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Flexible,high-density,laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy

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Bio-Design and Manufacturing 2024年第4期7卷 388-398页

作者： Yafeng Liu Zhouheng Wang Yang Jiao ying Chen Guangyuan xu Yinji Ma xue Feng Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Laboratory of Flexible Electronics Technology Tsinghua UniversityBeijing 100084China College of Artificial Intelligence Southwest UniversityChongqing 400715China Institute of Flexible Electronics Technology of THU Jiaxing 314000China Qiantang Science and Technology Innovation Center Hangzhou 310016China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China

High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer *** entails connecting hundreds or thousands of electrode wires on a limited *** study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode *** challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology *** flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic *** minimum spacing between electrodes was 15μm,comparable to the diameter of a single *** hundred electrodes were prepared with an electrode density of 4444 mm^(-2..In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter *** flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.

关键词： Electrocorticogram(ECoG)electrode Epilepsy High density High resolution Laminated structure

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Development of small molecule drugs targeting immune checkpoints

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Cancer Biology & Medicine 2024年第5期21卷 382-399页

作者： Luoyi Chen Xinchen Zhao Xiaowei Liu Yujie Ouyang Chuan xu ying Shi Department of Oncology Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054China Institute for Breast Health Medicine State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Acupuncture and Massage College Chengdu University of Traditional Chinese MedicineChengdu 611137China

Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune *** of small molecule drugs or biological materials,especially antibody-based ICIs,are actively being studied and antibodies are currently widely ***,such as anti-tumor efficacy,poor membrane permeability,and unneglected tolerance issues of antibody-based ICIs,remain evident but are thought to be overcome by small molecule *** structural studies have broadened the scope of candidate immune checkpoint molecules,as well as innovative chemical *** way of comparison,small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic *** ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions,including immune regulation,anti-angiogenesis,and cell cycle *** this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins,which will lay the foundation for further exploration.

关键词： Immune checkpoints small molecule drugs programmed death protein 1 CD47 signal-regulatory proteinα

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Rare earth inorganic-organic hybrid compounds based on Keggin-type polyoxometalate {SiW_(12.} with fast-responsive photochromism and switchable luminescence properties

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Journal of Rare Earths 2024年第2期42卷 286-292,I0003页

作者： Hong Cui Yanli Yang xue Bai xu Han Wensha Zhang ying Lu Shuxia Liu Key Laboratory of Polyoxometalate and Reticular Material Chemistry of the Ministry of Education College of ChemistryNortheast Normal UniversityChangchun 130024China

Four rare earth inorganic-organic hybrid compounds based on Keggin-type polyoxometalate {SiW_(12.}with general formula [{RE(DMF)_(4)(H_(2.O)_4RE(DMF)_(6)}_(2.{SiW_(12.O_(40)}_(3)](RE = La(1),Pr(2.,Sm(3),Eu(4),DMF=N,N-dimethylformamide) were synthesized by the conventional solution *** analyses indicate that four compounds are isostructural and are all built from three [SiW_(12.O_(40)]^(4-) polyoxoanions and DMF ligands linked by RE^(3+).Compounds 1-4 are extremely sensitive to UV light and present excellent photochromic properties,in which the coloring and fading time of samples are both no more than 2.min,and the reversible coloring-fading process can be repeated for at least 10 cycles with little fatigue,suggesting that compounds 1-4 can be a series of fast-responsive and durable photochromic ***,the solid-state photoluminescence spectra of compounds 3(Sm) and 4(Eu)display strong characteristic emissions of rare earth ions based on f-f ***,compound4(Eu) has a longer fluorescence lifetime up to 566.74 μ***,co mpounds 3(Sm) and 4(Eu) exhibit the switchable luminescence behavior induced by photochromism,which allows them to be used as potential molecular switches.

关键词： Inorganic-organic hybrid Keggin-type polyoxometalates Rare earths Photochromism Photoluminescence

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Non-contact and full-field online monitoring of curing temperature during the in-situ heating process based on deep learning

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Advances in Manufacturing 2024年第1期12卷 167-176页

作者： Qiang-Qiang Liu Shu-Ting Liu ying-Guang Li xu Liu Xiao-Zhong Hao College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816People’s Republic of China

Online monitoring of the curing temperature field is essential to improving the quality and efficiency of the manufacturing process of composite *** embedded sensor-based technologies have difficulty monitoring the full temperature field or have to introduce heterogeneous items that could have an undesired impact on the *** this paper,a non-contact,full-field monitoring method based on deep learning that predicts the internal temperature field of composite parts in real time using surface temperature measurements of auxiliary materials is *** the proposed method,an average temperature monitoring accuracy of 97%is achieved in various heating *** addition,this method also demonstrates satisfying feasibility when a stronger thermal barrier covers the *** method was experimentally validated during the self-resistance electric heating process,in which the monitoring accuracy reached 93.1%.This method can potentially be applied to automated manufacturing and process control in the composites industry.

关键词： Online monitoring Curing temperature field Deep learning(DL) In-situ heating

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Single-atomic activation on ZnIn_(2.S_(4)basal planes boosts photocatalytic hydrogen evolution

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Nano Research 2024年第7期17卷 5949-5955页

作者： Jianpeng Cui ying Wang Luxue Lin Xiaotian Yang xuyu Luo Shiying Guo Xiaoyong xu College of Physics Science and Technology and Center for Interdisciplinary ResearchYangzhou UniversityYangzhou 225002China

The use of single-atom cocatalysts plays a crucial role in enhancing artificial photocatalysis,where the precise construction of stable and efficient single-atom configuration is essential but remains ***,we report a simple one-step hydrothermal method for preparing single-atomic Mo modified ZnIn_(2.S_(4)(Mo-ZIS)nanosheets as a highly active photocatalytic hydrogen evolution(PHE)*** Mo substituting for portion of In atoms in ZIS nanosheets induces the spatial charge redistribution,which not only promotes the separation of photogenerated charge carriers but also optimizes the Gibbs free energy of adsorbing H*on S atoms at basal *** a result,Mo-ZIS exhibits an impressive PHE rate as high as 6.71 mmol·g^(−1)·h^(−1),over 10 times that of the pristine ZIS,with an apparent quantum efficiency(AQE)up to 38.8%at 42. *** study gains insights into the coordination configuration and electronic modulation resulting from single-atomic decoration,providing mechanistic cognitions for the development of advanced photocatalysts via non-precious metal atomic modification.

关键词： photocatalytic hydrogen evolution ZnIn_(2.S_(4) single-atom activation Gibbs free energy

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Ti_(3)C_(2.T_(x) MXene/carbon composites for advanced supercapacitors:Synthesis,progress,and perspectives

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Carbon Energy 2024年第2期6卷 113-142页

作者： Yanqing Cai Xinggang Chen ying xu Yalin Zhang Huijun Liu Hongjuan Zhang Jing Tang College of Materials Science and Engineering North China University of Science and TechnologyTangshanChina Hebei Iron and Steel Laboratory North China University of Science and TechnologyTangshanChina Songshan Lake Materials Laboratory DongguanChina Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghaiChina State Key Laboratory of Petroleum Molecular and Process Engineering(SKLPMPE) Sinopec Research Institute of Petroleum Processing Co.Ltd.BeijingChina Institute of Eco-Chongming ShanghaiChina

MXenes are a family of two-dimensional(2.)layered transition metal carbides/nitrides that show promising potential for energy storage applications due to their high-specific surface areas,excellent electron conductivity,good hydrophilicity,and tunable *** various types of MXenes,Ti_(3)C_(2.T_(x) is the most widely studied for use in capacitive energy storage applications,especially in supercapacitors(SCs).However,the stacking and oxidation of MXene sheets inevitably lead to a significant loss of electrochemically active *** overcome such challenges,carbon materials are frequently incorporated into MXenes to enhance their electrochemical *** review introduces the common strategies used for synthesizing Ti_(3)C_(2.T_(x),followed by a comprehensive overview of recent developments in Ti_(3)C_(2.T_(x)/carbon composites as electrode materials for ***_(3)C_(2.T_(x)/carbon composites are categorized based on the dimensions of carbons,including 0D carbon dots,1D carbon nanotubes and fibers,2. graphene,and 3D carbon materials(activated carbon,polymer-derived carbon,etc.).Finally,this review also provides a perspective on developing novel MXenes/carbon composites as electrodes for application in SCs.

关键词： electrochemical performance MXene/carbon composites supercapacitors

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Skeletal stem cells in bone development,homeostasis,and disease

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Protein & Cell 2024年第8期15卷 559-574页

作者： Guixin Yuan Xixi Lin ying Liu Matthew B.Greenblatt Ren xu The First Affliated Hospital of Xiamen University-ICMRS Collaborating Center for Skeletal Stem Cell State Key Laboratory of Cellular Stress BiologySchool of MedicineFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361005China Xiamen Key Laboratory of Regeneration Medicine Fujian Provincial Key Laboratory of Organ and Tissue RegenerationOrgan Transplantation InstituteSchool of MedicineXiamen UniversityXiamen 361102China Department of Pathology and Laboratory Medicine Weill Cormell Medical CollegeNew YorkNY 10065USA Research Division Hospital for Special SurgeryNew YorkNY10065USA

Tissue-resident stem cells are essential for development and repair,and in the skeleton,this function is fulfilled by recently identified skeletal stem cells(SSCs).However,recent work has identified that SSCs are not monolithic,with long bones,craniofacial sites,and the spine being formed by distinct stem *** studies have utilized techniques such as fluorescence-activated cell sorting,lineage tracing,and single-cell sequencing to investigate the involvement of ssCs in bone development,homeostasis,and *** investigations have allowed researchers to map the lineage commitment trajectory of ssCs in different parts of the body and at different time ***,recent studies have shed light on the characteristics of ssCs in both physiological and pathological *** review focuses on discussing the spatiotemporal distribution of ssCs and enhancing our understanding of the diversity and plasticity of ssCs by summarizing recent discoveries.

关键词： skeletal stem cells bone development endochondral ossification intramembranous ossification lineage tracing

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Recent advances in heterogeneous catalysis of solar-driven carbon dioxide conversion

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Journal of Environmental Sciences 2024年第6期140卷 165-182页

作者： Jun xu Farzaneh Arabpour Roghabadi ying Luo Vahid Ahmadi Qian Wang Zheng Wang Hong He State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuoHenan 454000China Department of Process Engineering Faculty of Chemical EngineeringTarbiat Modares UniversityTehranIran Optoelectronics and Nanophotonics Research Group Faculty of Electrical and Computer EngineeringTarbiat Modares UniversityTehranIran Graduate School of Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan

Solar-driven carbon dioxide(CO_(2.)conversion including photocatalytic(PC),photoelectrochemical(PEC),photovoltaic plus electrochemical(PV/EC)systems,offers a renewable and scalable way to produce fuels and high-value chemicals for environment and energy *** review summarizes the basic fundament and the recent advances in the field of solar-driven CO_(2.*** the visible-light absorption is an important strategy to improve solar energy conversion *** separation and migration of photogenerated charges carriers to surface sites and the surface catalytic processes also determine the photocatalytic *** engineering including co-catalyst loading,defect engineering,morphology control,surface modification,surface phase junction,and Z-scheme photocatalytic system construction,have become fundamental strategies to obtain high-efficiency *** to photocatalysis,these strategies have been applied to improve the conversion efficiency and Faradaic efficiency of typical PEC *** PV/EC systems,the electrode surface structure and morphology,electrolyte effects,and mass transport conditions affect the activity and selectivity of electrochemical CO_(2.***,the challenges and prospects are addressed for the development of solar-driven CO_(2.conversion system with high energy conversion efficiency,high product selectivity and stability.

关键词： Solar-driven CO_(2.reduction Photocatalytic system Photoelectrochemical system Photovoltaic plus electrochemical system Surface/interface engineering

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Effects of thinning and understory removal on water use efficiency of Pinus massoniana:evidence from photosynthetic capacity and stable carbon isotope analyses

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Journal of Forestry Research 2024年第2期35卷 42-53页

作者： Ting Wang Qing xu Beibei Zhang Deqiang Gao ying Zhang Jing Jiang Haijun Zuo Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of ForestryBeijing 100091People’s Republic of China College of Agronomy and Agricultural Engineering Liaocheng UniversityLiaocheng 252000People’s Republic of China Department of Forest and Conservation Sciences Faculty of ForestryUniversity of British ColumbiaVancouverBC V6T 1Z4Canada

Understanding the relationship between forest management and water use efficiency(WUE)is important for evaluating forest adaptability to climate ***,the effects of thinning and understory removal on WUE and its key controlling processes are not well understood,which limits our comprehension of the physiological mechanisms of various management *** this study,four forest management measures(no thinning:NT;understory removal:UR;light thinning:LT;and heavy thinning:HT)were carried out in Pinus massoniana plantations in a subtropical region of *** capacity and needle stable carbon isotope composition(δ^(13)C)were measured to assess instantaneous water use efficiency(WUE_(inst))and long-term water use efficiency(WUE_(i)).Multiple regression models and structural equation modelling(SEM)identified the effects of soil properties and physiological performances on WUE_(inst)and WUE_(i).The results show that WUE_(inst)values among the four treatments were ***,compared with the NT stand(35.8μmol·mol^(-1)),WUE_(i)values significantly increased to 41.7μmol·mol^(-1)in the UR,50.1μmol·mol^(-1)in the LT and 46.6μmol·mol^(-1)in HT treatments,largely explained by photosynthetic capacity and soil water *** removal did not change physiological performance(needle water potential and photosynthetic capacity).Thinning increased the net photosynthetic rate(A_n)but not stomatal conductance(g_s)or predawn needle water potential(ψ_(pd)),implying that the improvement in water use efficiency for thinned stands was largely driven by radiation interception than by soil water *** general,thinning may be an appropriate management measure to promote *** WUE to cope with seasonal droughts under future extreme climates.

关键词： Stable carbon isotope Water use efficiency Thinning Understory removal Photosynthetic capacity Needle water potential

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Methods,Mechanisms,and Application Prospects for Enhancing Extracellular Vesicle Uptake

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Current Medical Science 2024年第2期44卷 247-260页

作者： ying-peng xu Tao JIANG Xiao-fan YANG Zhen-bing CHEN Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Extracellular vesicles(EVs)are considered to be a new generation of bioinspired nanoscale drug delivery systems due to their low immunogenicity,natural functionality,and excellent ***,limitations such as low uptake efficiency,insufficient production,and inhomogeneous performance undermine their *** address these issues,numerous researchers have put forward various methods and applications for enhancing EV uptake in recent *** this review,we introduce various methods for the cellular uptake of EVs and summarize recent advances on the methods and mechanisms for enhancing EV *** addition,we provide further understanding regarding enhancing EV uptake and put forward prospects and challenges for the development of EV-based therapy in the future.

关键词： extracellular vesicles exosomes extracellular vesicle uptake extracellular vesiclebased therapy

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