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新年贺词的爱国主义教育价值:机理、特征与路径

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思想教育研究 2024年第4期 95-102页

作者：陶倩李静上海大学马克思主义学院上海200444

习近平在元旦前夕发表的新年贺词,既是对全国各族人民表达美好祝福的重要形式,也是在全体人民中开展爱国主义教育的重要载体。习近平的新年贺词蕴含丰富的时间、仪式和文化意蕴,彰显着丰富的爱国主义教育价值,有助于使民众增进爱国主义... 详细信息

习近平在元旦前夕发表的新年贺词,既是对全国各族人民表达美好祝福的重要形式,也是在全体人民中开展爱国主义教育的重要载体。习近平的新年贺词蕴含丰富的时间、仪式和文化意蕴,彰显着丰富的爱国主义教育价值,有助于使民众增进爱国主义认知、涵育爱国主义情感、强化爱国主义行为。回顾习近平的新年贺词,其在增进国家认同、激励团结奋斗和提振民众信心等方面发挥着重要的爱国主义教育价值。在迈向第二个百年奋斗目标的新征程上,我们需要在宣传教育、整合资源和支持保障等方面推动爱国主义教育走深走实,以此更好地彰显新年贺词的爱国主义教育价值。

关键词：新年贺词爱国主义教育价值

Enantioselective copper-catalyzed dearomative borylative cyclization of indoles and mechanistic insights

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Science China Chemistry 2024年

作者： Yanfei Li Xuetao Li Zheng Zhang Yiliang Zhang Xiuping Yuan Jianjun Yin Simin Wang Wei Guan qian Zhang tao Xiong Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Department of Chemistry Northeast Normal University School of Chemistry and Chemical Engineering Harbin Normal University Institute of Functional Material Chemistry Department of Chemistry Northeast Normal University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

Alicyclic nitrogen heterocycles, such as enantioenriched polycyclic fused [1,2.a]indoline derivatives, are widespread in natural products, agrochemicals and pharmaceutical agents. Existing methods predominantly rely on the recent emerging Heck-type catalytic asymmetric dearomatization（CADA） protocol, wherein noble palladium catalysts commonly necessitate the form arylPd species-triggered these transformations. In contrast, a more sustainable base metal catalysis paradigm through alkyl metal species disrupting the aromaticity, that is, the utilization of challenging asymmetric Csp3–Csp3bond formation entry to such important chiral densely functionalized polycyclic molecular scaffolds, remains an elusive task. Herein, we report the first copper-catalyzed dearomative borylative cyclization of indoles under mild reaction conditions, affording an array of valuable Bpin-containing pyrrolo-fused [1,2.a]indolines bearing four consecutive stereogenic centers with excellent enantioand diastereoselectivity. The synthetic potential was documented via an array of useful transformations. Density functional theory（DFT） calculation studies elucidated the origin of the chemo-, regio-, enantio-and diastereoselectivities of this conversion.

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Autophagy plays a pro-apoptotic role in arsenic trioxide-induced cell death of liver cancer

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Journal of Integrative Medicine 2024年第3期22卷 295-302页

作者： Zhengting Deng Shufang Liang Guokai Huang Yuqian Wang Xiaoyu Tu Yani Zhang Shu Li tao Liu Binbin Cheng Taizhou Hospital of Traditional Chinese Medicine Nanjing University of Chinese MedicineTaizhou 225300Jiangsu ProvinceChina Oncology Department of Traditional Chinese Medicine The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Gastroenterology Baoshan Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201900China

Objective: The effects of arsenic trioxide(As2.3) on hepatocellular carcinoma have been documented widely. Autophagy plays dual roles in the survival and death of cancer cells. Therefore, we investigated the exact role of autophagy in As2.3-induced apoptosis in liver cancer ***: The viability of hepatoma cells was determined using the MTT assay with or without fetal bovine serum. The rate of apoptosis in liver cancer cells treated with As2.3was evaluated using flow cytometry, Hoechst 332.8 staining, and TUNEL assays. The rate of autophagy among liver cancer cells treated with As2.3was detected using immunofluorescence, Western blot assay and transmission electron ***: Upon treatment with As2.3, the viability of HepG2.and SMMC-772. cells was decreased in a time-and dose-dependent manner. The apoptosis rates of both liver cancer cell lines increased with the concentration of As2.3, as shown by flow cytometry. Apoptosis in liver cancer cells treated with As2.3was also shown by the activation of the caspase cascade and the regulation of Bcl-2.Bax ***, As2.3treatment induced autophagy in liver cancer cells;this finding was supported by Western blot, immunofluorescence of LC3-II and beclin 1, and transmission electron microscopy. In liver cancer cells, As2.3inhibited the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR) signal pathway that plays a vital role in both apoptosis and autophagy. The PI3K activator SC-79 partially reversed As2.3-induced autophagy and apoptosis. Furthermore, inhibiting autophagy with 3-methyladenine partially reversed the negative effects of As2.3on cell *** starvation increased autophagy and amplified the effect of As2.3on cell ***: As2.3induces apoptosis and autophagy in liver cancer cells. Autophagy induced by As2.3may have a proapoptotic effect that helps to reduce the viability of liver cancer cells. This study provides novel insights

关键词： Apoptosis Arsenic trioxide Autophagy Primary liver cancer

基于深层卷积随机配置网络的电熔镁炉工况识别方法研究

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自动化学报 2024年第3期50卷 527-543页

作者：李帷韬童倩倩王殿辉吴高昌合肥工业大学电气与自动化工程学院合肥230009 中国矿业大学人工智能研究院徐州221116 东北大学流程工业综合自动化国家重点实验室沈阳110819

为解决电熔镁炉工况识别模型泛化能力和可解释性弱的缺陷,提出一种基于深层卷积随机配置网络(Deep convolutional stochastic configuration networks,DCSCN)的可解释性电熔镁炉异常工况识别方法.首先,基于监督学习机制生成具有物理含... 详细信息

为解决电熔镁炉工况识别模型泛化能力和可解释性弱的缺陷,提出一种基于深层卷积随机配置网络(Deep convolutional stochastic configuration networks,DCSCN)的可解释性电熔镁炉异常工况识别方法.首先,基于监督学习机制生成具有物理含义的高斯差分卷积核,采用增量式方法构建深层卷积神经网络(Deep convolutional neural network,DCNN),确保识别误差逐级收敛,避免反向传播算法迭代寻优卷积核参数的过程.定义通道特征图独立系数获取电熔镁炉特征类激活映射图的可视化结果,定义可解释性可信度评测指标,自适应调节深层卷积随机配置网络层级,对不可信样本进行再认知以获取最优工况识别结果.实验结果表明,所提方法较其他方法具有更优的识别精度和可解释性.

关键词：电熔镁炉深层卷积随机配置网络高斯差分卷积核类激活映射图可解释性

Adsorption behaviors and mechanisms of gold recovery from thiosulfate solution by ion exchange resin

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Transactions of Nonferrous Metals Society of China 2024年第10期34卷 3372-3385页

作者： Zhong-lin DONG tao JIANG Bin XU qian LI Yong-bin YANG School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

The adsorption behaviors and mechanisms of gold from thiosulfate solution on strong-base anion exchange resin were systematically *** comparison experiment of adsorption ability and selectivity for gold showed that gel Amberlite IRA-400 resin with Type Ⅰ quaternary ammonium functional group had better adsorption *** increases of resin dosage,ammonia concentration and solution pH were favorable to gold adsorption,whereas the rises of cupric and thiosulfate concentrations were disadvantageous to gold *** characterization results indicated that gold was adsorbed in the form of [Au(S_(2.O_(3))_(2.]^(3–) complex anion by exchanging with the counter ion Cl^(–) in the functional group of the *** functional theory calculation result manifested that gold adsorption was mainly depended on the hydrogen bond and van der Waals force generated between O atom in [Au(S_(2.O_(3))_(2.]^(3–) and H atom in the quaternary ammonium functional group of the resin.

关键词： gold thiosulfate solution resin adsorption behaviors and mechanisms density functional theory calculation

Impact of Onset Time, Number, Type, and Sequence of Extrahepatic Organ Failure on Prognosis of Acute-on-chronic Liver Failure

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 257-265页

作者： Shaotian Qiu qian Zhang Jiaxuan Hu Lewei Wang Rui Chen Yingying Cao Fang Liu Zhenjun Yu Caiyan Zhao Liaoyun Zhang Wanhua Ren Shaojie Xin Yu Chen Zhongping Duan tao Han The School of Medicine Nankai UniversityTianjinChina Department of Gastroenterology and Hepatology Tianjin Union Medical Center Affiliated to Nankai UniversityTianjinChina Department of Gastroenterology and Hepatology Tianjin Union Medical CenterTianjinChina Tianjin Medical University TianjinChina Department of Gastroenterology and Hepatology Tianjin Union Medical Center of Tianjin Medical UniversityTianjinChina Department of Hepatology and Gastroenterology The Third Central Clinical College of Tianjin Medical UniversityTianjinChina Department of Infectious Disease The Third Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Infection Disease First Hospital of Shanxi Medical UniversityTaiyuanShanxiChina Infectious Department of Shandong First Medical University Affiliated Shandong Provincial Hospital JinanShandongChina Liver Failure Treatment and Research Center The Fifth Medical Center of Chinese PLA General HospitalBeijingChina Liver Disease Center(Difficult&Complicated Liver Diseases and Artificial Liver Center) Beijing You’an Hospital Affiliated to Capital Medical UniversityBeijingChina

Background and Aims:The impact of the characteristics of extrahepatic organ failure(EHOF)including the onset time,number,type,and sequence on the prognosis of acute-onchronic liver failure(ACLF)patients remains *** study aimed to identify the association between the characteristics of EHOF and the prognosis of ACLF ***:ACLF subjects enrolled at six hospitals in China were included in the *** risk of mortality based on the characteristics of EHOF was *** of study groups was compared by Kaplan–Meier analysis and log-rank ***:A total of 736 patients with ACLF were *** was observed in 402.patients(54.6%),of which 2.5(73.4%)developed single EHOF(SEHOF)and 107(2..6%)developed multiple EHOF(MEHOF).The most commonly observed EHOF was coagulation failure(47.0%),followed by renal(13.0%),brain(4.9%),respiratory(4.3%),and circulatory(2.3%)*** analysis found that MEHOF or SEHOF patients with brain failure had a worse ***,no significant outcome was found in the analysis of the effect of onset time and sequence of failed organs on *** were further divided into three risk subgroups by the EHOF ***–Meier analysis showed that risk stratification resulted in the differentiation of patients with different risks of mortality both in the training and validation ***:The mortality of ACLF patients was determined by the number and type,but not the onset time and sequence of *** stratification applicable to clinical practice was established.

关键词： Extrahepatic organ failure Acute-on-chronic liver failure Prognosis Brain failure

Josephin domain containing 2.JOSD2.promotes lung cancer by inhibiting LKB1(Liver kinase B1)activity

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Signal Transduction and Targeted Therapy 2024年第2期9卷 693-708页

作者： tao Yuan Chenming Zeng Jiawei Liu Chenxi Zhao Fujing Ge Yuekang Li Meijia qian Jiamin Du Weihua Wang Yonghao Li Yue Liu Xiaoyang Dai Jianya Zhou Xueqin Chen Shenglin Ma Hong Zhu Qiaojun He Bo Yang Institute of Pharmacology&Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 311199China Ministry of Education Key Laboratory of Chinese Medicinal Plants Resource from Lingnan Research Center of Medicinal Plants Resource Science and EngineeringGuangzhou University of Chinese MedicineGuangzhou 510006China Center for Drug Safety Evaluation and Research of Zhejiang University Hangzhou 310058China Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310006China Department of Oncology Hangzhou Cancer HospitalHangzhou 310002China Cancer Center of Zhejiang University HangzhouChina Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHangzhouChina

Non-small cell lung cancer(NSCLC)ranks as one of the leading causes of cancer-related deaths *** the prominence and effectiveness of kinase-target therapies in NSCLC treatment,these drugs are suitable for and beneficial to a mere~30%of NSCLC ***,the need for novel strategies addressing NSCLC remains ***(DUBs),a group of diverse enzymes with well-defined catalytic sites that are frequently overactivated in cancers and associated with tumorigenesis and regarded as promising therapeutic ***,the mechanisms by which DUBs promote NSCLC remain poorly *** a global analysis of the 97 DUBs’contribution to NSCLC survival possibilities using The Cancer Genome Atlas(TCGA)database,we found that high expression of Josephin Domain-containing protein 2.JOSD2.predicted the poor prognosis of *** of JOSD2.significantly impeded NSCLC growth in both cell/patient-derived xenografts in ***,we found that JOSD2.restricts the kinase activity of LKB1,an important tumor suppressor generally inactivated in NSCLC,by removing K6-linked polyubiquitination,an action vital for maintaining the integrity of the LKB1-STRAD-MO2. ***,we identified the first small-molecule inhibitor of JOSD2.and observed that its pharmacological inhibition significantly arrested NSCLC proliferation in vitro/in *** findings highlight the vital role of JOSD2.in hindering LKB1 activity,underscoring the therapeutic potential of targeting JOSD2.in NSCLC,especially in those with inactivated LKB1,and presenting its inhibitors as a promising strategy for NSCLC treatment.

关键词： LKB1 inhibiting removing

先存构造对1985年8月2.日新疆乌恰M_(w)6.9地震地表破裂几何形态和变形样式的制约

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地球科学 2024年第2期49卷 511-521页

作者：赫洪哲李涛陈杰钱黎新疆帕米尔陆内俯冲国家野外科学观测研究站北京100029 中国地震局地质研究所地震动力学国家重点实验室北京100029

1985年8月2.日发生在新疆维吾尔自治区乌恰县境内的M_(w)6.9地震,是有地震仪器记录以来,帕米尔-南天山会聚带内发生的最强地震事件之一,也是碰撞造山带前陆地区少数形成显著地表破裂的强震事件之一.在前人研究工作基础上,我们通过对震后... 详细信息

1985年8月2.日发生在新疆维吾尔自治区乌恰县境内的M_(w)6.9地震,是有地震仪器记录以来,帕米尔-南天山会聚带内发生的最强地震事件之一,也是碰撞造山带前陆地区少数形成显著地表破裂的强震事件之一.在前人研究工作基础上,我们通过对震后Worldview卫星影像、无人机影像、野外调查获得的天然断层露头和人工探槽断层剖面的综合分析,对乌恰地震地表破裂的几何形态、变形样式、下伏断层结构进行了约束.研究表明,地表破裂东段呈弧形展布,其走向、运动性质和下伏断层倾角变化显著;相比较而言,西段虽因后期地表过程改造而非常不连续,其运动性质、走向和下伏断层倾角却更为稳定.由于地表破裂东、西两段分别位于明尧勒背斜南翼向形枢纽的南、北两侧,我们推测这种变形特征的显著差异,可能与向形枢纽两侧先存构造(先存的明尧勒背斜褶皱变形过程中形成的弯滑断层)的发育情况不同有关.

关键词：逆断层地震地表破裂先存构造帕米尔南天山

数字普惠金融与企业纳税遵从——基于企业数字化转型的视角

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税务与经济 2024年第3期 18-31页

作者：赵涛张茜茜中央财经大学财政税务学院北京102206

基于北京大学发布的“数字普惠金融指数”及2.11~2.2.年地区和企业层面数据,利用双向固定效应模型、双重差分模型、工具变量法、中介效应模型等多种计量模型检验我国数字普惠金融对纳税遵从的影响效果和作用机制。结果表明:数字普惠金... 详细信息

基于北京大学发布的“数字普惠金融指数”及2.11~2.2.年地区和企业层面数据,利用双向固定效应模型、双重差分模型、工具变量法、中介效应模型等多种计量模型检验我国数字普惠金融对纳税遵从的影响效果和作用机制。结果表明:数字普惠金融能够显著提高企业的纳税遵从度,且企业数字化转型能够发挥中介效应,该结论在进行一系列稳健性检验后仍然成立;在异质性分析中,该机制在小规模企业、民营企业、中西部企业以及高科技企业中影响效果更加明显。通过建立“数字普惠金融—企业数字化转型—纳税遵从”的理论框架,最终从推动数字普惠金融、建立数据共享平台、促进企业数字化转型三个层面提出政策建议。

关键词：数字普惠金融数字化转型纳税遵从