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Effects of hydroxyproline supplementation in low fish meal diets on collagen synthesis, myofiber development and muscular texture of juvenile Pacific white shrimp(Litopenaeus vannamei)

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Animal Nutrition 2024年第2期17卷 428-437页

作者： Menglin Shi Haoming Li Tianyu chen Bocheng Huang Xiaoyue Li Xiaohui Dong Shuyan Chi qihui Yang Hongyu Liu Junming Deng Beiping Tan Shuang Zhang Shiwei Xie Laboratory of Aquatic Nutrition and Feed College of Fisheries Guangdong Ocean University Aquatic Animals Precision Nutrition and High-Efficiency Feed Engineering Research Centre of Guangdong Province Key Laboratory of Aquatic Livestock and Poultry Feed Science and Technology in South China Ministry of Agriculture Guangdong Provincial Key Lab of Aquatic Animals Disease Control and Healthy Culture

This experiment aimed to evaluate the impact of dietary hydroxyproline(Hyp) supplementation on the muscle quality of juvenile Pacific white shrimp(Litopenaeus vannamei) fed a low fishmeal diet. Six formulated diets included one high fishmeal(HF; 25% fishmeal content) and five low fishmeal diets(1.%fishmeal content) with 0%, 0.2%, 0.4%, 0.6% and 0.8% Hyp(LF0, LF2, LF4, LF6 and LF8, respectively). Each diet was assigned to four replicates, and 40 shrimp(0.32 ± 0.00 g) per replicate were fed four times a day for 8 weeks. Dietary Hyp supplementation had little effects on growth performance, but increased the contents of Hyp, prolyl 4-hydroxylases(P4Hs), and collagen. The meat yield, springiness, hardness,chewiness, and cohesiveness of muscle were the highest in the LF4 group among the low fishmeal groups(P 1., col1.1. col1.2, igf-1., tgf-β and tor and down-regulated the mRNA expression of smyhc1. smyhc2,smyhc6a(P 1.P-AKT, AKT and P-AKT/AKT(P < 0.05). These results suggested that the addition of 0.4% Hyp to low fishmeal diets improved the muscle quality of L. vannamei.

关键词： Hydroxyproline Collagen Muscle quality Litopenaeus vannamei

Innovative integration of lung ultrasound and wearable monitoring for predicting pulmonary complications in colorectal surgery:A prospective study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2649-2661页

作者： chen Lin Pei-Pei Wang Zi-Yan Wang Guo-Ru Lan Kai-Wen Xu Chun-Hua Yu Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China School of Medicine Tsinghua UniversityBeijing 100084China Department of Anesthesiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Clinical Laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Postoperative pulmonary complications(PPCs)are common in patients who undergo colorectal *** have focused on how to accurately diagnose and reduce the incidence of *** ultrasound has been proven to be useful in preoperative monitoring and postoperative care after cardiopulmonary ***,lung ultrasound has not been studied in abdominal surgeries and has not been used with wearable devices to evaluate the influence of postoperative ambulation on the incidence of *** To investigate the relationship between lung ultrasound scores,PPCs,and postoperative physical activity levels in patients who underwent colorectal *** In this prospective observational study conducted from November 1.201. to August 1.2020,patients who underwent colorectal surgery underwent daily bedside ultrasonography from the day before surgery to postoperative day(POD)*** ultrasound scores and PPCs were recorded and analyzed to investigate their *** bracelets measured the daily movement distance for 5 days post-surgery,and the correlation between postoperative activity levels and lung ultrasound scores was *** Thirteen cases of PPCs was observed in the cohort of 1.1.*** mean(standard deviation)peak lung ultrasound score was 5.32(2.52).Patients with a lung ultrasound score of≥6 constituted the high-risk ***-risk lung ultrasound scores were associated with an increased incidence of PPCs after colorectal surgery(logistic regression coefficient,1.71.;odds ratio,5.556).Postoperative movement distance was negatively associated with the lung ultrasound scores[Spearman’s rank correlation coefficient(r),-0.356,P<0.05].CONCLUSION Lung ultrasound effectively evaluates pulmonary condition post-colorectal *** ambulation and respiratory exercises in the initial two PODs will reduce PPCs and optimize postoperative care in patients undergoing colorectal surgery.

关键词： Colorectal cancer Pulmonary complications Lung ultrasound Wearable devices Respiratory exercises

A novel multi-threshold coupling InAlN/GaN double-channel HEMT for improving transconductance flatness

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Science China(Information Sciences) 2024年第1期67卷 314-315页

作者： Sirui AN Minhan MI Pengfei WANG Sijia LIU qing ZHU Meng ZHANG Zhihong chen Jielong LIU Siyin GUO Can GONG Xiaohua MA Yue HAO School of Microelectronics Xidian University School of Advanced Materials and Nanotechnology Xidian University Hubei Jiufengshan Laboratory

GaN-based HEMTs have significant advantages, making them a prime choice for high-frequency, high-power switching [1.. However, the inherent poor linearity of GaN HEMT has yet to be solved, which can be reflected by the nonlinearity of the transconductance (Gm) profile [2]. This makes it hard to achieve high data transmission efficiency and less signal distortion in the wireless communication system [3].

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富含三酰甘油的脂蛋白胆固醇对老年患者冠状动脉病变的预测及评估价值分析

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中华老年心脑血管病杂志 2024年第5期26卷 527-530页

作者：齐炜丛洪良天津大学胸科医院心内科天津市心血管病研究所300222

目的探讨富含三酰甘油的脂蛋白胆固醇(TRL-C)水平与老年冠心病患者冠状动脉病变严重程度的相关性。方法选择2020年1.1.至2020年1.月31.在天津市胸科医院就诊并行冠状动脉造影检查的老年冠心病患者220例,根据SYNTAX评分将患者分为轻... 详细信息

目的探讨富含三酰甘油的脂蛋白胆固醇(TRL-C)水平与老年冠心病患者冠状动脉病变严重程度的相关性。方法选择2020年1.1.至2020年1.月31.在天津市胸科医院就诊并行冠状动脉造影检查的老年冠心病患者220例,根据SYNTAX评分将患者分为轻度冠状动脉病变组1.8例(1.22分)和中重度冠状动脉病变组62例(≥23分)。用logistic回归分析和ROC曲线分析。结果与轻度冠状动脉病变组比较,中重度冠状动脉病变组白蛋白、载脂蛋白A、血小板计数显著降低,肌钙蛋白T、N末端B型钠尿肽前体、TRL-C显著升高(P1.。多因素logistic回归分析显示,TRL-C是冠状动脉病变的危险因素(OR=4.450,95%CI:1.572~1..599,P=0.005),白蛋白是冠状动脉病变的保护因素(OR=0.880,95%CI:0.794~0.977,P=0.01.)。ROC曲线分析显示,TRL-C诊断中重度冠状动脉病变的曲线下面积为0.655(95%CI:0.580~0.731.。结论TRL-C对我国老年冠心病患者的冠状动脉病变严重程度具有预测价值,对中重度冠状动脉病变有一定评估价值。

关键词：冠状动脉疾病脂蛋白类预测 logistic模型富含三酰甘油的脂蛋白胆固醇

Heavy metal availability and impact on activity of soil microorganisms along a Cu/Zn contamination gradient

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Journal of Environmental Sciences 2007年第7期19卷 848-853页

作者： WANG Yuan-peng SHI Ji-yan LIN qi chen Xin-cai chen Ying-xu Department of Chemical and Biochemical Engineering College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China. Department of Environmental Science and Technology Zhejiang University Hangzhou 310029 China

All the regulations that define a maximum concentration of metals in the receiving soil are based on total soil metal concentration. However, the potential toxicity of a heavy metal in the soil depends on its speciation and availability. We studied the effects of heavy metal speciation and availability on soil microorganism activities along a Cu/Zn contamination gradient. Microbial biomass and enzyme activity of soil contaminated with both Cu and Zn were investigated. The results showed that microbial biomass was negatively affected by the elevated metal levels. The microbial biomass-C （Cmic）/organic C （Corg） ratio was closely correlated to heavy metal stress. There were negative correlations between soil microbial biomass, phosphatase activity and NH4NO3 extractable heavy metals. The soil microorganism activity could be predicted using empirical models with the availability of Cu and Zn. We observed that 72% of the variation in phosphatase activity could be explained by the NH4NO3-extractable and total heavy metal concentration. By considering different monitoring approaches and different viewpoints, this set of methods applied in this study seemed sensitive to site differences and contributed to a better understanding of the effects of heavy metals on the size and activity of microorganisms in soils. The data presented demonstrate the relationship between heavy metals availability and heavy metal toxicity to soil microorganism along a contamination gradient.

关键词： heavy metals availability speciation activity soil microorganism

黄芪多糖通过减轻免疫炎症抑制病毒性肝炎小鼠肝损伤

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中国免疫学杂志 2024年第3期40卷 556-563页

作者：陈辰胡丽霞武汉市第一医院武汉430000

目的:观察黄芪多糖对病毒性肝炎小鼠肝损伤的影响,并探讨其是否能通过调控核苷酸结合寡聚化结构域1.NOD1./受体相互作用蛋白2(RIP2)/核转录因子-κB(NF-κB)通路介导的免疫炎症发挥肝保护作用。方法:将60只雌性C3H/HeJ小鼠,采用随机数... 详细信息

目的:观察黄芪多糖对病毒性肝炎小鼠肝损伤的影响,并探讨其是否能通过调控核苷酸结合寡聚化结构域1.NOD1./受体相互作用蛋白2(RIP2)/核转录因子-κB(NF-κB)通路介导的免疫炎症发挥肝保护作用。方法:将60只雌性C3H/HeJ小鼠,采用随机数字表法分为建模组(50只)和正常组(1.只)。建模组采用3型鼠肝炎病毒(MHV-3)腹腔注射建立病毒性肝炎小鼠模型,并于确定建模成功后将存活小鼠采用随机数字表法分为胸腺肽组(1.μg)、黄芪多糖低、中、高剂量组(腹腔注射1.0、200、400 mg/kg黄芪多糖冻干溶于1.ml/1.0 g体质量的生理盐水)、模型组。模型组和正常组予以等量生理盐水腹腔注射,各组均每天给药1.,连续1.月。结果:经肝组织苏木素-伊红(HE)染色和病毒空斑数检测证实建模成功;与正常组比较,模型组小鼠肝脏指数,血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、肿瘤坏死因子-α(TNF-α)、IL-1.、IL-8水平,肝组织病毒空斑数,肝组织NOD1.RIP2、NF-κB p65表达与p-NF-κB p65水平均升高(P1.、IL-8水平,肝组织病毒空斑数,肝组织NOD1.RIP2、NF-κB p65表达与p-NF-κB p65水平均下降(P0.05)。结论:黄芪多糖可改善病毒性肝炎小鼠的肝功能,减轻炎症反应和肝组织病理改变,降低病毒水平,推测与抑制NOD1.RIP2/NF-κB通路,下调NOD1.RIP2、NF-κB p65 mRNA与蛋白表达,抑制NF-κB p65磷酸化有关,且高剂量的黄芪多糖效果最佳,并优于胸腺肽-α1.

关键词：黄芪多糖核苷酸结合寡聚化结构域1 受体相互作用蛋白2 核转录因子-κB 免疫炎症病毒性肝炎肝损伤

Structural basis of negative regulation of CRISPR-Cas7-1. by TPR-CHAT

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2716-2725页

作者： Tian Hong qinghua Luo Haiyun Ma Xin Wang Xinqiong Li Chongrong Shen Jie Pang Yan Wang Yuejia chen Changbin Zhang Zhaoming Su Haohao Dong Xiaodi Tang Department of Laboratory Medicine State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduChina Frontiers Medical Center Tianfu Jincheng LaboratoryWest China HospitalSichuan UniversityChengduChina

CRISPR‒Cas7-1. is a Type Ⅲ-E CRISPR-associated nuclease that functions as a potent RNA editing ***-peptide repeat fused with Cas/HEF1.associated signal transducer(TPR-CHAT)acts as a regulatory protein that interacts with CRISPR RNA(crRNA)-bound Cas7-1. to form a CRISPR-guided caspase complex(Craspase).However,the precise modulation of Cas7-1.’s nuclease activity by TPR-CHAT to enhance its utility requires further ***,we report cryo-electron microscopy(cryo-EM)structures of Desulfonema ishimotonii(Di)Cas7-1.-crRNA,complexed with or without the full length or the N-terminus of *** structures unveil the molecular features of the Craspase *** analysis,combined with in vitro nuclease assay and electrophoretic mobility shift assay,reveals that DiTPR-CHAT negatively regulates the activity of DiCas7-1. by preventing target RNA from binding through the N-terminal 65 amino acids of DiTPR-CHAT(DiTPR-CHAT_(NTD)).Our work demonstrates that DiTPRCHAT_(NTD) can function as a small unit of DiCas7-1. regulator,potentially enabling safe applications to prevent overcutting and offtarget effects of the CRISPR‒Cas7-1. system.

关键词： CRISPR crRNA TPR

Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury

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Neural Regeneration Research 2024年第11期19卷 2499-2512页

作者： Jiang Cao Xiao Yu Jingcheng Liu Jiaju Fu Binyu Wang Chaoqin Wu Sheng Zhang Hongtao chen Zi Wang Yinyang Xu Tao Sui Jie Chang Xiaojian Cao Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Trauma Surgery Subei People’s Hospital of JiangsuClinical Medical College of Yangzhou UniversityYangzhouJiangsu ProvinceChina Department of Orthopedics Zhongda HospitalSoutheast UniversityNanjingJiangsu ProvinceChina Department of Orthopedic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina

The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord ***,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arthritis,and managing inflammatory cytokine *** studies have shown the neuroprotective potential of ruxolitinib in neurological trauma,the exact mechanism by which it enhances functional recovery after spinal cord injury,particularly its effect on astrocytes,remains *** address this gap,we established a mouse model of T1. spinal cord contusion and found that ruxolitinib effectively improved hindlimb motor function and reduced the area of spinal cord *** sequencing analysis showed that ruxolitinib alleviated inflammation and immune response after spinal cord injury,restored EAAT2 expression,reduced glutamate levels,and alleviated excitatory ***,ruxolitinib inhibited the phosphorylation of JAK2 and STAT3 in the injured spinal cord and decreased the phosphorylation level of nuclear factor kappa-B and the expression of inflammatory factors interleukin-1.,interleukin-6,and tumor necrosis factor-α.Additionally,in glutamate-induced excitotoxicity astrocytes,ruxolitinib restored EAAT2 expression and increased glutamate uptake by inhibiting the activation of STAT3,thereby reducing glutamate-induced neurotoxicity,calcium influx,oxidative stress,and cell apoptosis,and increasing the complexity of dendritic ***,these results indicate that ruxolitinib restores glutamate homeostasis by rescuing the expression of EAAT2 in astrocytes,reduces neurotoxicity,and effectively alleviates inflammatory and immune responses after spinal cord injury,thereby promoting functional recovery after spinal cord injury.

关键词： astrocytes EAAT2 excitotoxicity glutamate homeostasis JAK-STAT pathway locomotor function neurotoxicity ruxolitinib spinal cord injury transcriptome analysis

Mallows Model Averaging Estimation for Linear Regression Model with Right Censored Data

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Acta Mathematicae Applicatae Sinica 2022年第1期38卷 5-23页

作者： Zhong-qi LIANG Xiao-lin chen Yan-qiu ZHOU School of Statistics and Mathematics Zhejiang Gongshang UniversityHangzhou 310018China School of Statistics Qufu Normal UniversityQufu 273165China School of Science Guangxi University of Science and TechnologyLiuzhou 545006China

This paper is concerned with an optimal model averaging estimation for linear regression model with right censored data. The weights for model averaging are picked up via minimizing the Mallows criterion. Under some mild conditions, it is shown that the identified weights possess the property of asymptotic optimality, that is,the model averaging estimator corresponding to these weights achieves the lowest squared error *** numerical studies are conducted to evaluate the finite-sample performance of our method and make comparisons with its intuitive competitors, while an application to the PBC dataset is provided to serve as an illustration.

关键词： model averaging right censoring asymptotic optimality synthetic data