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Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension

World Journal of Gastroenterology 2010年第15期16卷 1837-1844页

作者： Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H (straub) Jürgen Schlmerich Reiner Wiest Department of Internal Medicine I University Medical Center

AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90.

关键词： Heat shock protein-90 Nitric oxide Vasodilation Portal hypertension Mesenteric circulation

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Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice

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Cellular & Molecular Immunology 2019年第1期16卷 65-74页

作者： Vanessa Lamontain Tobias Schmid Dorothea Weber-Steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant Rainer H (straub) Daniela N Männel Institute of Immunology University of Regensburg93042 RegensburgGermany Laboratory of Experimental Rheumatology and Neuroendocrine Immunology Department of Internal MedicineUniversity Hospital Regensburg93042 RegensburgGermany Division of Molecular Internal Medicine Department of Internal Medicine IIUniversity Hospital Würzburg97070 WürzburgGermany

Tumor necrosis factor(TNF)and its receptors TNF receptor type 1(TNFR1)and type 2(TNFR2)have a central role in chronic inflammatory *** TNFR1 mainly confers inflammation,activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory *** this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collageninduced *** with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80,given every second *** days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were *** were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by *** with TNCscTNF80 increased arthritis-induced *** effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid *** treatment,frequency of regulatory T(Treg)cells in the CD4+T-cell population was increased in both spleen and inguinal lymph *** addition,the expression of TNFR2 on Treg cells was *** clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of *** histological score also revealed amelioration of joint inflammation in TNCscTNF80-treated versus control *** of TNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular Treg cells,and by attenuation of arthritis.

关键词： collagen type II-induced arthritis regulatory T cells TNF TNF receptor type 2 TNFR2-specific agonist TNCscTNF80

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A Pathway to Small Satellite Market Growth

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Advances in Aerospace Science and Technology 2016年第1期1卷 14-20页

作者： Anders Kose Nervold Joshua Berk Jeremy (straub) David Whalen Department of Entrepreneurship University of North Dakota Grand Forks USA Department of Space Studies University of North Dakota Grand Forks USA Department of Computer Science University of North Dakota Grand Forks USA

The United States is experiencing a renaissance in interest in space due to the advent of new lowercost small spacecraft. New launch entrants, such as Interorbital Systems, promise to lower launch cost levels. Many developers also benefit from free-to-developer launch services from NASA or the ESA. Unfortunately, existing commercial off the shelf (COTS) CubeSat hardware is priced based on amortization of design costs across low-sales volume. A lack of trained staff in any one of the numerous disciplines required for spacecraft design or other resources required for in-house development restricts entry into the small satellite industry to those who can afford expensive COTS hardware or pay for significant design expenses. With entry-level satellite hardware still priced in the six-figure range, limited market growth is expected even as the average CubeSat launch cost continues to decline. A new archetype could lower barriers to entry for building small satellites. A free, public-domain architecture for building a small satellite could allow low-cost, in-house satellite development. Under this paradigm, the expenses for initiating a small satellite program are limited to component and launch vehicle costs. The proposed framework allows for broad access to small satellite hardware, greatly increasing the size of the small satellite developer community. In the context of the small satellite market, freely offering plans to construct an entry-level satellite will court new non-traditional actors into building space hardware for launch on commercial and government small satellite launchers. The low-cost, high flight rate possible with the next generation of launch systems affords operators the freedom to experiment and innovate in a risktolerant environment. Successfully demonstrating products and services utilizing low-risk, publicdomain plans will stimulate demand for mature and more capable flight systems in the retail marketplace. If technical schools, community colle

关键词： CubeSat Small Spacecraft Educational Economics Market Growth

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^(99m)Tc标记血细胞——进展和展望

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国外医学（放射医学核医学分册） 1991年第5期15卷 228-230页

作者： Srivastava SC (straub) RF 张继和

近3年来,^(99m)Tc标记血细胞取得了有目共睹的进展,本文就1986年以来有关^(99m)Tc标记血细胞的成就作一综述.

关键词：血细胞同位素标记

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创新的干网清洗装置——DuoCleaner Express

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中华纸业 2009年第2期30卷 87-88页

作者： Karlheinz (straub) Maria Droscher Sissy Gu

今天的高技术纸机可以达到2000m／min的车速，甚至更高。为了在这样的条件下对产能，特别是成纸品质进行持续优化，细调纸机的运行参数是绝对必要的。纸机织物在这方面起着重要作用。运行期间，这些织物必须尽可能长时间地保持其最佳性... 详细信息

今天的高技术纸机可以达到2000m／min的车速，甚至更高。为了在这样的条件下对产能，特别是成纸品质进行持续优化，细调纸机的运行参数是绝对必要的。纸机织物在这方面起着重要作用。运行期间，这些织物必须尽可能长时间地保持其最佳性能。要确保做到这一点，最好的办法就是对织物进行连续不断的清洗，而福伊特的DuoC1eaner技术就能很好地做到这一点。

关键词：清洗装置 Express 干网创新机织物运行参数运行期间最佳性能

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Windows 95奥秘

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丛书名：美国IDG“奥秘”丛书

1996年

作者：（美）Brian Livingston （美）Davis (straub) 王志言等译

本书介绍了Windows 95的使用方法的技巧.

ISBN: (纸本)7505332775

本书介绍了Windows 95的使用方法的技巧.

关键词： Windows 操作系统

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Preseason hip strength associated with anterior cruciate ligament injuries

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中华物理医学与康复杂志 2016年第4期38卷 249-249页

作者： Khayambashi K Ghoddosi N (straub) RK

BACKGROUND AND OBJECTIVE The anterior cruciate ligament (ACL) is most commonly ruptured knee ligament in competitive athletics, with 70% of these injuries deemed noncontact in nature. This study assessed whether isometric hip strength is associated with noncontact ACL *** Subjects were 501 athletes enrolled in a prospective case control study. Preseason hip strength was assessed bilaterally with a hand-held dynamometer, measuring hip abductors and external rotators. All athletes were followed for ACL injuries during the season, which were further classified as contact or *** Among the athletes, 15 noncontact ACL injuries were identified during the following season. Baseline hip external rotation and hip abduction strength were associated with increased risk of noncontact ACL injury (P=0.001 for both comparisons). Strength cutoffs for high risk were determined. For hip external rotator strength, a cutoff of <20.3% of body weight corresponded with a 93% sensitivity and a 59% specificity, as well as a positive likelihood ratio of 2.3, and a negative likelihood ratio 0.11, for injury. For hip abductor strength, a clinical cutoff of <35.4% of body weight corresponded with a sensitivity of 87% and a specificity of 65%, with a positive likelihood ratio of 2.5 and a negative likelihood ratio of 0.21 for *** This prospective study found that both hip external rotation strength and hip abduction strength tests (measured preseason) distinguished between athletes who later sustained an ACL injury.

关键词：韧带损伤非接触性竞技运动 ACL 膝关节

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Management of telaprevir-based triple therapy for hepatitis C virus recurrence post liver transplant

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World Journal of Hepatology 2015年第9期7卷 1287-1296页

作者： Kerstin Herzer Angela Papadopoulos-Khn Anne Achterfeld Ali Canbay Katja Piras-(straub) Andreas Paul Andreas Walker Jrg Timm Guido Gerken Department of Gastroenterology and Hepatology University Hospital Essen Department of General-Visceral and Transplantation Surgery University Hospital Essen Institute for Virology Heinrich Heine University

AIM: To characterize management of telaprevir(TVR)-based triple therapy of hepatitis C virus(HCV) reinfection after liver transplantation(LT).METHODS: We retrospectively analyzed safety and efficacy of telaprevir- based triple therapy in a single center cohort of 19 patients with HCV genotype(GT) 1 recurrence after LT, with respect to factors possibly predicting sustained viral response(SVR) or non-SVR. All patients were treated with TVR, pegylated(PEG) and ribavirine(RBV) for 12 wk followed by a dual phase with PEG/RBV for 12 wk in 7 patients and for 36 wk in 5 patients. RESULTS: In total 11/19(58%) of patients achieved a sustained response. All(11/11) SVR patients showed a rapid viral response at treatment weeks 4 and 11/14 rapid virological response(RVR) patients achieved SVR. Notably, all(7/7) patients who completed 48 wk of therapy and 80%(4/5) patients who completed 24 wk of therapy achieved SVR24. Treatment failure was significantly(P > 0.049) more frequent in GT1 a infection(5/7) compared to GT1b(3/12) infection and was associated with emergence of resistance-associated mutations in the NS3 protease domain. Bilirubin level at baseline is also related to SVR(P > 0.030). None of the patients had to discontinue treatment due to side effects. CONCLUSION: RVR, GT and bilirubin are clearly related to achievement of SVR. Providing a thorough patient selection and monitoring, a full course of TVR-based triple therapy in LT patients is feasible and achieves high SVR rates.

关键词： Liver transplantation Telaprevir HepatitisC virus recurrence Predictors Hepatitis C virus therapy

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安全性的关键可扩展且灵活的ESC系统

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汽车与配件 2011年第40期 30-31页

作者： Thomas (straub) TRW汽车集团

为所有的轿车、轻型商用车和高性能车型，以及使用各种动力的车辆，包括从传统的内燃发动机车到纯电动车，提供全系列产品，是TRW的EBC460ESC产品目前面临的挑战。

关键词： C系统可扩展安全性 ES 轻型商用车纯电动车 TRW 产品

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Draft Genome Sequence of Mentha Iongifolia and Development of Resources for Mint Cultivar Improvement

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Molecular Plant 2017年第2期10卷 323-339页

作者： Kelly J. Vining Sean R. Johnson Amirhossein Ahkami Iris Lange Amber N. Parrish Susan C. Trapp Rodney B. Croteau Shannon C.K. (straub) Iovanna Pandelova B. Markus Lange Department of Horticulture Oregon State University Corvallis OR 97331 USA M. J. Murdock Metabolomics Laboratory Institute of Biological Chemistry Washington State University Pullman WA 99164-6340 USA Department of Biology Hobart and William Smith Colleges Geneva NY 14456 USA Present address: Pacific Northwest National Laboratory Environmental Molecular Sciences Laboratory (EMSL) Richiand WA 99354 USA Present address: Medifluidics Inc. Fort Collins. CO 80525 USA

The genus Mentha encompasses mint species cultivated for their essential oils, which are formulated into a vast array of consumer products. Desirable oil characteristics and resistance to the fungal disease Verti- cillium wilt are top priorities for the mint industry. However, cultivated mints have complex polyploid ge- homes and are sterile. Breeding efforts, therefore, require the development of genomic resources for fertile mint species. Here, we present draft de novo genome and plastome assemblies for a wilt-resistant South African accession of Mentha Iongifolia （L.） Huds., a diploid species ancestral to cultivated peppermint and spearmint. The 353 Mb genome contains 35 597 predicted protein-coding genes, including 292 disease resistance gene homologs, and nine genes determining essential oil characteristics. A genetic linkage map ordered 1397 genome scaffolds on 12 pseudochromosomes. More than two million simple sequence repeats were identified, which will facilitate molecular marker development. The M. Iongifolia genome is a valuable resource for both metabolic engineering and molecular breeding. This is exemplified by employing the genome sequence to clone and functionally characterize the promoters in a peppermint cultivar, and demonstrating the utility of a glandular trichome-specific promoter to increase expression of a biosynthetic gene, thereby modulating essential oil composition.

关键词： aromatic plant essential oil genome mint Verticillium wilt

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