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Association of CD14/-2.0 polymorphism with gastric cancer risk in Highland Tibetans

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World Journal of Gastroenterology 2014年第10期20卷 2688-2694页

作者： Kang Li Zeng Dan Xue-Jun Hu Luo-Bu Gesang yong-Ge Ze Zha-Xi Bianba Cuo-Mu Ciren yu-Qiang Nie Department of Gastroenterology People’s Hospital of Tibet Autonomous Region Department of Oncology People’s Hospital of Tibet Autonomous Region Department of Gastroenterology Guangzhou First People’s Hospital Guangzhou Medical University

AIM: To investigate the relationship between CD14-2.0 and -651 polymorphisms and the risk of developing gastric cancer.

关键词： CD14 Single nucleotide polymorphisms Cancer susceptibility Gastric cancer Tibetans

Activation of natural killer T cells contributes to Th1 bias in the murine liver after 14 d of ethinylestradiol exposure

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World Journal of Gastroenterology 2022年第26期28卷 3150-3163页

作者： Meng-Zhi Zou Wei-Chao Kong Heng Cai Meng-Tao Xing Zi-Xun yu Xin Chen Lu-yong Zhang Xin-Zhi Wang New Drug Screening Center China Pharmaceutical UniversityNanjing 210009Jiangsu ProvinceChina Department of Pharmacology China Pharmaceutical UniversityNanjing 210009Jiangsu ProvinceChina Center for Drug Research and Development Guangdong Pharmaceutical UniversityGuangzhou 510006Guangdong ProvinceChina

BACKGROUND As the main component of oral contraceptives(OCs),ethinylestradiol(EE)has been widely applied as a model drug to induce murine intrahepatic *** clinical counterpart of EE-induced cholestasis includes women who are taking OCs,sex hormone replacement therapy,and susceptible pregnant *** intrahepatic cholestasis of pregnancy(ICP)as an example,ICP consumes the medical system due to its high-risk fetal burden and the impotency of ursodeoxycholic acid in reducing adverse perinatal *** To explore the mechanisms and therapeutic strategies of EE-induced cholestasis based on the liver immune *** Male C57BL/6J mice or invariant natural killer T(iNKT)cell deficiency(Jα18-/-mice)were administered with EE(10 mg/kg,subcutaneous)for 14 *** Both Th1 and Th2.cytokines produced by NKT cells increased in the liver skewing toward a Th1 *** expression of the chemokine/chemokine receptor Cxcr6/Cxcl16,toll-like receptors,Ras/Rad,and PI3K/Bad signaling was upregulated after EE *** also influenced bile acid synthase Cyp7a1,Cyp8b1,and tight junctions ZO-1 and Occludin,which might be associated with EEinduced *** cell deficiency(Jα18-/-mice)robustly alleviated cholestatic liver damage and lowered the expression of the abovementioned signaling *** Hepatic NKT cells play a pathogenic role in EE-induced intrahepatic *** research improves the understanding of intrahepatic cholestasis by revealing the hepatic immune microenvironment and also provides a potential clinical treatment by regulating iNKT cells.

关键词： Natural killer T cell Th1/Th2 IFN-γ Estrogen Cholestasis

用于菜籽油酯交换过程的Mg-Al复合氧化物催化剂

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石油化工 2003年第9期32卷 800-804页

作者：吴玉秀李永丹张全忠梁斌天津大学化工学院天津300072 四川大学化工学院四川成都610065 1四川大学化工学院四川成都610065

以共沉淀法制备了Mg -Al复合氧化物催化剂 ,XRD表征结果表明 ,沉淀所得催化剂前体晶相均一 ,为层状Mg6 Al2.(OH) 1 6 CO3·4H2.O水滑石结构。经 5 0 0℃煅烧后得到具有良好酯交换活性的Mg -Al复合氧化物催化剂 ,在常压、(65± 1)℃、4h... 详细信息

以共沉淀法制备了Mg -Al复合氧化物催化剂 ,XRD表征结果表明 ,沉淀所得催化剂前体晶相均一 ,为层状Mg6 Al2.(OH) 1 6 CO3·4H2.O水滑石结构。经 5 0 0℃煅烧后得到具有良好酯交换活性的Mg -Al复合氧化物催化剂 ,在常压、(65± 1)℃、4h、醇 /油摩尔比为 6、催化剂加入量 (催化剂质量 /油质量 )为 1 5 %的条件下 ,菜籽油 -甲醇酯交换反应甲酯收率达到 90 %。CO2.-TPD实验表明 ,制备的催化剂比MgO具有更强和更多的碱性位 ,其催化性能与所拥有的碱中心性质直接相关。

关键词： Mg-Al复合氧化物催化剂水滑石酯交换菜籽油甲酯

Hepatitis B virus infection in patients with Wilson disease:A large retrospective study

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世界胃肠病学杂志:英文版 2023年第32期29卷 4900-4911页

作者： Hua-Ying Zhou Xu Yang Kai-Zhong Luo yong-Fang Jiang Wen-Long Wang Jun Liang Ming-Ming Li Hong-yu Luo Department of Infectious Diseases Institute of HepatologyThe Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Wilson disease(WD)is the most common genetic metabolic liver *** studies have shown that comorbidities may have important effects on *** on hepatitis B virus(HBV)infection in patients with WD are *** To investigate the prevalence and clinical impact of HBV infection in patients with *** The clinical data of patients with WD were analyzed retrospectively,and the data of patients with concurrent WD and HBV infection were compared with those of patients with isolated *** Among a total of 915 WD patients recruited,the total prevalence of current and previous HBV infection was 2.1%[95%confidence interval(CI):1.2.-3.0%]and 9.2.(95%CI:7.3%-11.1%),*** main finding of this study was the identification of 19 patients with concurrent WD and chronic hepatitis B(CHB)*** diagnosis of WD was missed in all but two patients with CHB *** mean delay in the diagnosis of WD in patients with concurrent WD and CHB infection was 32.5 mo,which was significantly longer than that in patients with isolated WD(10.5 mo).The rates of severe liver disease and mortality in patients with concurrent WD and CHB infection were significantly higher than those in patients with isolated WD(63.1%vs 19.3%,P=0.000 and 36.8%vs 4.1%,P2.890-2..774;P=0.000)]or previous HBV infection(OR=5.52.;95%CI:3.159-8.739;P=0.000)than in patients with isolated *** The total prevalence of current HBV infection in patients with WD was 2.1%.The diagnosis of WD in CHB patients is usually *** infection is an independent risk factor for severe liver disease in WD *** diagnosis of WD should be ruled out in some patients with CHB infection.

关键词： Wilson disease Hepatitis B virus Chronic hepatitis B Kayser-Fleischer ring Ceruloplasmin Concurrent Wilson disease and hepatitis B virus infection

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论道德的保护功能

哲学动态 2019年第9期 98-106页

作者：余涌中国社会科学院哲学研究所

道德作为一种社会意识形态和规范体系,除具有调节功能、认识功能、描述功能、评判功能和教育功能外,还应包含保护功能。对社会共同体不同道德主体的平等保护是道德的基本和重要功能之一。道德的保护功能在作为道德规范的道德义务和道德... 详细信息

道德作为一种社会意识形态和规范体系,除具有调节功能、认识功能、描述功能、评判功能和教育功能外,还应包含保护功能。对社会共同体不同道德主体的平等保护是道德的基本和重要功能之一。道德的保护功能在作为道德规范的道德义务和道德权利上都能得到充分的体现。正确理解和认识道德的保护功能在当前具有重要的现实意义。

关键词：道德保护功能道德义务道德权利

Development of a novel rat model of heterogeneous hepatic injury by injection with colchicine via the splenic vein

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World Journal of Gastroenterology 2018年第44期24卷 5005-5012页

作者： Yan-Yan Zhang Chao-Xu Zhang yu Li Xuan Jiang yong-Fang Wang Yang Sun Jun Wang Wan-Ying Ji Yi Liu Medical Imaging Center The Affiliated Hospital of Liaoning Traditional Chinese Medical University Department of Radiology The First Hospital of China Medical University Department of Medical Oncology The First Hospital of China Medical University Department of Cardiac Surgery The First Hospital of China Medical University

AIM To develop a novel rat model of heterogeneous hepatic *** Seventy male Sprague-Dawley rats were randomly divided into a control group(n = 10) and a colchicine group(n =60). A 0.2.% colchicine solution(0.4 mL/kg) was injected via the splenic vein in the colchicine group to develop a rat model of heterogeneous hepatic injury. An equal volume of normal saline was injected via the splenic vein in the control group. At days 3, 7, and 14 and weeks 4, 8, and 12.after the operation, at least seven rats of the colchicine group were selected randomly for magnetic resonance imaging(MRI) examinations, and then they were euthanized. Ten rats of the control group underwent MRI examinations at the same time points, and then were euthanized at week 12. T2.weighted images(T2.WI) and diffusion weighted imaging(DWI) were used to evaluate the heterogeneous hepatic injury. The heterogeneous injury between the left and right hepatic lobes was assessed on liver sections according to the histological scoring criteria, and correlated with the results of MRI study. RESULTS Obvious pathological changes occurred in the hepatic parenchyma in the colchicine group. Hepatic injury scores were significantly different between the left and right lobes at each time point(P 2.WI between the left and right lobes of rats in the colchicine group(P 2. P = 0.000; r =-0.2.5, P = 0.018).CONCLUSION Injection with colchicine via the splenic vein can be used to successfully develop a rat model of heterogeneous hepatic injury. DWI and T2.WI may help evaluate the heterogeneous injury among liver lobes.

关键词： Heterogeneous hepatic injury Rat model Colchicine T2.weighted images Diffusion weighted imaging

Payload topography camera of Chang'e-3

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Research in Astronomy and Astrophysics 2015年第11期15卷 1881-1892页

作者： Guo-Bin yu En-Hai Liu Ru-Jin Zhao Jie Zhong Xiang-Dong Zhou Wu-Lin Zhou Jin Wang yuan-Pei Chen yong-Jie Hao Institute of Optics and Electronics Chinese Academy of Sciences

Chang＇e-3 was China＇s first soft-landing lunar probe that achieved a successful roving exploration on the Moon. A topography camera functioning as the lander＇s “eye” was one of the main scientific payloads installed on the lander. It was composed of a camera probe, an electronic component that performed image compression, and a cable assembly. Its exploration mission was to obtain optical images of the lunar topography in the landing zone for investigation and research. It also observed rover movement on the lunar surface and finished taking pictures of the lander and rover. After starting up successfully, the topography camera obtained static images and video of rover movement from different directions, 360？panoramic pictures of the lunar surface around the lander from multiple angles, and numerous pictures of the Earth. All images of the rover, lunar surface, and the Earth were clear, and those of the Chinese national flag were recorded in true color. This paper describes the exploration mission, system design, working principle, quality assessment of image compression, and color correction of the topography camera. Finally, test results from the lunar surface are provided to serve as a reference for scientific data processing and application.

关键词： camera correction rover lunar topography lander PSNR directions pixel coordinates

Impression of prognosis regarding pathologic stage after preoperative chemoradiotherapy in rectal cancer

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World Journal of Gastroenterology 2015年第2期21卷 563-570页

作者： Kyungyeon Hwang In Ja Park Chang Sik yu Seok-Byung Lim Jong Lyul Lee yong Sik Yoon Chan Wook Kim Jin Cheon Kim Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical CenterSeoul 138-736South Korea

AIM: To ascertain pathologic stage as a prognostic indicator for rectal cancer patients receiving preoperative chemoradiotherapy(PCRT).METHODS: Patients with mid- and low rectal carcinoma(magnetic resonance imaging- based clinical stage Ⅱ or Ⅲ) between 2.00 and 2.09 and treated with curative radical resection were identified. Patients were divided into two groups: PCRT and No-PCRT. Recurrence-free survival(RFS) was examined according to pathologic stage and addition of adjuvant ***: Overall, 894 patients were identified. Of these, 500 patients received PCRT. Adjuvant chemotherapy was delivered to 81.5% of the No-PCRT and 94.8% of the PCRT patients. Adjuvant radiotherapy was given to 2..4% of the patients in the No PCRT group. The 5-year RFS for the No-PCRT group was 92.6% for StageⅠ, 83.3% for Stage Ⅱ, and 72.9% for Stage Ⅲ. The 5-year RFS for the PCRT group was 95.2. for yp Stage 0, 91.7% for yp StageⅠ, 73.9% for yp Stage Ⅱ, and 50.7% for yp Stage Ⅲ.CONCLUSION: Pathologic stage can predict prognosis in PCRT patients. Five-year RFS is significantly lower among PCRT patients than No-PCRT patients in pathologic stage Ⅱ and Ⅲ. These results should be taken into account when considering adjuvant treatment for patients treated with PCRT.

关键词： Preoperative Chemoradiotherapy Rectal cancer Patho

Recurrent abdominal liposarcoma: Analysis of 19 cases and prognostic factors

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World Journal of Gastroenterology 2013年第25期19卷 4045-4052页

作者： Wei Lu James Lau Mei-Dong Xu yong Zhang Ying Jiang Han-Xing Tong Juan Zhu Wei-Qi Lu Xin-yu Qin General Surgery Department Zhongshan Hospital Fudan University Department of Surgery Stanford School of Medicine

AIM: To evaluate the clinical outcome of re-operation for recurrent abdominal liposarcoma following multidis-ciplinary team cooperation. METHODS: Nineteen consecutive patients who had re-current abdominal liposarcoma underwent re-operation by the retroperitoneal sarcoma team at our institution from May 2.09 to January 2.12. Patient demographic and clinical data were reviewed retrospectively. Multidisciplinary team discussions were held prior to treatment, and re-operation was deemed the best treatment. The categories of the extent of resection were as follows: gross total resection (GTR), palliative resection and partial resection. Surgical techniques were divided into discrete lesion resection and combined contiguous multivisceral resection (CMR). Tumor size was determined as the largest diameter of the specimen. Patients were followed up at approximately 3-monthly intervals. For survival analysis, a univariate analysis was performed using the Kaplan-Meier method, and a multivariate analysis was performed using the Cox pro-portional hazards model. RESULTS: Nineteen patients with recurrent abdominal liposarcoma (RAL) underwent 32.re-operations at our institute. A total of 51 operations were reviewed with a total follow-up time ranging from 4 to 12. (47.4 ± 34.2. mo. The GTR rate in the CMR group was higher than that in the non-CMR group (P = 0.034). CMR was positively correlated with intra-operative bleeding (correlation coefficient = 0.514, P = 0.010). Six cases with severe postoperative complications were recorded. Patients with tumor sizes greater than 2. cm carried a significant risk of profuse intra-operative bleeding (P = 0.009). The ratio of a highly malignant subtype (de-differentiated or pleomorphic) in recurrent cases was higher compared to primary cases (P = 0.02.). Both single-factor survival using the Kaplan-Meier model and multivariate analysis using the Cox proportional hazards model showed that overall survival was corre-lated with resection extent a

关键词： Overall survival Recurrent abdominal lipo-sarcoma Relapse-free interval