检索结果-南通市图书馆

Chain Extender-induced Hydrogen Bonding Organization Determines the Morphology and Properties of Thermoplastic Polycarbonate Polyurethane

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第1期42卷 87-96,I0009页

作者： Yi-Lang qin Ping Zhu Chen-Xi Ouyang Xia Dong Fuwai Hospital Chinese Academyof Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBejing 100037China CASKey Laboratoryof Engineering Plastics CAS Research/Education Centerfor Excellence in Molecular SciencesInstitute ofChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoplastic polycarbonate polyurethanes(PCUs) are multiblock copolymers that have been applied for medical devices for long time. Aliphatic diols are common chain extenders(CE) involved in the composition of the hard segments of PCU. However, limited knowledge was discovered about how the chemical structure of CE affects the hydrogen bonding organization within PCUs and their mechanical *** investigate this problem, a group of PCUs were synthesized respectively by extending the polymer chain with 1.4-butanediol(BDO),aminoethanol(MEA), ethanediol(EO) as three kinds of chain extenders. Tiny differences in the CE chemical structure results in remarkable variations in phase separation, condensed morphologies, thermal and mechanical properties, which are characterized by Fourier transform infrared spectrometer, atomic force microscopy, small-angle X-ray scattering, differential scanning calorimetry, and tensile tests. The microstructural evolution during unilateral deformation and the different mechanism induced by the different CEs was probed and unveil by in situ wide-and small-angle X-ray diffraction. Symmetry of CE can improve the organization of the hydrogen bonding. The coherence strength of the urethane/urea group also plays a key role by comparing the two PCUs with ethanediol and aminoethanol.

关键词： Thermoplastic polycarbonate polyurethane Chain extender Hydrogen bonding Mechanical properties

In vivo evaluation of guide-free Cas9-induced safety risks in a pig model

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第8期9卷 3493-3506页

作者： Weikai Ge Shixue Gou Xiaozhu Zhao qin Jin Zhenpeng Zhuang Yu Zhao Yan{1. Liang Zhen Ouyang Xiaoyi Liul Fangbing Chen {1. Shi Haizhao Yan Han Wu Liangxue Lai Kepin Wang China-New Zealand Joint Laboratory on Biomedicine and Health CAS Key Laboratory of Regenerative BiologyGuangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineJoint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Sanya institute of Swine resource Hainan Provincial Research Center of Laboratory AnimalsSanya 572000China Guangdong Provincial Key Laboratory of Large Animal models for Biomedicine Wuyi UniversityJiangmen 529020China Guangzhou National Laboratory Guangzhou 510005China SUniversity of Chinese Academy of Sciences 100049 BeijingChina Research Unit of Generation of Large Animal Disease Models Chinese Academy of Medical Sciences(2019RU015)Guangzhou 510530China

The CRISPR/Cas9 system has shown great potential for treating human genetic diseases through gene ***,there are concerns about the safety of this system,specifically related to the use of guide-free *** studies have shown that guidefree Cas9 can induce genomic instability in ***,the in vivo safety risks associated with guide-free Cas9 have not been evaluated,which is necessary for the development of gene therapy in clinical *** this study,we used doxycycline-inducible Cas9-expressing pigs to evaluate the safety risks of guide-free Cas9 in *** findings demonstrated that expression of guide-free Cas9 could induce genomic damages and transcriptome changes in *** severity of the genomic damages and transcriptome changes were correlate with the expression levels of Cas9 ***,prolonged expression of Cas9 in pigs led to abnormal phenotypes,including a significant decrease in body weight,which may be attributable to genomic damage-induced nutritional absorption and metabolic ***,we observed an increase in whole-genome and tumor driver gene mutations in pigs with long-term Cas9 expression,raising the risk of tumor *** in vivo evaluation of guide-free Cas9 in pigs highlights the necessity of considering and monitoring the detrimental effects of Cas9 alone as genome editing via the CRISPR/Cas9 system is implemented in clinical gene *** research emphasizes the importance of further study and implementation of safety measures to ensure the successful and safe application of the CRiSPR/Cas9 system in clinical practice.

关键词： CRISPR/Cas9 vivo alone

Mandarin fish von Hippel-Lindau protein regulates the NF-κB signaling pathway via interaction with IκB to promote fish ranavirus replication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第5期45卷 990-1000页

作者： Zhi-Min Li Xiao-Wei qin Qi Zhang Jian He Min-Cong Liang Chuan-Rui Li Yang Yu Weng-{1. Liu Shao-Ping Weng Jian-Guo He Chang-Jun Guo School of Marine Sciences State Key Laboratory for BiocontrolSouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Guangdong Province Key Laboratory of Aquatic Economic Animals&Guangdong Provincial Observation and Research Station for Marine Ranching of the Lingdingyang BaySun Yat-sen UniversityGuangzhouGuangdong 510275China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouGuangdong 510640China

The von Hippel-Lindau tumor suppressor protein(VHL),an E3 ubiquitin ligase,functions as a critical regulator of the oxygen-sensing pathway for targeting hypoxia-inducible *** evidence suggests that mammalian VHL may also be critical to the NF-κB signaling pathway,although the specific molecular mechanisms remain ***,the roles of mandarin fish(Siniperca chuatsi)VHL(scVHL)in the NF-κB signaling pathway and mandarin fish ranavirus(MRV)replication were *** transcription of scVHL was induced by immune stimulation and MRV infection,indicating a potential role in innate ***-luciferase reporter gene assays and reverse transcription quantitative PCR(RT-qPCR)results demonstrated that scVHL evoked and positively regulated the NF-κB signaling *** with NF-κB signaling pathway inhibitors indicated that the role of scVHL may be mediated through scIKKα,scIKKβ,scIκBα,or ***-immunoprecipitation(Co-IP)analysis identified scIκBαas a novel target protein of ***,scVHL targeted scIκBαto catalyze the formation of K63-linked polyubiquitin chains to activate the NF-κB signaling *** MRV infection,NF-κB signaling remained activated,which,in turn,promoted MRV *** findings suggest that scVHL not only positively regulates NF-κB but also significantly enhances MRV *** study reveals a novel function of scVHL in NF-κB signaling and viral infection in fish.

关键词： VHL NF-κB IκBα Ranavirus Mandarin fish

Thick Electrodes of a Self-Assembled MXene Hydrogel Composite for High-Rate Energy Storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第4期7卷 255-261页

作者： Leiqiang qin Jianxia Jiang Lintao Hou Fengling Zhang Johanna Rosen Department of Physics Chemistry and Biology (IFM) Link?ping University Flexible Electronics Innovation Institute (FEII) Jiangxi Key Laboratory of Flexible Electronics Jiangxi Science and Technology Normal University Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy Materials Physics Department Jinan University

Supercapacitors based on two-dimensional MXene （Ti3C2Tz） have shown extraordinary performance in ultrathin electrodes with low mass loading,but usually there is a significant reduction in high-rate performance as the thickness increases,caused by increasing ion diffusion *** limitations include restacking of the nanosheets,which makes it challenging to realize the full potential of these electrode materials.

关键词： energy storage high-rate hydrogel MXene self-assemble

Regulatable Orthotropic 3D Hybrid Continuous Carbon Networks for Efficient Bi-Directional Thermal Conduction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第10期16卷 136-148页

作者： huitao Yu Lianqiang Peng Can Chen Mengmeng {1. Wei Feng School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin 300350People's Republic of China

Vertically oriented carbon structures constructed from low-dimen-sional carbon materials are ideal frameworks for high-performance thermal inter-face materials(TIMs).However,improving the interfacial heat-transfer efficiency of vertically oriented carbon structures is a challenging ***,an orthotropic three-dimensional(3D)hybrid carbon network(VSCG)is fabricated by depositing vertically aligned carbon nanotubes(VACNTs)on the surface of a horizontally oriented graphene film(HOGF).The interfacial interaction between the VACNTs and HOGF is then optimized through an annealing *** regulating the orientation structure of the VACNTs and filling the VSCG with polydimethylsi-loxane(PDMS),VSCG/PDMS composites with excellent 3D thermal conductive properties are *** highest in-plane and through-plane thermal conduc-tivities of the composites are 1.3.61.and 24.37 W m^(-1.K^(-1.,*** high contact area of HOGF and good compressibility of VACNTs imbue the VSCG/PDMS composite with low thermal *** addition,the interfacial heat-transfer efficiency of VSCG/PDMS composite in the TIM performance was improved by 71.3%compared to that of a state-of-the-art thermal *** new structural design can potentially realize high-performance TIMs that meet the need for high thermal conductivity and low contact thermal resistance in interfacial heat-transfer processes.

关键词： Orthotropic continuous structures Hybrid carbon networks Carbon/polymer composites Thermal interface materials

An effective catalyst carrier SiO_(2):Enhancing catalytic and combustion properties of CuFe_(2)O_(4)on energetic components

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第2期32卷 383-392页

作者： Li Ding Chong Wan Suhang Chen Zhao qin Kangzhen Xu School of Chemical Engineering/Xi'an Key Laboratory of Special Energy Materials Northwest UniversityXi'an710069China Xi’an Modern Chemistry Research Institute Xi'an710065China

To enhance the catalytic activity of copper ferrite(CuFe_(2)O_(4))nanoparticle and promote its application as combustion catalyst,a low-cost silicon dioxide(SiO_(2))carrier was employed to construct a novel CuFe_(2)O_(4)/SiO_(2)binary composites via solvothermal *** phase structure,morphology and catalytic activity of CuFe_(2)O_(4)/SiO_(2)composites were studied firstly,and thermal decomposition,combustion and safety performance of ammonium perchlorate(AP)and 1.3,5-trinitroperhydro-1.3,5-triazine(RDX)with it affecting were then systematically *** results show that CuFe_(2)O_(4)/SiO_(2)composite can remarkably either advance the decomposition peak temperature of AP and RDX,or reduce the apparent activation energy at their main decomposition ***,the flame propagation rate of RDX was promoted by about 2.73 times with SiO_(2)content of 3 wt%,and safety property of energetic component was also improved greatly,in which depressing the electrostatic discharge sensitivity of pure RDX by about 1.89 *** addition,the effective range of SiO_(2)carrier content in the binary catalyst is found to be 3 to 5 wt%.Therefore,SiO_(2)opens a new insight on the design of combustion catalyst carrier and will promote the application of CuFe_(2)O_(4)catalyst in solid propellant.

关键词： Copper ferrite Silicon dioxide Combustion catalyst Thermal decomposition Laser ignition

Rapid Energy Exchange between In Situ Formed Bromine Vacancies and CO_(2)Molecules Enhances CO_(2)Photoreduction

在线全文

学校读者我要写书评

暂无评论

Research 2024年第2期2023卷 763-771页

作者： qin Ren Ye He Hong Wang Yanjuan Sun Fan Dong Research Center for Environmental and Energy Catalysis Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China

Photocatalytic reduction of CO_(2)into fuels provides a prospective tactic for regulating the global carbon balance utilizing renewable solar ***,CO_(2)molecules are difficult to activate and reduce due to the thermodynamic stability and chemical *** this work,we develop a novel strategy to promote the adsorption and activation of CO_(2)molecules via the rapid energy exchange between the photoinduced Br vacancies and CO_(2)*** in situ continuous wave-electron paramagnetic resonance(cw-EPR)and pulsed EPR technologies,we observe that the spin-spin relaxation time(T_(2))of BiOBr is decreased by 1.8 ns during the CO_(2)photoreduction reaction,which is further confirmed by the broadened EPR *** result reveals that there is an energy exchange interaction between in situ formed Br vacancies and CO_(2)molecules,which promotes the formation of high-energy CO_(2)molecules to facilitate the subsequent reduction *** addition,theoretical calculations indicate that the bended CO_(2)adsorption configuration on the surface of BiOBr with Br vacancies caused the decrease of the lowest unoccupied molecular orbital of the CO_(2)molecule,which makes it easier for CO_(2)molecules to acquire electrons and get *** situ diffuse reflectance infrared Fourier transform spectroscopy further shows that the activated CO_(2)molecules are favorably converted to key intermediates of COOH*,resulting in a CO generation rate of 9.1.mol g^(-1.h^(-1.and a selectivity of 1.0%.This study elucidates the underlying mechanism of CO_(2)activation at active sites and deepens the understanding of CO_(2)photoreduction reaction.

关键词： reaction. adsorption activation

The stance and factors of international organizations towards countries from a Chinese perspective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Data Intelligence 2024年第1期6卷 158-182页

作者： qin Zhang Haili Xue Yaotian Wang Yao Wang Ziqin Zhang qinghua qin Haoguang Liang National Science Library Chinese Academy of Sciences100190China China Center for Modernization Research 100190China Beijing International Studies University 100024China Beijing Key Laboratory of National Belt and Road Data Analysis and Decision Support 100024China University College London WC1E 6BTUK

The degree and scope of constraints imposed by International Organizations(IOs)on States are increasing,and identifying the factors affecting the IOs’stances on States is helpful to enhance the state's discourse power and influence in the international ***,by coding the records of Regular Press Conferences of the Speaking Office of the Chinese Ministry of Foreign Affairs during the period of 201.2022,we obtained a dataset of IOs’stances on China-related ***,we constructed political relation,economic relation,and humanistic relation indicators to complement the influence factors,adopted the Bayesian logit model,and applied the Monte Carlo Markov chain algorithm and Gibbs sampling to analyze the probability of IOs’positive stances towards *** result shows that IOs’category,length of establishment,functional position,and relationship with China are all related to their tendency of making a statement about *** terms of the heterogeneity of event types,forum-type IOs are significantly inclined to give positive assessment compared to service-type IOs on events focusing on China's own *** analysis reveals that the model for analyzing and predicting the attitudes of IOs is more effective when the international situation is in a stable period.

关键词： Bayesian Logit Model IOs' stances Attitude analysis Monte Carlo Markov chain International relation indicator

Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis:A Multi-center,Double-Blinded and Randomized Controlled Trial

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第7期30卷 579-587页

作者： ZHANG Shao-yan QIU Lei ZHANG Shun-xian XIAO He-ping CHU Nai-hui ZHANG Xia ZHANG hui-qiang ZHENG Pei-yong ZHANG hui-yong LU Zhen-hui Institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Clinical Research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tuberculosis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tuberculosis the Second Hospital of NanjingNanjing210003China Department of Tuberculosis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods: A large-scale, multi-center, double-blinded, and randomized controlled trial was conducted in 1. sentinel hospitals in China from December 201. to December 201.. A total of 31. MDR-PTB patients were randomly assigned to BFJD Granules or placebo groups(1.1. using a stratified randomization method, which both received the long-course chemotherapy regimen for 1. months(6 Am-Lfx-P-Z-Pto, 1. Lfx-P-Z-Pto). Meanwhile, patients in both groups also received BFJD Granules or placebo twice a day for a total of 1. months, respectively. The primary outcome was cure rate. The secondary outcomes included time to sputum-culture conversion, changes in lung cavities and quality of life(QoL) of patients. Adverse reactions were monitored during and after the trial. Results: A total of 21. cases completed the trial, 1.1.in the BFJD Granules group and 1.5 in the placebo group. BFJD Granules, as adjuvant treatment, increased the cure rate by 1..6% at the end of treatment, compared with the placebo(58.4% vs. 44.8%, P=0.02), and accelerated the median time to sputum-culture conversion(5 months vs. 1. months). The cavity closure rate of the BFJD Granules group(50.6%, 43/85) was higher than that of the placebo group(32.1., 26/81.P=0.02) in patients who completed the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granules significantly improved physical functioning, general health, and vitality of patients relative to the placebo group(all P1.. Overall, the death rates in the two groups were not significantly different;5.1.(8/1.6) in the BFJD Granules group and 2.6%(4/1.6) in the placebo group. Conclusions: Supplementing BFJD Granules with the long-course chemotherapy regimen significantly increased the cure rate and cavity closure rate, and rapidly improved QoL of pati

关键词： alternative medicine Chinese herbal formula Bufei Jiedu Granules multidrug-resistant tuberculosis long-course chemotherapy regimen randomized controlled trial