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LonP1 Links Mitochondria–ER Interaction to Regulate Heart Function

Research 2024年第1期2023卷 595-609页

作者： Yujie Li Dawei Huang Lianqun Jia Fugen Shangguan Shiwei Gong Linhua Lan Zhiyin Song Juan Xu Chaojun Yan Tongke Chen Yin Tan Yongzhang Liu Xingxu Huang Carolyn K.Suzuki zhongzhou Yang Guanlin Yang Bin Lu The Affiliated Nanhua Hospital and School of Basic Medical Sciences Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325035China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410008China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Ministry of Education of ChinaLiaoning University of Traditional Chinese MedicineShenyangLiaoning 110847China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei 430072China Nanjing Maternity and Child Health Care Hospital Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing 210004China Animal Center Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunanChina School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Department of Microbiology Biochemistry and Molecular GeneticsNew Jersey Medical School-RutgersThe State University of New JerseyNewarkNJUSA State Key Laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and *** particular,the mitochondria–endoplasmic reticulum(ER)membrane contact site(MAM)is known to regulate ion and lipid transfer,as well as signaling and organelle ***,the regulatory mechanisms of MAM formation and their function are still ***,we identify mitochondrial Lon protease(LonP1),a highly conserved mitochondrial matrix protease,as a new MAM tethering *** removal of LonP1 substantially reduces MAM formation and causes mitochondrial ***,deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER(UPR^(ER)).Consequently,cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming and pathological heart *** findings demonstrate that LonP1 is a novel MAM-localized protein orchestrating MAM integrity,mitochondrial dynamics,and UPR^(ER),offering exciting new insights into the potential therapeutic strategy for heart failure.

关键词： offering programming insight

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扬子地块北缘毕机沟岩体下部带堆晶岩结构定量化分析:对层状岩体冷却早期粒间熔体排出机制的约束

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地质学报 2024年第7期98卷 2110-2127页

作者：王洁李中州王梦玺长安大学地球科学与资源学院陕西西安710054 中国科学院广州地球化学研究所中国科学院矿物学与成矿学重点实验室广东广州510640 中国科学院大学地球与行星科学学院北京100049

层状岩体冷却中—晚期晶粥中粒间熔体的排出被认为与铁钛氧化物的大量结晶关系密切,但在岩体冷却早期铁钛氧化物尚未大量结晶时,粒间熔体能否被有效排出、以及如何排出还需要深入探究。扬子地块北缘毕机沟岩体是我国目前发现的规模最大... 详细信息

层状岩体冷却中—晚期晶粥中粒间熔体的排出被认为与铁钛氧化物的大量结晶关系密切,但在岩体冷却早期铁钛氧化物尚未大量结晶时,粒间熔体能否被有效排出、以及如何排出还需要深入探究。扬子地块北缘毕机沟岩体是我国目前发现的规模最大、分异程度较高且赋存有钒钛磁铁矿矿床的层状岩体。岩体下部带、中部带和上部带分别由斜长橄榄岩、辉长岩和闪长岩组成。本研究以下部斜长橄榄岩相带为对象,通过对斜长石和单斜辉石进行晶体粒度分布(CSDs)和空间展布形式(SDPs)分析,探讨层状岩体冷却早期粒间熔体的排出方式及其控制因素。模拟计算结果表明,样品中封闭粒间熔体比例(FTL)为9%~13%,暗示岩体冷却早期粒间熔体被有效排出。单斜辉石和斜长石的CSD曲线斜率主要为3.36~2.45和2.99~1.87,截距分别为0.45~3.35和1.06~2.83,均具有斜率一致而截距变化较大的特征,与机械压实的CSD曲线一致。单斜辉石和斜长石在SDP图解上均显示负相关关系,也与机械压实趋势一致。因此,毕机沟岩体冷却早期粒间熔体的排出机制为机械压实。在此基础上,我们将毕机沟与全球其他典型层状岩体从岩体规模、粒间熔体和堆晶矿物密度差、晶体堆积速率与压实速率以及晶粥层厚度等方面进行系统对比后发现,在层状岩体冷却早期没有岩浆补给和对流的情况下,当岩体规模相近时,压实受控于堆晶矿物与粒间熔体密度差,密度差越大压实越容易发生;而当岩体规模不同时,规模越大压实越容易发生。

关键词：晶体粒度分布空间展布形式粒间熔体压实作用层状岩体

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Theoretical predictions on cluster radioactivity of superheavy nuclei with Z=119,12.

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Chinese Physics C 2024年第1期48卷 125-137页

作者：刘洁洁王震张涵韬任中洲 School of Physics Science and Engineering Tongji UniversityShanghai 200092China Key Laboratory of Advanced Micro-Structure Materials Ministry of EducationShanghai 200092China

In this study,we investigate the cluster radioactivity(CR)of new superheavy elements with Z=119 and 12. based on two successful theoretical methods with modified parameters:the density-dependent cluster model(DDCM)and unified decay formula(UDF).First,we employ the DDCM and UDF to accurately reproduce the experimental half-lives of cluster emissions,which demonstrates the high reliability of our theoretical ***,we systematically predict the probable cluster modes of ^(2.3-311)119 and ^(2.3-302.12. as well as their corresponding decay energies and *** half-lives of cluster decay derived from the DDCM are consistent with those from the ***,our results reveal that the cluster emission of ^(8)Be,emitted from the Z=119 and 12. isotopic chains,exhibits the minimum half-life for cluster emission,and hence,^(8)Be emission is considered the most probable cluster decay ***,we explore the competition betweenαdecay and CR and find thatαdecay may be the dominant decay mode against ***,the good linear relationship between the decay energy and the number ofαparticles within the emitted cluster is extended to the range of superheavy nuclei(SHN).We anticipate that our theoretical predictions for CR will provide valuable references for the experimental synthesis of new SHN.

关键词： cluster radioactivity superheavy nuclei density-dependent cluster model

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信息化技术在电力通信业务中的应用

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今日自动化 2024年第8期 137-139页

作者：李中周山东宏业发展集团有限公司山东济南250101

信息化技术作为重要技术支撑,能够有效提升电力通信网络的感知水平,优化通信网络资源利用和系统数据处理能力。文章对电力通信业务现状进行梳理和分析,并结合当下电力通信网现状,探讨了信息化技术在电力通信网络业务中的运行维护及故障... 详细信息

信息化技术作为重要技术支撑,能够有效提升电力通信网络的感知水平,优化通信网络资源利用和系统数据处理能力。文章对电力通信业务现状进行梳理和分析,并结合当下电力通信网现状,探讨了信息化技术在电力通信网络业务中的运行维护及故障诊断、路由优化、通信网络资源智能分配、通信网规划设计及网络状态感知分析方面的具体应用。

关键词：电力通信业务信息化技术路由优化故障诊断

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数字化技术在电力工程设计中的应用

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今日自动化 2024年第6期 117-118,179页

作者：李中周山东宏业发展集团有限公司山东济南250101

随着社会经济的不断发展,电力行业规模不断壮大,对电力工程设计的要求也日益提高。传统的设计方法已经难以满足日益复杂的电力工程需求,因此迫切需要引入更先进的数字化技术来提升设计效率和质量。文章阐述了数字化技术体系的特点,分析... 详细信息

随着社会经济的不断发展,电力行业规模不断壮大,对电力工程设计的要求也日益提高。传统的设计方法已经难以满足日益复杂的电力工程需求,因此迫切需要引入更先进的数字化技术来提升设计效率和质量。文章阐述了数字化技术体系的特点,分析了数字化技术在电力工程设计中的具体应用,并提出了电力工程设计中数字化技术的应用优化策略,以供参考。

关键词：数字化技术电力工程设计三维模型技术

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颈动脉及椎动脉狭窄的诊疗现状及对策

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中国血管外科杂志（电子版） 2024年第1期16卷 1-7页

作者：陈忠胡忠洲首都医科大学附属北京安贞医院血管外科北京100029

近30年来,全球脑卒中新发病例数增加了70%,是全球第二大死亡原因[1]。《中国脑卒中防治报告2.2.》指出,我国40岁及以上人群现患和曾患卒中人数约1704万例,卒中现患人数高居世界首位,已成为我国成人致死、致残的首位病因[2.。研究表明,2.... 详细信息

近30年来,全球脑卒中新发病例数增加了70%,是全球第二大死亡原因[1]。《中国脑卒中防治报告2.2.》指出,我国40岁及以上人群现患和曾患卒中人数约1704万例,卒中现患人数高居世界首位,已成为我国成人致死、致残的首位病因[2.。研究表明,2.%脑卒中的发生与动脉粥样硬化性颈动脉狭窄相关[3]。同时,约2.%缺血性脑卒中的发生与椎基底动脉狭窄相关[4]。目前对于颈动脉狭窄的治疗理念及手段受到广泛关注且基本成熟,但对椎动脉狭窄的关注相对较少。因此,及时科学规范地治疗颈动脉狭窄及椎动脉狭窄对于预防脑卒中的发生十分重要。本文将结合最新的相关研究及指南,对颈动脉及椎动脉狭窄的诊疗现状及对策做出介绍和总结。

关键词：颈动脉狭窄椎动脉狭窄新发病例数预防脑卒中治疗理念椎基底动脉狭窄缺血性脑卒中脑卒中防治

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Probing proton halo of the exotic nucleus ^(2.)S by elastic electron scattering

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Science China(Physics,Mechanics & Astronomy) 2004年第1期47卷 42-51页

作者： WANG Zaijun1 & REN zhongzhou1’2.1. Department of Physics, Nanjing University, Nanjing 2.0008, China 2. Center of Theoretical Nuclear Physics, National Laboratory of Heavy-Ion Accelerator at Lanzhou, Lanzhou 730000, China Correspondence should be addressed to Ren zhongzhou (email: zren@*** zren99@***) Received June 16, 2.03 1. Department of Physics Nanjing University 210008 Nanjing China 2. Center of Theoretical Nuclear Physics National Laboratory of Heavy-Ion Accelerator at Lanzhou 730000 Lanzhou China

Elastic electron scattering on the exotic light nucleus 2.S is investigated in the plane wave Born approximation. The variation of the squared form factors of 2.S with momentum transfer is compared with that of 32.. It is found that the behavior of the form factors near the second minimum (with a moderate momentum transfer) is sensitive to the alteration of the charge density distribution of halo protons in 2.S. This indicates that elastic electron scattering can be a good probe of the structure of proton-halo nuclei.

关键词： elastic electron scattering, cross section, form factor, proton-halo nucleus.

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Half-lives of double β^+-decay with two neutrinos

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Science China(Physics,Mechanics & Astronomy) 2015年第1期58卷 38-41页

作者： REN YueJiao REN zhongzhou Department of Physics Nanjing University Center of Theoretical Nuclear Physics National Laboratory of Heavy-Ion Accelerator

Nuclear double β^--decays with two neutrinos were observed for many years and a systematic law describing the relation between their half-lives and decay energies was also proposed recently [Phys Rev C, 2.14, 89： 064603]. However, double β^＋ -decay （β^＋β^＋） with emission of both two positrons and two neutrinos has not been observed up to date. In this article, we pcrform a systematic analysis on the candidates of double β^＋-decay, based on the 2.12.nuclear mass table. Eight nuclei are found to be the good candidates for double β^＋-decay and their half-lives are predicted according to the generalization of the systematic law to double β^＋-decay. As far as we know, there is no theoretical result on double β^＋-decay of nucleus ^154Dy and our result is the first prediction on this nucleus. This is also the first complete research on eight double β^＋-decay candidates based on the available data of nuclear masses. It is expected that the calculated half-lives of double β^＋-decay in this article will be useful for future experimental search of double β^＋-decay.

关键词： double β^+-decay with two neutrinos half-lives systematic law weak interaction.

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Alpha-clustering effects in heavy nuclei

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Frontiers of physics 2018年第6期13卷 133-144页

作者： zhongzhou Ren Bo Zhou School of Physics Science and Engineering Tongji University Shanghai 200092 China Institute for International Collaboration Hokkaido University Sapporo 060-0815 Japan

The study of cluster structures in light nuclei is extending to the heavy nuclei in these years. As for the stable N = Z nuclei, from the lighter 8Be, 12. nuclei to the heavier 2.Ne and even the 40Ca and 44Ti medium nuclei, the a cluster structures have been well studied and confirmed. In heavy nuclei, due to the dominated mean field, the existence of α cluster structure is not clear as light nuclei but some clues were found for indicating the core＋ α cluster structure in some nuclei, in particular, the 2.8 pb＋α structure in 2.2.o. We review some recent progress about the theoretical and experimental explorations of the a-clustering effects in heavy nuclei. We also discuss the possible a cluster structure of heavy nuclei from the view of a decay.

关键词： α cluster structure nuclear cluster model α correlations α decay

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Limiting current oxygen sensor based on Y,In co-doped SrTiO_(3)as a dense diffusion barrier layer

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Nano Research 2022年第6期15卷 4880-4885页

作者： Ke Shan zhongzhou Yi Jing Wang College of Science Honghe UniversityMengzi 661199China

A novel dense diffusion barrier material(Y_(x)Sr_(1−x)Ti_(0.9)In_(0.1)O_(3−δ)(x=0.03,0.05,0.07))was prepared by using a sol-gel *** crystal structure,microstructures,electrical conductivity and ionic conductivity of barrier material were *** results show that the samples exhibit the formation of cubic perovskite structure *** increase of Y-doping amount on A-site improved electrical conductivity and sinterability of materials.A limiting current oxygen sensor based on Y_(0.07)Sr_(0.97)Ti_(0.9)In_(0.1)O_(3–δ)as a dense diffusion barrier shows excellent sensing *** linear relationship between limiting current logIL and 1000/T can described logIL=4.603,8−3.847,5·1,000/*** 750°C,0.2.%≤x(O_(2.)≤5.0%,the linear relationship between limiting current(IL)and oxygen amount(x(O_(2.))can described as I_(L)=7.047,6+3.875,1·x(O_(2.).

关键词： limiting current oxygen sensor dense diffusion barrier strontium titanate mixed conductivity

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