloping toroidal worm drive has been shown to be an excellent new-fashioned hourglass worm set.

关键词： hourglass worm angle modification double-enveloping osculation normal transversal