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A Study on Solid/melt Interfaces and the Formation of<100> Texture in Solidified FCC metals

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journal of materials Science & Technology 1997年第6期13卷 457-461页

作者： D.Y.Li(Dept. of mater. Sci & Eng., The pennsylvania State university, university park, pA 1680{2. USA )B.Debray and j.A.Szpunar(Dept. of metall. Eng., mcGill university, 3450 Uuiversity street, molitreal, pQ, canada H3A {2.7) Dept. of mater. Sci and Eng. Pennsylvania State University University Park PA 16802 United States Dept. of metall. Eng. McGill University 3450 University Street Montreal PQ H3A 2A7 Canada

The (100) texture of solidified fcc metals, caused by the preferential (100) dendrite growth, could be closeIy related to solid/melt interfaces which behave differently along different crystallographic orientation. The stability and roughness of {111} and {100} solid/melt interfaces of fcc metals were investigated using a modified Temkin multi-layer model. It is demonstrated that {100}crystal/melt interface is more unstable and rougher than {111} interface. The effect of the stability of crystal/melt interface on the (100) texture formation in solidified fcc metals has been analysed and discussed.

关键词： FCC A Study on Solid/melt Interfaces and the Formation of<100 Texture in Solidified FCC metals

An inexact multi-objective programming approach for strategic environmental assessment on regional development plan

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progress in Natural Science:materials International 2004年第11期 14-23页

作者： WANG jihua 1, GUO Huaicheng 1*, LIU Lei 2.*, HAO mingjia 3, ZHANG ming 3, LU Xiaojian 1 and XING Kexia 1(1. College of Environmental Sciences, peking university, Beijing 100871, China 2. department of Civil Engineering, Dalhousie university, Halifax, NS B3j 1Z1, canada 3. Shenyang Institute of Environmental Science, Shenyang 110005, China) CollegeofEnvironmentalSciences PekingUniversityBeijing100871China departmentofCivilEngineering DalhousieUniversityHalifaxNSB3J1Z1Canada ShenyangInstituteofEnvironmentalScience Shenyang110005China

This paper presents the development of an inexact multi-objective programming (ImOp) model and its application to the strategic environmental assessment (SEA) for the regional development plan for the Hunnan New Zone (HNZ) in Shenyang City, China. Inexact programming and multi-objective programming methods are employed to effectively account for extensive uncertainties in the study system and to reflect various interests from different stakeholders, respectively. In the case study, balancing-economy-and-environment scenario and focusing-industry-development scenario are analyzed by the interactive solution process for addressing the preferences from local authorities and compromises among different objectives. Through interpreting the model solutions under both scenarios, analysis of industrial structure, waste water treatment plant (WWTp) expansion, water consumption and pollution generation and treatment are undertaken for providing a solid base to justify and evaluate the HNZ regional development plan. The study results show that the developed ImOp-SEA framework is feasible and applicable in carrying comprehensive environmental impact assessments for development plan in a more effective and efficient manner.

关键词： inexact multi-objective programming regional development plan strategic environmental assessment.

Structure and function of aggrecan

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Cell Research 2002年第1期12卷 19-32页

作者： CHRIS KIANI, LIWEN CHEN, YAO jIONG WU, ALBERT j YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and department of Laboratory medicine and patobiology, 2.department of Surgeny, Faculty of medicine, {2. of toronto, canada Sunnybrook and Women' s College Health Sciences Centre and department of Laboratory medicine and pathobiology University of Toronto Canada Sunnybrook and Women' s College Health Sciences Centre and department of Surgeny Faculty of Medicine University of Toronto Canada

Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2. and G3) and a large extended region (CS) between G2.and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2.is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan.

关键词： proteoglycan chondroitin sulfate glycosaminoglycan G1 domain G3 domain.

ON THE TOTAL DISTANCE BETWEEN NODES IN TREES

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Systems Science and mathematical Sciences 1996年第1期9卷 93-96页

作者： moon,j.W.(mathematics department,university of Alberita,Edmonton,{{2.,T6G {2.1) university of Alberta 加拿大

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关键词： Distance degree tree.

processing of tailings in Canadian oil sands industry

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中国有色金属学会会刊：英文版 2002年第3期12卷 524-528页

作者： j.masliyah (department of Chemical and materials Engineering, university of Alberta, Edmonton Alberta,{{2., T6G {2.6) department of Chemical and materials Engineering University of Alberta Edmonton Alberta Canada T6G 2G6

Vast amounts of tailings are produced daily in bitumen extraction from the Athabasca oil sands. The coarse sand from the tailings stream is used to build dykes around the containment basin. The run off slurry arrives at the water’s edge in the tailings pond at a solids concentration of about 3%～8% by mass. Settling of the solids takes place "relatively fast", over several days, creating a "free water zone" that contains little solids. When the fine mineral solids concentration has reached about 15% by mass, the suspension develops non Newtonian properties. After 2.3 years, the suspension concentration reaches a value of about 30% by mass at which the settling rate becomes extremely slow. methods to handle the already created tailings ponds and new approaches to eliminate the creation of new ones will be discussed both from the industrial and fundamental prospective.

关键词：石油工业加拿大废渣处理沥青抽提

GAS-SOLIDS FLOW BEHAVIOR WITH A GAS VELOCITY CLOSE TO ZERO

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particuology 2006年第Z1期 167-177页

作者： H. Zhang and j.-X. Zhu* department of Chemical Engineering, university of Western{{2., London,{{2., canada N6A 5B9, canada

In a 9.3 m high and 0.10 m i.d. gas-solids downflow fluidized bed (downer), the radial and axial distribu- tions of the local solids holdups and particle velocities along the downer column were measured with the superficial gas velocity set to zero. A unique gas-solids flow structure was found in the downer system with zero gas velocity, which is completely different from that under conditions with higher gas velocities, in terms of its radial and axial flow structures as well as its micro flow structure. The gas-solids flow pattern under zero gas velocity conditions, together with that under low gas velocity conditions, can be considered as a special regime which differs from that under higher gas velocity conditions. According to the hydrodynamic properties of the two regimes, they can be named the “dense annulus” regime for the flow pattern under zero or low gas velocity conditions and the “dense core” regime for that under higher gas ve- locity conditions.

关键词： downer reactor gas-solids cocurrent downflow fluidized bed hydrodynamics flow development particle velocity solids holdup solids flux flow regime

Lercanidipine对心肌病仓鼠心力衰竭过程中冠状反应和重构的作用(英文)

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Acta pharmacologica Sinica 2003年第3期24卷 9-16页

作者： julie mASSICOTTE, Antoine VIENS, ming-Hui YAO~1, Amedeo LEONARDI~2.Giorgio SIRONI~2. Hongbo WANG, Louis DUmONT~3 Département de pharmacologie, faculté de médecine, Universitéde montréal, montréal, QC,{2. H3C 3j7 1~department of pharmacology, School of medicine, Fudan {2., Shanghai 2.0032. China 2.pharmaceutical R&D Division, Recordati SpA, milan, Italy Departement de pharmacologie faculte de medecine Universite de Montreal Montreal QC 加拿大 H3C 3J7 department of pharmacology School of Medicine Fudan University 上海 200032 pharmaceutical R&D Division Recordati SpA Milan Italy

AIm: Lercanidipine is a new vasoselective dihydropyridine calcium channel blocker with a short plasma half-life,long duration of action, and demonstrated cardioprotective properties. We hypothesized that it might be effective at attenuating the adverse impact observed on the coronary compartment and myocardium in the transition phase to heart failure in the Um-X7.1 cardiomyopathic (Cm) hamster. mETHODS: The effects of 4-month exposure to lercanidipine 3 and 10 mg/kg (daily oral administration) Were evaluated in 150-day-old Cm hamsters and in agematched normal hamsters. Coronary reactivity (reactive hyperemia to 30-s coronary occlusion) and the response to the administration of acetylcholine (100 nmol/L) and sodium nitroprusside (1 μmol/L) were assessed monthly, using the isolated perfused heart model. The left ventricular chamber dilatation index and wall thickness, myocardial fibrosis and myocardial capillary density (papillary muscle) were estimated in selected subgroups at monthly intervals. RESULTS

关键词：钙通道阻滞药心肌病冠状血管心力衰竭 lercanidipine 心肌

Ground-based and additional science support for SmILE

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Earth and planetary physics 2024年第1期8卷 275-298页

作者： j.A.Carter m.Dunlop C.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.milan T.Sergienko R.C.Fear D.G.Sibeck m.Connors T.Yeoman X.Tan m.G.G.T.Taylor K.mcWilliams j.Gjerloev R.Barnes D.D.Billet G.Chisham A.Dimmock m.p.Freeman D.-S.Han m.D.Hartinger S.-Y.W.Hsieh Z.-j.Hu m.K.james L.juusola K.Kauristie E.A.Kronberg m.Lester j.manuel j.matzka I.mcCrea Y.miyoshi j.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun m.-T.Walach B.Walsh C.Wang j.Weygand j.Wild j.Yan j.Zhang Q.-H.Zhang planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment monitoring and Information processing Ministry of Industry and Information TechnologyBeijing 100017China department of Space and Climate physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway department of physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space physics KirunaSweden West Highfield Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca university AthabascaCanada ESTEC European Space AgencyNetherlands university of Saskatchewan SaskatoonCanada The johns Hopkins university Applied physics Laboratory LaurelMarylandUSA Swedish Institude of Space physics UppsalaSE 75121Sweden Tongji university Shanghai 200092China Center for Space plasma physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA polar Research Institute of China Shanghai 200136China Finnish meteorological Institute(FmI) Finland department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFZ German Research Centre for Geosciences PotsdamGermany Nagoya university Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria university Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of Sciences Solar wind magnetosphere Ionosphere Link Explorer(SmILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SmILE ***,we describe current community efforts to prepare for SmILE,and the benefits and context various experiments that have explicitly expressed support for SmILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SmILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SmILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SmILE conjunctions missions

Thermal ablation versus conventional regional hyperthermia has greater anti-tumor activity against melanoma in mice by upregulating CD4~+ cells and enhancing IL-2.secretion

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progress in Natural Science:materials International 2009年第12期19卷 1699-1704页

作者： Yingying Zhang~(a,b),Wei Zhang~b,Cuanying Geng~c,Tongjun Lin~d,Xiaowen Wang~b, Lingyun Zhao~b,jintian Tang~(b,*) a department of Oncology,Xiangya Hospital,Central South university,Changsha 410008,China b Institute of medical physics and Engineering,department of Engineering physics,Tsinghua university,Beijing 100084,China c Clinical medical Research Center,China-japan Friendship Hospital,Beijing 10002.,China d department of microbiology & Immunology,department of pediatrics,IWK Health Centre,Dalhousie university,5850 university Avenue, Halifax,NS,canada B3j 3G9 department of Oncology Xiangya Hospital Central South University Changsha 410008 China Institute of medical physics and Engineering Department of Engineering Physics Tsinghua University Beijing 100084 China Clinical medical Research Center China–Japan Friendship Hospital Beijing 100029 China department of microbiology & Immunology Department of Pediatrics IWK Health Centre Dalhousie University 5850 University Avenue Halifax NS Canada B3J 3G9

To determine whether conventional hyperthermia(42.15℃) or ablation therapy(>50℃) achieves better synergistic effects on direct cytotoxicity and anti-tumor immunity,we compared the therapeutic effects of two hyperthermia temperatures,43 and 55℃,in terms of cytotoxicity and upregulation of immune functions in a mouse malignant melanoma ***-bearing mice were treated by directly applying regional hyperthermia to the tumor nodule with a heating light at a temperature of 43℃for 30 min or 55℃for 10 *** tumor growth curve and mice survival rate were *** investigate the hyperthermia-induced immunological response,peripheral blood CD4~+ and CD8~+ T cells and the serum IL-2.level were *** results indicated that application of regional hyperthermia at the ablation temperature(such as 55℃) achieved better synergistic anti-tumor effects than did conventional hyperthermia(43℃).Significant increases in the number of peripheral blood CD4~+ T cells and the serum IL-2.level likely contributed to the underlying mechanism.

关键词： Hyperthermia Thermal ablation melanoma Immunity response