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Unraveling the contribution of Co(IV)and free radicals in Co^(2.)-activated Peroxymonosulfate process:Reaction mechanism,degradation pathway,and DFT calculation

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Emerging Contaminants 2024年第1期10卷 60-71页

作者： Tao Yuan Yueyuan Zhao Yujiao An xiaowan Li Gansu Key Laboratory for Environmental Pollution Prediction and Control College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansu730000PR China

The Co^(2.)and Peroxymonosulfate(PMS)reaction is a highly regarded advanced oxidation process(AOP)that has been extensively *** consensus regarding the relative contribution of reactive species in the Co2./PMS system under different pH conditions has not been *** this study,quenching experiments and electron spin resonance(ESR)tests demonstrated the coexistence of Co(IV),sulfate radical(SO_(4)^(•-)),hydroxyl radical(•OH),and singlet oxygen(1O2.,and there fell to CBZ degradation were Co(IV)>SO_(4)^(•-)->•OH≈1O2.in the optimal conditions,where almost 100%of CBZ was degraded in the Co2./PMS system within 30 ***,Cl−would suppress the formation of Co(IV),SO_(4)^(•-),and•OH but enhance the yield of 1O2.thereby showing a trend of inhibiting CBZ *** probe compound used in this study was Methyl Phenyl Sulfoxide(PMSO),while methyl phenyl sulfone(PMSO_(2.)as the indicator of Co(IV),the generation efficiency of PMSO_(2.(η'[PMSO_(2.])increased with reaction time and reached 70%–98%at 40 min at all set pH values(3,4,6,and 8).These results suggest that Co(IV)played a significant role in the Co^(2.)/PMS system and its importance became more pronounced as the reaction *** probe and SO_(4)^(•-)quantification experiments jointly revealed that Co(IV)had the greatest performance at pH 4,and compared to other pH values,SO_(4)^(•-)had the largest contribution in the initial stage of the reaction at pH *** Ecological Structure Activity Relationships(ECOSAR)software was utilized to predict the toxicity of the degradation ***,luminescent bacteria experiments were conducted to assess the acute toxicity of the reaction *** results of these experiments demonstrated that the Co^(2.)/PMS process exhibited a remarkable ability to detoxify the solution.

关键词： Co(IV) Peroxymonosulfate DFT calculation Toxicity assessment

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Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： xiaowan Fan Tao Zhang Xin Ding Yushuo Gu Qing Li Wei Jiang Kelong Fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

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Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression

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Cancer Biology & Medicine 2024年第2期21卷 175-192页

作者： Lulu Han Yuxin Chen Nan Huang xiaowan Zhou Yanfang Lv Huizhong Li Dafei Chai Junnian Zheng Gang Wang Cancer Institute Xuzhou Medical University209 Tongshan RoadXuzhou 221004China Center of Clinical Oncology The Affiliated Hospital of Xuzhou Medical University99 West Huaihai RoadXuzhou 221002China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Xuzhou Medical University209 Tongshan RoadXuzhou 221004China Department of Oncology Suzhou Xiangcheng People’s HospitalSuzhou 215131China

Objective:Neutrophils are one of the most predominant infiltrating leukocytes in lung cancer tissues and are associated with lung cancer *** neutrophils promote lung cancer progression,however,has not been ***:Kaplan–Meier plotter online analysis and tissue immunohistochemistry were used to determine the relationship between neutrophils and overall survival in lung cancer *** effect of neutrophils on lung cancer was determined using the Transwell migration assay,a proliferation assay,and a murine tumor *** knockdown was used to determine poly ADPribose polymerase(PARP)-1 function in lung cancer-educated *** blot analysis and gelatin zymography were used to demonstrate the correlation between PARP-1 and matrix metallopeptidase 9(MMP-9).Immunoprecipitation coupled to mass spectrometry(IP/MS)was used to identify the proteins interacting with ***-immunoprecipitation(Co-IP)was used to confirm that PARP-1 interacts with arachidonate 5-lipooxygenase(ALOX5).Neutrophil PARP-1 blockage by AG14361 rescued neutrophil-promoted lung cancer ***:An increased number of infiltrating neutrophils was negatively associated with overall survival in lung cancer patients(P<0.001).Neutrophil activation promoted lung cancer cell invasion,migration,and proliferation in vitro,and murine lung cancer growth in ***,PARP-1 was shown to be involved in lung cancer cell-induced neutrophil activation to increase MMP-9 expression through interacting and stabilizing ALOX5 by post-translational protein modification(PARylation).Blocking PARP-1 by gene knockdown or AG14361 significantly decreased ALOX5 expression and MMP-9 production,and eliminated neutrophil-mediated lung cancer cell invasion and in vivo tumor ***:We identified a novel mechanism by which PARP-1 mediates lung cancer cell-induced neutrophil activation and PARylates ALOX5 to regulate MMP-9 expression,which exacerbates lung cancer

关键词： Lung cancer neutrophils PARP-1 ALOX5 MMP-9

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Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp(Ctenopharyngodon idella):in vitro and in vivo studies

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1638-1656页

作者： Piao Zhao Lin Feng Weidan Jiang Pei Wu Yang Liu Hongmei Ren xiaowan Jin Lu Zhang Haifeng Mi Xiaoqiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory of Animal Disease‑Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130SichuanChina Tongwei Co. Ltd.Healthy Aquaculture Key Laboratory of Sichuan ProvinceChengdu 610041SichuanChina

Background Ochratoxin A(OTA),a globally abundant and extremely hazardous pollutant,is a significant source of contamination in aquafeeds and is responsible for severe food *** developmental toxicity of OTA and the potential relieving strategy of natural products remain *** study screened the substance curcumin(Cur),which had the best effect in alleviating OTA inhibition of myoblast proliferation,from 96 natural products and investigated its effect and mechanism in reducing OTA myotoxicity in vivo and in *** A total of 72. healthy juvenile grass carp,with an initial average body weight of 11.06±0.05 g,were randomly assigned into 4 groups:the control group(without OTA and Cur),1.2.mg/kg OTA group,400 mg/kg Cur group,and 1.2.mg/kg OTA+400 mg/kg Cur *** treatment consisted of 3 replicates(180 fish)for 60 *** Firstly,we cultured,purified,and identified myoblasts using the tissue block culture *** preliminary screening and re-screening of 96 substances,we examined cell proliferation-related indicators such as cell viability and ultimately found that Cur had the best ***,Cur could alleviate OTA-inhibited myoblast differentiation and myofibrillar development-related proteins(Myo G and MYHC)in vivo and in vitro and improve the growth performance of grass ***,Cur could also promote the expression of OTA-inhibited protein synthesis-related proteins(S6K1 and TOR),which was related to the activation of the AKT/TOR signaling ***,Cur could downregulate the expression of OTA-enhanced protein degradation-related genes(murf1,foxo3a,and ub),which was related to the inhibition of the Fox O3a signaling *** In summary,our data demonstrated the effectiveness of Cur in alleviating OTA myotoxicity in vivo and in *** study confirms the rapidity,feasibility,and effectiveness of establishing a natural product screening method targeting myoblasts to alleviate fungal toxin toxicity.

关键词： Curcumin Grass carp Myotoxic Ochratoxin A Protein deposition

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Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy

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Chinese Chemical Letters 2024年第4期35卷 316-320页

作者： Ling-Ling Wu Xiangchuan Meng Qingyang Zhang xiaowan Han Feiya Yang Qinghua Wang Hai-Yu Hu Nianzeng Xing Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

Photoacoustic agents combining photodynamic therapy(PDT) and photothermal therapy(PTT) functions have emerged as potent theranostic agents for combating cancer. The molecular approaches for enhancing the near-infrared(NIR)-absorption and maximizing non-radiative energy transfer are essential for effective photoacoustic imaging(PAI) and therapy applications. In addition, such molecules with high specificity and affinity to cancer cells are urgently needed, which would further decrease the side effect during treatments. In this study, we applied a heavy-atom engineering strategy and introduced p-aminophenol,-thio, and-seleno moieties into NIR heptamethine cyanine(Cy7) skeleton(Cy7-X-NH_(2., X = O, S, Se) to significantly increase photothermal conversion efficiency for PTT and promote intersystem crossing for ***, we designed a series of nitroreductase(NTR)-activated photoacoustic probes(Cy7-X-NO_(2.,X = O, S, Se), and target hypoxic tumors with NTR overexpression. Our prostate cancer targeting probe,Cy7-Se-NO_(2.-KUE, exhibited specific tumor photoacoustic signals and effective tumor killing through outstanding synergistic PTT/PDT in vivo. These findings highlighted a versatile strategy for cancer photoacoustic diagnosis and enhanced phototherapy.

关键词： Heavy-atom effect Phototherapy Photoacoustic imaging Hypoxia-responsive Prostate cancer

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Establishing the link between D-mannose and juvenile grass carp(Ctenopharyngodon idella):Improved growth and intestinal structure associated with endoplasmic reticulum stress,mitophagy,and apical junctional complexes

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Animal Nutrition 2024年第3期18卷 450-463页

作者： Chong Zhang Lin Feng Pei Wu Yang Liu xiaowan Jin Hongmei Ren Hua Li Fali Wu Xiaoqiu Zhou Weidan Jiang Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130China Fish Nutrition and Safety Production University Key Laboratory of Sichuan ProvinceSichuan Agricultural UniversityChengdu 611130China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130China

D-mannose,essential for protein glycosylation,has been reported to have immunomodulatory effects and to maintain intestinal flora *** addition to evaluating growth performance,we examined the impact of D-mannose on the structure of epithelial cells and apical junction complexes in the animal *** 1800 grass carp(16.2.±0.01 g)were randomly divided into six treatments with six replicates of 50 fish each and fed with six different levels of D-mannose(0.52.1.75,3.02.4.2.,5.50 and 6.78 g/kg diet)for 70 *** study revealed that D-mannose increased feed intake(P 0.05).D-mannose supplementation at 1.75 g/kg increased crude protein content in fish and lipid production value(P2. g/kg increased intestinal length,intestinal weight and fold height of grass carp compared to the control group(P2. or 3.02.g/kg reduced serum diamine oxidase activity or D-lactate content(P2.interacting protein 3-like(BNIP3L),BCL2.interacting protein 3(BNIP3),and FUN14 domain containing 1(FUNDC1)]mitophagy may play a role in maintaining cellular redox *** enhancement of intercellular structures includes enhancing tight junction and adherent junction structures,which may be closely associated with the small Rho GTPase pr

关键词： Grass carp(Ctenopharyngodon idella) D-mannose Intestine structure Endoplasmic reticulum stress Mitophagy Apical junctional complex

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Anisotropy-free arrayed waveguide gratings on X-cut thin film lithium niobate platform of in-plane anisotropy

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Light(Science & Applications) 2024年第7期13卷 1416-1426页

作者： Junjie Yi Changjian Guo Ziliang Ruan Gengxin Chen Haiqiang Wei Liwang Lu Shengqi Gong Xiaofu Pan xiaowan Shen Xiaowei Guan Daoxin Dai Kangping Zhong Liu Liu State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058China. Guangdong Provincial Key Laboratory of Optical Information Materials and Technology South China Academy of Advanced OptoelectronicsSouth China Normal UniversityHigher-Education Mega-CenterGuangzhou 510006China. National Center for International Research on Green Optoelectronics South China Normal UniversityGuangzhou 510006China Photonics Research Institute Department of Electrical and Electronic EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong Kong(SAR)China. Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Intelligent Optics&Photonics Research CenterJiaxing Research Institute Zhejiang UniversityJiaxing 314000China

Arrayed waveguide grating is a versatile and scalable integrated light dispersion device,which has been widely adopted in various applications,including,optical communications and optical ***,thin-film lithium niobate emerges as a promising photonic integration platform,due to its ability of shrinking largely the size of typical lithium niobate based optical *** would also enable multifunctional photonic integrated chips on a single lithium niobate ***,due to the intrinsic anisotropy of the material,to build an arrayed waveguide grating on X-cut thin-film lithium niobate has never been ***,a universal strategy to design anisotropyfree dispersive components on a uniaxial in-plane anisotropic photonic integration platform is introduced for the first *** leads to the first implementation of arrayed waveguide gratings on X-cut thin-film lithium niobate with various configurations and *** best insertion loss of 2.4 dB and crosstalk of−2..1 dB is obtained for the fabricated arrayed waveguide grating *** of such arrayed waveguide gratings as a wavelength router and in a wavelength-division multiplexed optical transmission system are also demonstrated.

关键词： waveguide arrayed lithium

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多措并举标本兼治有力有效做好基督教工作

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中国宗教 2024年第5期 33-34页

作者： 1.中共山东省委统战部 2.山东省民宗委中共山东省委统战部山东省民宗委

近年来,山东省结合实际,采取有力举措,扎实做好基督教工作,有效推进基督教中国化山东实践,全省基督教领域呈现出和谐稳定的良好局面。一、严格落实宗教工作责任制,着力构建齐抓共管的宗教事务管理格局山东严格落实各级各部门宗教工作责... 详细信息

近年来,山东省结合实际,采取有力举措,扎实做好基督教工作,有效推进基督教中国化山东实践,全省基督教领域呈现出和谐稳定的良好局面。一、严格落实宗教工作责任制,着力构建齐抓共管的宗教事务管理格局山东严格落实各级各部门宗教工作责任制,通过强化组织保障“小切口”,推动基层宗教事务管理“大文章”。一是压实主体责任。将宗教工作纳入各级党委重要议事日程,构建起各级党委齐抓共管的工作体制。

关键词：基督教中国化齐抓共管宗教事务管理主体责任工作责任制和谐稳定严格落实标本兼治

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党纪效力辐射情形下党纪严于国法理论探讨与再阐释——基于自我约束理论视角

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政治与法律 2024年第10期 2-18页

作者：赵小婉清华大学法学院北京100084

党纪效力辐射是指以党纪为标准约束非党员公职人员的现象。随着党的领导不断加强,党纪与国法在法治体系内部由相对分离发展为相互交融。特别是在党的执政领域,党纪不仅约束党组织内部成员,而且对非党员公职人员产生实质拘束力。作为党... 详细信息

党纪效力辐射是指以党纪为标准约束非党员公职人员的现象。随着党的领导不断加强,党纪与国法在法治体系内部由相对分离发展为相互交融。特别是在党的执政领域,党纪不仅约束党组织内部成员,而且对非党员公职人员产生实质拘束力。作为党纪严于国法正当性理论依据的“特别权力关系理论”“无产阶级政党的先进性理论”“基本权利放弃理论”等,都暗含了党纪仅用于调整党内关系的价值预设,已经不能作为党纪效力辐射情形下党纪严于国法的理论支撑。因此,有必要对党纪严于国法的正当性理论加以探讨与再阐释。中国共产党作为执政党,有权对所有执政主体设定统一行为准则以保证政权的廉洁性,从而完成党和国家“实现中华民族伟大复兴”的目标。可以借鉴公法学自我约束理论,以党的目标与国家目标一致性为前提,将自我约束作为党自我革命在执政领域的延伸,以证成党纪效力辐射情形下党纪严于国法的正当性。与此同时,党纪约束非党员公职人员应限于党的执政领域之内,并借鉴比例原则予以审查。

关键词：党纪严于国法效力辐射自我革命自我约束比例原则

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论党章的基本规范

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政法论坛 2024年第3期42卷 180-191页

作者：赵小婉清华大学法学院清华大学国家治理研究院

习近平法治思想提出坚持全面依法治国需要处理好依法治国与依规治党有机统一关系。党章是开展依规治党、全面从严治党的根本性规范。通过党章基本规范提炼总结党章的核心价值,是形成具有内在统一秩序的党内法规体系的前提与基础。虽然... 详细信息

习近平法治思想提出坚持全面依法治国需要处理好依法治国与依规治党有机统一关系。党章是开展依规治党、全面从严治党的根本性规范。通过党章基本规范提炼总结党章的核心价值,是形成具有内在统一秩序的党内法规体系的前提与基础。虽然建党百年来党章的文本和结构已发生重大变迁,但其中居于基础地位,并被历史验证、洗礼、沉淀后而形成的规范性命题应作为党章基本规范,类似框架在公法中已经形成,可以作为借鉴。党章中“党的最终目标是实现共产主义”“少数服从多数”“服从党中央领导”“党的全国代表大会作为最高权力机关”和“党员三人至五人均得成立一组”等条款始终作为党章的基本规范,发挥了宣示党的性质、构建党的领导制度和组织制度基本框架的功能。并在此基础上抽象出共产主义原则、党的领导原则和民主集中制原则,三大原则共同指向“人民至上”精神,应作为党章的核心价值。党章“人民至上”价值与宪法“人民主权原则”统一,构成依法治国与依规治党在价值层面相统一的基础。

关键词：依规治党基本规范人民至上党的领导民主集中制

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