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Cisplatin-based miRNA delivery strategy inspired by the circCPNE1.miR-330-3p pathway for oral squamous cell carcinoma

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2748-2760页

作者： Hua-yang fan Ming-da Zhao Hong-jie Jiang Zhen-wei yu yu-jiang fan Xin-hua Liang Ya-ling Tang Yong Sun State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral Pathology West China Hospital of StomatologySichuan UniversityChengdu 610041China

Circular RNAs(circRNAs)are ideal biomarkers of oral squamous cell carcinoma(OSCC)because of their highly stable closed-loop structure,and they can act as microRNA(miRNA)sponges to regulate OSCC *** analyzing clinical samples,we identified circCPNE1.a dysregulated circRNA in OSCC,and its expression level was negatively correlated with the clinical stage of OSCC ***-of-function assays revealed the tumor-suppressive effect of circCPNE1.which was then identified as a miR-330-3p ***-330-3p was recognized as a tumor promoter in multiple studies,consistent with our finding that it could promote the proliferation,migration,and invasion of OSCC *** results indicated that selective inhibition of miR-330-3p could be an effective strategy to inhibit OSCC ***,we designed cationic polylysine-cisplatin prodrugs to deliver antagomiR-330-3p(a miRNA inhibitory analog)via electrostatic interactions to form PP@miR nanoparticles(NPs).Paratumoral administration results revealed that PP@miR NPs effectively inhibited subcutaneous tumor progression and achieved partial tumor elimination(2/5),which confirmed the critical role of miR-330-3p in OSCC *** findings provide a new perspective for the development of OSCC treatments.

关键词： Oral squamous cell carcinoma CircRNA MiRNA sponge Antagomir MiRNA delivery Cisplatin-based nanoparticles Drug delivery systems Tumor elimination

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Outer-surface Covering of Nanochannels with Hydrogel for Highly Sensitive and Specific Cr(VI)Detection Through Analyte-caused Charge Change in Hydrogel

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Chemical Research in Chinese Universities 2024年第2期40卷 326-332页

作者： LIU Huan SUN Xueting DAI yu ZHANG Xiaojin XIA fan Faculty of Materials Science and Chemistry China University of GeosciencesWuhan430074P.R.China

Nanochannels have made great progress and are a promising platform for detecting a series of ***,most nanochannels are modified on the inner wall,while ignoring the outer ***,we modified the outer surface of nanochannels with *** from other reported outer-surface modification methods,we directly cover nanochannels with hydrogel to form heterogeneous *** selected hydrogel hardly adsorbs other ions and shows specific adsorption for Cr(VI).The adsorption sites in hydrogel are homogeneous,and Cr(VI)adsorption onto hydrogel is endothermic and *** charge in hydrogel changes after Cr(VI)adsorption,and the resulting current changes can be used for the detection of Cr(VI)with the detection limit of 1.−1. mol/*** platform is expected to be used for Cr(VI)detection in living organisms,especially within *** work provides a new approach for outer-surface modification of nanochannels and offers a new choice for nanochannel detection platforms.

关键词： Nanochannel Hydrogel Heterogeneous membrane Cr(VI)detection

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Cross-Project Software Defect Prediction Based on SMOTE and Deep Canonical Correlation Analysis

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Computers, Materials & Continua 2024年第2期78卷 1687-1711页

作者： Xin fan Shuqing Zhang Kaisheng Wu Wei Zheng yu Ge School of Software Nanchang Hangkong UniversityNanchang330063China Software Testing and Evaluation Center Nanchang Hangkong UniversityNanchang330063China

Cross-Project Defect Prediction(CPDP)is a method that utilizes historical data from other source projects to train predictive models for defect prediction in the target ***,existing CPDP methods only consider linear correlations between features(indicators)of the source and target *** models are not capable of evaluating non-linear correlations between features when they exist,for example,when there are differences in data distributions between the source and target *** a result,the performance of such CPDP models is *** this paper,this paper proposes a novel CPDP method based on Synthetic Minority Oversampling Technique(SMOTE)and Deep Canonical Correlation Analysis(DCCA),referred to as *** Correlation Analysis(CCA)is employed to address the issue of non-linear correlations between features of the source and target projects.S-DCCA extends CCA by incorporating the MlpNet model for feature extraction from the *** redundant features are then eliminated by maximizing the correlated feature subset using the CCA loss ***,cross-project defect prediction is achieved through the application of the SMOTE data sampling *** Under Curve(AUC)and F1.scores(F1.are used as evaluation *** paper conducted experiments on 27 projects from four public datasets to validate the proposed *** results demonstrate that,on average,our method outperforms all baseline approaches by at least 1.2%in AUC and 5.5%in F1.*** indicates that the proposed method exhibits favorable performance characteristics.

关键词： Cross-project defect prediction deep canonical correlation analysis feature similarity

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Microstructure evolution,mechanical properties and fracture behavior of Al-xSi/AZ91. bimetallic composites prepared by a compound casting

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Journal of Magnesium and Alloys 2024年第5期12卷 1944-1964页

作者： Guangyu Li Wenming Jiang Feng Guan Junwen Zhu Yang yu Zitian fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In this paper,the effect of the Si content on microstructure evolution,mechanical properties,and fracture behavior of the Al-xSi/AZ91. bimetallic composites prepared by compound casting was investigated *** obtained results showed that all the Al-xSi/AZ91. bimetallic composites had a metallurgical reaction layer(MRL),whose thickness increased with increasing Si content for the hypoeutectic Al-Si/AZ91. composites,while the hypereutectic Al-Si/AZ91. composites were *** MRL included eutectic layer(E layer),intermetallic compound layer(IMC layer)and transition region layer(T layer).In the IMC layer,the hypereutectic Al-Si/AZ91. composites contained some Si solid solution and flocculent Mg_(2)Si+Al-Mg IMCs phases not presented in the hypoeutectic Al-Si/AZ91. ***,increasing Si content,the thickness proportion of the T layer increased,forming an inconsistent preferred orientation of the *** shear strengths of the Al-xSi/AZ91. bimetallic composites enhanced with increasing Si content,and the Al-1.Si/AZ91. composite obtained a maximum shear strength of 58.6 MPa,which was 73.4% higher than the Al-6Si/AZ91. *** fractures of the Al-xSi/AZ91. bimetallic composites transformed from the T layer into the E layer with the increase of the Si *** improvement of the shear strength of the Al-xSi/AZ91. bimetallic composites was attributed to the synergistic action of the Mg_(2)Si particle reinforcement,the reduction of oxidizing inclusions and the ratio of Al-Mg IMCs as well as the orientation change of the MRL.

关键词： Al/Mg bimetallic composites Si content Mg_(2)Si reinforcement Microstructure Mechanical properties Fracture behavior

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Solid-state lithium-ion batteries for grid energy storage:opportunities and challenges

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Science China Chemistry 2024年第1期67卷 43-66页

作者： Xin Chang yu-Ming Zhao Boheng yuan Min fan Qinghai Meng yu-Guo Guo Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The energy crisis and environmental pollution drive more attention to the development and utilization of renewable *** the capricious nature of renewable energy resource,it has difficulty supplying electricity directly to consumers stably and efficiently,which calls for energy storage systems to collect energy and release electricity at peak *** to their flexible power and energy,quick response,and high energy conversion efficiency,lithium-ion batteries stand out among multiple energy storage technologies and are rapidly deployed in the *** superior performance and ensuring the safety of energy storage systems,intrinsically safe solid-state electrolytes are expected as an ideal alternative to liquid *** this review,we systematically evaluate the priorities and issues of traditional lithium-ion batteries in grid energy *** lithium-ion batteries containing liquid electrolytes,solid-state lithium-ion batteries have the potential to play a more significant role in grid energy *** challenges of developing solid-state lithium-ion batteries,such as low ionic conductivity of the electrolyte,unstable electrode/electrolyte interface,and complicated fabrication process,are discussed in ***,the safety of solid-state lithium-ion batteries is *** the obtained insights,inspiring prospects for solid-state lithium-ion batteries in grid energy storage are depicted.

关键词： lithium-ion batteries grid energy storage solid-state electrolytes interface stability

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Ultra-high sensitivity fiber optic microphone with corrugated graphene-oxide diaphragm for voice recognition

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Nano Research 2024年第8期17卷 7593-7602页

作者： Yang Liu Cheng Li Lingxiao yu Zhengwei Wu Shangchun fan Ruitao Lv School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Shenzhen Institute of Beihang University Shenzhen 518063China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100190China

To avoid interference from unexpected background noises and obtain high fidelity voice signal,acoustic sensors with high sensitivity,flat frequency response,and high signal-to-noise ratio(SNR)are urgently needed for voice ***(GO)has received extensive attention due to its advantages of controllable thickness and high fracture ***,low mechanical sensitivity(SM)introduced by undesirable initial stress limits the performance of GO material in the field of voice *** alleviate the aforementioned issue,GO diaphragm with annular corrugations is *** means of the reusable copper mold machined by picosecond laser,the fabrication and transfer of corrugated GO diaphragm are realized,thus achieving a Fabry–Perot(F–P)acoustic *** from the structural advantage of the corrugated GO diaphragm,our F–P acoustic sensor exhibits high S_(M)(43.70 nm/Pa@1. kHz),flat frequency response(−3.2 to 3.7 dB within 300–3500 Hz),and high SNR(76.66 dB@1.kHz).In addition,further acoustic measurements also demonstrate other merits,including an excellent frequency detection resolution(0.01.Hz)and high time stability(output relative variation less than 6.7% for 90 min).Given the merits presented before,the fabricated F–P acoustic sensor with corrugated GO diaphragm can serve as a high-fidelity platform for acoustic detection and voice *** conjunction with the deep residual learning framework,high recognition accuracy of 98.4%is achieved by training and testing the data recorded by the fabricated F–P acoustic sensor.

关键词： corrugated graphene-oxide(GO)diaphragm Fabry-Perot(F-P)acoustic sensor mechanical sensitivity voice recognition

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Combined effects of ultrasonic vibration and FeCoNiCrCu coating on interfacial microstructure and mechanical properties of Al/Mg bimetal by compound casting

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China Foundry 2024年第5期21卷 588-598页

作者： yuan-cai Xu Wen-ming Jiang Qing-qing Li Ling-hui yu Xiao-peng yu Zi-tian fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In this work,a new treatment method combining ultrasonic vibration with FeCoNiCrCu high entropy alloy(HEA)coating was used to prepared Al/Mg bimetal through the lost foam compound *** effects of composite treatment involving ultrasonic vibration and HEA coating on interfacial microstructure and mechanical properties of Al/Mg bimetal were *** demonstrate that the interface thickness of the Al/Mg bimetal with composite treatment significantly decreases to only 26.99%of the thickness observed in the untreated Al/Mg *** HEA coating hinders the diffusion between Al and Mg,resulting the significant reduction in Al/Mg intermetallic compounds in the *** Al/Mg bimetal interface with composite treatment is composed of Al_(3)Mg_(2)and Mg_(2)Si/AlxFeCoNiCrCu+FeCoNiCrCu/δ-Mg+Al_(1.)Mg_(1.)eutectic *** interface resulting from the composite treatment has a lower hardness than that without *** acoustic cavitation and acoustic streaming effects generated by ultrasonic vibration promote the diffusion of Al elements within the HEA coating,resulting in a significant improvement in the metallurgical bonding quality on the Mg *** fracture position shifts from the Mg side of the Al/Mg bimetal only with HEA coating to the Al side with composite *** shear strength of the Al/Mg bimetal increases from 32.1. MPa without treatment to 63.44 MPa with ultrasonic vibration and HEA coating,increasing by 97.26%.

关键词： ultrasonic vibration FeCoNiCrCu HEA coating Al/Mg bimetal interfacial microstructure shear strength compound casting

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Recent advances in droplet-based microfluidics in liquid biopsy for cancer diagnosis

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Droplet 2024年第1期3卷 1-27页

作者： Jingyu Shi yu Zhang Yadi fan Yi LiuMo Yang Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Mechanical and Automotive Engineering Royal Melbourne Institute of TechnologyMelbourneAustralia

Liquid biopsy,a noninvasive technique to obtain tumor information from body fluids,is an emerging technology for cancer diagnosis,prognosis,and monitoring,providing crucial support for the realization of precision *** main biomarkers of liquid biopsy include circulating tumor cells,circulating tumor DNA,microRNA,and circulating tumor *** liquid biopsy detection methods include flow cytometry,immunoassay,polymerase chain reaction(PCR)-based methods,and next-generation sequencing(NGS)-based methods,which are time-consuming,labor-intensive,and cannot reflect cell ***-based microfluidics with high throughput,low contamination,high sensitivity,and single-cell/single-molecule/single-exosome analysis capabilities have shown great potential in the field of liquid *** review aims to summarize the recent development in droplet-based microfluidics in liquid biopsy for cancer diagnosis.

关键词： diagnosis biopsy fluid

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Artificial selection of the Green Revolution gene Semidwarf 1.is implicated in upland rice breeding

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Journal of Integrative Agriculture 2024年第3期23卷 769-780页

作者： Shuliang Jiao Qinyan Li fan Zhang Yonghong Tao Yingzhen yu fan Yao Qingmao Li Fengyi Hu Liyu Huang Key Laboratory of Biology and Germplasm Innovation of Perennial Rice Ministry of Agriculture and Rural Affairs/School of AgricultureYunnan UniversityKunming 650091China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Wenshan Academy of Agricultural Sciences Wenshan 663000China

Semidwarf breeding has boosted crop production and is a well-known outcome from the first Green Revolution. The Green Revolution gene Semidwarf 1.SD1., which modulates gibberellic acid(GA) biosynthesis, plays a principal role in determining rice plant height. Mutations in SD1.reduce rice plant height and promote lodging resistance and fertilizer tolerance to increase grain production. The plant height mediated by SD1.also favors grain yield under certain conditions. However, it is not yet known whether the function of SD1.in upland rice promotes adaptation and grain production. In this study, the plant height and grain yield of irrigated and upland rice were comparatively analyzed under paddy and dryland conditions. In response to dryland environments, rice requires a reduction in plant height to cope with water deficits. Upland rice accessions had greater plant heights than their irrigated counterparts under both paddy and dryland conditions, and appropriately reducing plant height could improve adaptability to dryland environments and maintain high grain yield formation. Moreover, upland rice cultivars with thicker stem diameters had stronger lodging resistance, which addresses the lodging problem. Knockout of SD1.in the upland rice cultivar IRAT1.4 reduced the plant height and grain yield, demonstrating that the adjustment of plant height mediated by SD1.could increase grain production in dryland fields. In addition, an SD1.genetic diversity analysis verified that haplotype variation causes phenotypic variation in plant height. During the breeding history of rice, SD1.allelic mutations were selected from landraces to improve the grain yield of irrigated rice cultivars, and this selection was accompanied by a reduction in plant height. Thus, five known mutant alleles were analyzed to verify that functional SD1.is required for upland rice production. All these results suggest that SD1.might have undergone artificial positive selection in upland rice, which provides

关键词： Green Revolution Semidwarf 1 high-yield breeding upland rice plant height

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BreedingAIDB: A database integrating crop genome-to-phenotype paired data with machine learning tools applicable to breeding

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Plant Communications 2024年第7期5卷 12-15页

作者： Zijie Shen Enhui Shen Kun Yang Zuoqian fan Qian-Hao Zhu Longjiang fan Chu-yu Ye Hainan Institute Zhejiang UniversitySanya 572025China Institute of Crop Science&Institute of Bioinformatics College of Agriculture&BiotechnologyZhejiang UniversityHangzhou 310058China CSIRO Agriculture and Food CanberraACT 2601Australia

Machine learning(ML)is one of the key technologies for next-generation breeding,and“big data”is the cornerstone for development of ML algorithms that are applicable to crop breeding ***,there is a shortage of databases containing phenotype data and corresponding genomic data,i.e.,genome-to-phenotype(G2P)paired data,that can be used in the development of ML algorithms for *** fill this gap,we constructed a user-friendly database named the BreedingAIDB(http://***/BreedingAIDB)to provide breeders and ML experts with easily accessible G2P paired data for crops,as well as ML tools.

关键词： database learning breeding

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