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Data Quality Control Method of a New Drifting Observation Technology Named Drifting Air-Sea Interface Buoy

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Journal of Ocean University of China 2024年第1期23卷 11-22页

作者： LI Shuo WANG Bin DENG Zeng’an WU Baoqin ZHU xiande CHEN Zhaohui National Ocean Technology Center Tianjin 300112China School of Marine Science and Technology Tianjin UniversityTianjin 300072China Key Laboratory of Ocean Observation Technology Ministry of Natural ResourcesTianjin 300112China People’s Liberation Army 92859 Tianjin 300061China Physical Oceanography Laboratory Ocean University of ChinaQingdao 266100China

An integral quality control(QC)procedure that integrates various QC methods and considers the design indexes and operational status of the instruments for the observations of drifting air-sea interface buoy was developed in the order of basic in-spection followed by targeted *** innovative method of combining a moving Hampel filter and local anomaly detection com-plies with statistical laws and physical processes,which guarantees the QC performance of meteorological *** sets of observation data were used to verify the applicability and effectiveness of the QC procedure,and the effect was evaluated using the observations of the Kuroshio Extension Observatory buoy as the *** results showed that the outliers in the time series can be correctly identified and processed,and the quality of data improved *** linear correlation between the quality-controlled observations and the reference increased,and the difference *** correlation coefficient of wind speed before and after QC increased from 0.77 to 0.82,and the maximum absolute error decreased by approximately 2.8ms^(-1..In addition,air pressure and relative humidity were optimized by 1.^(-3)–1.^(-2) orders of *** the sea surface temperature,the weight of coefficients of the continuity test algorithm was optimized based on the sea area of data acquisition,which effectively expanded the applicability of the algorithm.

关键词： drifting air-sea interface buoy quality control oceanic variables meteorological variables continuity test

Synchrotron radiation X-ray diffraction in situ study of fine-grained minerals in shock veins of Suizhou meteorite

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Science China Earth Sciences 2005年第6期48卷 815-821页

作者： XIE xiande1. SHU Jinfu2 & CHEN Ming1.1. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 51.640, China 2. Geophysical Laboratory, Carnegie Institution of Washington, Washington, DC, 2001., USA Correspondence should be addressed to Xie xiande 1. Guangzhou Institute of Geochemistry Chinese Academy of Sciences 510640 Guangzhou China 2. Geophysical Laboratory Carnegie Institution of Washington 20015 Washington DC USA

The synchrotron radiation X-ray diffraction technique developed for in situ study ahigh pressure and temperature has also been used to investigate microscopic mineral inclusionsin ultrahigh-pressure metamorphic rocks and deep-mantle samples. Present study added twomore examples of successful utilization of synchrotron radiation X-ray diffraction technique for insitu investigations of fine-grained (0.5―30 μm in size) minerals in very thin shock melt veins othe Suizhou meteorite: ( i ) X-ray diffraction measurement of extremely small-sized vein matrixminerals, and (ii) identification of the micron-sized new mineral tuite embedded in the vein matrixIt has been revealed that the fine-grained vein matrix consists of well crystallized garnet, kamacite and troilite, and the powder diffraction pattern consisting of 1. lines with d-values, intensities( I ), relative intensities (I/Io) and Miller indices, as well as the cell parameters for the new mineratuite has also been successfully obtained. The result of present investigations has enriched thecontent of dynamic high-pressure mineralogy and that of Earth’s mantle geochemistry.

关键词： synchrotron radiation, X-ray diffraction, fine-grained minerals, Suizhou meteorite.

地塞米松通过调节中性粒细胞和巨噬细胞向肿瘤的浸润增强减毒鼠伤寒沙门菌介导的肿瘤免疫治疗的抗肿瘤效果

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微生物学报 2024年第9期64卷 3489-3505页

作者：王珍朴伶华申铉日柳贤德海南大学生命科学学院海南海口570228 海南医学院生理学系海南海口571199 海南热带海洋学院食品科学与工程学院海南三亚572022

细菌介导的肿瘤免疫治疗(bacterium-mediated cancer immunotherapy,BCI)在癌症治疗中具有诸多优势,但地塞米松(dexamethasone,DEX)联合BCI治疗肿瘤的免疫反应机制仍不清晰。【目的】探究DEX联合减毒鼠伤寒沙门氏菌St.Δpp Gpp介导的BC... 详细信息

细菌介导的肿瘤免疫治疗(bacterium-mediated cancer immunotherapy,BCI)在癌症治疗中具有诸多优势,但地塞米松(dexamethasone,DEX)联合BCI治疗肿瘤的免疫反应机制仍不清晰。【目的】探究DEX联合减毒鼠伤寒沙门氏菌St.Δpp Gpp介导的BCI肿瘤治疗效果及机制。【方法】通过鼠源结直肠癌小鼠模型,测定St.Δpp Gpp+DEX联合治疗的肿瘤抑制效果。使用活体成像测定St.Δpp Gpp的肿瘤靶向性与定殖时间。通过伊红(hematoxylin and eosin,H&E)染色,测试St.Δpp Gpp+DEX联合治疗的器官毒性。基于流式细胞术和免疫荧光切片,测定巨噬细胞极化、中性粒细胞的募集和T细胞反应。通过qRT-PCR,检测肿瘤微环境中的炎症因子变化。通过人源结直肠癌症小鼠模型,验证T细胞缺失对St.Δpp Gpp+DEX联合治疗的影响。【结果】St.Δpp Gpp+DEX联合治疗可显著降低肿瘤大小,并提高小鼠生存率。DEX可延长St.Δpp Gpp在肿瘤细胞的定殖。St.Δpp Gpp+DEX联合治疗不会损伤重要免疫器官,并可促进M2向M1.巨噬细胞极化,同时抑制中性粒细胞的募集。T细胞缺失不会影响St.Δpp Gpp+DEX联合治疗效果。【结论】DEX通过抑制中性粒细胞募集,增加肿瘤微环境中的M1.巨噬细胞比例,进而提高减毒鼠伤寒沙门氏菌St.Δpp Gpp的抗肿瘤疗效。

关键词：细菌介导的肿瘤免疫治疗鼠伤寒沙门氏菌地塞米松肿瘤微环境细胞免疫反应

基于GlobeLand 30的柬埔寨森林覆被变化及影响因素分析

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世界地理研究 2024年第9期33卷 94-103页

作者：李敏褚劲风李仙德上海师范大学环境与地理科学学院上海200234 上海开放大学上海200443

柬埔寨境内丰富的森林资源对湄公河流域生态安全具有重要意义。鉴于此,基于GlobeLand 30数据,采用森林覆盖率、景观格局指数等指标分析柬埔寨森林流失情况;并采用多元线性回归方法分析影响柬埔寨森林流失的主要因素。研究发现:(1.2000-2... 详细信息

柬埔寨境内丰富的森林资源对湄公河流域生态安全具有重要意义。鉴于此,基于GlobeLand 30数据,采用森林覆盖率、景观格局指数等指标分析柬埔寨森林流失情况;并采用多元线性回归方法分析影响柬埔寨森林流失的主要因素。研究发现:(1.2000-2020年柬埔寨森林面积从1.4 009.92 km^(2)减少至89 702.30 km^(2),覆盖率由57.45%降至49.55%。高原和山地地区森林减少最显著,面积减少8 002.87 km^(2),覆盖率下降1..36%。土地利用转移分析显示,84.85%森林保持不变,1..90%转为耕地。(2)森林景观破碎化加剧,最大斑块指数下降。(3)回归分析表明,人口增长和耕地面积增加是森林流失的主要驱动因素。建议柬埔寨政府加强森林法规管理,遏制滥砍滥伐;积极发展工业、生态旅游等,促进经济多元化,创造更多非农业就业机会,降低森林转耕地压力。

关键词：柬埔寨森林覆被变化土地利用 GlobeLand 30 森林流失

Formation of FeNi metal nodules in the Jilin H5 chondrite,the largest stone meteorite in the world

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Acta Geochimica 2023年第6期42卷 961-970页

作者： xiande Xie Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Materials Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

The Jilin H5 chondrite, the largest known stony meteorite in the world, with its No.1.fragment weighing1.70 kg. It contains submillimeter-to centimeter-sized FeNi metal particles/nodules. Our optical microscopic and electron microprobe analyses revealed that the formation of metal nodules in this meteorite is a complex and long-term process, The early stage is the thermal diffusion-caused migration and concentration of dispersed metallic material along fractures to form root-hair shaped metal grains during thermal metamorphism of this meteorite. The later two collision events experienced by this meteorite led to the further migration and aggregation of metallic material into the shock-produced cracks and openings to form largersized metal grains. The shock-produced shear movement and frictional heating occurred in this meteorite greatly enhanced the migration and aggregation of metallic material to form the large-sized nodules. It was revealed that the metal nodule formation process in the Jilin H5 chondrite might perform in the solid or subsolidus state, and neither melting of chondritic metal grains nor shock-induced vaporization of bulk chondrite material are related with this process.

关键词： Jilin chondrite Metal nodules Thermal diffusion Shock metamorphism Shear movement Frictional heating

饲养密度对断奶羔羊生长性能及血清激素、生化和抗氧化指标的影响

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动物营养学报 2024年第7期36卷 4544-4553页

作者：左权吴启超杨开伦杨红建邓先德新疆农业大学动物科学学院乌鲁木齐830052 中国农业大学动物科学技术学院北京100193 农业农村部规划设计研究院北京100125 农业农村部农业设施结构设计与智能建造重点实验室北京100125

本试验旨在研究饲养密度对2~4月龄断奶羔羊生长性能及血清激素、生化和抗氧化指标的影响。选取2月龄、平均体重为(1..86±1.24)kg的健康澳洲白公羔72只,随机分为3组,分别命名为试验Ⅰ组、试验Ⅱ组和试验Ⅲ组,每组3个重复,每个重复8只羊... 详细信息

本试验旨在研究饲养密度对2~4月龄断奶羔羊生长性能及血清激素、生化和抗氧化指标的影响。选取2月龄、平均体重为(1..86±1.24)kg的健康澳洲白公羔72只,随机分为3组,分别命名为试验Ⅰ组、试验Ⅱ组和试验Ⅲ组,每组3个重复,每个重复8只羊。试验Ⅰ组、试验Ⅱ组和试验Ⅲ组的饲养密度分别为0.875、0.625和0.375 m^(2)/只。试验期60 d。结果表明:1.随着饲养密度的增大,各组羔羊终末体重(FW)、平均日采食量(ADFI)、平均日增重(ADG)和料重比(F/G)均没有显著差异(P>0.05),但试验Ⅲ组、试验Ⅱ组的F/G较试验Ⅰ组有降低的趋势(P=0.091.。2)试验第40天,试验Ⅲ组羔羊血清中甲状腺素(T_(4))浓度显著高于试验Ⅱ组、试验Ⅰ组(P0.05)。试验第60天,试验Ⅲ组羔羊血清中总抗氧化能力(T-AOC)与过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活性均显著低于试验Ⅱ组、试验Ⅰ组(P<0.05),血清中丙二醛(MDA)含量显著高于试验Ⅱ组、试验Ⅰ组(P<0.05)。由此可见,试验Ⅲ组羔羊有应激反应发生。从经济效益和动物福利的角度考虑,建议2~4月龄断奶羔羊的饲养密度为0.625 m^(2)/只,羊舍栏位宽度可以设置成2 m。

关键词：饲养密度断奶羔羊生长性能激素生化抗氧化

电针联合高强度间歇训练对阿尔兹海默病模型大鼠TREM2信号通路的影响

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中华物理医学与康复杂志 2024年第4期46卷 289-294页

作者：曹灵修马贤德郭君刘骞豪金雪明郑州大学第五附属医院康复医学科郑州450052 辽宁中医药大学教学实验中心沈阳110000

目的探讨电针和高强度间歇训练(HIIT)联合治疗阿尔兹海默病(AD)模型大鼠的作用机制。方法将大鼠随机分为正常组、模型组、电针组、HIIT组、联合组(电针+HIIT组)。除正常组外,其余各组采用1.0 mg/(kg·d)D-半乳糖皮下注射和1.0 mg/(kg·d... 详细信息

目的探讨电针和高强度间歇训练(HIIT)联合治疗阿尔兹海默病(AD)模型大鼠的作用机制。方法将大鼠随机分为正常组、模型组、电针组、HIIT组、联合组(电针+HIIT组)。除正常组外,其余各组采用1.0 mg/(kg·d)D-半乳糖皮下注射和1.0 mg/(kg·d)无水AlCl_(3)腹腔注射进行AD模型大鼠造模。于造模成功后第2天开始干预,电针组和联合组采用0.25 mm×1. mm不锈钢针灸针平刺百会穴、直刺肾俞穴,深度2~3 mm,接电针仪强度1.0 mA,2.0 Hz疏密波,20 min/日,每周治疗5 d,连续3周;HIIT组和联合组均采用HIIT运动方案进行训练,每日训练50 min,每周训练5 d,为期3周;正常组和模型组不行任何干预。分别于造模第4周后和干预3周后,观察大鼠一般情况,并采用水迷宫实验和旷场实验观察大鼠行为学变化。HE染色观察海马区组织形态变化,ELISA检测血清中的超氧化物歧化酶(SOD)、丙二醛(MDA)、胆碱乙酰基转位酶神经元(chAT)、乙酰胆碱酯酶(AchE)含量;用RT-PCR法检测大鼠海马髓细胞触发受体2(TREM2)信号通路相关基因表达。结果干预后,与正常组相比,模型组、电针组、HIIT组和联合组认知功能降低、海马区组织病理形态改变、血清中SOD、chAT水平和海马中TREM2 mRNA、DAP1. mRNA水平均明显降低,血清中MDA、AchE含量和海马中的ERK1.mRNA和ERK2 mRNA水平均明显增加(P1. mRNA水平差异无统计学意义(P>0.05)外,电针组、HIIT组和联合组的其余行为学指标均明显改善,且血清中的SOD、chAT和海马中TREM2 mRNA水平均明显增加,血清中的MDA、AchE和海马中的ERK1.mRNA、ERK2 mRNA水平均明显降低(P1. mRNA水平显著提高(P1. mRNA水平均明显降低,血清中的MDA和AchE及海马中的ERK1.mRNA、ERK2 mRNA水平均明显增加(P<0.05)。结论电针联合HIIT可能通过激活TREM2通路来促进大鼠抗氧化能力,改善AD大鼠的认知功能。

关键词：电针高强度间歇训练阿尔兹海默病髓细胞触发受体2

Analysis of novel immune-related genes and microsatellite markers in the transcriptome of Paphia undulata

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Journal of Oceanology and Limnology 2019年第4期37卷 1301-1316页

作者： WU Xiangwei LIU xiande YU Ziniu Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Animal Science and Technology College Yunnan Agricultural University Kunming 650201 China Key Laboratory of Healthy Mariculture for the East China Sea Ministry of Agriculture of ChinaFisheries College Jimei University Xiamen 361021 China University of Chinese Academy of Sciences Beijing 100049 China

Increasingly,exogenous stressors such as pathogen infections,variable water conditions,and pollution are resulting in high mortality of Paphia undulata,deleteriously affecting the quality of clam *** foot is a burrowing organ in *** damage and constant contact with the external environment cause the foot to be highly sensitive to pathogen invasion and water condition *** the present study,the foot tissue transcriptome was analyzed to identify genes involved in immune and stress *** *** transcriptome included 5 286 668 078 bp reads generated by Illumina Hiseq 2000 sequencing and were assembled into 1.785 226 contigs by de novo *** contigs were clustered into 99 339 transcripts and further grouped into 60 201.*** them,22 260 unigenes were successfully annotated using public *** genes that were response to immune and stress were identified with abundant expression levels,including heat shock protein 70,cold shock protein,complement C3,cathepsin L,ubiquitin carboxyl-terminal hydrolase L5,and translationally controlled tumor ***,566 unigenes were found homologous to genes involved in the immune response systems of pathogen discrimination,signal transduction,and immune effector,such as lectins,toll-like receptors,complement pathway,toll-like receptor signaling pathway,heat shock proteins,antioxidant enzymes,lysozymes,and mucins,indicating that *** could have a complete set of innate immune *** addition,4 270 microsatellite markers(SSRs)were identified from 60 201.unigenes,of which trinucleotide repeats were most abundant and 1. SSRs were tested to be *** present study provides a new insight into innate immunity and stress response mechanisms in ***.

关键词： Paphia undulata foot tissue transcriptome innate immunity unigene microsatellite

High-pressure polymorph of TiO_2-Ⅱ from the Xiuyan crater of China

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Chinese Science Bulletin 2013年第36期58卷 4655-4662页

作者： CHEN Ming GU XiangPing XIE xiande YIN Feng State Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences School of Geosciences and Info-Physics Central South University Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of Geochemistry Chinese Academy of Sciences

Abundant TiO2-Ⅱ,a high-pressure polymorph of titanium dioxide,was found in the gneiss fragments of impact-produced breccias from the Xiuyan *** in the gneiss was severely fragmented and fine-grained clasts less than 2 m in size had been transformed to *** thin layered TiO2-Ⅱ is also observed in coarse-grained rutile fragments,where the TiO2-Ⅱ layers distributes along fractures and cracks in *** 30 percent of rutile in the gneiss had been transformed to TiO2-Ⅱ.Fine grains of TiO2-Ⅱ display light bluish grey to light yellow brown in plane-polarized reflected *** investigation shows that TiO2-Ⅱ has an orthorhombic structure with space group *** cell parameters are a=4.543(1.,b=5.491.9)and c=4.895(2).Its empirical formula calculated on the basis of two oxygen atoms can be written as(Ti0.985Fe0.008Nb0.006-Si0.003Zr0.001.1.003O2,or simply formula *** to the shock effects of quartz and feldspars,the peak shock pressure and post-shock temperature in the TiO2-Ⅱ-bearing gneiss are estimated to be between 35 and 43 GPa and 300–900°C,*** finding of TiO2-Ⅱ in the shock-metamorphosed gneiss provides another mineral physics evidence for shock origin of the Xiuyan crater.

关键词：陨石坑纳米岫岩高压二氧化钛中国经验公式平面偏振光