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Human immunodeficiency virus-associated dementia complex with positive 14-3-3 protein in cerebrospinal fluid:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2065-2073页

作者： Yun-Sen He Xiao-Hong Qin min Feng Qin-Jiang Huang Meng-Jun Zhang Li-Li Guo ming-Bin Bao Ye Tao Hong-{2. Dai Bo Wu Department of Neurosurgery Sichuan Lansheng Brain Hospital&Shanghai Lansheng Brain Hospital Investment Co.Ltd.Chengdu 610036Sichuan ProvinceChina Department of Psychiatry Sichuan Provincial Center for Mental HealthChengdu 610072Sichuan ProvinceChina Department of Geriatrics Municipal People’s Hospital in LuzhouLuzhou 646000Sichuan ProvinceChina Department of Neurosurgery Wenjiang District People’s Hospital of ChengduChengdu 611100Sichuan ProvinceChina Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China ChengduChengdu 610072Sichuan ProvinceChina Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-associated dementia(HAD)is a subcortical form of dementia characterized by memory deficits and psychomotor ***,HAD often presents with symptoms similar to those of Creutzfeldt-Jakob disease(CJD),particularly in patients with acquired immune deficiency syndrome(AIDS).CASE SUMMARY We report the case of a 54-year-old male who exhibited cognitive dysfunction and secondary behavioral changes following HIV infection and suspected prion *** patient was diagnosed with HIV during hospitalization and his cerebrospinal fluid tested positive for 14-3-3 *** electroencephalogram showed a borderline-abnormal periodic triphasic wave ***-enhanced magnetic resonance imaging revealed moderate encephalatrophy and ***,symptomatic treatment and administration of amantadine were pursued for presumed CJD,but the patient’s condition continued to *** contrast,the patient’s condition improved following anti-HIV *** individual is also the only patient with this prognosis to have survived over 4 ***,the diagnosis was revised to *** In the diagnostic process of rapidly progressive dementia,it is crucial to rule out as many potential causes as possible and to consider an autopsy to diminish diagnostic *** 14-3-3 protein should not be regarded as the definitive marker for *** laboratory screening for infectious diseases is essential to enhance diagnostic precision,especially in AIDS patients with potential ***,a trial of diagnostic treatment may be considered when additional testing is not feasible.

关键词： HIV-associated dementia Cognitive dysfunction Creutzfeld-Jakob disease Rapidly progressive dementia Case report

Strength and ductility optimization of HPDC AlSi8MgCuZn2.alloys by modifying pre-aging treatment

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China Foundry 2024年第4期21卷 343-351页

作者： yuan-hang Jiang Hui-ting Zheng Fei Liu Hai-dong Zhao National Engineering Research Center of Near-net Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510641China

Considering the components produced by high pressure die casting(HPDC)process usually with ultra-large sizes and complex morphologies,high temperature solid solution treatment is not a suitable method to further improve their mechanical *** this study,two-stage aging treatment with different pre-aging times was designed and employed to further improve the mechanical properties of HPDC Al8SiMgCuZn *** characteristics of precipitates were evaluated by a transmission electron microscope(TEM),and the precipitation strengthening mechanism was *** results reveal that the strengthening is mainly contributed by the precipitation ofβ″phase after two-stage aging,and the number density and size of the precipitates are significantly depended on the pre-aging *** number density of precipitates is increased with the pre-aging time prolonged from 0 h to 4 h,and then decreases with the further increase of pre-aging time from 4 h to 6 *** precipitates with the highest density and smallest size are observed after pre-aging for 4 *** pre-aged at 100℃for 4 h and then artificial aged at 2.0℃for 30 min,the yield strength of 2.7 MPa,ultimate tensile strength of 32. MPa and elongation of 7.6%are achieved.

关键词： high pressure die cast aluminum alloy microstructural heterogeneity mechanical properties precipitation strengthening two-stage aging

Analysis of quality of life in patients after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 318-325页

作者： min-Yu Zhang Sen-yuan Zheng Zheng-Yu Ru Zhi-Qiang Zhang Department of Gastroenterology The First Affiliated Hospital of Xinjiang Medical UniversityUrimuqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND At present,laparoscopic cholecystectomy(LC)is the main surgical treatment for ***,after gallbladder removal,there are many ***,it is hoped to remove stones while preserving the function of the gallbladder,and with the development of endoscopic technology,natural orifice transluminal endoscopic surgery came into *** To compare the quality of life,perioperative indicators,adverse events after LC and transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery(EGPS)in patients with *** Patients who were admitted to The First Affiliated Hospital of Xinjiang Medical University from 2.2. to 2.2. were retrospectively *** adopted propen-sity score matching(1:1)to compare EGPS and LC *** A total of 662.cases were collected,of which 589 cases underwent LC,and 73 cases underwent *** score matching was performed,and 40 patients were included in each of the *** the EGPS group,except the gastr-ointestinal defecation(P=0.603),the total score,physical well-being,mental well-being,and gastrointestinal digestion were statistically significant compared with the preoperative score after surgery(P2.between the two groups,there was no statistically significant difference in the total postoperative score and the other three *** the surgery duration,hospital stay and cost,LC group were lower than EGPS *** recurrence factors of gallstones after EGPS were analyzed:and recurrence was not correlated with gender,age,body mass index,number of stones,and preoperative *** Whether EGPS or LC,it can improve the patient’s symp

关键词： Gallstones Natural orifice transluminal endoscopic surgery Gallbladder preservation Cholecystolithotomy Laparoscopic cholecystectomy Gastrointestinal quality of life index

Mental health and insomnia problems in healthcare workers after the COVID-19 pandemic:A multicenter cross-sectional study

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World Journal of Psychiatry 2024年第5期14卷 704-714页

作者： Wei Ding min-Zhong Wang Xian-Wei Zeng Zhen-Hua Liu Yao Meng Hui-Ting Hu yuan Zhang Yu-Guang Guan Fan-Gang Meng Jian-Guo Zhang Shu Wang Department of Public Health Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Sleep Medicine Center Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of Neurology Heze Mudan People’s HospitalHeze 274000Shandong ProvinceChina Neonatal Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Neurosurgery SanBo Brain HospitalCapital Medical UniversityBeijing 100093China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Healthcare workers(HCWs)are at increased risk of contracting coronavirus disease 2.19(COVID-19)as well as worsening mental health problems and *** problems can persist for a long period,even after the ***,less is known about this *** To analyze mental health,insomnia problems,and their influencing factors in HCWs after the COVID-19 *** This multicenter cross-sectional,hospital-based study was conducted from June 1,2.2. to June 30,2.2.,which was a half-year after the end of the COVID-19 ***-stratified population-based cluster sampling was applied at the provincial level for Chinese *** such as anxiety,depression,and insomnia were evaluated by the Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Insomnia Severity *** influencing the symptoms were identified by multivariable logistic *** A total of 2.00 participants were invited,for a response rate of 70.6%.A total of 1412.HCWs[618(43.8%)doctors,583(41.3%)nurses and 2.1(14.9%)nonfrontline],2.4(18.0%),2.1(16.4%),and 2.9(2..5%)had symptoms of anxiety,depression,and insomnia,respectively;severe symptoms were found in 58(4.1%),49(3.5%),and 111(7.9%)of the ***,female sex,and hospitalization for COVID-19 were risk factors for anxiety,depression,and insomnia symptoms;moreover,death from family or friends was a risk factor for insomnia *** the COVID-19 outbreak,most[1086(76.9%)]of the participating HCWs received psychological interventions,while nearly all[994(70.4%)]of them had received public psychological *** 102.7.2.)of the HCWs received individual counseling from *** Although the mental health and sleep problems of HCWs were relieved after the COVID-19 pandemic,they still faced challenges and greater risks than did the general *** risk factors would help in providing targeted *** addition,although a major proportion of

关键词： COVID-19 Mental health Psychological symptoms Insomnia Sleep disorders Cross-sectional study Epidemiological study

引入超导带材堆叠块体的混合眼型高温超导磁体的力学特性分析

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Acta Mechanica Sinica 2024年第4期40卷 27-37页

作者：廖恒沛袁炜嘉张玟 Applied Superconductivity Laboratory Department of Electronics and Electrical EngineeringUniversity of StrathclydeGlasgowG11XQUnited Kingdom

高温超导磁体具有零电阻特性,通过适当的磁化过程,就可以在没有外部电源的情况下保持强磁场.使用商用高温超导带制造的眼型高温超导磁体已经证明了其具有稳定的强磁场捕获能力,并且相对于传统超导块材,其尺寸更加灵活.然而,在场冷磁化... 详细信息

高温超导磁体具有零电阻特性,通过适当的磁化过程,就可以在没有外部电源的情况下保持强磁场.使用商用高温超导带制造的眼型高温超导磁体已经证明了其具有稳定的强磁场捕获能力,并且相对于传统超导块材,其尺寸更加灵活.然而,在场冷磁化过程中,由洛伦兹力引起应力应变可能会对磁体造成损伤.因此,在本论文的研究中,建立并验证了三维数值计算模型,以研究混合眼型高温超导磁体中的应力和应变.计算了场冷磁化下磁体的应力分布,并讨论了样品的固定方法对应力集中和应变的影响.研究还发现,增强中心捕获磁场的高温超导带材堆叠块体在磁化过程中受到不平衡的洛伦兹力,这是由于眼型磁体的不对称捕获磁场而导致的,此不平衡力产生在高温超导堆叠中的不对称应力分布.这些发现为眼型高温超导磁体的机械行为提供了重要的见解,可以指导其设计的优化,以适应各种应用,如核磁共振、磁悬浮和高温超导电机等.

关键词：高温超导磁体高温超导带材零电阻特性磁化过程洛伦兹力高温超导电机外部电源不平衡力

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二氧化钒在太赫兹超材料中的研究进展

硅酸盐学报 2024年第7期52卷 2371-2380页

作者：高敏罗毅恒路畅林媛电子科技大学材料与能源学院成都610054

超材料具有在亚波长尺度下操控电磁波的能力,近年来,通过对光场、电场、机械或温度场动态调控可以改变其光学特性的主动式超材料受到了广泛的研究。二氧化钒具有在68℃的临界温度下从低温绝缘相转变为高温金属相的特性,其电导率能够实现... 详细信息

超材料具有在亚波长尺度下操控电磁波的能力,近年来,通过对光场、电场、机械或温度场动态调控可以改变其光学特性的主动式超材料受到了广泛的研究。二氧化钒具有在68℃的临界温度下从低温绝缘相转变为高温金属相的特性,其电导率能够实现4~5个数量级的变化,将二氧化钒与超材料相互结合,能够满足可调谐性、高调制深度、多种调谐手段等优点。本文从二氧化钒的相变特性出发,归纳总结了二氧化钒在太赫兹超材料中的不同应用方向,主要包括可调谐太赫兹超材料吸波器、太赫兹调制器、太赫兹波前调控器以及可编程超材料,最后讨论了二氧化钒在太赫兹超材料应用中所面临的挑战和未来的发展方向。

关键词：超材料二氧化钒相变材料可调谐

Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-yuan Niu Geng-Ting Dong Yi Li Qing Luo Liu Cao Xi-min Wang Qi-Wen Wang Yi-Ting Wang Zhe Zhang Xi-Wen Zhong Wei-Bo Dai Le-Yu Li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2.diabetes mellitus(T2.M)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2.cells were treated with free fatty acid for 2. hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 2. hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress

Experimental Study on the Molten Salt at Micron Scale during the Melting Process

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Journal of Thermal Science 2024年第1期33卷 70-85页

作者： TIAN Ziqian LIAO Zhirong XU Chao FANG Yongzhe JIANG Kaijun yuan Mengdi Key Laboratory of Power Station Energy Transfer Conversion and System Ministry of Education of ChinaSchool of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing 102206China

The investigation of the melting behaviors of the molten salt at micron scale during the melting process is critical for explaining the solid-liquid phase transition *** this paper,a novel experimental system and analysis method were proposed to study the melting process with three heating rates in the range of1-10℃/min of the solar salt at micron *** solid-liquid boundary morphology and phase transition kinetics of molten salt particles were focused ***,the correlations between liquid fraction,temperature and time under different heating rates were *** solid-liquid boundary morphology was depicted by the visualized experimental set-up,and the instantaneous liquid volume fraction during the non-isothermal phase transition was ***,the correlation between temperature and liquid volume fraction was proposed to reveal the evolution of the solid-liquid boundary with temperature at different heating ***,the non-isothermal phase transition kinetic equation was established by introducing a constant parameter(V_(a,b)),and more kinetic parameters such as 1g V_(a,b) and-lg V_(a,b)/b were *** results showed that the exponent b is not sensitive to the heating rate with a range of 3-5 for solar salt ***,the heating rate influences the value of V_(a,b) and presents a positive ***,the non-isothermal phase transition kinetic equations at different heating rates in the range of 1-10℃/min can be quickly predicted by the proposed improved experimental test *** study could fill the research insufficiency and provide significant guidance for future research on the solid-liquid transition mechanism of molten salts at micron scale.

关键词： molten salt non-isothermal phase transition solid-liquid boundary morphology liquid volume fraction micron scale melting process

^(18)F-FDG PET-CT检测母细胞性浆细胞样树突细胞肿瘤1例

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中华肿瘤杂志 2024年第8期46卷 801-804页

作者：赵彤白敏原凌山西省肿瘤医院中国医学科学院肿瘤医院山西医院山西医科大学附属肿瘤医院核医学PET-CT中心太原030013 山西省肿瘤医院中国医学科学院肿瘤医院山西医院山西医科大学附属肿瘤医院血液科太原030013

患者男,54岁。2.2.年10月右下肢膝关节内侧皮肤无诱因出现暗红色斑块,无疼痛、瘙痒等伴随症状,之后红斑进行性增多,遍及头皮、颜面及四肢、胸前壁、背部皮肤。于外院行头皮和右膝关节处皮肤红斑活检术,病理诊断为皮肤蕈样霉菌病。为进... 详细信息

患者男,54岁。2.2.年10月右下肢膝关节内侧皮肤无诱因出现暗红色斑块,无疼痛、瘙痒等伴随症状,之后红斑进行性增多,遍及头皮、颜面及四肢、胸前壁、背部皮肤。于外院行头皮和右膝关节处皮肤红斑活检术,病理诊断为皮肤蕈样霉菌病。为进一步诊治,2.2.年3月2.到我院血液科就诊。入院体格检查:全身皮肤多发暗红色斑块,多为圆形或椭圆形,直径约0.5~5.0 cm,隆起于皮肤表面,总面积约占全身皮肤的50%(图1).

关键词：母细胞性浆细胞样树突细胞肿瘤正电子发射计算机体层摄影术脱氧葡萄糖