检索结果-南通市图书馆

Nuclear Science and Techniques 2024年第9期35卷 82-91页

作者： Bing-bao Mei Liang-{1. Wang Song-Qi Gu Xiao-Zhi Su Shuo Zhang Yao Wei Jing-Yuan Ma Zheng Jiang Fei Song Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201800China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China

A Johann-type X-ray spectrometer was successfully developed at the hard X-ray branch(in-vacuum undulator with a 24-mm periodic length)of the energy material beamline(E-line)at the Shanghai Synchrotron Radiation Facility(SSRF).This spectrometer was utilized to implement X-ray emission spectroscopy(XES),high-energy resolution fluorescence-detected X-ray absorption spectroscopy(HERFD-XAS),and resonant inelastic X-ray *** spherically bent crystals were positioned on the respective vertical 500-mm-diameter Rowland circles,adopting an area detector to increase the solid angle to 1.75%of 4πsr,facilitating the study of low-concentrate systems under complex reaction *** under the atmosphere pressure,the spectrometer covers the energy region from 3.5 to 1. keV,with the Bragg angle ranging from 73°to 86°during vertical *** offers a promised energy resolution of sub-eV(XES)and super-eV(HERFD-XAS).Generally,these comprehensive core-level spectroscopy methods based on hard X-rays at the E-line with an extremely high photon flux can meet the crucial requirements of a green energy ***,they provide substantial support for scientific advances in fundamental research.

关键词： X-ray emission spectroscopy High-energy-resolution X-ray spectrometer Johann geometry Energy materials SSRF

A triboelectric nanogenerator based on a spiral rotating shaft for efficient marine energy harvesting of the hydrostatic pressure differential

在线全文

学校读者我要写书评

暂无评论

Materials Reports(Energy) 2024年第3期4卷 69-76页

作者： Xuemei Song Yuan Chao Pan Chang bao Han Chang {1. Liu Yaxiaer Yalikun Hui Yan Yang Yang Key Laboratory of Advanced Functional Materials(Beijing University of Technology) Ministry of EducationBeijing Key Lab of Microstructure and Property of Advanced MaterialsBeijing University of TechnologyBeijing100124PR China Institute of Deep-Sea Science and Engineering Chinese Academy of SciencesSanya572000PR China Division of Materials Science Nara Institute of Science and Technology8916-5 Takayama-choIkomaNara630-0192Japan

Equipment used in underwater sensing and exploration typically relies on cables or batteries for energy supply,resulting in a limited and inconvenient energy supply and marine environmental pollution that hinder the sustainable development of distributed ocean sensing ***,we design a deep-sea differential-pressure triboelectric nanogenerator(DP-TENG)based on a spiral shaft drive using modified polymer materials to harness the hydrostatic pressure gradient energy at varying ocean depths to power underwater *** spiral shaft structure converts a single compression into multiple rotations of the TENG rotor,achieving efficient conversion of differential pressure *** multi-pair electrode design enables the DP-TENG to generate a peak current of 61.7μA,the instantaneous current density can reach 0.69μA cm^(-2),and the output performance can be improved by optimizing the spiral angle of the *** DP-TENG can charge a 33μF capacitor to 1..5 V within five working *** can also power a digital calculator and light up 1.6 commercial power light-emitting diodes,demonstrating excellent output *** its simple structure,low production cost,and small form factor,the DP-TENG can be seamlessly integrated with underwater *** results hold broad prospects for underwater blue energy harvesting and are expected to contribute to the development of self-powered equipment toward emerging“smart ocean”and blue economy applications.

关键词： Triboelectric nanogenerators Blue energy Energy harvesting Differential pressure energy Self-power sensor

MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第4期40卷 483-499页

作者： Xiaohong Dong Zhi Zhang xin Shu Zi Zhuang Pinyi Liu Renyuan Liu Shengnan Xia xinyu bao Yun Xu Yan Chen Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China Department of Neurology Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing210008China Department of Neurology Drum Tower Hospital of Nanjing Medical UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Jiangsu Provincial Key Discipline of Neurology Nanjing210008China

Chronic cerebral hypoperfusion is one of the pathophysiological mechanisms contributing to cognitive decline by causing white matter *** phagocytosing myelin debris in a timely manner can promote remyelination and contribute to the repair of white ***,milk fat globule-epidermal growth factor-factor 8(MFG-E8),a microglial phagocytosis-related protein,has not been well studied in hypoperfusion-related cognitive *** found that the expression of MFG-E8 was significantly decreased in the brain of mice after bilateral carotid artery stenosis(BCAS).MFG-E8 knockout mice demonstrated more severe BCAS-induced cognitive impairments in the behavioral *** addition,we discovered that the deletion of MFG-E8 aggravated white matter damage and the destruction of myelin microstructure through fluorescent staining and electron ***,MFG-E8 overexpression by AAV improved white matter injury and increased the number of mature oligodendrocytes after ***,in vitro and in vivo experiments showed that MFG-E8 could enhance the phagocytic function of microglia via theαVβ3/αVβ5/Rac1.pathway and IGF-1.production to promote the differentiation of oligodendrocyte progenitor cells into mature ***,we found that MFG-E8 was mainly derived from astrocytes,not *** findings suggest that MFG-E8 is a potential therapeutic target for cognitive impairments following cerebral hypoperfusion.

关键词： White matter injury Cognitive dysfunction MFG-E8 Remyelination Microglial phagocytosis

A sustainable process to 1.0%bio-based nylons integrated chemical and biological conversion of lignocellulose

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第2期9卷 390-402页

作者： Ruijia Hu Ming Li Tao Shen xin Wang Zhuohua Sun xinning bao Kequan Chen Kai Guo Lei Ji Hanjie Ying Pingkai Ouyang Chenjie Zhu College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjingChina National Engineering Research Center for Biotechnology Nanjing Tech UniversityNanjingChina Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijingChina

Considerable progress has been made in recent years to the development of sustainable polymers from bio-based *** this study,1.0%bio-based nylons were prepared via an integrated chemical and biological process from *** novel nylons were obtained by the melt polymerization of 3-propyladipic acid derived from lignin and 1.5-pentenediamine/1.4-butanediamine derived from carbohydrate *** to the concept is a three-step noble metal free catalytic chemical funnelling sequence(Raney Ni mediated reductive catalytic fractionation-reductive funnelling-oxidative funnelling),which allowed for obtaining a single component 3-propyladipic acid from lignin with high *** structural and thermodynamic properties of the obtained nylons have been systematically investigated,and thus obtained transparent bio-based nylons exhibited higher Mw(>32,000)and excellent thermal stability(Td5%>265℃).Considering their moderate Tg and good melt strength,these transparent bio-based nylons could serve as promising functional additives or temperature-responsive materials.

关键词： Lignocellulose Lignin Reductive catalytic fractionation Bio-based nylon

Biochar with self-doped N to activate peroxymonosulfate for bisphenol-A degradation via electron transfer mechanism:The active edge graphitic N site

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第9期35卷 351-355页

作者： Yun-xin Huang Lin-Qian Yu Ke-Yu Chen Hao Wang Shou-Yan Zhao {1.-Cheng Huang Ren-Cun Jin School of Engineering Hangzhou Normal UniversityHangzhou 311121China Zhejiang Provincial Key Laboratory of Urban Wetlands and Regional Change Hangzhou 311121China

Environmental endocrine disruptors,represented by bisphenol A(BPA),have been widely detected in the environment,bringing potential health risks to human ***-containing biocarbon catalyst can activate peroxymonosulfate(PMS)to degrade BPA in water,but its active sites remain ***,in this work,nitrogen-containing biochar,i.e.,C–Nedge,enriched with graphitic-N defects at the edges was prepared by one-pot co-pyrolysis of chitosan and potassium *** results showed that the C–Nedge/PMS system can effectively degrade 98%of BPA(50 mg/L).The electron transfer based non-radical oxidation mechanism was responsible for BPA *** graphitic-N doping endows biochar with strong electron transfer *** catalyst had good recovery and reuse *** catalytic oxidation was also feasible for other refractory pollutants removal and worked well for treating practical *** work may provide valuable information in unraveling the N doping configurationactivity relationship during activating PMS by biochar.

关键词： Peroxymonosulfate Carbon-based catalysts Edge graphitic-N Non-radicals Bisphenol A

Mechanical Behavior and Failure Mechanism of an As-Extruded Mg-1.wt%Y Alloy at Elevated Temperature

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 969-981页

作者： Lan Zhang Dao-Kui Xu bao-Jie Wang Cui-Lan Lu Shuo Wang Xiang-Bo Xu Dong-Liang Wang {1. Lv En-Hou Han School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159China Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China Institute of Corrosion Science and Technology Guangdong510070China

Through carrying out the high-temperature tensile experiments on an as-extruded Mg-1.wt%Y alloy at 350℃,400℃,450℃,500℃and 550℃,the mechanical behavior and fracture mechanisms at elevated temperatures are investigated and *** results show that with the increase of temperature,the yield strength and ultimate tensile strength of the alloy increase at first and then decrease,while that the elongation ratio decreases firstly and then *** the sample being tested at 350℃,the values of yield strength,ultimate tensile strength and the elongation ratio are 1.8 MPa,266 MPa and 1.%,*** 400℃,the yield strength and ultimate tensile strength reach the maximum values of,respectively,1.8 MPa and 277 MPa,but the elongation ratio is the lowest and its value is only 8%.When the applied temperature is increased to 550℃,the values of yield strength and ultimate tensile strength,respectively,decrease to 1.0 MPa and 1.2 MPa and the elongation ratio increases to 38%.Failure analysis demonstrates that the fracture surfaces of different samples are mainly composed of plastic dimples and exhibit the typical characteristic of ductile *** observation to the fracture side surfaces indicates that at the temperatures of 350℃and 400℃,microcracks mainly initiate in the interior of Mg_(24)Y_(5)*** the temperatures are 450℃,500℃and 550℃,the cracks preferentially initiate at the Mg_(24)Y_(5)/α-Mg interfaces.

关键词： Mg-Y alloy High-temperature tensile properties Fracture mechanism Failure analysis

Mitochondrial GRIM1. Loss Induces Liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-κB Signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第6期12卷 539-550页

作者： Xiaohui Xu Jinmei Feng xin Wang xin Zeng Ying Luo xinyu He Meihua Yang Tiewei Lv Zijuan Feng Liming bao Li Zhao Daochao Huang Yi Huang Institute of Pediatrics Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Pediatric Metabolism and Inflammatory DiseasesChongqingChina Department of Cardiology Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Key Cardiovascular SpecialtyLaboratory of Children’s Important Organ Development and Diseases of Chongqing Municipal Health CommissionChongqingChina Department of Laboratory Medicine Chongqing Western HospitalChongqingChina Key Laboratory of Molecular Biology for Infectious Diseases Ministry of EducationInstitute for Viral HepatitisChongqing Medical UniversityChongqingChina Department of Laboratory Medicine The Third People’s Hospital of ChengduChengduSichuanChina Departments of Neurology Epilepsy CenterBarnes-Jewish Hospital and Washington University School of MedicineSt.LouisMOUSA Department of Clinical Pathology and Laboratory Medicine Weill Cornell Medical College of Cornell UniversityNew YorkNYUSA Departments of Medicine(Oncology) Washington University School of MedicineSt.LouisMOUSA

Background and Aims:Hepatic fibrosis(HF)is a critical step in the progression of hepatocellular carcinoma(HCC).Gene associated with retinoid-IFN-induced mortality 1.(GRIM1.),an essential component of mitochondrial respiratory chain complex I,is frequently attenuated in various human cancers,including ***,we aimed to investigate the potential relationship and underlying mechanism between GRIM1. loss and HF ***:GRIM1. expression was evaluated in normal liver tissues,hepatitis,hepatic cirrhosis,and HCC using human liver disease spectrum tissue *** studied hepatocyte-specific GRIM1. knockout mice and clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein-9(Cas9)lentivirus-mediated GRIM1. gene-editing in murine hepatocyte AML1. cells in vitro and in *** performed flow cytometry,immunofluorescence,immunohistochemistry,western blotting,and pharmacological intervention to uncover the potential mechanisms underlying GRIM1. loss-induced ***:Mitochondrial GRIM1. was progressively downregulated in chronic liver disease tissues,including hepatitis,cirrhosis,and HCC ***-specific GRIM1. heterozygous deletion induced spontaneous hepatitis and subsequent liver fibrogenesis in *** addition,GRIM1. loss caused chronic liver injury through reactive oxygen species(ROS)-mediated oxidative stress,resulting in aberrant NF-κB activation via an IKK/IKB partner in ***-more,GRIM1. loss activated NLRP3-mediated IL33 signaling administration of the NLRP3 inhibitor MCC950 dramatically via the ROS/NF-κB pathway in *** alleviated GRIM1. loss-driven HF in ***:The mitochondrial GRIM1. loss facilitates liver fibrosis through NLRP3/IL33 activation via ROS/NF-κB signaling,providing potential therapeutic approaches for earlier HF prevention.

关键词： Liver fibrosis GRIM1. Reactive Oxygen Species NF-κB NLRP3 inflammasome IL33.

Improvement for creep strength of a second-generation single crystal superalloy by design of heat treatments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第1期43卷 342-350页

作者： Wan-Shun Xia xin-{1. Zhao Jia-Chen Xu Quan-Zhao Yue Qing-Qing Ding Huan-Chang Duan Yue-Feng Gu Hong-Bin Bei Ze Zhang Institute of Superalloys Science and Technology School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Silicon and Advanced Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Design of heat treatments is related to the key technology for development of nickel-based single crystal superalloys(Ni-SXs). Based on the full understanding of the solidification characteristics, this work applies optimization design of heat treatments for a second-generation Ni-SX. Microstructure evolution and creep properties are compared in the material under conventional/standard(Std.) and optimized(Opt.) treatments. For the Std. sample,strong dendritic segregations determine inconsistent microstructure evolution in the dendritic(D) and interdendritic region(ID), while the latter serves as weak area to have the prior microcrack initiation, damaging overall performance of the alloy. The Opt. treatment applies higher homogenization temperature, leading to overall reduced segregations, while not inducing incipient melting. A lower temperature of first-step ageing is used to lower the size ofγ'particles. These help to form the more uniform microstructure in dendritic and interdendritic region and relieve the inconsistent microstructure evolution. The balanced local strength makes ID no longer as the weak area,thus restricting microcrack initiation. Great improvement of high temperature and low stress property is obtained by this progress, leading to the pronounced increase of creep rupture life under 1.00 °C/1.0 MPa.

关键词： Single crystal superalloy Heat treatment Segregation Solidification Creep property

Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第17期30卷 2354-2368页

作者： Kai Zhou Cai-Ling Li Hua Zhang bao-Jun Suo Yu-{1. Zhang {1.-Lu Ren Yu-{1. Wang Chang-Min Mi Ling-Ling Ma Li-Ya Zhou Xue-Li Tian Zhi-Qiang Song Department of Gastroenterology Peking University Third HospitalBeijing 100191China

BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple ***,the search for new alternative drugs has become one of the research *** recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(***)infection,but the systematic evaluation of its role remains *** To explore the efficacy,safety,and compliance of minocycline in eradicating *** *** We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on *** eradication with minocycline-containing regimens as per the inclusion and exclusion *** eradication rates of *** were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were *** The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall *** eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1.]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol *** overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse *** of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(1.%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and

关键词： Helicobacter pylori Minocycline Eradication Safety Resistance

RPRD1./CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 307-318页

作者： Lu Xu Zhi-Hao Xie Jun Li Shi Tao Fang-Li Ren Yin-Yin Wang Zhi-Jie Chang xin-{1. Hao Department of Hematology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Heya Beijing Med-Biotech Inc. Beijing 100084China Department of Hematology Roswell Park Comprehensive Cancer CenterNY 14263USA

Objective:To investigate the role of RPRD1. in the progression of diffuse large B-cell lymphoma(DLBCL)and its potential as a therapeutic ***:This study analyzed RPRD1. expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival *** vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1. influences tumor growth and ***:RPRD1. expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor *** vitro and in vivo experiments demonstrated that RPRD1. promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling ***:RPRD1. plays a critical role in the progression of DLBCL by modulating apoptosis and cellular *** RPRD1. may offer a novel therapeutic strategy for DLBCL,suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

关键词： RPRD1. RNAPⅡ Diffuse large B-cell lymphoma NF-κB Apoptosis