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Failure mechanisms and destruction characteristics of cemented coal gangue backfill under compression effect of non-uniform load

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Journal of Central South University 2024年第8期31卷 2676-2693页

作者： FENG Guo-rui GUO Wei QI Ting-ye LI Zhu cui Jia-qing WANG Hao-chen cui Ye-{2. MA Jing-{2. College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Province Research Center of Green Mining Engineering Technology Taiyuan 030024China Shanxi Province Coal-based Resources Green and High-efficiency Development Engineering Center Taiyuan 030024China Shanxi Key Laboratory of Mine Rock Strata Control and Disaster Prevention Taiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China

Backfill mining is one of the most important technical means for controlling strata movement and reducing surface subsidence and environmental damage during exploitation of underground coal resources. Ensuring the stability of the backfill bodies is the primary prerequisite for maintaining the safety of the backfilling working face, and the loading characteristics of backfill are closely related to the deformation and subsidence of the roof. Elastic thin plate model was used to explore the non-uniform subsidence law of the roof, and then the non-uniform distribution characteristics of backfill bodies’ load were revealed. Through a self-developed non-uniform loading device combined with acoustic emission (AE) and digital image correlation (DIC) monitoring technology, the synergistic dynamic evolution law of the bearing capacity, apparent crack, and internal fracture of cemented coal gangue backfills (CCGBs) under loads with different degrees of non-uniformity was deeply explored. The results showed that: 1) The uniaxial compressive strength (UCS) of CCGB increased and then decreased with an increase in the degree of non-uniformity of load (DNL). About 40% of DNL was the inflection point of DNL-UCS curve and when DNL exceeded 40%, the strength decreased in a cliff-like manner;2. A positive correlation was observed between the AE ringing count and UCS during the loading process of the specimen, which was manifested by a higher AE ringing count of the high-strength specimen. 3) Shear cracks gradually increased and failure mode of specimens gradually changed from “X” type dominated by tension cracks to inverted “Y” type dominated by shear cracks with an increase in DNL, and the crack opening displacement at the peak stress decreased and then increased. The crack opening displacement at 40% of the DNL was the smallest. This was consistent with the judgment of crack size based on the AE b-value, i. e., it showed the typical characteristics of “small b-value-large crack and

关键词： cemented coal gangue backfill non-uniform load degree of non-uniformity of load failure mode crack opening displacement

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A novel live attenuated vaccine candidate protects chickens against subtype B avian metapneumovirus

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Journal of Integrative Agriculture 2024年第5期23卷 1658-1670页

作者： Lingzhai Meng Mengmeng Yu Suyan Wang Yuntong Chen Yuanling Bao Peng Liu Xiaoyan Feng Tana He Ru Guo Tao Zhang Mingxue Hu Changjun Liu Xiaole Qi kai Li Li Gao Yanping Zhang Hongyu cui Yulong Gao Avian Immunosuppressive Diseases Division State Key Laboratory for Animal Disease Control and PreventionHarbin Veterinary Research InstituteChineseAcademy of Agricultural SciencesHarbin150069China Avian ImmunosuppressiveDiseases DivisionStateKey LaboratoryforAnimal Disease Cont National Poultry Laboratory Animal Resource Center Harbin 150069China

Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the dominant epidemic strain in China. We developed an attenuated aMPV subtype B strain by serial passaging in Vero cells and evaluated its safety and efficacy as a vaccine candidate. The safety test showed that after the 30th passage, the LN16-A strain was fully attenuated, as clinical signs of infection and histological lesions were absent after *** LN16-A strain did not revert to a virulent strain after five serial passages in chickens. The genomic sequence of LN16-A differed from that of the parent wild-type LN16(wtLN16) strain and had nine amino acid mutations. In chickens, a single immunization with LN16-A induced robust humoral and cellular immune responses, including the abundant production of neutralizing antibodies, CD4^(+) T lymphocytes, and the Th1(IFN-γ) and Th2.IL-4 and IL-6)cytokines. We also confirmed that LN16-A provided 100% protection against subtype B aMPV and significantly reduced viral shedding and turbinate inflammation. Our findings suggest that the LN16-A strain is a promising live attenuated vaccine candidate that can prevent infection with subtype B aMPV.

关键词： avian metapneumovirus attenuated protection vaccine candidate chickens

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Identification and distribution of 13003 landslides in the northwest margin of Qinghai-Tibet Plateau based on human-computer interaction remote sensing interpretation

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China Geology 2024年第2期7卷 171-187页

作者： Wei Wang Yuan-dong Huang Chong Xu Xiao-yi Shao Lei Li Li-ye Feng Hui-ran Gao Yu-long cui Shuai Wu Zhi-qiang Yang kai Ma National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of Chin12eijing 100085China School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China School of Civil Engineering and Architecture Anhui University of Science and TechnologyHuainan 232001China No.3 Bureau of China Metallurgical Geology Bureau Taiyuan 030031China

The periphery of the Qinghai-Tibet Plateau is renowned for its susceptibility to ***,the northwestern margin of this region,characterised by limited human activities and challenging transportation,remains insufficiently explored concerning landslide occurrence and *** the planning and construction of the Xinjiang-Tibet Railway,a comprehensive investigation into disastrous landslides in this area is essential for effective disaster preparedness and mitigation *** using the human-computer interaction interpretation approach,the authors established a landslide database encompassing 13003 landslides,collectively spanning an area of 3351.2. km^(2.(36°N-40°N,73°E-78°E).The database incorporates diverse topographical and environmental parameters,including regional elevation,slope angle,slope aspect,distance to faults,distance to roads,distance to rivers,annual precipitation,and *** statistical characteristics of number and area of landslides,landslide number density(LND),and landslide area percentage(LAP)are *** authors found that a predominant concentration of landslide origins within high slope angle regions,with the highest incidence observed in intervals characterised by average slopes of 2.°to 30°,maximum slope angle above 80°,along with orientations towards the north(N),northeast(NE),and southwest(SW).Additionally,elevations above 4.5 km,distance to rivers below 1 km,rainfall between 2.-30 mm and 30-40 mm emerge as particularly susceptible to landslide *** study area’s geological composition primarily comprises Mesozoic and Upper Paleozoic *** fault and human engineering activities have different degrees of influence on landslide ***,the significance of the landslide database,the relationship between landslide distribution and environmental factors,and the geometric and morphological characteristics of landslides are *** landslide H/L ratios in the study area are

关键词： Landslides Human-computer interaction interpretation Landslide database Spatial distribution Earthquake Rainfall Human engineering activity Qinghai-Tibet Plateau Geological hazards survey engineering

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ESG投资赋能民营企业高质量发展的机制分析

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技术经济与管理研究 2024年第5期 147-152页

作者：崔宏楷哈尔滨学院经济管理学院黑龙江哈尔滨150086

选取2.10—2.2.年A股上市民营企业的经验证据,考察ESG投资对民营企业高质量发展的影响效应及作用机制。研究结果表明,ESG投资对资产收益率、环保投入、研发创新有显著的正向促进效应,能够赋能民营企业高质量发展;ESG投资通过缓解融资约... 详细信息

选取2.10—2.2.年A股上市民营企业的经验证据,考察ESG投资对民营企业高质量发展的影响效应及作用机制。研究结果表明,ESG投资对资产收益率、环保投入、研发创新有显著的正向促进效应,能够赋能民营企业高质量发展;ESG投资通过缓解融资约束、提高企业创新能力推动民营企业高质量发展;异质性分析发现,与高创新型、管制型行业相比,ESG投资对低创新型、非管制型行业民营企业高质量发展的正向影响更大;ESG投资与民营企业高质量发展之间的正向关系在营商环境较差企业中更显著。据此,提出构建合理化ESG投资体系、释放ESG投资多元赋能效应、制定个性化民营企业发展策略的政策建议,为推动民营企业高质量发展提供有益参考。

关键词： ESG投资民营企业高质量发展营商环境融资约束企业创新能力

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Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities

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The Innovation 2024年第2期5卷 42-50页

作者： Yali Liu Jianqing Du Yanfen Wang Xiaoyong cui Jichang Dong Pan Gu Yanbin Hao kai Xue Hongbo Duan Anquan Xia Yi Hu Zhi Dong Bingfang Wu Jüurgen P.Kropp Bojie Fu School of Grassland Science Beijing Forestry UniversityBeijing 100083China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China School of Humanities University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China School of Innovation and Entrepreneurship University of Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China Potsdam Institute for Climate Impact Research 14412 PotsdamGermany Institute for Environmental Science and Geography University of Potsdam14412 PotsdamGermany State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Differences in progress across sustainable development goals(SDGs)are widespread globally;meanwhile,the rising call for prioritizing specific SDGs may exacerbate such ***,how these progress differences would influence global sustainable development has been long ***,we present the first quantitative assessment of SDGs’progress differences globally by adopting the SDGs progress evenness *** results highlight that the uneven progress across SDGs has been a hindrance to sustainable development because(1)it is strongly associated with many public health risks(e.g.,air pollution),social inequalities(e.g.,gender inequality,modern slavery,wealth gap),and a reduction in life expectancy;(2.it is also associated with deforestation and habitat loss in terrestrial and marine ecosystems,increasing the challenges related to biodiversity conservation;(3)most countries with low average SDGs performance show lower progress evenness,which further hinders their fulfillment of SDGs;and(4)many countries with high average SDGs performance also showcase stagnation or even retrogression in progress evenness,which is partly ascribed to the antagonism between climate actions and other *** findings highlight that while setting SDGs priorities may be more realistic under the constraints of multiple global stressors,caution must be exercised to avoid new problems from intensifying uneven progress across ***,our study reveals that the urgent needs regarding SDGs of different regions seem complementary,emphasizing that regional collaborations(e.g.,demand-oriented carbon trading between SDGs poorly performed and well-performed countries)may promote sustainable development achievements at the global scale.

关键词： globally priori inequality

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后来者的传承——武汉大学城市设计学院设计拾遗

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建筑学报 2024年第5期 56-59页

作者：喻弢崔愷中国建筑设计研究院有限公司北京100044

初春三月,当北方还是枝头料峭,这里的校园里已是落樱纷飞,满山满树如云似雪,这就是被誉为国内校园风景最美的大学——武汉大学。还是在大学的时候,我就读的学校离武大不远,会时常骑着单车到东湖湖畔的武大校园里游玩写生。

关键词：武汉大学拾遗校园武大

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-Na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing Zhang kai-Wen Liu Na Li Jia-Chen cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

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Rastall gravity:accretion disk image in the context of radiation fields and visual transformations compared to Reissner-Nordström black hole

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Chinese Physics C 2024年第4期48卷 174-182页

作者：黄宇翔郭森梁宇崔宇昊蒋青权林恺 School of Physics and Astronomy China West Normal UniversityNanchong 637000China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Hubei Subsurface Multi-scale Imaging Key Laboratory Institute of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China

In this study,we investigated the astronomical implications of Rastall gravity,particularly its behavior amidst a radiation field compared to Reissner-Nordström(RN)black *** found a crucial correlation between the dynamics of the accretion disk and the parameters Q and Nr,which properly reflect the influence of spacetime metrics on the disk’s *** electric charge Q causes contraction in the disk’s orbit due to enhanced gravitational effects,while higher Nr values lead to outward expansion,influenced by the attributes of the radiation ***,the charged black holes surrounded by radiation fields exhibit distinct visual disparities from RN black *** decreases and expansion occurs within the innermost stable circular orbit of the accretion disk with rising Nr *** study also reveals the process by which the accretion disk transitions from a conventional disk-like structure to a hat-like form at different observation angles,with the redshift effect gradually ***,the results of the considered Rastall gravity radiation field are consistent with the constraints of the gravitational lensing of the host galaxy on Rastall gravity parameters,thereby enhancing the consistency between theoretical predictions and actual observations.

关键词： Rastall theory optical appearance thin accretion disk

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Bowel preparation protocol for hospitalized patients ages 50 years or older:A randomized controlled trial

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World Journal of Gastrointestinal Endoscopy 2024年第1期16卷 18-28页

作者： Yu He Qi Liu Yi-Wen Chen Li-Jian cui kai Cao Zi-Hao Guo Department of Geriatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Gastroenterology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND The incidence and mortality rate of colorectal cancer progressively increase with age and become particularly prominent after the age of 50 ***,the population that is≥50 years in age requires long-term and regular *** bowel preparation is the main reason preventing patients from undergoing regular *** standard bowel preparation regimen of 4-L polyethylene glycol(PEG)is effective but poorly *** To investigate an effective and comfortable bowel preparation regimen for hospitalized patients≥50 years in *** Patients were randomly assigned to group 1(2.L PEG+30-mL lactulose+a lowresidue diet)or group 2.4-L PEG).Adequate bowel preparation was defined as a Boston bowel preparation scale(BBPS)score of≥6,with a score of≥2.for each ***-inferiority was prespecified with a margin of 10%.Additionally,the degree of comfort was assessed based on the comfort *** The proportion of patients with a BBPS score of≥6 in group 1 was not significantly different from that in group 2.as demonstrated by intention-to-treat(91.2.vs 91.0%,P=0.953)and per-protocol(91.8%vs 91.0%,P=0.802.***,in patients≥75 years in age,the proportion of BBPS scores of≥6 in group 1 was not significantly different from that in group 2.90.9%vs 97.0%,P=0.716).Group 1 had higher comfort scores(8.85±1.162.vs 7.59±1.735,P2.4 h vs 5.80±1.730 h,P2.1.183 vs 2.04±1.835,P=0.02.)than group *** For hospitalized patients≥50 years in age,the bowel preparation regimen comprising 2.L PEG+30-mL lactulose+a low-residue diet produced a cleanse that was as effective as the 4-L PEG regimen and even provided better comfort.

关键词： Aged 50 years or older Hospitalized 2.L polyethylene-glycol+30-mL lactulose+a low-residue diet Comfort

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面向6G移动通信的极化多址接入技术

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中兴通讯技术 2024年第1期30卷 19-25页

作者：崔宏基牛凯北京邮电大学泛网无线通信教育部重点实验室中国北京100876

极化码是第一种达到信道容量的编码方案,是5G信道编码方案之一。面对6G更高可靠度、更低时延、更大连接的业务需求,提出面向6G的极化多址接入技术。极化多址接入技术能够充分利用多用户之间的极化效应,以实现更高的系统容量和系统接入... 详细信息

极化码是第一种达到信道容量的编码方案,是5G信道编码方案之一。面对6G更高可靠度、更低时延、更大连接的业务需求,提出面向6G的极化多址接入技术。极化多址接入技术能够充分利用多用户之间的极化效应,以实现更高的系统容量和系统接入能力。有源极化编码接入方案能够满足6G大容量高可靠的传输需求,无源极化编码随机接入方案能够提高系统的接入能力。这些方案表明,极化多址接入技术能够满足6G移动通信系统的超高可靠、高频谱效率、大容量的传输需求,是重要的候选技术之一。

关键词：多址接入极化编码随机接入非正交多址接入

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