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Single-cell RNA sequencing reveals abnormal transcriptome signature of erythroid progenitors in pure red cell aplasia

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Genes & Diseases 2024年第1期11卷 49-52页

作者： Yumei liu Haiyue Niu Jie Ren Zhiqin Wang Li Yan Limin Xing Zonghong Shao Rong Fu Zhigang Cai Huaquan Wang Department of Hematology Tianjin Medical University General HospitalTianjin 300052China School of Basic Medical Sciences Tianjin Medical UniversityTianjin 300070China

Pure red cell aplasia(PRCA)is a bone marrow failure syndrome characterized by severe anemia,reticulocytopenia,selective reduction,and even the absence of bone marrow erythroid precursors,while leukocyte and platelet counts are normal.1.Acquired PRCA can be divided into primary and *** are mediated by immune *** in the quantity and dysfunction of committed erythroid progenitors(EPs),including burst forming uniterythroid(BFU-E)and colony forming unit-erythroid(CFU-E),may be the source of reduced erythropoiesis and needs to be elucidated.

关键词： progenitor anemia leukocyte

Bioinspired design of integral molded Janus silk fibroin-MXene evaporator for efficient solar vapor generation

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Nano Research 2024年第4期17卷 2824-2835页

作者： Ling-Qing Kong Zhi-Cheng Zeng Guang-Zong Min Zhao-Hui Meng Guo-Qing Meng Xiao-Xiao Guo Nai-Bo Lin Xiang-Yang liu The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005China The State Key Laboratory of Marine Environmental Science(MEL) College of Ocean and Earth SciencesXiamen UniversityXiamen 361005China

Solar vapor generation is a promising sustainable technology that uses solar distillation to produce fresh water from seawater and wastewater,helping relieve global water resource ***,inspired by naturally grown integrally molded mulberry leaves with a Janus hydrophilic and hydrophobic structure,a novel,simple,and efficient integrated molding method is proposed to break through the limitations of the traditional split manufacturing strategy and realizes the integrated formation of Janus *** on the spontaneous sedimentation characteristics of MXene in silk fibroin solution and its regulation of mesoscopic structure and hydrophilicity of silk fibroin,layered structures with different compositions and hydrophilicities were obtained in one ***,ethanol and glutaraldehyde were added to construct a physical crystallization-chemical crosslinking dual stabilization structure in silk *** evaporator has the evaporation rate of 3.07 kg·m^(-2)·h^(-1. and the efficiency of 86.8%under 1.sun and maintains high evaporation performance under various extreme test conditions including vigorous washing,repeated compression,and high-intensity ultraviolet(UV)***,the evaporator performs well in practical application scenarios,its evaporation rate in the simulated Dead Sea seawater exceeds 2.1. kg·m^(-2)·h^(-1.,and more than 99.9%of the salt,heavy metal ions,oil pollution,and dyes are purified.

关键词： silk fibroin MXene bioinspired integrated molding Janus structure solar vapor generation

The roles and mechanisms of SREBP1.in cancer development and drug response

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Genes & Diseases 2024年第4期11卷 258-269页

作者： Ying He Shasha Qi Lu Chen Jinyu Zhu Linda Liang Xudong Chen Hao Zhang Lvjia Zhuo Shujuan Zhao Shuiping liu Tian Xie School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang 311121China Laboratory of Cancer Genomics Division of Cellular and Molecular ResearchNational Cancer Centre SingaporeSingapore 169610Singapore

Cancer occurrence and development are closely related to increased lipid produc-tion and glucose *** are the basic component of the cell membrane and play a significant role in cancer cell processes such as cell-to-cell recognition,signal transduction,and energy supply,which are vital for cancer cell rapid proliferation,invasion,and *** regulatory element-binding transcription factor 1.SREBP1.is a key transcription factor regulating the expression of genes related to cholesterol biosynthesis,lipid homeostasis,and fatty acid *** addition,SREBP1.and its upstream or downstream target genes are implicated in various metabolic diseases,particularly ***,no review of sREBP1.in cancer biology has yet been ***,we summarized the roles and mechanisms of SREBP1.biological processes in cancer cells,including SREBP1.modification,lipid metabolism and reprogramming,glucose and mitochondrial metabolism,immunity,and tumor microenvi-ronment,epithelial-mesenchymal transition,cell cycle,apoptosis,and ***-ally,we discussed the potential role of SREBP1.in cancer prognosis,drug response such as drug sensitivity to chemotherapy and radiotherapy,and the potential drugs targeting SREBP1.and its corresponding pathway,elucidating the potential clinical application based on SREBP1.and its corresponding signal pathway.

关键词： Cancer Drug Lipid metabolism reprogramming Resistance SREBP1

Extremely thin but very robust:Surprising cryptogam trait combinations at the end of the leaf economics spectrum

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Plant Diversity 2024年第5期46卷 621-629页

作者： Tana Wuyun Lu Zhang Tiina Tosens Bin liu Kristiina Mark JoséÁngel Morales-Sanchez Jesamine Jöneva Rikisahedew Vivian Kuusk Ülo Niinemets Institute of Agricultural and Environmental Sciences Estonian University of Life SciencesKreutzwaldi 1Tartu 51014Estonia College of Landscape and Architecture Zhejiang A&F University666 Wusu StreetHangzhou 311300China Estonian Academy of Sciences Kohtu 6Tallinn 10130Estonia

Leaf economics spectrum(LES)describes the fundamental trade-offs between leaf structural,chemical,and physiological ***,structurally robust thick leaves with high leaf dry mass per unit area(LMA)exhibit lower photosynthetic capacity per dry mass(Amass).Paradoxically,“soft and thinleaved”mosses and spikemosses have very low Amass,but due to minute-size foliage elements,their LMA and its components,leaf thickness(LT)and density(LD),have not been systematically ***,we characterized LES and associated traits in cryptogams in unprecedented details,covering five evolutionarily different *** found that mosses and spikemosses had the lowest LMA and LT values ever measured for terrestrial *** a broad range of species from different lineages,Amass and LD were negatively *** contrast,Amass was only related to LMA when LMA was greater than 1. g cm^(-2).In fact,low Amass reflected high LD and cell wall thickness in the studied *** conclude that evolutionarily old plant lineages attained poorly differentiated,ultrathin mesophyll by increasing *** plant lineages,LD,not LMA,is the trait that represents the trade-off between leaf robustness and physiology in the LES.

关键词： Investment strategy Leaf density Leaf structural traits LMA estimation bias Non-seed plants Trait trade-offs

基于改进交替方向乘子法的配电网柔性负荷分层集群调控方法

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中国电力 2024年第1期57卷 140-147页

作者：张俊成黎敏刘志文谭靖陶毅刚罗天禄广西电网有限责任公司广西南宁530023 南方电网能源发展研究院有限责任公司广东广州510670

可调负荷、电动汽车等各种负荷侧资源快速发展,对其进行精准调控是目前重要的研究热点。为充分发挥配电网柔性负荷的调节能力,提出一种基于改进交替方向乘子法的配电网柔性负荷分层集群调控方法。首先,采用综合层次聚类算法对柔性负荷... 详细信息

可调负荷、电动汽车等各种负荷侧资源快速发展,对其进行精准调控是目前重要的研究热点。为充分发挥配电网柔性负荷的调节能力,提出一种基于改进交替方向乘子法的配电网柔性负荷分层集群调控方法。首先,采用综合层次聚类算法对柔性负荷进行分层集群;其次,基于纳什谈判理论,将原问题分解为成本最小化和收益分配2个子问题,建立配电网柔性负荷集群调控模型;然后,引入自适应变参数加速因子,提出改进的交替方向乘子法;最后,通过模拟算例验证所提方法的有效性。结果表明,所提方法能够有效实现大规模柔性负荷接入情况下的集群调控,收敛性能较常规方法有所提高。

关键词：柔性负荷配电网运行集群方法分布式计算交替方向乘子法

引种美国红枫在两种紫色土区的生长和光合特性比较

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南京林业大学学报（自然科学版） 2024年第1期48卷 97-105页

作者：魏静谭星王昌盛闫瑞李林珂宁月刘芸西南大学资源环境学院重庆400715 重庆市荣昌区岚峰林场重庆402460

【目的】研究引种美国红枫(Acer rubrum)在两种紫色土区的生长和光合特性,为美国红枫在重庆地区的发展和适地适品种提供参考。【方法】以生长在重庆地区中性紫色土区(NS1.和石灰性紫色土区(AS2)的引种美国红枫‘马莫’(***×freemanii‘... 详细信息

【目的】研究引种美国红枫(Acer rubrum)在两种紫色土区的生长和光合特性,为美国红枫在重庆地区的发展和适地适品种提供参考。【方法】以生长在重庆地区中性紫色土区(NS1.和石灰性紫色土区(AS2)的引种美国红枫‘马莫’(***×freemanii‘Marmo’)和‘金叶美国槭’(文中为‘金叶槭’***‘Aurea’)为研究对象,在生长旺盛的夏季,对美国红枫在两种紫色土区生长、叶色和光合特性进行测定。【结果】(1.‘马莫’的净株高、冠幅、叶面积与土壤碱解氮(AN)、速效钾(AK)和有机质(SOM)含量、碳氮比(C/N)呈极显著正相关(P1.1. m,地径分别增加5.1.、2.22 cm,引种前后叶面积、比叶面积差异显著(P0.05)。【结论】‘马莫’在中性紫色土区通过增加光能捕获面积提高PSⅡ光合电子传递速率和光合速率,降低有机物质的消耗,从而增强光合能力,表现出较强的生长适应性,而在石灰性紫色土区的表现较差,说明该品种对碱性紫色土壤的适应性一般;两种紫色土区‘金叶槭’的光合特性和生长均表现出较强的适应性。

关键词：引种美国红枫生长适应性光合特性叶绿素荧光参数叶色参数

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Atmospheric oxidation capacity and O_(3) formation in a coastal city of southeast China:Results from simulation based on four-season observation

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Journal of Environmental Sciences 2024年第2期136卷 68-80页

作者： Gaojie Chen Taotao liu Jinsheng Chen Lingling Xu Baoye Hu Chen Yang Xiaolong Fan Mengren Li Youwei Hong Xiaoting Ji Jinfang Chen Fuwang Zhang Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China College of Harbour and Coastal Engineering Jimei UniversityXiamen 361021China Environmental Monitoring Center of Fujian Fuzhou 350013China

The pollution of atmospheric ozone in China shows an obvious upward trend in the past ***,the studies on the atmospheric oxidation capacity and O_(3)formation in four seasons in the southeastern coastal region of China with the rapid urbanization remain ***,a four-season field observation was carried out in a coastal city of southeast China,using an observation-based model combining with the Master Chemical Mechanism,to explore the atmospheric oxidation capacity(AOC),radical chemistry,O_(3)formation pathways and *** results showed that the average net O_(3)production rate(1..55 ppbv/hr)in summer was the strongest,but the average O_(3)concentrations in autumn was *** AOC and ROx levels presented an obvious seasonal pattern with the maximum value in summer,while the OH reactivity in winter was the highest with an average value of 22.75 sec^(-1..The OH reactivity was dominated by oxygenated VOCs(OVOCs)(30.6%-42.8%),CO(23.2%-26.8%),NO_(2)(1..6%-22.0%),and alkenes(8.4%-1..5%)in different *** photolysis dominated OH primary source on daytime in winter,while in other seasons,HONO photolysis in the morning and ozone photolysis in the afternoon contributed *** analysis indicated that O_(3)production was controlled by VOCs in spring,autumn and winter,but a VOC-limited and NOx-limited regime in summer,and alkene and aromatic species were the major controlling factors to O_(3)***,the study characterized the atmospheric oxidation capacity and elucidated the controlling factors for O_(3)production in the coastal area with the rapid urbanization in China.

关键词： Atmospheric oxidation capacity Radical chemistry Ozone production Sensitivity analysis

Brain circuits for retching-like behavior

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National Science Review 2024年第1期11卷 145-160页

作者： Lifang Huo Zhimin Ye Meiling liu Ziqing He Meizhu Huang Dapeng Li Qian Wu Qian Wang Xiaoqun Wang Peng Cao Ji Dong Congping Shang School of Basic Medical Sciences Guangzhou National Laboratory The Fifth Afflliated Hospital Guangzhou Medical University Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Department of Neurobiology School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and Repair Advanced Innovation Center for Human Brain Protection Capital Medical University State Key Laboratory of Cognitive Neuroscience and Learning IDG/McGovern Institute for Brain Research Beijing Normal University Changping Life Science Laboratory National Institute of Biological Sciences

Nausea and vomiting are important defensive responses to cope with pathogens and toxins that invade the body. The nucleus of the solitary tract(NTS) is important for initiating these responses. However, the molecular heterogeneities and cellular diversities of the NTS occlude a better understanding of these defensive responses. Here, we constructed the single-nucleus transcriptomic atlas of NTS cells and found multiple populations of NTS neurons that may be involved in these defensive responses. Among these, we identified Calbindin1.positive(Calb1.) NTS neurons that are molecularly distinct from Tac1.*** Calb1.neurons are critical for nausea and retching induced by cereulide; an emetic toxin secreted by Bacillus Cereus. Strikingly, we found that cereulide can directly modulate vagal sensory neurons that innervate Calb1.NTS neurons, a novel mechanism distinct from that for nausea and retching induced by Staphylococcal enterotoxin A. Together, our transcriptomic atlas of NTS neurons and the functional analyses revealed the neural mechanism for cereulide-induced retching-like behavior. These results demonstrate the molecular and cellular complexities in the brain that underlie defensive responses to the diversities of pathogens and toxins.

关键词： vomiting nausea nucleus of the solitary tract Calbindin1 neural circuits

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不同旋流器作用下气液螺旋环状流动特性研究

化工学报 2024年第8期75卷 2744-2755,F0002页

作者：王皓宇杨杨荆文婕杨斌唐雨刘毅上海理工大学能源与动力工程学院上海市动力工程多相流动与传热重点实验室上海200093

管内气液螺旋环状流动可以通过设置固定叶片的旋流器形成,旋流器的结构极大地影响了形成的螺旋环状流动的稳定性。对此,选取了四种典型旋流器结构开展三个典型来流工况下螺旋环状流形成的实验研究。通过图像处理结合概率密度函数(probab... 详细信息

管内气液螺旋环状流动可以通过设置固定叶片的旋流器形成,旋流器的结构极大地影响了形成的螺旋环状流动的稳定性。对此,选取了四种典型旋流器结构开展三个典型来流工况下螺旋环状流形成的实验研究。通过图像处理结合概率密度函数(probability density function,PDF)拟合的方法分析了形成螺旋环状流的稳定性,同时结合液膜波动特性与旋流器内部作用过程分析发现:平板式及平板有中心柱式旋流器在不同来流工况下产生的液膜相较于螺旋叶片式A/B旋流器都更加稳定,相同工况下的失稳距离也更长,而螺旋叶片式A/B旋流器产生的螺旋环状流的稳定性较差,在更短的距离内即发生了螺旋环状流失稳现象;不同工况下液相折算速度的上升有助于提高液膜稳定性与螺旋环状流失稳距离,从而形成更稳定的螺旋环状流;叶片作用下流体内部压力梯度和气液相分布规律高度相关,压力梯度和周向速度是形成螺旋环状流动的主要因素,并且压力梯度和周向速度的大小一定程度决定了螺旋环状流动气液交界面的稳定性。

关键词：气液两相流成像旋流器螺旋环状流动概率密度函数液膜稳定性