检索结果-南通市图书馆

Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

A cell transcriptomic profile p ovides insights into adipocytes of porcine mammary gland across development

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第1期15卷 182-200页

作者： Yongliang Fan Long Jin zhiping He Tiantian Wei Tingting Luo Jiaman Zhang Can Liu Changjiu Dai Chao A Yan Liang Xuan Tao Xuebin Lv Yiren Gu Mingzhou Li State Key Laboratory of Swine and Poultry Breeding Industry College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Key Laboratory of Qinghai‑Tibetan Plateau Animal Genetic Resource Reservation and Utilization Southwest Minzu UniversityChengdu 610041China Animal Breeding and Genetics Key Laboratory of Sichuan Province Sichuan Animal Science AcademyChengdu 610000China

Background Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous, and its physiological function dependents on the gene expression of multiple cell types. Most studies focused on epithelial cells, disregarding the role of neighboring *** Here, we constructed the largest transcriptomic dataset of porcine mammary gland cells thus far. The dataset captured 12.,82. high-quality nuclei from physiological mammary glands across five developmental stages(d 90 of gestation, G90;d 0 after lactation, L0;d 2. after lactation, L2.;2.d post natural involution, PI2.7 d post natural involution, PI7). Seven cell types were identified, including epithelial cells, adipocytes, endothelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells. Our data indicate that mammary glands at different developmental stages have distinct phenotypic and transcriptional signatures. During late gestation(G90), the differentiation and proliferation of adipocytes were inhibited. Meanwhile, partly epithelial cells were completely differentiated. Pseudo-time analysis showed that epithelial cells undergo three stages to achieve lactation, including cellular differentiation, hormone sensing, and metabolic activation. During lactation(L0 and L2.), adipocytes area accounts for less than 0.5% of mammary glands. To maintain their own survival, the adipocyte exhibited a poorly differentiated state and a proliferative capacity. Epithelial cells initiate lactation upon hormonal stimulation. After fulfilling lactation mission, their undergo physiological death under high intensity lactation. Interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCL2.-ACKR4 pathway. This biological process may be an important mechanism for maintaining homeostasis of the mammary gland. During natural involution(PI2.and PI7), epithelial cell populatio

关键词： Adipocytes Cell–cell interaction Development Mammary gland snRNA-seq

在线全文

学校读者我要写书评

暂无评论

新一轮家电“以旧换新”行动方案影响

日用电器 2024年第3期 1-2页

作者： 1.华创证券 2.光大证券 3.中信期货华创证券光大证券中信期货

国务院印发《推动大规模设备更新和消费品以旧换新行动方案》（以下简称《行动方案》），明确了5方面2.项重点任务和实施设备更新、消费品以旧换新、回收循环利用、标准提升四大行动，提出积极开展家电等消费品以旧换新。《行动方案》...

国务院印发《推动大规模设备更新和消费品以旧换新行动方案》（以下简称《行动方案》），明确了5方面2.项重点任务和实施设备更新、消费品以旧换新、回收循环利用、标准提升四大行动，提出积极开展家电等消费品以旧换新。《行动方案》家电直接相关内容1.到2.2.年废旧家电回收量较2.2.年增长30%,

关键词：

Amelioration of habitat since the early Holocene contributed to the origin of agriculture in the farming-pastoral zone of northern China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第8期67卷 2535-2546页

作者： Xin JIA zhiping ZHANG Yonggang SUN Runqi JIANG Shuangwen YI Wei CHEN Jue SUN Guoqiang LI Shuzhi WANG Enrui LI Xiaonong HU Qingchun BAO Harry F.LEE Huayu LU Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Schlool of History and Culture Chifeng UniversityChifeng 024000China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Institute of Archaeology Chinese Academy of Social SciencesBeijing 100710China Ulanqab Museum Ulanqab 012000China The Institute of Cultural Relics and Archaeology Hohhot 010011China Department of Geography and Resource Management The Chinese University of Hong KongHong Kong 999077China Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China School of Geography Nanjing Normal UniversityNanjing 210023China Institute of Environmental Archaeology Nanjing Normal UniversityNanjing 210023China

The origin of agriculture in the farming-pastoral zone of northern China remains in *** central region of the Inner Mongolia Plateau is located in the core area of the farming-pastoral zone;thus,it is a critical region for exploring the origin of the dryland farming system in northern *** study selected the Yumin Site and Banan Site,which belong to the Yumin Culture-the beginning of Neolithic culture in Inner Mongolia-as the research *** on the quartz optically stimulated luminescence(OSL)dating on the sedimentary sections from the Yumin site(YM)and Banan site(BN1 and BN2.,the Holocene chronology framework of each section was *** that,by identifying carbonized grains in the Yumin site and the multi-proxy analysis of each section,we investigated the relationship between the origin of agriculture and climate change in this *** results revealed that the timing of the origin of agriculture recorded in the Yumin site lagged behind the timing of a significant increase of precipitation during the early Holocene but coincided with the timing of a significant increase of vegetation around 8.4 *** phenomenon was further confirmed by the published high-resolution paleoenvironmental records from the surrounding area of the Yumin *** propose that with the gradual amelioration of hydrothermal conditions since the beginning of the Holocene,the regional ecosystem had been improved,resulting in the gradual conversion of the land surface from infertile sand to organic-rich soil,providing an appropriate environmental foundation for the origin of dryland farming in northern China around 8.4 *** study highlighted that the“accumulative environmental effects”during the early Holocene played a vital role in the origin of agriculture in northern China and provided a reference for agricultural management in the context of future climate change.

关键词： Origin of agriculture Accumulative environmental effects Yumin Culture Northern China Holocene

Stretchable,Transparent,and Ultra-Broadband Terahertz Shielding Thin Films Based on Wrinkled MXene Architectures

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第9期16卷 110-122页

作者： Shaodian Yang Zhiqiang Lin Ximiao Wang Junhua Huang Rongliang Yang Zibo Chen Yi Jia zhiping Zeng Zhaolong Cao Hongjia Zhu Yougen Hu Enen Li Huanjun Chen Tianwu Wang Shaozhi Deng Xuchun Gui State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China National Key Laboratory of Materials for Integrated Circuits Shenzhen Institute of Advanced Electronic MaterialsShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Guangdong Province Key Laboratory of Display Material and Technology Guangzhou 510275People’s Republic of China China Academy of Aerospace Science and Innovation Beijing 100176People’s Republic of China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China GBA Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhou 510700People’s Republic of China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049People’s Republic of China Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics Guangzhou 510700People’s Republic of China

With the increasing demand for terahertz(THz)technology in security inspection,medical imaging,and flexible electronics,there is a significant need for stretchable and transparent THz electromagnetic interference(EMI)shielding *** EMI shielding materials,like opaque metals and carbon-based films,face challenges in achieving both high transparency and high shielding efficiency(SE).Here,a wrinkled structure strategy was proposed to construct ultra-thin,stretchable,and transparent terahertz shielding MXene films,which possesses both isotropous wrinkles(height about 50 nm)and periodic wrinkles(height about 500 nm).Compared to flat film,the wrinkled MXene film(8 nm)demonstrates a remarkable 36.5%increase in SE within the THz *** wrinkled MXene film exhibits an EMI SE of 2..1 dB at the thickness of 100 nm,and an average EMI SE/t of 700 dBμm^(−1)over the 0.1-10 *** calculations suggest that the wrinkled structure enhances the film’s conductivity and surface plasmon resonances,resulting in an improved THz wave ***,the wrinkled structure enhances the MXene films’stretchability and *** bending and stretching(at 30%strain)cycles,the average THz transmittance of the wrinkled film is only 0.5%and 2.4%,*** outstanding performances of the wrinkled MXene film make it a promising THz electromagnetic shielding materials for future smart windows and wearable electronics.

关键词： Terahertz Wrinkle structure Electromagnetic interference shielding MXene

Chinese expert consensus on the clinical application of drugcoated balloon(2.(nd) Edition)

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第2期21卷 135-152页

作者： The Expert Writing Committee of the Chinese Expert Consensus on Clinical Applications of Drug-Coated Balloon(2.(nd)Edition) Jun-Bo GE Yun-Dai CHEN 不详 Zhongshan Hospital Fudan University Chinese PLA General Hospital

Percutaneous coronary interventions have progressed through the era of plain balloon dilation, bare-metal stent insertion to drug-eluting stent treatment, which has significantly reduced the acute occlusion and restenosis rates of target vessels and improved patient prognosis, making drug-eluting stents the mainstream interventional treatment for coronary artery disease. In recent years, drug-coated balloons(DCBs) have become a new treatment strategy for coronary artery disease, and the drugs used in the coating and the coating technology have progressed in the past years. Without permanent implant, a DCB delivers antiproliferative drugs rapidly and uniformly into the vessel wall via the excipient during a single balloon dilation. Many evidence suggests that DCB angioplasty is an effective measure for dealing with in-stent restenosis and de novo lesions in small coronary *** more clinical studies are published, new evidence is emerging for the use of DCB angioplasty in a wide range of coronary diseases, and the indications are expanding internationally. Based on the latest research from China and elsewhere, the Expert Writing Committee of the Chinese Expert Consensus on Clinical Applications of Drug-Coated Balloon has updated the previous DCB consensus after evidence-based discussions and meetings in terms of adequate preparation of in-stent restenosis lesions, expansion of the indications for coronary de novo lesions, and precise guidance of DCB treatment by intravascular imaging and functional evaluation.

关键词： balloon drugs dealing

在线全文

学校读者我要写书评

暂无评论

共晶高熵合金成分设计的研究进展

稀有金属材料与工程 2024年第7期53卷 2083-2093页

作者：陈凯旋熊志平中国航空工业集团中国航空综合技术研究所北京100028 北京理工大学材料学院北京100081

近年来,共晶高熵合金由于优异的铸造性能以及优良的强塑性匹配受到了广泛关注,然而,目前存在着开发共晶高熵合金效率过低的问题,共晶高熵合金的成分设计始终是一项挑战。针对这一项挑战,国内外学者开发了多种共晶高熵合金的成分设计方... 详细信息

近年来,共晶高熵合金由于优异的铸造性能以及优良的强塑性匹配受到了广泛关注,然而,目前存在着开发共晶高熵合金效率过低的问题,共晶高熵合金的成分设计始终是一项挑战。针对这一项挑战,国内外学者开发了多种共晶高熵合金的成分设计方法来加快共晶高熵合金的开发速度,由最初的试错法,发展到后来的d轨道能级法、简单混合法、混合焓法、相图计算法以及机器学习辅助的方法等等。每种方法各有特点和局限性,本文对共晶高熵合金的成分设计方法进行了全面评述。

关键词：共晶合金高熵合金成分设计机器学习

制造“大儒”:官学一体的理论准备——《荀子·儒效》文本语境下的哲学阐发

在线全文

学校读者我要写书评

暂无评论

四川大学学报（哲学社会科学版） 2024年第2期 108-114,213,214页

作者：余治平上海交通大学人文学院上海200240

为建构儒家崇拜谱系,《荀子·儒效》在历代先王中寻找资源,塑造“大儒”偶像,以曾经的圣君为最好的取法对象,以礼义为儒者最高的学术追求。其对战国时期儒之流品“雅儒”“俗儒”基本现状的记载,反衬出“大儒”的超越性——真正能够践... 详细信息

为建构儒家崇拜谱系,《荀子·儒效》在历代先王中寻找资源,塑造“大儒”偶像,以曾经的圣君为最好的取法对象,以礼义为儒者最高的学术追求。其对战国时期儒之流品“雅儒”“俗儒”基本现状的记载,反衬出“大儒”的超越性——真正能够践行仁道理想的,唯有“大儒”。大儒“法后王”,既遵从后王之道,又效法先王之功,“以今持古”;既立足当下,又敢于对现实加以改造。如此“大儒之效”显然难以达到,“非圣人莫之能为”。即便是孔子,因为其只有立言、立德而无立功,就被排除在事功大儒的崇拜系统之外。而把天子、三公归为“大儒”,则有利于为儒家培养后备力量,推进儒家队伍官僚化、官僚队伍儒家化,在理论上为后世官学一体、道统涵摄政统奠基。

关键词：《儒效》大儒荀子先王法后王官学一体

The sedimentary structure characteristics and spatial distribution pattern of the Zhaoji Salt Mine derived from dense array ambient noise tomography

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年

作者： Hongwei Wang Xiaofeng Tian Qiaoxia Liu Jia Cheng Ming Zhou zhiping Xu Jiyan Lin Shuaipeng Zhu Geophysics Exploration Center China Earthquake Administration School of Earth Sciences and Resources， China University of Geosciences (Beijing)

Due to the lack of the three-dimensional structure of the Zhaoji salt basin， the salt mining enterprises have obvious clustering when choosing sites. Production capacity declines rapidly as mining deepens， the enterprises are entering a stage of stagnation in production. In this study， a dense seismic array of 12. short-period stations was deployed around the core mining area and its vicinity of the salt mine industry， we use the ambient noise tomography (ANT) method to image the three-dimensional shear wave velocity structure at the depth shallower than 3 km. The results indicate: (1) The overall shear wave velocity in the study area is relatively lower， ranging from 0.8 and 1.8 km/s， which could be related to the loose and thick deposition of the Zhaoji Sub-Depression. (2. The three-dimensional shear wave velocity structure reveals that the sedimentary thickness of the Zhaoji Sub-Depression is deeper in the southeast and shallower in the northwest， with the sedimentary center located around Heping Town and Dahuangzhuang Town. (3) The Zhaoji salt mine is a low-velocity anomalous zone in the shear wave velocity structure with an inverse 'C' character spreading along Nanchenji Town and Zhaoji Town， with a depth ranging from approximately 1.2.to 2.8 km， it may be caused by the development of rock fissures due to water extraction and injection. The surrounding rock exhibits relatively high velocity， which reflects the morphological characteristics of the Zhaoji salt basin. The three-dimensional shear wave velocity model obtained in this study provides scientific guidance for the industrial exploitation of the Zhaoji salt mine and reference for salt exploration of the Hongze Salt Basin. It also provides an important basis for the seismic risk assessment of the salt basins. Simultaneously， it holds significant implications for exploring the application of ambient noise tomography method in spatial detection of salt mine belt.

关键词：