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Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

Military Medical Research 2024年第2期11卷 206-227页

作者： guang-Hui Deng Chao-Feng Wu Yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-Jie Li Jia-Min Zhao Chang Liu Meng-Chen Qin zhi-Yun Zeng Wei-Min Zhang Ken Kin Lam Yung zhi-Ping Lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW2.4.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress

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Ground states and first radial excitations of vector tetraquark states with explicit P-waves via QCD sum rules

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Chinese Physics C 2024年第10期48卷 40-47页

作者： zhi-Gang Wang Department of Physics North China Electric Power UniversityBaoding 071003China

In this study,we chose the diquark-antidiquark type four-quark cuents with an explicit P-wave betweenthe diquark and antidiquark pairs to study the ground states and first radial exeitations of the hidden-charm *** states with quantum numbers J^(PC)=1^(--).We also obtained the lowest vector tetraguark masses and made *** assignments of the existing Ystates,There indeed exists a hidden-charm tetraquark state with J^(PC)=1^(--) at anenergy of approximately 4.75 GeV as the first radial exeitation that accounts for the BESIII data.

关键词： tetraguark state QCD sum rules

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Relationship between seismic structures and the diverse rupture processes of the 2.2. Türkiye earthquake doublet

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Science China Earth Sciences 2024年第9期67卷 2810-2823页

作者： zhi WANG Yi FU Shunping PEI CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering guangdong Laboratory(guangzhou) Guangzhou 511458China Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Recent geodetic and seismological observations of two major earthquakes in southeastern Türkiye in February 2.2. have revealed complex rupture initiation,propagation,and segmentation along the East Anatolian Fault Zone(EAFZ)and surrounding ***,the role of upper crust structures along the EAFZ in determining the diverse rupture processes of this earthquake doublet remains *** further investigate this,we employed double-difference location and seismic tomography techniques to determine high-resolution seismic velocities(V_(P),V_(S))and Poisson’s ratio(σ)structures using a multiparameter joint tomographic *** dataset includes 100,833 high-quality source-receiver travel-time pairs of P-and *** find that the unique rupture processes of this earthquake doublet were primarily influenced by contrasting crustal seismic structures and localized geological *** M_(w)7.8 mainshock was initiated within a transitional edge zone characterized by a rigid part(asperity)of the seismogenic zone with sharp contrast variations in rock strength ranging from low to high along the *** comparison,the M_(w)7.6 rupture originated in a ductile belt featuring fluid saturation with low-VP,low-VS,and high-σvalues that extended parallel to the Cardak *** pronounced contrast structures observed along the former rupture can be attributed to the oblique collision system between the weakened section of the east Anatolian plateau and the brittle Arabian platform,while the latter rupture was initiated within the ductile structure associated with fluid intrusion caused by the northward subduction of the Cyprus slab and subsequent ***,the occurrence of the first earthquake(E1)serves to alleviate shear stress on the second earthquake(E2.fault,potentially impeding the initiation of an E2.*** the contrary,this event also significantly reduces the normal stress acting on the E2.fault due to a double left-lateral strike-slip system

关键词： 2.2. Turkiye earthquake doublet Joint seismic tomography Tomographic transition edge Seismic rupture process Strong fault coupling

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Hepatitis B surface antigen-negative but hepatitis B envelope antigen-positive false occult hepatitis B virus infection:A case report

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World Journal of Hepatology 2024年第10期16卷 1199-1207页

作者： Shu-Sheng Yang Fei Fu Qian-Kun Xuan Zhou-Xiang Zhang zhi-Jun Li guang-Bo Li Xiao-Yu Yu Department of Laboratory Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Obstetrics and Gynecology Shanghai East HospitalTongji University School of MedicineShanghai 200123China

BACKGROUND Occult hepatitis B infection(OBI)is characterized by the detection of hepatitis B virus(HBV)DNA in serum(usually HBV DNA<2.0 IU/mL)or the liver but negativity for hepatitis B surface antigen(HBsAg).The diag... 详细信息

BACKGROUND Occult hepatitis B infection(OBI)is characterized by the detection of hepatitis B virus(HBV)DNA in serum(usually HBV DNA2.0 IU/mL)or the liver but negativity for hepatitis B surface antigen(HBsAg).The diagnosis of OBI relies on the sensitivity of assays used in the detection of HBV DNA and *** assays with inadequate sensitivity or inability to detect HBV S variants may lead to misdiagnosis of OBI in people with overt HBV *** SUMMARY We report a HBsAg-negative but hepatitis B envelope antigen-positive patient who had a significant HBV DNA *** patient was initially diagnosed as having ***,sequence analysis revealed a unique insertion of amino acid residues at positions 12.-12. in the S protein,which affects the formation of a disulfide bond that is associated with the formation of a *** is well known that there is an overlap between the S protein and Pol *** found that this new insertion site occurred in polymerase/reverse transcriptase domain,indi-cating that this insertion might be involved in HBV *** patient was finally diagnosed with a false *** An insertion of amino acid residues at positions 12.-12. of the S protein affects the formation of immunodominant epitopes and results in negative HBsAg levels.

关键词： Occult hepatitis B infection Hepatitis B virus Hepatitis B surface antigen Hepatitis B envelope antigen Immunodominant epitopes Case report

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Influence of Vanes and Blades on Ingress in Axial Rim Seal for Turbine Stages

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Journal of Thermal Science 2024年第3期33卷 833-846页

作者： REN Ran DU Qiang LIU guang ZENG Yanlian XIE Lei Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine Beijing100190China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing100190China

Hot gas ingestion refers to the phenomenon of mainstream hot gas flowing into the space cavity of a turbine *** studies have found that mainstream annulus pressure distribution plays an important role in hot gas ingestion,but due to its complexity,the mechanism of the interaction between mainstream flow and hot gas ingestion remains *** paper adopts the URANS method,and three sealing flow rates are considered,named C_(w)=0,C_(w)=500,and C_(w)=*** time-averaged annulus pressure distribution shows that an increase in the sealing flow decreases the pressure value,and the effects of the sealing flow on the pressure distribution of the leading edge of the blade are much more influential than that of the trailing edge of the *** unsteady pressure time-space distribution in the annulus indicates that a time-space tilted distribution of pressure at the rim exits when the sealing flow *** phenomenon is mainly due to the strong feedback mechanism of the sealing flow to the annulus pressure field.A comparison of the pressure and mean radial velocity distribution of the mainstream shows that the ingestion mainly occurs on the blade side,where the pressure is lower than on the vane *** flow characteristics at the wheel rim are analyzed with a sealing flow rate C_(w)=5000,and under these conditions,both pressure-induced ingestion and ingestion caused by a passage vortex can be *** three-dimensional and inertial effects of the mainstream at the wheel rim lead to the generation of separation vortices on the blade side,and the presence of separation vortices leads to ingestion along the blade *** the same time,pressure on the blade side will cause the fluid to have a radial inward flow tendency,which will promote the formation of separation vortices,leading to more serious ingestion in the high-pressure region on the blade *** blade pressure field can be more significant than the vane trailing pressure field in the rim sea

关键词： separation vortex unsteady rim seal the effect of blade on ingestion

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B_(c) meson and its scalar cousin with QCD sum rules

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Chinese Physics C 2024年第10期48卷 48-58页

作者： zhi-Gang Wang Department of Physics North China Electric Power UniversityBaoding 071003China

In this study,we use the optical theorem to calculate the next-to-leading order corrections to the QCD spectral densities directly in the QCD sum rules for the pseudoscalar and scalar B_(c) *** use experimental data for guidance to perform an updated *** obtain the masses and,in particular,decay constants,which are the fundamental input parameters in high energy ***,we obtain the pure leptonic decay widths,which can be compared with experimental data in the future.

关键词： next-to-leading order contributions QCD sum rules

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Highly Thermoconductive,Strong Graphene‑Based Composite Films by Eliminating Nanosheets Wrinkles

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Nano-Micro Letters 2024年第1期16卷 328-340页

作者： guang Xiao Hao Li zhizhou Yu Haoting Niu Yagang Yao College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNational Laboratory of Solid State MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China Institute of Laser Manufacturing Henan Academy of SciencesZhengzhou 450052People’s Republic of China Center for Quantum Transport and Thermal Energy Science School of Physics and TechnologyNanjing Normal UniversityNanjing 210023People’s Republic of China

Graphene-based thermally conductive composites have been proposed as effective thermal management materials for cooling high-power electronic ***,when flexible graphene nanosheets are assembled into macroscopic thermally conductive composites,capillary forces induce shrinkage of graphene nanosheets to form wrinkles during solution-based spontaneous drying,which greatly reduces the thermal conductivity of the ***,graphene nanosheets/aramid nanofiber(GNS/ANF)composite films with high thermal conductivity were prepared by in-plane stretching of GNS/ANF composite hydrogel networks with hydrogen bonds andπ-π*** in-plane mechanical stretching eliminates graphene nanosheets wrinkles by suppressing inward shrinkage due to capillary forces during drying and achieves a high in-plane orientation of graphene nanosheets,thereby creating a fast in-plane heat transfer *** composite films(GNS/ANF-60 wt%)with eliminated graphene nanosheets wrinkles showed a significant increase in thermal conductivity(146 W m^(−1)K^(−1))and tensile strength(2.7 MPa).The combination of these excellent properties enables the GNS/ANF composite films to be effectively used for cooling flexible LED chips and smartphones,showing promising applications in the thermal management of high-power electronic devices.

关键词： Graphene Aramid nanofiber Wrinkles elimination In-plane stretching Thermal conductivity

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Kinematic calibration method with high measurement efficiency and robust identification for hybrid machine tools

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Chinese Journal of Aeronautics 2024年第3期37卷 468-482页

作者： Liping WANG Mengyu LI guang YU Weitao LI Xiangyu KONG State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Precision/Ultra-precision Manufacturing Equipment and Control Beijing 100084China

Geometric error is the main factor affecting the machining accuracy of hybrid machine *** calibration is an effective way to improve the geometric accuracy of hybrid machine *** necessity to measure both position and orientation at each pose,as well as the instability of identification in case of incomplete measurements,severely affects the application of traditional calibration *** this study,a kinematic calibration method with high measurement efficiency and robust identification is proposed to improve the kinematic accuracy of a five-axis hybrid machine ***,the configuration is introduced,and an error model is ***,by investigating the mechanism error characteristics,a measurement scheme that only requires tool centre point position error measurement and one alignment operation is ***,by analysing the effects of unmeasured degrees of freedom(DOFs)on other DOFs,an improved nonlinear least squares method based on virtual measurement values is proposed to achieve stable parameter identification in case of incomplete measurement,without introducing additional ***,the proposed calibration method is verified through simulations and *** proposed method can efficiently accomplish the kinematic calibration of the hybrid machine *** accuracy of the hybrid machine tool is significantly improved after calibration,satisfying actual aerospace machining requirements.

关键词： Hybrid machine tool Calibration Measurement scheme Improved nonlinear least squares method Virtual measurement values

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Immune states:integrated views of immunity by combining traditional Chinese medicine and modern medicine

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Science China(Life Sciences) 2024年第10期67卷 2271-2273页

作者： Anlong Xu Yuxing zhi School of Life Sciences and Qi-Huang School of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China

Human immune system is an extraordinarily complex physiological system composed of multiple anatomical systems,diverse tissues and molecules from macroscopic to microscopic *** cells and molecules collectively partici... 详细信息

关键词： immunity homeostasis Immune

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Research progress on micro-force measurement of a hydrate particle system

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Petroleum Science 2024年第4期21卷 2169-2183页

作者： Qiang Luo Wei Li zhi-Hui Liu Feng Wang zhi-Chao Liu Fu-Long Ning Faculty of Engineering China University of Geosciences (Wuhan) Suzhou Laboratory

It remains a great challenge to understand the hydrates involved in phenomena in practical oil and gas systems. The adhesion forces between hydrate particles, between hydrate particles and pipe walls, and between hydrate particles and reservoir particles are essential factors that control the behaviors of clathrate hydrates in different applications. In this review, we summarize the typical micro-force measurement apparatus and methods utilized to study hydrate particle systems. In addition, the adhesion test results, the related understandings, and the applied numerical calculation models are systematically discussed.

关键词： Clathrate hydrates Hydrate particle Micro-force measurements Adhesion Interactions

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