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Charles Bonnet syndrome:a condition of the visually impaired

Annals of Eye Science 2022年第3期7卷 4-6页

作者： Patty P.A.Dhooge B.Jeroen klevering Department of Ophthalmology Radboud University Medical CentreNijmegenThe Netherlands Donders Institute for Brain Cognition and BehaviourRadboud University Medical CentreNijmegenThe Netherlands

The number of low vision patients that suffer from visual hallucinations is shockingly *** systematic review and meta-analysis by Subhi et *** this edition of AES shows that the prevalence of Charles Bonnet syndrome(CBS)in the low vision population is approximately one in *** is defined by the World Health Organization(WHO)as‘the experience of complex visual hallucinations in a person who has experienced partial or complete loss of vision’(1).The hallucinations are exclusively visual,usually temporary,and not associated with mental and behavioral *** hallucinations negatively affect daily activities and result in anxiety and stress in as many as one third of CBS patients(2-4).Understanding the phenomenon of CBS by these patients can alleviate these problems,however,most CBS patients are reluctant to share their hallucinogenic experiences out of fear of being labelled mentally unstable.

关键词： visual impaired unstable

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由ABCA4基因突变引起的视网膜表现型系谱

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 51-52页

作者： klevering B.J. Deutman A.F. Maugeri A. 司冰心 Department of Ophthalmology University Medical Centre Nijmegen P.O. Box 9101 6500 HB Nijmegen Netherlands

Background: The majority of studies on the retina-specific ATP-binding casse tte transporter (ABCA4) gene have focussed on molecular genetic analysis; compar atively few studies have described the clinical aspects of ABCA4-associated ret inal disorders. In this study, we demonstrate the spectrum of retinal dystrophie s associated with ABCA4 gene mutations. Methods: Nine well-documented patients representing distinct phenotypes in the continuum of ABCA4-related disorders we re selected. All patients received an extensive ophthalmologic evaluation, inclu ding kinetic perimetry, fluorescein angiography, and electroretinography (ERG). Mutation analysis had been performed previously with the genotyping microarray ( ABCR400 chip) and/or single-strand conformation polymorphism analysis in combin ation with direct DNA sequencing. Results: In all patients, at least one patholo gic ABCA4 mutation was identified. Patient 10034 represented the mild end of the phenotypic spectrum, demonstrating exudative age-related macular degeneration (AMD). Patient 24481 received the diagnosis of late-onset fundus flavimaculatus (FFM), patient 15168 demonstrated the typical FFM phenotype, and patient 19504 had autosomal recessive Stargardt disease (STGD1). Patients 11302 and 7608 exhib ited progression from FFM/STGD1 to cone-rod dystrophy (CRD). A more typical CRD phenotype was found in patients 15680 and 12608. Finally, the most severe ABCA4 -associated phenotype was retinitis pigmentosa (RP) in patient 11366. This phen otype was characterised by extensive atrophy with almost complete loss of periph eral and central retinal functions. Conclusion: We describe nine patients during different stages of disease progression; together, these patients form a contin uum of ABCA4-associated phenotypes. Besides characteristic disorders such as FF M/STGD1, CRD and RP, intermediate phenotypes may be encountered. Moreover, as th e disease progresses, marked differences may be observed between initially co

关键词：视网膜疾病 ABCA4 基因突变表现型视网膜色素变性荧光造影视杆基因芯片眼科检查老年性黄斑变性

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静谧黑白间

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现代装饰（家居） 2014年第12期 60-65页

作者： Anatology Bao-nghi Droste Fanny Richard Florian Kallus Sebastian Schneider House of Hackney &klevering Manuel Barbieri molo design NikaZupanc Piet Boon Rometti Sylvie Renoux-Editeur Néazoé Simon Stevens Tina Frey 伏平范嘉苑

对设计师而言,黑白色既是一对最简洁、最朴素的色彩,也是最复杂、最神奇的设计元素。黑色沉稳,白色轻灵,虽然不如彩色那么绚丽,却给人一种高贵的气质。以其为基础,加之人类的智慧,展现出别样的魅力与优雅神韵。黑与白的经典搭配褪去了... 详细信息

对设计师而言,黑白色既是一对最简洁、最朴素的色彩,也是最复杂、最神奇的设计元素。黑色沉稳,白色轻灵,虽然不如彩色那么绚丽,却给人一种高贵的气质。以其为基础,加之人类的智慧,展现出别样的魅力与优雅神韵。黑与白的经典搭配褪去了缤纷的色彩,产生简洁、和谐且富有美感的视觉效果,将五彩缤纷、千变万化的繁杂生态概括于一体,将简约风尚化身为低调的奢华,内敛而不失深刻,且历久弥新,令人回味无穷。＂天为阳,地为阴;阳为白,阴为黑。日月交替,阴阳转换。＂古老的谚语,将世间万物归纳到对立统一的黑白之中。黑白本身就是一门艺术,它源远流长,几乎与人类文明同步发展,经历了五千年来的文化沉淀。在迷离的色彩世界中,黑与白以其独有的简洁、单纯、朴素与概括为各个时代的艺术家所青睐。

关键词：色彩世界文化沉淀黑白色灵感来源令人聚酯材料家居饰品系列产品内部填充启瓶器

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