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Pathological diagnosis and immunohistochemical analysis of giant retrosternal goiter in the elderly: A case report

World Journal of Clinical Cases 2024年第3期12卷 643-649页

作者： Yong-Chang Meng Liu-sheng Wu Ning Li Hong-Wei Li Jing Zhao Jun Yan Xiao-qiang Li Peng Li Jiang-qi Wei Department of Cardiothoracic Surgery Xinxiang First People's HospitalXinxiang 453000Henan ProvinceChina School of Clinical Medicine Tsinghua UniversityBeijing 100084China Graduate School Qinghai UniversityXining 810016Qinghai ProvinceChina Department of Pathology Xinxiang First People's HospitalXinxiang 453000Henan ProvinceChina Department of Thoracic Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

BACKGROUND Elderly giant retrosternal thyroid goiter is a rare yet significant medical condition,often presenting clinical symptoms that can be confused with other diseases,posing diagnostic and therapeutic *** study aims to delve into the characteristics and potential mechanisms of this ailment through pathological diagnosis and immunohistochemical analysis,providing clinicians with more precise diagnostic and treatment strategies.A 77-year-old male,was admitted to hospital with the chief complaint of finding a goiter in the semilunar month during physical examination,accompanied by *** protruding into the superior mediastinum,the adjacent structure was compressed,the trachea was compressed to the right,and the local lumen was slightly *** patient was diagnosed with giant retrosternal *** dyspnea caused by trachea compression,our department planned to perform giant retrosternal *** results:Tg(+),TTF-1(+),Calcitonin(CT)(I),Ki-67(+,about 2.%),CD34(-).Retrosternal goiter means that more than 50%of the volume of the thyroid gland is below the upper margin of the *** retrosternal goiter disease is a relatively rare disease,once the disease is diagnosed,it should be timely surgical treatment,and the treatment is more difficult,the need for professional medical team for comprehensive *** The imaging manifestations of giant retrosternal goiter are atypical,histomorphology and immunohistochemistry can assist in its *** article reviews the relevant literature of giant retrosternal goiter immunohisto-chemistry and shows that giant retrosternal goiter is positive for Tg,TTF-1,and Ki-67.

关键词： Giant retrosternal goiter Pathology Immunohistochemistry Case report

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Roles of combined femoral and acetabular anteversion in pathological changes of hip dysplasia and hip reconstructive surgery

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World Journal of Orthopedics 2024年第5期15卷 390-399页

作者： Can Liu Zheng Xu Jian-Fa Zeng Zhen-qi Song Yu-Yin Xie Zhong-Wen Tang Jie Wen sheng Xiao Department of Anatomy Hunan Normal University School of MedicineChangsha 410003Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Combined femoral and acetabular anteversion is the sum of femoral and acetabular anteversion,representing their morphological relationship in the axial *** with the increasing understanding of hip dysplasia in recent years,numerous scholars have confirmed the role of combined femoral and acetabular anteversion in the pathological changes of hip *** present,the reconstructive surgery for hip dysplasia includes total hip replacement and redirectional hip preservation *** an important surgery index,combined femoral and acetabular anteversion have a crucial role in these ***,we discuss the role of combined femoral and acetabular anteversion in pathological changes of hip dysplasia,total hip replacement,and redirectional hip preservation surgery.

关键词： Combined anteversion Femoral anteversion Acetabular anteversion Hip dysplasia Hip preservation surgery Total hip replacement

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Discrimination of polysorbate 2. by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-qi Wang Xun Zhao Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng Wang sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee Lee Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 2.(PS2.)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS2. components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS2. samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 132. to 1511 compounds in 4 batches of PS2. from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 2. Component Database Discrimination Degradation

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Evidence for distortion-induced local electric polarization in α-RuCl_(3)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 165-173页

作者： Xinrun Mi De Hou Xiao Wang Sabreen Hammouda Caixing Liu Zijian Xiong Han Li Yan Liu Guiwen Wang Aifeng Wang Yisheng Chai Yang qi Wei Li Xiaoyuan Zhou Yixi Su DIKhomskii Mingquan He Zhigao sheng Young Sun College of Physics Center of Quantum Materials and DevicesChongqing UniversityChongqing 401331China Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceAnhuiChinese Academy of SciencesHefei 230031 China University of Science and Technology of China Hefei 230026China Jülich Centre for Neutron Scienceat Heinz Maier-Leibnitz Zentrum(JCNS-MLZ) Forschungszentrum Jülich GmbHGarching D-85747Germany School of Physics Beihang UniversityBeijing 100191China Analytical and Testing Center Chongqing UniversityChongqing 401331China State Key Laboratory of Surface Physics Department of PhysicsFudan UniversityShanghai 200433China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Ⅱ.Physikalisches Institut Universität zu KölnKöln D-50937Germany

The spin-orbit assisted Mott insulator α-RuCl_(3) is a prime candidate for material realization of the Kitaev quantum spin *** little attention has been paid to charge degrees of freedom,charge effects,such as electric polarization,may arise in this ***,we report distortion-induced local electric polarization in α-RuCl_(3) as evidenced by single-crystal X-ray diffraction,second harmonic generation(SHG)and dielectric *** SHG signal appears at room temperature and develops substantially in the Kitaev paramagnetic state when short-range spin correlations come into *** sizable pyroelectric currents in the Kitaev paramagnetic state,the absence of hysteresis in the polarization-electric field(P-E)points to the shortrange nature of electric *** localized electric polarization is likely the result of distortion-induced charge dimerization,achieved through virtual hopping-induced charge *** addition,the electric polarization is boosted by short-range spin correlations via spin-phonon coupling in the Kitaev paramagnetic *** results emphasize the importance of charge degrees of freedom in α-RuCl_(3),which establish a novel platform to investigate charge effects in Kitaev materials.

关键词： Mott insulator Kitaev quantum spin liquid electric polarization

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Ultra-wide dual-band Rydberg atomic receiver based on space division multiplexing radio-frequency chip modules

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Chip 2024年第2期3卷 53-61页

作者： Li-Hua Zhang Bang Liu Zong-Kai Liu Zheng-Yuan Zhang Shi-Yao Shao qi-Feng Wang Yu Ma Tian-Yu Han Guang-Can Guo Dong-sheng Ding Bao-Sen Shi Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

Detecting microwave signals over a wide frequency range is endowed with numerous advantages as it enables simultaneous transmission of a large amount of information and access to more spectrum *** capability is crucial for applications such as microwave communication,remote sensing and ***,conventional microwave receiving systems are limited by amplifiers and band-pass filters that can only operate efficiently in a specific frequency ***,these systems can only process signals within a three-fold frequency range,which limits the data transfer bandwidth of the microwave communication *** novel atom-integrated microwave sensors,for example,radio-frequency(RF)chip–coupled Rydberg atomic receiver,provides opportunities for a large working bandwidth of microwave sensing at the atomic *** the current work,an ultrawide dual-band RF sensing scheme was demonstrated by spacedivision multiplexing two RF-chip-integrated atomic receiver *** system can simultaneously receive dual-band microwave signals that span a frequency range exceeding 6 octaves(300 MHz and 2. GHz).This work paves the way for multi-band microwave reception applications within an ultra-wide range by RF-chip-integrated Rydberg atomic sensor.

关键词： Dual-band Rydberg Radio-frequency chip Atomic receiver Space-division multiplexing

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Circ_0012.52.Accelerates Acute Myeloid Leukemia Progression through the miR-652.3p/SOX4 Axis

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Current Medical Science 2024年第3期44卷 611-622页

作者： Ying CHEN Bi-xia LI Ting-ting NIU Shu-jun YANG Li-chao WU Le-huai SHI Duo-bing ZOU Ning-ning WU Li-xia sheng Xiao YAN Gui-fang OUYANG qi-tian MU Laboratory of Stem Cell Transplantation The First Affiliated Hospital of Ningbo UniversityNingbo315300China Ningbo Clinical Research Center For Hematologic Malignancies Ningbo315300China Department of Hematology The First Affiliated Hospital of Ningbo UniversityNingbo315300China School of Medicine Hangzhou City UniversityZhejiang UniversityHangzhou310000China Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo315300China

Objective Acute myeloid leukemia(AML)is an aggressive hematological malignancy characterized by abnormal myeloid blast *** studies have demonstrated that circular RNAs play a role in AML *** this study,we aimed to investigate the clinical significance of circ_0012.52.in AML and elucidate its underlying molecular mechanism in the pathogenesis of this *** Circ_0012.52.expression was detected by quantitative real-time polymerase chain reaction in samples obtained from 2.7 patients with AML and 40 healthy controls.A systematic analysis of clinical characteristics and prognostic factors was also *** growth was assessed using the Cell Counting Kit-8(CCK-8)assay,and apoptosis and cell cycle progression were evaluated by flow ***,RNA pull-down was performed to identify target microRNAs,and transcriptome RNA sequencing and bioinformatics analyses were utilized to identify downstream mRNA *** Circ_0012.52.was significantly upregulated in samples from patients with AML and served as an independent adverse prognostic factor for overall survival(OS)(hazard ratio:2.357;95%confidence interval 1.2.8–4.415).The circ_0012.52.knockdown reduced cell growth,increased apoptosis,and inhibited cell cycle progression in AML cell *** pull-down and sequencing identified miR-652.3p as a target microRNA of circ_*** growth inhibition by circ_0012.52.knockdown was significantly relieved by miR-652.3p *** suggested that miR-652.3p targeted SOX4,as the decrease in SOX4 expression resulting from circ_0012.52.knockdown was upregulated by miR-652.3p inhibitors in AML *** Circ_0012.52.is an independent poor prognostic factor for OS in AML,and it promotes AML cell growth by upregulating SOX4 through miR-652.3p.

关键词： acute myeloid leukemia circ_0012.52 miR-652.3p SOX4 cell growth

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Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

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Neuroscience Bulletin 2024年第8期40卷 1104-1114页

作者： Man Chen Yun‑Hui Chu Wen‑Xiang Yu Yun‑Fan You Yue Tang Xiao‑Wei Pang Hang Zhang Ke Shang Gang Deng Luo‑qi Zhou sheng Yang Wei Wang Jun Xiao Dai‑Shi Tian Chuan qin Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhan 430030China Department of Neurology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China

Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune inflammatory demyelinating disease of the central nervous system(CNS)accompanied by blood-brain barrier(BBB)*** in microglial lipid metabolism is believed to be closely associated with the neuropathology of ***,there is limited evidence on the functional relevance of circulating lipids in CNS demyelination,cellular metabolism,and microglial ***,we found that serum low-density lipoprotein(LDL)was positively correlated with markers of neurological damage in NMOSD *** addition,we demonstrated in a mouse model of NMOSD that LDL penetrates the CNS through the leaky BBB,directly activating *** activation leads to excessive phagocytosis of myelin debris,inhibition of lipid metabolism,and increased glycolysis,ultimately exacerbating myelin *** also found that therapeutic interventions aimed at reducing circulating LDL effectively reversed the lipid metabolic dysfunction in microglia and mitigated the demyelinating injury in *** findings shed light on the molecular and cellular mechanisms underlying the positive correlation between serum LDL and neurological damage,highlighting the potential therapeutic target for lowering circulating lipids to alleviate the acute demyelinating injury in NMOSD.

关键词： Neuromyelitis optica spectrum disorder Low-density lipoprotein Microglia

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国有建筑业企业发展效率的评价与优化

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东北大学学报（自然科学版） 2024年第1期45卷 137-144页

作者：齐锡晶张升进张梦星东北大学资源与土木工程学院辽宁沈阳110819

为助力国有建筑业企业高质量发展,提升企业及行业发展效率,通过分析建筑业发展现状,认知行业转型升级趋势,对国有建筑业企业发展效率进行概念界定.利用超效率SBM-Malmquist模型测算了不同所有制建筑业企业、不同地区国有建筑业企业的静... 详细信息

为助力国有建筑业企业高质量发展,提升企业及行业发展效率,通过分析建筑业发展现状,认知行业转型升级趋势,对国有建筑业企业发展效率进行概念界定.利用超效率SBM-Malmquist模型测算了不同所有制建筑业企业、不同地区国有建筑业企业的静态、动态发展效率.研究结果表明,2.12.2.2.年建筑业企业整体发展效率相对有效,但受制于技术的创新与进步,发展效率有所下降;国有建筑业企业的发展效率相对有效,且呈上升趋势,并与所在地区的综合发展水平呈正相关.通过剖析研究过程中发现的问题和结论,从政策和企业两方面给出优化国有建筑业企业发展效率的对策建议.

关键词：国有建筑业企业发展效率超效率SBM-Malmquist 评价优化

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融合多尺度Transformer的皮肤病变分割算法

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吉林大学学报（工学版） 2024年第4期54卷 1086-1098页

作者：梁礼明周珑颂尹江盛校棋江西理工大学电气工程与自动化学院江西赣州341000 华南理工大学计算机科学与工程学院广东广州510006

针对现有皮肤病变图像分割时缺乏多尺度特征提取,从而导致细节信息缺失和病变区域误分割的问题,本文提出一种融合多尺度Transformer的编解码网络皮肤病变分割算法。首先运用Transformer模块构建分层编码器,分层编码器从全局特征变化角... 详细信息

针对现有皮肤病变图像分割时缺乏多尺度特征提取,从而导致细节信息缺失和病变区域误分割的问题,本文提出一种融合多尺度Transformer的编解码网络皮肤病变分割算法。首先运用Transformer模块构建分层编码器,分层编码器从全局特征变化角度出发,多尺度分析皮肤病变区域;然后利用多尺度融合模块、通道注意力模块和联合层构建融合解码器,多尺度融合模块互补分层编码器中浅层网络信息与深层网络信息,增强空间信息和语义信息间的依赖关系,通道注意力模块能够有效识别特征丰富的通道,提高算法分割精度;最后引入扩展模块恢复图像大小以匹配实际需求。将该算法在ISBI2.16、ISBI2.17和ISIC2.18三个公共数据集上进行实验测试,其像素精度分别为96.70%、94.50%和95.39%,平均交并比分别为91.69%、85.74%和89.2.%,算法测试整体性能优于现有算法。仿真实验证明,多尺度Transformer编解码网络能够有效地分割皮肤病变图像。

关键词：计算机应用技术皮肤病变图像分割 Transformer 多尺度融合模块通道注意力模块

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Burden landscape of hepatobiliary and pancreatic cancers in Chinese young adults:30 years’overview and forecasted trends

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4177-4193页

作者： De-sheng Chen Ze-Ping Chen Dong-Zi Zhu Lv-Xin Guan qi Zhu Yi-Chao Lou Ze-Ping He Hao-Nan Chen Hong-Cheng Sun Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of General Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shenzhen Institute of Translational Medicine The First Affiliated Hospital of Shenzhen UniversityShenzhen 518035Guangdong ProvinceChina Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Hepatobiliary and pancreatic(HBP)cancers impose a considerable burden on young populations(aged 15 to 49 years),resulting in a substantial number of new cases and fatalities each *** young populations,the HBP cancers shows extensive variance worldwide and the updated data in China is *** To investigate the current status,trends,projections,and underlying risk factors of HBP cancers among young populations in *** The Global Burden of Disease Study 2.19 provided data on the annual incidence,mortality,disability-adjusted life years(DALYs),age-standardized incidence rate(ASIR),mortality rate(ASMR),and DALYs rate(ASDR)of HBP cancers in young Chinese adults between 1990 and *** trends were assessed using estimated annual percentage change and hierarchical ***-specific mortality and DALYs caused by various risks were analyzed across China and other regions,with future trends until 2.35 projected using the Bayesian age-period-cohort *** From 1990 to 2.19,incident cases,deaths,DALYs,ASIR,ASMR,and ASDR for liver cancer(LC)in young Chinese individuals decreased,classified into'significant decrease'***,cases of gallbladder and biliary tract cancer and pancreatic cancer rose,categorized as either'significant increase'or'minor increase'*** contribution of risk factors to mortality and DALYs for HBP tumors increased to varying *** lifestyle behaviors,such as tobacco control,weight management,alcohol moderation,and drug avoidance,could lower HBP cancers ***,except for LC in females,which is likely to initially decline slightly and then rise,the forecasting model predicted that the ASIR and ASMR for all HPB cancers subtypes by gender will increase among young *** HBP cancers burden among young adults in China is expected to increase until 2.35,necessitating lifestyle interventions and targeted treatment strategies to mitigate the public health impact of these

关键词： Hepatobiliary and pancreatic cancers Burden landscape Young adults Projection China

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