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Fresh Processing Technology in Polygonatum odoratum Production Area and Its Comparison with Traditional Processing

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Medicinal Plant 2024年第1期15卷 38-40,44页

作者： Miao YANG Chufan PENG Haixia LU Rufeng LIANG hui TANG Zhongmei qin Shengjiu GU Guilin Medical University Guilin 541000China Guangxi Institute of Botany Chinese Academy of SciencesGuilin 541006China Blood Purification Center of Guilin People's Hospital Guilin 541002China

[Objectives]To compare the effects of traditional processing and fresh processing on the quality of Polygonatum odoratum decoction piece.[Methods]The effects of fresh processing and traditional processing on the quality of *** decoction piece were compared and analyzed with appearance characteristics,total ash content,extract content,total polysaccharides content,and total flavonoids content as the evaluation indexes.[Results]Fresh processing method in different production areas has different effects on *** decoction *** was dried in oven of 50℃.When moisture content was 41.44%-59.67%,it was *** complete drying at 50℃,the moisture content of dried *** was 8.94%-9.60%,and ethanol-soluble extract content was 77.29%-78.20%,and water-soluble extract was 77.7%-78.14%.At this time,the appearance characteristics of section of *** decoction piece were better than that of traditional processing,which was yellowish *** total polysaccharide content was higher than that of traditional processing,and the content of total flavonoids was statistically significant different from that of traditional processing.[Conclusions]The quality of *** decoction piece by fresh processing is better than that of the traditional processing,and it is feasible to use fresh processing.

关键词： Processing technique Plygonatum odoratum Fresh processing Total polysaccharide Total flavonoids

Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

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Military Medical Research 2024年第2期11卷 206-227页

作者： Guang-hui Deng Chao-Feng Wu Yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-Jie Li Jia-Min Zhao Chang Liu Meng-Chen qin Zhi-Yun Zeng Wei-Min Zhang Ken Kin Lam Yung Zhi-Ping Lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress

盐、碱胁迫对4份梯牧草苗期生物量及生理特性的影响

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草地学报 2024年第4期32卷 1184-1193页

作者：袁惠张鲜花韩禧卿熊辉撒成辉新疆农业大学草业学院新疆乌鲁木齐830052 新疆草地资源与生态实验室新疆乌鲁木齐830052

为探究盐、碱胁迫对不同梯牧草(Phleum pratense)材料苗期生物量及生理特性的影响,本研究以4份梯牧草材料(L,S,T,W)为研究对象,以不同盐胁迫浓度以及碱胁迫浓度为试验处理,对梯牧草苗期生物量、脯氨酸及可溶性糖含量、抗氧化酶活性进行... 详细信息

为探究盐、碱胁迫对不同梯牧草(Phleum pratense)材料苗期生物量及生理特性的影响,本研究以4份梯牧草材料(L,S,T,W)为研究对象,以不同盐胁迫浓度以及碱胁迫浓度为试验处理,对梯牧草苗期生物量、脯氨酸及可溶性糖含量、抗氧化酶活性进行测定分析。结果表明,随着盐、碱胁迫程度增加,4份梯牧草材料根冠比、抗氧化酶活性、可溶性糖及脯氨酸含量均呈增加趋势,盐胁迫下地上、地下生物量呈降低趋势,碱胁迫下呈先增后降的趋势;不同梯牧草材料经过盐胁迫及碱胁迫处理后各指标间存在较高的相关性;通过隶属函数进行综合评价发现4份材料耐盐性排序为T>W>S>L,耐碱性排序为T>S>W>L。

关键词：梯牧草盐胁迫碱胁迫地上生物量地下生物量

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社会物质主义视角下外语教材与外语教育学其他维度关系研究

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外语学刊 2024年第3期 71-77页

作者：李会钦张虹北京外国语大学中国外语与教育研究中心/外语教学与研究出版社北京100089 北京外国语大学中国外语与教育研究中心/国家语言能力发展研究中心北京100089

本文以社会物质主义为视角,重新定义外语教材,耙梳并剖析外语教材与外语教育学其他维度之间的关系,包括外语教材与外语教育政策、外语教材与外语教师发展、外语教材与外语教学、外语教材与外语课程、外语教材与教育技术、外语教材与外... 详细信息

本文以社会物质主义为视角,重新定义外语教材,耙梳并剖析外语教材与外语教育学其他维度之间的关系,包括外语教材与外语教育政策、外语教材与外语教师发展、外语教材与外语教学、外语教材与外语课程、外语教材与教育技术、外语教材与外语测评6个方面。准确把握和深入理解外语教材的内涵及其与其他各维度之间缠绕与内动联系,对于辨证分析外语教材在外语教育中的独特性与关联性具有重要意义,为在外语教育学宏观视野下加强外语教材建设、使用及研究提供重要启示与参考。

关键词：外语教材外语教育学社会物质主义外语教材内涵外语教材知识体系

中老年人听力损失与肌肉减少症发病风险的前瞻性队列研究

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现代预防医学 2024年第9期51卷 1574-1579页

作者：殷海芹李辉中国人民解放军联勤保障部队第九六〇医院消毒供应中心中国人民解放军联勤保障部队第九六〇医院耳鼻咽喉头颈外科

目的探究中老年人听力损失与肌肉减少症发病风险的关联，以期为中老年人肌肉减少症的预防和干预提供科学依据。方法本研究选取2011—2015年中国健康与养老追踪调查（CHARLS）中的45岁及以上中老年人作为研究对象，采用自我报告听力状... 详细信息

目的探究中老年人听力损失与肌肉减少症发病风险的关联，以期为中老年人肌肉减少症的预防和干预提供科学依据。方法本研究选取2011—2015年中国健康与养老追踪调查（CHARLS）中的45岁及以上中老年人作为研究对象，采用自我报告听力状况评价听力损失，基于亚洲肌肉减少症工作组2019年共识判定肌肉减少症，采用Cox比例风险模型探索中老年人听力损失与肌肉减少症发病风险的关联。结果 11 528名中老年人中，基线听力损失发生率为12.8%。在4年的随访中，新发肌肉减少症558名，发生率为6.4%。Cox比例风险模型结果显示，与无听力损失的研究对象相比，存在听力损失的研究对象肌肉减少症发病风险增加31.1%(HR=1.311,95%CI:1.059～1.625)。分层分析结果显示，听力损失与肌肉减少症的关联在女性、老年人、农村户籍、已婚者、教育程度初中及以上者、家庭年收入高者中更明显。结论中国中老年人群中听力损失与肌肉减少症发病风险增加有关。对听力损失进行早期筛查并实施干预可能有助于降低未来肌肉减少症的发生。

关键词：听力损失肌肉减少症中老年人队列研究

Effects of the fertilizer and water management on amino acids and volatile components in Cabernet Sauvignon grapes and wines

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 69-79页

作者： Kui Zhang Wenhuai Kang Weihua Han Haijun Ma Daozhi Gong Ling qin College of Food Science and Biology Hebei University of Science and TechnologyShijiazhuang 050018China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China College of Biological Science and Engineering North Minzu UniversityYinchuan 750021China

The amino acids and the volatile substances in grapes and wines play important roles in their quality,and the concentrations of these substances can be changed by how a vineyard is managed,e.g.,irrigation and fertigation *** study aimed to evaluate the effect of fertilizer and water management on the distribution of amino acids,the volatile component profiles,and the sensory characteristics of Cabernet Sauvignon grapes and *** results showed that the amino acid concentration in grape berries was the highest under the 100%local fertilizer rate(HF)and 100%water irrigation quota(HW)treatment,and the volatile component concentration in wine was the highest under HF and 80%water irrigation quota(MW)*** effect of irrigation on the amino acid content in grapes was greater than that of *** synergistic effect of fertilizer and water on arginine,serine,and glutamine in grape berries was *** interactive effect of fertigation and irrigation on the volatile substance in grapes was greater than that of fertigation and irrigation *** influence of irrigation on volatile substances in wines was greater than that of *** addition,there was also a correlation between the concentrations of multiple amino acids in grapes and volatile components in *** component analysis showed that the wine from the HFMW treatment had the best quality among all treatments.

关键词： fertilizer and water management grape ine amino acids volatile components

Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract:a randomized clinical trial

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 528-536页

作者： Wei-Bo Feng Lei Zheng Ying-Qi Li Yong-Hao Li Guo-Ming Zhang Xian Wang Bing-Qian Liu Ling Jin Yi-Nuo Huang Yang-Fan Yang Zi-Dong Chen Da-hui Ma qing-Shan Chen Chao-Jun qin Bing-Min Feng Zhu-Min Yang Xing Huang Cheng-Jie Yang Sheng-hui Liu Ming-Xing Wu State Key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen 518040Guangdong ProvinceChina The Affiliated Hospital of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Guangzhou Aier Eye Hospital Guangzhou 510000Guangdong ProvinceChina

●AIM:To evaluate the effectiveness and safety of early lens extraction during pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR)compared to those of PPV with subsequent cataract surgery.●METHODS:This multicenter randomized controlled trial was conducted in three Chinese hospitals on patients with PDR,aged>45y,with mild *** participants were randomly assigned to the combined(PPV combined with simultaneously cataract surgery,i.e.,phacovitrectomy)or subsequent(PPV with subsequent cataract surgery 6mo later)group and followed up for *** primary outcome was the change in best-corrected visual acuity(BCVA)from baseline to 6mo,and the secondary outcomes included complication rates and medical expenses.●RESULTS:In total,129 patients with PDR were recruited and equally randomized(66 and 63 in the combined and subsequent groups respectively).The change in BCVA in the combined group[mean,36.90 letters;95%confidence interval(CI),30.35–43.45]was significantly better(adjusted difference,16.43;95%CI,8.77–24.08;P22.40 letters;95%CI,15.55–29.24)6mo after the PPV,with no significant difference between the two groups at *** overall surgical risk of two sequential surgeries was significantly higher than that of the combined surgery for neovascular glaucoma(17.65%vs 3.77%,P=0.005).No significant differences were found in the photocoagulation spots,surgical time,and economic expenses between two *** the subsequent group,the duration of work incapacity(22.54±9.11d)was significantly longer(P2.44±6.48d).●CONCLUSION:PDR patients aged over 45y with mild cataract can also benefit from early lens extraction during PPV with gratifying effectiveness,safety and convenience,compared to sequential surgeries.

关键词： lens extraction pars plana vitrectomy proliferative diabetic retinopathy cataract simultaneously operations

基于细胞系和类器官研究c-Myc在肝癌治疗和耐药中的作用

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中国肿瘤临床 2024年第8期51卷 385-391页

作者：程景辉秦艺萱杨慧北京大学第一医院肿瘤转化研究中心北京市100034

目的:基于肝癌细胞系与类器官的药物基因组学数据探讨骨髓细胞瘤癌基因(c-Myc)的潜在治疗效果。方法:收集肝癌细胞系的药敏、功能基因组和基因表达数据,评估c-Myc的表达与药敏的关联。统计c-Myc表达在肝癌测序队列中的差异和预后相关性... 详细信息

目的:基于肝癌细胞系与类器官的药物基因组学数据探讨骨髓细胞瘤癌基因(c-Myc)的潜在治疗效果。方法:收集肝癌细胞系的药敏、功能基因组和基因表达数据,评估c-Myc的表达与药敏的关联。统计c-Myc表达在肝癌测序队列中的差异和预后相关性。免疫组织化学染色验证c-Myc在肝癌患者的表达,检测其与类器官生物库类器官的药敏关联。选取三种不同的c-Myc抑制剂在肝癌细胞系和类器官上进行药物筛选,检测干预c-Myc对二维、三维水平的肿瘤杀伤作用。生物信息学分析探究c-Myc与靶向耐药的相关性。结果:生物信息学分析联合免疫组织化学鉴定c-Myc在肝癌中调控药敏的潜在作用。c-Myc在癌组织中的表达明显高于癌旁组织,而且c-Myc的表达在靶向药耐药患者中高于靶向药敏感患者(P1)。进一步的类器官生物库数据分析显示,c-Myc与干性介导的靶向耐药显著正相关(R=0.87)。结论:c-Myc在在靶向治疗耐药患者中高表达,并且抑制c-Myc可在二维、三维体外模型中起到很好的肿瘤杀伤效果,肝癌中可作为一个新的靶点。

关键词：肝癌 c-Myc 耐药性

非线性相互作用引起的双模Dicke模型的新奇量子相变

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物理学报 2024年第16期73卷 16-27页

作者：赵秀琴张文慧王红梅太原师范学院物理系晋中030619 太原师范学院计算与应用物理研究所晋中030619 太原师范学院智能优化计算与区块链技术山西省重点实验室晋中030619

量子相变是量子光学和凝聚态物理领域的一个重要课题.本文在标准双模Dicke模型的基础上引入原子-光的非线性相互作用,研究其所引起的量子相变.利用自旋相干态变分法从理论上给出有两个参量的基态能量泛函.两模光场采用四种不同的比例关... 详细信息

量子相变是量子光学和凝聚态物理领域的一个重要课题.本文在标准双模Dicke模型的基础上引入原子-光的非线性相互作用,研究其所引起的量子相变.利用自旋相干态变分法从理论上给出有两个参量的基态能量泛函.两模光场采用四种不同的比例关系进行研究,并且在实验参数下,通过可调的原子-光的非线性相互作用参量,给出了宏观多粒子量子态的丰富结构.本文主要呈现了在蓝失谐和红失谐下,双稳的正常相、共存的正常-超辐射相和原子数反转态等丰富的基态特性.原子-光的非线性相互作用在蓝失谐可以引起标准的双模Dicke模型的正常相到超辐射相的二级量子相变.在红失谐时引起新奇的基态特性,新奇的量子相变,即反转的超辐射相到反转的正常相的二级逆量子相变.原子-光的非线性相互作用和两模光场比例不同时,对量子相变的相边界和基态物理量的值有较大影响.

关键词：双模Dicke模型原子-光的非线性相互作用量子相变自旋相干态法

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