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Express,on of the novel adipokine ClqTNF-related protein 4 （CTRP4） suppresses colitis and colitis- associated colorectal cancer in mice

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Cellular & Molecular Immunology 2016年第5期13卷 688-699页

作者： Yang Luo Xiaotong Wu Zhuang ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang Department of Immunology Key Laboratory of Medical Immunology (Ministry of Health) School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China Department of Pathology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China These authors contributed equally to the article. Correspondence: Dr L Wang MD PhD Department of Immunology Key Laboratory of Medical Immunology (Ministry of Health) School of Basic Medical Sciences Peking University Health Science Center 38# Xueyuan Road Beijing 100191 China

Inflammatory bowel disease （IBD） is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer （CAC） models induced using both dextran sulfate sodium （DSS） and the azoxymethane/DSS protocol were established in wild-type （WT） and CTRP4 transgenic （CTRP4-tg） C57BL6/J mice. Body weight, stool consistency and the presence of blood in the stool were analyzed; tumor quantity, size and histological characteristics were analyzed during the development of CAC. The CTRP4-tg mice exhibited significantly reduced colitis and developed far fewer macroscopic tumors; these tumors were smaller in size, and a majority of the colon tumors in these mice were restricted to the superficial mucosa. Tumors of lower grades were observed in the CTRP4-tg mice. Interleukin-6 was markedly downregulated in the CTRP4-tg mice during CAC tumorigenesis. The phosphorylation of ERK, signal transducer and activator of transcription 3 and Akt in the colon and the proliferation of intestinal epithelial cells were decreased in the CTRP4-tg mice. The injection of recombinant CTRP4 protein significantly reduced the colitis symptoms of the WT mice. CTRP4 plays an important role in inflammation and inflammation-associated colon tumorigenesis, and our research may provide a novel method for the treatment of IBD and CAC.

关键词： CAC CTRP4 DSS/AOM IBD

基于线性四分树的空间关键词最近邻查询方法研究

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计算机应用与软件 2018年第11期35卷 81-88,107页

作者：于启迪吴雷马昂石家庄铁道大学经济管理学院河北石家庄050043 燕山大学信息科学与工程学院河北秦皇岛066004

随着移动互联网的快速发展和智能移动设备的广泛普及,空间文本对象的数量在不断增大,随之而来的是开展空间关键词查询技术的研究。Top-k空间关键词搜索是从空间数据库中探索有用信息的重要途径。近年来已经提出了各种各样的混合索引技术... 详细信息

随着移动互联网的快速发展和智能移动设备的广泛普及,空间文本对象的数量在不断增大,随之而来的是开展空间关键词查询技术的研究。Top-k空间关键词搜索是从空间数据库中探索有用信息的重要途径。近年来已经提出了各种各样的混合索引技术,主要是将R树和倒排表结合起来,从而同时执行空间修剪和文本修剪。然而,随着数据量的快速增长,在索引维护成本和查询处理时间两个方面对现有的方法提出了很大的挑战。针对这一问题,在改进的线性四分树的基础上,提出一种基于自适应虚拟四分树的空间关键词最近邻查询算法Avqt。在真实数据上进行实验验证,结果表明该算法的有效性。

关键词：自适应线性四分树空间文本对象最近邻查询空间关键词查询移动计算

First report on establishment and characterization of the extrahepatic cholangiocarcinoma sarcoma cell line CBC2T-2

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World Journal of Gastroenterology 2023年第41期29卷 5683-5698页

作者： Ning-Zu Jiang Ming-Zhen Bai Chong-Fei Huang Ze-Long ma Ru-Yang Zhong Wen-Kang Fu Long Gao Liang Tian Ning-Ning Mi Hai-Dong ma Ya-Wen Lu Zi-ang Zhang Jin-Yu Zhao Hai-Ying Yu Bao-Ping Zhang Xian-Zhuo Zhang Yan-Xian Ren Chao Zhang Yong Zhang Ping Yue Yan-Yan Lin Wen-Bo Meng The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou University and Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu ProvinceLanzhou 730000Gansu ProvinceChina

BACKGROUND Extrahepatic cholangiocarcinoma sarcoma is extremely rare in clinical *** cells consist of both epithelial and mesenchymal ***-derived cell lines that maintain tumor characteristics are valuable tools for studying the molecular mechanisms associated with ***,cholangiocarcinoma sarcoma cell lines are not available in cell *** To establish and characterize a new extrahepatic cholangiocarcinoma sarcoma cell line,namely *** We conducted a short tandem repeat(STR)test to confirm the identity of the CBC2T-2 cell ***,we assessed the migratory and invasive properties of the cells and performed clonogenicity assay to evaluate the ability of individual cells to form *** tumorigenic potential of CBC2T-2 cells was tested in vivo using nonobese diabetic/severe combined immunodeficient(NOD/SCID)*** cells were injected subcutaneously and tumor formation was *** addition,immunohistochemical analysis was carried out to examine the expression of epithelial marker CK19 and mesenchymal marker vimentin in both CBC2T-2 cells and *** CBC2T-2 cell line was used to screen the potential therapeutic effects of various clinical agents in patients with cholangiocarcinoma ***,whole-exome sequencing was performed to identify genetic alterations and screen for somatic mutations in the CBC2T-2 cell *** The STR test showed that there was no cross-contamination and the results were identical to those of the original *** cells showed round or oval-shaped epithelioid cells and mesenchymal cells with spindle-shaped or elongated *** cells exhibited a high proliferation ratio with a doubling time of 47.11 *** cell line has migratory,invasive,and clonogenic *** chromosomes in the CBC2T-2 cells were polyploidy,with numbers ranging from 69 to *** subcutaneous tumorigenic assay confirmed the in vivo tumorigenic ability of CBC2T-2 cells in NOD/

关键词： Carcinosarcoma Drug resistance Xenograft Cell line Establishment

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电站锅炉常规无损检测技术与新技术

工程技术研究 2019年第18期4卷 87-89页

作者：马昂中国特种设备检测研究院

电站锅炉是火力发电厂的三大主机之一,其设备复杂,运行工况为高温高压的极端环境,一旦失效将导致蒸汽泄漏或爆炸等严重后果,无损检测技术可以降低设备发生失效的概率。文章分阶段(制造、安装、定期检验)地对无损检测技术的应用进行阐述... 详细信息

电站锅炉是火力发电厂的三大主机之一,其设备复杂,运行工况为高温高压的极端环境,一旦失效将导致蒸汽泄漏或爆炸等严重后果,无损检测技术可以降低设备发生失效的概率。文章分阶段(制造、安装、定期检验)地对无损检测技术的应用进行阐述;分析了电站锅炉应用无损检测技术的重要性;阐述了电站锅炉无损检测新技术的应用,包括定量光谱分析、TOFD、相控阵超声检测、X射线数字成像和声发射检测;对未来电站锅炉的无损检测技术发展方向进行总结,指出了急需发展的方向。

关键词：电站锅炉制造检验安装监督检验定期检验无损检测新技术

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1株溶磷青霉的溶磷特性及抗真菌作用

吉林农业大学学报 2024年第3期46卷 457-464页

作者：尚宁张伟王丽李孝军马桂云崔俊涛吉林农业大学资源与环境学院长春130118 长春职业技术学院长春130033 长春市朝阳区农业技术推广总站长春130012 长春市土壤肥料工作站长春130033 吉林省德惠市植物检疫站长春130300

以1株多功能的溶磷青霉(Penicillium sp. 18)为研究对象,在纯培养条件下,对其溶磷和聚磷特性进行初步研究。结果表明:溶磷青霉能够利用难溶的Ca_(3)(PO_(4))_(2),AlPO_(4),FePO_(4)为唯一磷源生长,并表现出溶解难溶磷酸盐释放有效磷的特... 详细信息

以1株多功能的溶磷青霉(Penicillium sp. 18)为研究对象,在纯培养条件下,对其溶磷和聚磷特性进行初步研究。结果表明:溶磷青霉能够利用难溶的Ca_(3)(PO_(4))_(2),AlPO_(4),FePO_(4)为唯一磷源生长,并表现出溶解难溶磷酸盐释放有效磷的特性,在培养的第5天,溶液中有效磷质量浓度分别达到392.27,53.37,62.84 mg/L;溶磷青霉与已报道的溶磷菌株的区别为具有聚磷特性,在好氧条件下,随着培养时间的延长,菌体生物量和摄磷量均呈增加趋势,在培养第5天时,菌体干质量及摄磷量分别为1.65 g和16.89 mg/L,溶液中84%的有效磷被吸收到菌丝体内,形成大量多聚磷酸盐,即异染颗粒;不同碳源、氮源和环境因子对青霉菌株的生长和摄磷作用影响不同;在生长繁殖方面,葡萄糖和铵盐具有促进作用;摄磷方面,小分子有机酸(乙酸盐和丙酸盐)和好氧条件下有利于其摄磷。分析和讨论青霉菌株的聚磷特性及其驱动因素,提出根据聚磷菌“好氧吸磷、厌氧释磷”特性,在生产实践中,通过耕作、灌溉或水旱轮作等农业措施调节土壤溶解氧的含量,调控该类菌株在土壤无机磷转化过程中的作用,进而调节土壤有效磷含量,改善作物的磷素营养状况和提高磷肥利用率。

关键词：青霉菌溶磷特性抗真菌作用难溶磷聚磷能力

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监控信息系统网络安全策略实践

江苏电机工程 2006年第1期25卷 73-74页

作者：马昂徐州发电有限公司江苏徐州221166

对火电厂厂级监控信息系统的安全提出了要求,分析了SIS安全隔离方案存在的问题。结合江苏徐州发电有限公司的实际应用,介绍了该公司具有特色安全隔离方法及网络拓扑结构,阐述了监控信息系统与分散控制系统、管理信息系统等安全隔离的具... 详细信息

对火电厂厂级监控信息系统的安全提出了要求,分析了SIS安全隔离方案存在的问题。结合江苏徐州发电有限公司的实际应用,介绍了该公司具有特色安全隔离方法及网络拓扑结构,阐述了监控信息系统与分散控制系统、管理信息系统等安全隔离的具体实施。

关键词： SIS网络安全隔离高速串口 XML Web传输

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基于粒子群的动态无功优化

控制工程 2019年第1期26卷 150-154页

作者：董昂马立新上海理工大学光电信息与计算机工程学院上海200093

传统的无功优化针对某一电网络的瞬时时刻进行的无功优化,动态无功优化以全天负荷变化曲线为负荷依据,实行全天的无功控制,从而降低整条网络的无功损耗。实际电力系统中各节点负荷随时间变化而改变,传统静态无功优化难以实现。采用粒子... 详细信息

传统的无功优化针对某一电网络的瞬时时刻进行的无功优化,动态无功优化以全天负荷变化曲线为负荷依据,实行全天的无功控制,从而降低整条网络的无功损耗。实际电力系统中各节点负荷随时间变化而改变,传统静态无功优化难以实现。采用粒子群算法根据静态时无功优化,确定网络中的控制设备动作次数。从而每个时段控制设备的预动作,再根据研究当前时段的设备的动作情况进行优化,进一步完成实际运行中负荷变化的动态无功优化。建立动态模型运用于IEEE14节点系统中进行仿真,验证其可行性。

关键词：动态无功优化粒子群分时段

椎旁肌间隙入路选择性减压及短节段融合术对多节段腰椎管狭窄并腰椎失稳患者术后疼痛程度及腰椎功能的影响

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四川生理科学杂志 2024年第1期46卷 174-177页

作者：吕超马胜利赵强信阳市第三人民医院骨科河南信阳464000 信阳市中心医院骨科河南信阳464000

目的:探究短节段融合联合椎旁肌间隙(Wiltse)入路选择性减压治疗多节段腰椎管狭窄(Lumbar Spinal Stenosis,LSS)并腰椎失稳(Lumbar segmental instability,LSI)患者的效果。方法:选取我院2020年2月至2022年12月间收治的174例多节段LSS并... 详细信息

目的:探究短节段融合联合椎旁肌间隙(Wiltse)入路选择性减压治疗多节段腰椎管狭窄(Lumbar Spinal Stenosis,LSS)并腰椎失稳(Lumbar segmental instability,LSI)患者的效果。方法:选取我院2020年2月至2022年12月间收治的174例多节段LSS并LSI患者,按随机数字表法分成研究组和对照组(n=87)。研究组接受短节段融合联合Wiltse入路选择性减压术治疗,对照组接受长节段融合联合后正中入路全狭窄节段减压治疗。对比两组手术指标、手术效果、椎间融合情况,手术前后采用日本矫形外科学会(Japanese Orthopaedic Association,JOA)评分、视觉模拟评分法(Visual Analogue Score,VAS)评分评估腰椎功能、疼痛程度,并以酶联免疫法测定应激指标,如肾素(Renin,R)、乳酸脱氢酶(Lactate dehydrogenase,LDH)、血管紧张素Ⅱ(angiotensin Ⅱ,angⅡ)、肌红蛋白(Myoglobin,MYO)水平,同时记录并发症发生率。结果:与对照组对比,研究组术后引流量、术中失血量更少,手术耗时更短(P1 m、3 m研究组JOA评分更高,VAS评分更组低(P1%(77/87)对比,研究组97.70%(85/87)更高,与对照组融合节段100.00%(207/207)对比,研究组44.81%(95/212)更低(P1 d、3 d研究组血清R、LDH、angⅡ、MYO水平均更低(P16.09%(14/87)对比,研究组3.45%(3/87)更低(P<0.05)。结论:短节段融合联合Wiltse入路选择性减压术治疗多节段LSS并LSI患者效果显著,可优化手术指标,减少椎间融合及并发症,减轻疼痛感,提高腰椎功能,且具备微创特点。

关键词：椎旁肌间隙腰椎管狭窄腰椎失稳应激

Kinetics of non-catalyzed hydrolysis of tannin in high temperature liquid water

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第5期9卷 401-406页

作者： Li-li LU Xiu-yang LU Nan ma Institute of Pharmaceutical Engineering Department of Chemical and Biochemical Engineering Zhejiang University Hangzhou 310027 China

High temperature liquid water(HTLW) has drawn increasing attention as an environmentally benign medium for organic chemical reactions,especially acid-/base-catalyzed reactions. Non-catalyzed hydrolyses of gallotannin and tara tannin in HTLW for the simultaneous preparation of gallic acid(GA) and pyrogallol(PY) are under investigation in our laboratory. In this study,the hydrolysis kinetics of gallotannin and tara tannin were determined. The reaction is indicated to be a typical consecutive first-order one in which GA has formed as a main intermediate and PY as the final product. Selective decomposition of tannin in HTLW was proved to be possible by adjusting reaction temperature and time. The present results provide an important basic data and reference for the green preparation of GA and PY.

关键词： High temperature liquid water Gallotannin Tara tannin Non-catalyzed hydrolysis Kinetics