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Temperature-sensitive cytoophidium assembly in Schizosaccharomyces pombe

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Journal of Genetics and Genomics 2019年第9期46卷 423-432页

作者： jing Zhang Ji-Long {1. MRC Functional Genomics Unit Department of PhysiologyAnatomy and GeneticsUniversity of OxfordOxford0X13PTUnited Kingdom School of Life Science and Technology ShanghaiTech UniversityShanghai201210China

The metabolic enzyme CTP synthase(CTPS) is able to compartmentalize into filaments,termed cytoophidia,in a variety of organisms including bacteria,budding yeast,fission yeast,fruit flies and mammals.A previous study in budding yeast shows that the filament-forming process of CTPS is not sensitive to temperature *** we study CTPS filamentation in the fission yeast Schizosaccharomyces *** our surprise,we find that both the length and the occurrence of cytoophidia in *** decrease upon cold shock or heat *** temperature-dependent changes of cytoophidia are fast and *** advantage of yeast genetics,we demonstrate that heat-shock proteins are required for cytoophidium assembly in *** sensitivity of cytoophidia makes *** an attractive model system for future investigations of this novel membraneless organelle.

关键词： CTP synthase Cytoophidium Schizosaccharomyces pombe Heat-shock protein Nucleoside/nucleotide metabolism Cell biology Yeast genetics Cell compartmentalization

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中成药均一化投料研究策略

中国中药杂志 2024年第16期49卷 4537-4544页

作者：刘佳萌刘岩彭佳慧孙博杨晶凡付钰马生军朱广伟中国中医科学院中药研究所北京100700 河南中医药大学河南郑州450046 北京中医药大学北京102488 中国医学科学院医药生物技术研究所北京100050 新疆农业大学食品科学与药学学院新疆乌鲁木齐830052 中国中医科学院博士后科研流动站北京100700

中成药是中医药产业的重要组成部分,也是中医药现代化的重要标志。目前,中成药制剂批间质量稳定性问题成为制约中药产业高质量发展的关键因素之一,投料饮片质量不均一是影响该问题的直接因素。该文就提高中成药投料饮片质量的均一性问题... 详细信息

中成药是中医药产业的重要组成部分,也是中医药现代化的重要标志。目前,中成药制剂批间质量稳定性问题成为制约中药产业高质量发展的关键因素之一,投料饮片质量不均一是影响该问题的直接因素。该文就提高中成药投料饮片质量的均一性问题,提出了均一化投料研究方案。分别从均一化对象及前处理、均一化投料操作规程、均一化评价指标的选择、均一化投料算法、均一化投料工艺等方面进行系统阐述,依据关键质控指标作为均一化目标,探讨均一化投料工艺及其质量分析,形成中成药均一化投料示范性工艺策略,以期为推进中成药制剂批间质量一致性研究提供科学依据。

关键词：中成药中药制剂质量标准均一性均一化投料

Large Deviation for Supercritical Branching Processes with Immigration

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Acta Mathematica Sinica,English Series 2016年第8期32卷 893-900页

作者： jing Ning {1. Mei ZHANG School of Mathematical Sciences Laboratory of Mathematics and Complex SystemsBeijing Normal University

In this paper, we study the large deviation for a supercritical branching process with immigration controlled by a sequence of non-negative integer-valued independently identical distributed random variables, improving the previous results for non immigration processes. We rely heavily on the detail description and limit property of the generating function of immigration processes.

关键词： Supercritical branching processes large deviation immigration

Induced Lie Algebras of a Six-Dimensional Matrix Lie Algebra

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Communications in Theoretical Physics 2008年第8期50卷 289-294页

作者： ZHANG Yu-Feng liu {1. Mathematical School Liaoning Normal University Dalian 116029 China

By using a six-dimensional matrix Lie algebra [*** and ***,***.A 360 (2006) 92], three induced Lie algebras are *** of them is obtained by extending Lie bracket,the others are higher- dimensional complex Lie algebras constructed by using linear *** equivalent Lie algebras of the later two with multi-component forms are obtained as *** their applications,we derive an integrable coupling and quasi-Hamiltonian structure of the modified TC hierarchy of soliton equations.

关键词： Lie algebra soliton equation Hamiltonian structure

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新型解冻技术及其在水产品中应用进展

粮食与油脂 2024年第3期37卷 1-3,10页

作者：胡航伟张楠楠刘云国程晶晶游新侠郑州科技学院食品科学与工程学院河南郑州450064 临沂大学生命科学学院山东临沂276000

介绍了微波解冻、超声波解冻等新型解冻技术的基本原理、特点及其在水产品中的应用现状,以期为高效低耗水产品解冻技术的开发及工业化应用提供相关指导。

关键词：解冻技术水产品品质特性

Optimal Investment and Excess of Loss Reinsurance with Short-selling Constraint

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Acta Mathematicae Applicatae Sinica 2011年第3期27卷 527-534页

作者： Sheng liu {1.-xiao Zhang Center for Applied Statistics School of Statistics Renmin University of China Beijing 100872 China

This paper considers the optimal control problem with constraints for an insurance company. The risk process is assumed to be a jump-diffusion process and the risk can be reduced through an excess of loss （XL） reinsurance. In addition, the surplus can be invested in the financial market. In the financial market, the short-selling constraint is one of the main factors which make models more realistic. Our goal is to find the optimal investment-reinsurance policy without short-selling, which maximizes the expected exponential utility of the terminal wealth. By solving the corresponding Hamilton-Jacobi-Bellman equation, the value function and the optimal investment-reinsurance policy are given in a closed form.

关键词： Hamilton-Jacobi-Bellman equation jump-diffusion process short-selling constraint XL reinsurance

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沙漠资源利用——沙漠砂混凝土研究

价值工程 2024年第26期43卷 148-150页

作者：刘铮瑶黄荆陕西省地质调查院陕西省地质环境监测总站(陕西省地质灾害中心) 西安710054 长安大学建筑工程学院西安710061 自然资源部矿山地质灾害成灾机理与防控重点实验室西安710054

我国沙漠资源丰富,随着我国基础建设的不断发展,对于用砂需求量不断增加,而目前的砂大多采用的是河砂,这造成了河砂资源的短缺,为有效缓解建设用砂的供需矛盾,采用沙漠砂替换或部分替换河砂制备沙漠砂混凝土,既可满足绿色发展要求,又极... 详细信息

我国沙漠资源丰富,随着我国基础建设的不断发展,对于用砂需求量不断增加,而目前的砂大多采用的是河砂,这造成了河砂资源的短缺,为有效缓解建设用砂的供需矛盾,采用沙漠砂替换或部分替换河砂制备沙漠砂混凝土,既可满足绿色发展要求,又极大地缓解了砂的供需矛盾,因此,沙漠砂混凝土的力学性能成为研究的热点。回顾总结了沙漠砂混凝土的主要力学性能,并对目前提出的沙漠砂混凝土抗压本构模型进行了梳理,最后提出了沙漠砂混凝土的发展展望及有价值的研究方向。

关键词：沙漠砂沙漠砂混凝土本构关系力学性能

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Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia:a prospective,single arm,phase I trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2250-2259页

作者： Yunfei Chen Yanmei Xu Ying Chi Ting Sun Yuchen Gao Xueqing Dou Zhibo Han Feng Xue Huiyuan Li Wei liu Xiaofan liu Huan Dong Rongfeng Fu Mankai Ju Xinyue Dai Wentian Wang Yueshen Ma Zhen Song Jundong Gu Wei Gong Renchi Yang Lei Zhang State Key Laboratory of Experimental Hematology National Clinical Research Centre for Blood DiseasesHaihe Laboratory of Cell EcosystemTianjin Key Laboratory of Gene Therapy for Blood DiseasesCAMS Key Laboratory of Gene Therapy for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215006China National Engineering Research Centre of Cell Products Tianjin Key Laboratory of Engineering Technologies for Cell PharmaceuticalAmCellGene Engineering Co.LtdTianjin 300457China School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College100730 BeijingChina

Patients with refractory immune thrombocytopenia(ITP)frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing *** cord-derived mesenchymal stem cells(UC-MSCs)present a promising alternative,capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune *** prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory *** research design included administering UC-MSCs at escalating doses of 0.5×1.^(6)cells/kg,1.0×1.^(6)cells/kg,and 2.0×1.^(6)cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase,followed by a dose of 2.0×1.^(6)cells/kg weekly for the dose-expansion *** events,platelet counts,and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up ***,1.(with an addition of three patients in the 2.0×1.^(6)cells/kg group due to dose-limiting toxicity)and six patients were enrolled in the dose-escalation and dose-expansion phase,*** patients(1./1.,72.2%)experienced one or more treatment emergent adverse *** adverse events occurred in four patients(4/1.,22.2%),including gastrointestinal hemorrhage(2/4),profuse menstruation(1.4),and acute myocardial infarction(1.4).The response rates were 41.7%in the dose-escalation phase(5/1.,two received 1.0×1.^(6)cells/kg per week,and three received 2.0×1.^(6)cells/kg per week)and 50.0%(3/6)in the dose-expansion *** overall response rate was 44.4%(8/1.)among all enrolled *** sum up,UC-MSCs are effective and well tolerated in treating refractory ITP(*** ID:NCT0401.1.6).

关键词： doses immunity treatment

CT征象联合血清外泌体CDH5鉴别直径5~30 mm磨玻璃样肺腺癌浸润的价值

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现代生物医学进展 2024年第16期24卷 3128-3133页

作者：赵波李京京刘永利王景诗张晶晶董旭鹏河北医科大学附属秦皇岛市第一医院影像科河北秦皇岛066000 秦皇岛市海港医院CT室河北秦皇岛066000

目的:探究CT征象联合血清外泌体钙粘蛋白5(CDH5)鉴别直径5~30 mm磨玻璃样肺腺癌浸润的价值。方法:选取1.4例CT表现为磨玻璃样肺腺癌(腺体前驱病变和腺癌)患者和20例良性肺结节患者作为研究对象。用蛋白质免疫印迹法检测外泌体CDH5水平... 详细信息

目的:探究CT征象联合血清外泌体钙粘蛋白5(CDH5)鉴别直径5~30 mm磨玻璃样肺腺癌浸润的价值。方法:选取1.4例CT表现为磨玻璃样肺腺癌(腺体前驱病变和腺癌)患者和20例良性肺结节患者作为研究对象。用蛋白质免疫印迹法检测外泌体CDH5水平。比较肺腺癌和良性肺结节患者外泌体CDH5水平;比较肺腺癌非浸润和浸润患者的CT征象和外泌体CDH5水平差异。用Logistic回归分析肺腺癌浸润的风险因素。用受试者工作特征(ROC)曲线、平均绝对误差和决策曲线分析(DCA)评价模型价值。结果:肺腺癌患者血清外泌体CDH5水平低于良性肺结节患者(P1.肺腺癌未浸润的保护因素(P1.00,模型B的净收益高于模型A。结论:混合磨玻璃结节、毛刺征、瘤肺界面不清晰和外泌体CDH5均与肺腺癌浸润有关,由上述因素构成的模型可辅助评估5~30 mm磨玻璃样肺腺癌是否浸润。

关键词：肺腺癌 CT征象外泌体 CDH5 浸润