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Phosphorylation of CAX transporters controls Ca^(2+)homeostasi

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Plant Communications 2024年第9期5卷 8-11页

作者： jinggeng Zhou Yunxia He Xiangzong meng Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China

Plants rely on a sophisticated innate immune system to recognize and defend against invading *** first line of plant innate immunity,called pattern-triggered immunity(PTI),is initiated upon detection of pathogen-associated molecular patterns(PAMPs)by plasma-membrane-localized pattern recognition receptors(PRRs)(jones and Dangl,2006).

关键词： immunity pattern innate

j-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy,older Chinese individuals

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General Psychiatry 2024年第1期37卷 44-52页

作者： Chengzhang Liu Qiguo meng Yuanxiu Wei Xinyue Su Yuanyuan Zhang Panpan He Chun Zhou mengyi Liu Ziliang Ye Xianhui Qin Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefeiAnhuiChina institute of Biomedicine Anhui Medical UniversityHefeiAnhuiChina Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhouGuangdongChina

Background The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains *** To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese *** The study included a total of 3106 participants capable of completing repeated cognitive function *** nutrient intake information was collected through 3-day dietary recalls and using a 3-day food-weighed method to assess cooking oil and condiment *** decline was defined as the 5-year decline rate in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive *** The median follow-up duration was 5.9 *** was a j-shaped relationship between dietary thiamine intake and the 5-year decline rate in global and composite cognitive scores,with an inflection point of 0.68 mg/day(95%confidence interval(Cl):0.56 to 0.80)and a minimal risk at 0.60-1.00 mg/day of dietary thiamine *** the inflection point,thiamine intake was not significantly associated with cognitive *** the inflection point,each unit increase in thiamine intake(mg/day)was associated with a significant decrease of 4.24(95%Cl:2.22 to 6.27)points in the global score and 0.49(95%Cl:0.23 to 0.76)standard units in the composite score within 5 years.A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension,obesity and those who were non-smokers(all pj-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals,with an inflection point at 0.68 mg/day and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.

关键词： intake shaped cognitive

L-Ergothioneine ameliorates MPTP-induced Parkinson's disease in C57BL/6j mice by activating Dj-1

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Food Science and Human Wellness 2024年

作者： Xianshe meng# Huawen meng# Shuzeng Hou Zequn Yin Xuerui Wang Ke Gong Feng Zhang Qingshan Li Shuang Zhang Yuanli Chen Xiaoxiao Yang Zhiwei Zhao Chenzhong Liao Yajun Duan Department of Cardiology， the First Affiliated Hospital of USTC， Division of Life Sciences and Medicine， University of Science and Technology of China Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes， Hefei University of Technology

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. The loss of dopaminergic (DAergic) neurons in the substantia nigra and the decrease of dopamine (DA) levels accelerate the process of PD. L-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms， especially in edible mushrooms. EGT can penetrate blood-brain barrier and its levels are significantly decreased in the plasma of PD patients. Therefore， we speculated that EGT could ameliorate PD， and determined its effect on PD development by using 1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine (MPTP)-induced PD mouse models and neurotoxin 1-methyl-4-phenylpyridinium (MPP+)-induced cell models. Our results show that EGT alleviated MPTP-induced behavioral dysfunction in mice. Mechanistically， we innovatively revealed that EGT is a key regulator of Dj-1. EGT restored DA levels by activating the Dj-1-Nuclear receptor-related factor 1(Nurr1) axis. Furthermore， it reduced reactive oxygen species (ROS) levels by regulating the Dj-1-Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway， which inhibited oxidative stress-induced DAergic neuronal apoptosis. Combined treatment with Dj-1-siRNA transfection revealed that blocking Dj-1 reversed EGT upregulated Nurr1 and Nrf2 expression in the nucleus， which significantly decreased the benefits of EGT. Taken together， our study suggests that EGT can ameliorate PD and be considered as a strategy for PD treatment.

关键词：

A novel(Sm_(0.2)Eu_(0.2)Gd_(0.2)Ho_(0.2)Yb_(0.2))CrO_(3)high-entropy ceramic nanofiber as a negative temperature coefficient thermistor

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journal of Rare Earths 2024年第10期42卷 1937-1942页

作者： Weijun Zhao meng Zhang Liyan Xue Kaixian Wang Fan Yang jiuping Zhong Heng Chen School of Materials Sun Yat-sen UniversityShenzhen518107China Xiamen Institute of Rare Earth Materials Haixi InstituteChinese Academy of SciencesXiamen361021China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China Advanced Energy Science and Technology Guangdong Laboratory Huizhou516003China Sichuan jcc Rare Earth Metals New Material Co. Ltd.Chengdu610000China

The electrical properties of high-entropy ceramics(HECs)have been extensively studied in recent years due to their unique structural characteristics and fascinating functional properties induced by entropy *** high-entropy(Sm_(0.2)Eu_(0.2)Gd_(0.2)Ho_(0.2)Yb_(0.2))CrO_(3)(HE-RECrO_(3))nanofibers were prepared by electro *** work demonstrates that HE-RECrO_(3)nanofibe rs were successfully synthesized at a low temperature(800℃),which is approximately 400℃lower than the temperatures at which chromate ceramics were synthesized via the sol-gel method and the solid-state reaction *** resistivity of HE-RECrO_(3)nanofibers decreases exponentially with increasing temperature from 25 to600℃.The logarithm of the resistivity is linearly related to the inverse of the temperature,confirming the negative temperature coefficient property of HE-RECrO_(3)*** B_(25/50)value of the HERECrO_(3)nanofibers reaches 4072 *** conclusion,HE-RECrO_(3)nanofibers are expected to be potential candidates for negative-temperature-coefficient(NTC)thermistors.

关键词： Rare earths High-entropy ceramics Ceramic fiber materials Negative temperature coefficient thermistors

Identifying Three New AGNs among Fermi Unidentified Gigaelectronvolt Sources

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Research in Astronomy and Astrophysics 2024年第7期24卷 257-267页

作者： Shun-Hao ji Zhong-Xiang Wang Qiang-meng Huang Ruo-Heng Yang Department of Astronomy School of Physics and AstronomyYunnan UniversityKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We report our identification of three gigaelectronvoltγ-ray sources,4FGL j0502.6+0036,4FGL j1055.9+6507,and 4FGL j1708.2+5519,as Active Galactic Nuclei(AGNs).They are listed in the latest Fermi-Large Area Telescope source catalog as unidentified *** find that the sources all showedγ-ray flux variations in recent *** different survey catalogs,we are able to find a radio source within the error circle of each source's *** analysis of optical sources in the fields allows us to determine the optical counterparts,which showed similar variation patterns to those seen inγ-*** optical counterparts have reported redshifts of 0.6,1.5,and 2.3,respectively,estimated from photometric *** addition,we also obtain an X-ray spectrum of 4FGL j0502.6+0036 and a flux upper limit on the X-ray emission of 4FGL j1055.9+6507 by analyzing the archival *** broadband spectral energy distributions of the three sources from radio toγ-rays are *** mainly theγ-ray properties of the three sources with those of different sub-classes of AGNs,we tentatively identify them as *** optical spectroscopy is highly warranted for obtaining their spectral features and thus verifying the identification.

关键词： gamma-rays galaxies-(galaxies)BL Lacertae objects general-(galaxies)quasars general

Effect of Active–Passive Deformation on the Thrust by the Pectoral Fins of Bionic Manta Robot

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journal of Bionic Engineering 2024年第2期21卷 718-728页

作者： Yang Lu Shaomin meng Cheng Xing Yiwei Hao Yonghui Cao Guang Pan Yong Cao School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China Unmanned Vehicle Innovation Center Ningbo Institute of NPUNingbo315103China State Key Lab of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou310027China Zhejiang Key Laboratory of Advanced Manufacturing Technology School of Mechanical EngineeringZhejiang UniversityHangzhou310027China

Bionic manta underwater vehicles will play an essential role in future oceans and can perform tasks,such as long-duration reconnaissance and exploration,due to their efficient *** manta wings’deformation is evident during the swimming *** improve the propulsion performance of the unmanned submersible,the study of the deformation into the bionic pectoral fin is *** this research,we designed and fabricated a flexible bionic pectoral fin,which is based on the Fin Ray®effect with active and passive deformation(APD)*** APD fin was actively controlled by two servo motors and could be passively deformed to variable *** APD fin was moved at 0.5 Hz beat frequency,and the propulsive performance was experimentally verified of the bionic pectoral fins equipped with different extents of *** results showed that the pectoral fin with active–passive deformed capabilities could achieve similar natural biological deformation in the wingspan *** average thrust(T)under the optimal wingspan deformation is 61.5%higher than the traditional passive deformed pectoral *** obtained results shed light on the design and optimization of the bionic pectoral fins to improve the propulsive performance of unmanned underwater vehicles(UUV).

关键词： Manta ray Bionic pectoral fin Fin Ray®effect Active-passive deformation(APD)

Transient Stability Analysis of Converter-based Islanded Microgrids Based on Iterative Equal Area Criterion Considering Reactive Power Loop Dynamics and Varying Damping

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journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1170-1182页

作者： Xilin Li jingyi Zhang Zhen Tian Xiaoming Zha Wei Wang meng Huang Chong Shao Hubei Key Laboratory of Power Equipment&System Security for Integrated Energy School of Electrical Engineering and AutomationWuhan UniversityWuhanChina NARI Technology Co. Ltd.NanjingChina State Grid Gansu Electric Power Company LanzhouChina

With the rapid increase in the installed capacity of renewable energy in modern power systems,the stable operation of power systems with considerable power electronic equipment requires further *** converter-based islanded mi-crogrid(CIM)systems equipped with grid-following(GFL)and grid-forming(GFM)voltage-source converters(VSCs),it is chal-lenging to maintain stability due to the mutual coupling effects between different VSCs and the loss of voltage and frequency sup-port from the power *** previous studies,quantitative transient stability analysis was primarily used to assess the active power loop of ***,frequency and voltage dy-namics are found to be strongly coupled,which strongly affects the estimation result of stability *** addition,the vary-ing damping terms have not been fully *** bridge these gaps,this paper investigates the transient stability of CIM consid-ering reactive power loop dynamics and varying ***,an accuracy-enhanced nonlinear model of the CIM is derived based on the effects of reactive power loop and post-disturbance frequency jump *** these effects will elimi-nates the risk of *** reactive power loop dynamics make the model coefficients be no longer constant and thus vary with the power *** evaluate quantitatively the effects of re-active power loop and varying damping on the transient stability of CIM,an iterative criterion based on the equal area criterion theory is *** addition,the effects of parameters on the stable boundary of power system are analyzed,and the dynamic interaction mechanisms are *** and experiment results verify the merits of the proposed method.

关键词： Transient stability converter iterative criterion reactive power loop post-disturbance frequency jump

基于ARMAV模型和j-散度的结构损伤识别

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振动与冲击 2024年第1期43卷 123-130,152页

作者：李孟郭惠勇重庆大学土木工程学院重庆400045 重庆大学山地城镇建设与新技术教育部重点实验室重庆400045

损伤识别技术是结构健康监测系统的关键组成部分,为了进一步提高损伤识别的准确性和适用性,提出一种融合信息距离函数j-散度与向量自回归滑动平均(vector autoregressive moving average,ARMAV)模型的损伤识别方法。采用预白化过滤器对... 详细信息

损伤识别技术是结构健康监测系统的关键组成部分,为了进一步提高损伤识别的准确性和适用性,提出一种融合信息距离函数j-散度与向量自回归滑动平均(vector autoregressive moving average,ARMAV)模型的损伤识别方法。采用预白化过滤器对加速度时域数据进行消除激励相关性以及降噪处理;建立了ARMAV模型,并由模型的自回归参数和残差方差构建损伤判别指标;采用三层框架试验数据,并进行转播塔模型的损伤识别试验研究验证了该方法的有效性。结果表明:基于ARMAV模型和j-散度距离的损伤识别方法可操作性强,能够准确、高效地定位框架和塔架结构的损伤,且该方法受环境变化的影响较小,可为在线结构健康监测提供一种新思路。

关键词：损伤识别试验研究向量自回归滑动平均(ARMAV)模型 j-散度时间序列分析

Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6j mice by inactivating STAT3 and NF-κB

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Food Science and Human Wellness 2024年第1期13卷 211-224页

作者： Xianshe meng Shihong Zheng Zequn Yin Xuerui Wang Daigang Yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong Liao Zhouling Xie Xiaodong Fan jihong Han Yajun Duan Xiaoxiao Yang Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230601China Tianjin Key Laboratory of human Development and Reproductive Regulation Department of General GynecologyTianjin Central Hospital of Gynecology and ObstetricsTianjin 300100China Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Psoriasis is a chronic autoimmune disease featured by patches on the *** is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key ***(API)is a natural flavonoid with anti-inflammatory and immunoregulatory ***,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis by using imiquimod(IMQ)-induced psoriasis mouse *** results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic *** differentiation of immune cells was restored in API-treated ***,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses by reducing interleukin-23(IL-23)/STAT3/IL-17A ***,it suppressed IMQ-caused cell hyperproliferation by inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κB(NF-κB)***,API reduced expression of inflammatory cytokines through inactivation of NF-κ*** together,our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment.

关键词： Psoriasis Apigenin Imiquimod Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB)