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Comparative study of anti-inflammatory effects of different processed products through the COX-2/PGE2 signaling pathway: based on network pharmacology and molecular docking

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Pharmacology Discovery 2024年第2期4卷 32-45页

作者： Ping Chen yun-yun Quan An-Qi Zeng Ying dai Jin Zeng Translational Chinese Medicine Key Laboratory of Sichuan Province Sichuan Academy of Chinese Medicine SciencesChengdu 610041China Translational Chinese Medicine Key Laboratory of Sichuan Province Sichuan Institute for Translational Chinese MedicineChengdu 610041China

Background:Radix Aconiti Lateralis Preparata(Fu-zi)is a traditional Chinese medicinal herb,which has been widely used in the clinic and has potent anti-inflammatory *** aimed to explore the mechanisms of extract containing alkaloids from different Fu-zi Processed Products(FPP)in treating inflammation,especially rheumatoid arthritis(RA).Methods:Firstly,using network pharmacology technology,the ingredients,and targets of Fu-zi were obtained by searching and screening,the targets involving RA were acquired,the intersection targets were constructed a"component-target-pathway"network.A comprehensive investigation was conducted on the anti-rheumatoid arthritis mechanisms of 5 FPPs in lipopolysaccharide(LPS)induced RAW264.7 cells,which serve as a model for *** production of NO and inflammatory cytokines were measured by ELISA *** Real-time PCR(qRT-PCR)was utilized to measure the mRNA ***-2/PGE2 signaling pathway-associated proteins were determined by western ***:According to a network pharmacological study,16 chemical components and 43 common targets were found in Fu-zi and 6 key targets including PTGS2 were closely related to the mechanism of Fu-zi in treating *** in vitro study revealed that the levels of NO,TNF-α,and IL-1βwere substantially decreased by the 5 *** 5 FPPs significantly suppressed the expression of proteins COX-2,iNOS,and NF-κB,with particularly notable effects observed for PFZ and ***:Altogether,these results demonstrated that the 5 PPS containing alkaloids have a good anti-RA-related inflammatory effect,and the mechanism may be related to COX-2/PGE2 signaling pathway,particularly,Fu-zi prepared utilizing a traditional Chinese technique.

关键词： Radix Aconiti Lateralis Preparata(Fu-zi) rheumatoid arthritis anti-inflammatory network pharmacology COX-2/PGE2 signaling pathway

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Maximizing conditional independence for unsupervised domain adaptation

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Science China(Information Sciences) 2024年第5期67卷 136-149页

作者： Yiming ZHAI Chuanxian REN Youwei LUO Daoqing dai School of Mathematics Sun Yat-Sen University

Unsupervised domain adaptation(UDA) studies how to transfer a learner from a labeled source domain to an unlabeled target domain with different distributions. Existing methods mainly focus on matching marginal distributions of the source and target domains, which probably leads to a misalignment of samples from the same class but different domains. In this paper, we tackle this misalignment issue by achieving the class-conditioned transferring from a new perspective. Specifically, we propose a method named maximizing conditional independence(MCI) for UDA, which maximizes the conditional independence of feature and domain given class in the reproducing kernel Hilbert spaces. The optimization of conditional independence can be viewed as a surrogate for minimizing class-wise mutual information between feature and domain. An interpretable empirical estimation of the conditional dependence measure is deduced and connected with the unconditional case. Besides, we provide an upper bound on the target error by taking the class-conditional distribution into account, which provides a new theoretical insight for class-conditioned transferring. Extensive experiments on six benchmark datasets and various ablation studies validate the effectiveness of the proposed model in dealing with UDA.

关键词： conditional independence kernel method domain adaptation class-conditioned transferring

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Experimental investigation on the gravity driven discharge of cohesive particles from a silo with two outlets

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Particuology 2024年第6期89卷 11-21页

作者： Li dai Zhulin Yuan Fengxian Fan Conghui Gu School of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China Shanghai Key Laboratory of Multiphase Flow and Heat Transfer in Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China

An experimental study on the gravity driven discharge of cohesive particles from a silo with two outlets was *** discharge behaviors under the conditions that a single outlet was open and two outlets were open were investigated by varying the moisture content of the particles and the filling height of the particles in the *** results show that the discharge rate of the cohesive particles increases gradually at the beginning,then almost keeps constant,and finally drops *** discharge rate in case of two openings is around 1.1–1.6 times that in case of a single *** filling height leads to lower discharge rate in case of a single opening but results in higher discharge rate in case of two ***,the avalanche dynamics in case of a single opening was examined,and the mixing behavior of the cohesive particles was *** is observed that the discharge flow is promoted by the avalanche phenomenon in the silo,generating a general trend that the normalized mass of discharge increases with the filling height at higher moisture *** case of a single opening,the transition from mass flow to funnel flow favors the particle mixing,resulting in an increasing mixing index as the moisture content *** general,a better performance of mixing can be achieved in case of a single opening compared with in case of two *** study provides vital information for fundamental understanding of the gravity driven discharge of cohesive particles from the silo with multiple outlets.

关键词： Cohesive particles Moisture content Discharge rate Avalanche Mixing

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Finite-Time Stabilization for Constrained Discrete-time Systems by Using Model Predictive Control

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1656-1666页

作者： Bing Zhu Xiaozhuoer Yuan Li dai Zhiwen Qiang IEEE the Seventh Research Division Beihang UniversityBeijing 100191China the School of Automation Beijing Institute of TechnologyBeijing 100081China

In this paper, a model predictive control(MPC)framework is proposed for finite-time stabilization of linear and nonlinear discrete-time systems subject to state and control constraints. The proposed MPC framework guarantees the finite-time convergence property by assigning the control horizon equal to the dimension of the overall system, and only penalizing the terminal cost in the optimization, where the stage costs are not penalized explicitly. A terminal inequality constraint is added to guarantee the feasibility and stability of the closed-loop *** feasibility can be improved via augmentation. The finite-time convergence of the proposed MPC is proved theoretically,and is supported by simulation examples.

关键词： Constraints deadbeat control finite-time stabilization model predictive control(MPC)

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Grain refinement of 5A06 aluminum alloy welds caused by tungsten inert gas welding arc characteristics under Ar-He alternating gas supply conditions:a coupled method of water-cooled copper plate test/numerical simulation

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Journal of Iron and Steel Research International 2024年第3期31卷 767-777页

作者： Hong-bin dai Jian Miao Jia-xin Lin School of Materials Science and Engineering Harbin University of Science and TechnologyHarbin 150040HeilongjiangChina

The welding arc,as a carrier for the conversion of electrical energy to thermal energy,has a direct impact on the quality of welding by its properties and *** the tungsten inert gas(TIG)welding process under the condition of Ar-He alternating gas supply,the arc is alternately converted between Ar arc and He arc with an alternating gas supply cycle,which has obvious arc change *** FLUENT software was used to numerically simulate the characteristics of the TIG arc under the condition of alternating gas supply,and the arc temperature field,arc pressure,electric potential and current density distribution under the condition of alternating gas supply were *** with the real-time data of arc pressure measured by the water-cooled copper plate with holes,it is proved that the TIG arc has obvious dynamic characteristics under the condition of Ar-He alternating gas *** unique dynamic TIG arc acts on the 5A06 aluminum alloy weld,causing the molten pool to stir,resulting in uniform microstructure and grain refinement at the weld,and thereby improving the mechanical properties of the welded joint.

关键词： Alternating gas supply Grain refinement Numerical simulation Tungsten argon arc morphology Microstructure Mechanical property

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Recent progress in photocatalytic NAD(P)H regeneration for photocatalytic-enzymatic-coupling system

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 1-24页

作者： Wei Lan Maodi Wang Huicong dai Qihua Yang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Zhejiang Key Laboratory for Reactive Chemistry on Solid SurfacesInstitute of Physical ChemistryZhejiang Normal UniversityJinhua 321004China

The enzymatic redox reactions in natural photosynthesis rely much on the participation of cofactors,with reduced nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate(NADH/NADPH)or their oxidized form(NAD+/NADP+)as an important redox *** photocatalytic regeneration of expensive and unstable NADH/NADPH in vitro is an important process in enzymatic reduction and has attracted much research *** different types of photocatalysts have been developed for photocatalytic NADH/NADPH regeneration,the efficiency is still relatively *** elucidate the key factors affecting the performance of photocatalytic NADH/NADPH regeneration is helpful to rationally design the photocatalyst and improve the photocatalytic *** this paper,we overview the recent progress in photocatalytic NADH/NADPH regeneration with the focus on the strategies to improve the visible light adsorption,the charge separation and migration efficiency,as well as the surface reaction,which jointly determine the overall photocatalytic regeneration *** potential development of photocatalytic NADH/NADPH regeneration and photocatalyticenzymatic-coupling system is prospected finally.

关键词： photocatalytic-enzymatic coupling NAD(P)H regeneration photocatalysis efficiency

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Aerodynamic characteristics of a pitching airfoil with leading-edge morphing

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Chinese Journal of Aeronautics 2024年第7期37卷 81-92页

作者： Chaoyuan WEN Yuting dai yuntao XU Chao YAng School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Tianmushan Laboratory Hangzhou 311115China

This paper focuses on the effect of the phase offset of Leading-Edge(LE)morphing on the aerodynamic characteristics of a pitching NACA0012 *** an unstretched camber and using polynomial interpolation,an explicit expression for LE nonlinear morphing is proposed and implemented for the large pitching motion of the *** field results and aerodynamic forces are obtained by solving the unsteady Reynolds-averaged Navier-Stokes equations for both the airfoil’s pitching motion and LE ***,the index of instantaneous aerodynamic power is used to quantify the work done by the airflow in a dynamic *** to the instantaneous aerodynamic power and energy map,which denotes the energy transfer between the airfoil’s oscillation and flow field,the airfoil is subject to stall *** results show that LE morphing with an optimal phase offset of 315°reduces the energy extraction from the flow field,suppressing the stall flutter *** optimal phase offset is effective at different pitching axis positions of the *** results signify that LE morphing can suppress stall flutter by advancing the occurrence of the first LE vortex and increasing the nose-down moment during the upstroke period.

关键词： Aerodynamics Computational fluid dynamics Leading-edge morphing OpenFOAM Dynamic stall Dynamic mesh

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Microwave-accelerated direct regeneration of LiCoO_(2)cathodes for Li-ion batteries

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Science China Chemistry 2024年第7期67卷 2181-2189页

作者： Xueshan Hu yun-Chao Yin Chao Li Lihui Zhou Lin Yang Yitian Feng Daxian Zuo Chenhui Ning Das Soham Sheng dai Longbin Qiu Lin Zeng Haw Jiunn Woo Jiayu Wan Future Battery Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Centre for Ionics University of Malaya Department of PhysicsFaculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Natural and Applied Sciences Duke Kunshan UniversityKunshan 215316China

Recycling spent lithium-ion batteries is integral to today's low-carbon environmental protection *** concept of direct regeneration,acknowledged for its environmental sustainability,economic viability,and consistent performance of recycled materials,is gaining *** study presents an efficient and nondestructive approach by utilizing an ultrafast microwave technology to directly regenerate spent lithium cobaltate(LCO)cathode *** contrast to conventional furnacebased processes,this method significantly reduces the regeneration *** subjecting the spent LCO mixed with lithium sources to three microwave heating cycles(at approximately 1,350 K),LCO regeneration is achieved,yielding a specific capacity of 140.8 mAh g^(-1)(0.2 C)with a robust cycle *** further environmental and economic benefits,the ultrafast microwave technology holds scientific promise for directly regenerating cathode materials,while establishing competitiveness for industrial applications.

关键词： battery recycling spent lithium cobaltate microwave directly regeneration cathode materials

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Construction of conjugated scaffolds driven by mechanochemistry towards energy storage applications

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Green Chemical Engineering 2024年第2期5卷 155-172页

作者： Juntian Fan Zhenzhen Yang Sheng dai Department of Chemistry Institute for Advanced Materials and ManufacturingUniversity of TennesseeKnoxvilleTN37996USA Chemical Sciences Division Oak Ridge National LaboratoryOak RidgeTN37831USA

Mechanochemistry has been recognized as an efficient and sustainable methodology to provide a unique driven force and reaction environments under ambient and neat conditions for the construction of functionalized materials possessing promising *** them,highly porous conjugated scaffolds with attractive electronic conductivities and high surface areas are one of the representative categories exhibiting diverse taskspecific applications,especially in electrochemical energy *** recent years,the mechanochemistry-driven procedures have been deployed to construct conjugated scaffolds with engineered structures and properties leveraging the tunability in chemical structures of building blocks and polymerization capability of diverse ***,a thorough review of related works is required to gain an in-depth understanding of the mechanochemical synthesis procedure and property-performance relationship of the as-produced conjugated ***,the mechanochemistry-driven construction of conjugated porous networks(CPNs),the carbon-based materials(e.g.,graphite and graphyne),and carbon supported single atom catalysts(CS-SACs)are discussed and *** electrochemical performance of the afforded conductive scaffolds as electrode materials in supercapacitors and alkali-ion batteries is ***,the challenges and potential opportunities related to the construction of conjugated scaffolds driven by mechanochemistry are also discussed and concluded.

关键词： Mechanochemistry Conjugated scaffolds Porous organic networks Alkali-ion battery Supercapacitor

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GCAGA: A Gini Coefficient-Based Optimization Strategy for Computation Offloading in Multi-User-Multi-Edge MEC System

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Computers, Materials & Continua 2024年第6期79卷 5083-5103页

作者： Junqing Bai Qiuchao dai Yingying Li School of Computing Xi’an Shiyou UniversityXi’an710065China Product Center Wingtech Technology(Wuxi)Co.Wuxi214028China

To support the explosive growth of Information and Communications Technology(ICT),Mobile Edge Comput-ing(MEC)provides users with low latency and high bandwidth service by offloading computational tasks to the network’s ***,resource-constrained mobile devices still suffer from a capacity mismatch when faced with latency-sensitive and compute-intensive emerging *** address the difficulty of running computationally intensive applications on resource-constrained clients,a model of the computation offloading problem in a network consisting of multiple mobile users and edge cloud servers is studied in this *** a user benefit function EoU(Experience of Users)is proposed jointly considering energy consumption and time *** EoU maximization problem is decomposed into two steps,i.e.,resource allocation and offloading *** offloading decision is usually given by heuristic algorithms which are often faced with the challenge of slow convergence and poor ***,a combined offloading algorithm,i.e.,a Gini coefficient-based adaptive genetic algorithm(GCAGA),is proposed to alleviate the *** proposed algorithm optimizes the offloading decision by maximizing EoU and accelerates the convergence with the Gini *** simulation compares the proposed algorithm with the genetic algorithm(GA)and adaptive genetic algorithm(AGA).Experiment results show that the Gini coefficient and the adaptive heuristic operators can accelerate the convergence speed,and the proposed algorithm performs better in terms of convergence while obtaining higher *** simulation code of the proposed algorithm is available:https://***/Grox888/Mobile_Edge_Computing/tree/GCAGA.

关键词： Mobile edge computing multi-user-multi-edge joint optimization Gini coefficient adaptive genetic algorithm

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