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青贮玉米瑞德2号选育及栽培要点

农业科技通讯 2006年第10期 19-19页

作者：杜志宏张福耀平俊爱郭建文吕鑫程庆军山西省农业科学院饲草遗传育种研究重点实验室山西省农业科学院高粱研究所榆次030600

青贮玉米是指在玉米乳熟期到腊熟期整株收获,然后整株青贮的专用玉米品种.欧美发达国家如法国、加拿大、美国等国及印度均作为饲草在生产上广泛应用.

关键词：青贮玉米栽培要点选育天然草原饲草资源畜牧业发展玉米品种发达国家

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一种国六重卡发动机故障检测维修方法简介

汽车实用技术 2020年第18期45卷 183-184页

作者：颉延萌吕鑫薛伟张秦君侯博搏田江陕西重型汽车有限公司陕西西安710200

文章对天燃气发动机和柴油发动机进行了简单对比,介绍天然气发动机特有系统,结合平时工作中遇到的问题,简介判断故障过程和维修过程,从而提高工作效率。国六天燃气发动机构造复杂、维修难度高但因其排放清洁度高,是我国受欢迎的一种动... 详细信息

文章对天燃气发动机和柴油发动机进行了简单对比,介绍天然气发动机特有系统,结合平时工作中遇到的问题,简介判断故障过程和维修过程,从而提高工作效率。国六天燃气发动机构造复杂、维修难度高但因其排放清洁度高,是我国受欢迎的一种动力单元。

关键词：内燃机天然气发动机国六维修

Clinical Efficacy and Molecular Mechanism of Nourishing Shen and Supplementing Marrow Principle in Treating β Thalassemia

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Chinese Journal of Integrated Traditional and Western Medicine 2003年第4期9卷 248-253页

作者：吴志奎方素萍张新华蔡辉国王蕾易杰柴立民吕鑫霞陈玉英黄有文王荣新陈佩珍 DepartmentofMolecular-Biology Guang‘anmenHospi-talChinaAcademyofTraditionalChineseMedicineBei-Jing100053 不详 The303HospitolofPLA InstituteofHematology ChineseAcademyofMedicalSciencesCorrespondence

Objective: To explore the possibility of using traditional Chinese medicine (TCM) in treating β thalassemia, its clinical effect and molecular mechanism of the ***: According to the TCM theory of“Shen producing marrow”, the composite recipe, Yisui Shenxueling Granule (YSSXL), consisting of Chinese drugs for nourishing Shen and supplementing marrow (NS&SM) was given orally to 7 8 patients with β thalassemia (49 of the severe type and 29 of moderate type ), 3 times a day, 10 g each time (for children, the dose would be reduced proper ly), with 3 months as one therapeutic course, and no blood transfusion used in t he course. The clinical therapeutic efficacy and hematologic parameters in patie nts were observed, and systemic gene analysis was conducted with PAGE, PCR, PCR SSCP, RT PCR and DNA sequences analysis and mRNA detection, in order to s tudy the molecular mechanism from the relationships between genetic mutation and clinical efficacy, gene expression and its regulation. Results: YSSXL showed obvious therapeutic effect in treating β thalassemia. Gene analysis revealed that it did not change the genetic mutatio n type, but could obviously increase hemoglobin, fetal hemoglobin (HbF), γ/(β+ γ) globin ratio, γ globin mRNA expression and GM CSF mRNA expression in patients, as well as the GM CSFmRMA in marrow of mice after 60 Co radia tion. Conclusion: YSSXL has a remarkable therapeutic effect on β tha lassemia, and its possible mechanism is its action in unlocking γ gene, in creasing the γ globin expression and enhancing HbF synthesis so as to compe nsate for the gene defect. This study has opened a new path for the treatment of β thalassemia with TCM.

关键词： nourishing Shen and supplementing marrow principle Shen producing marrow β-thalassemia gene analysis mRNA gene ex pression molecular mechanism

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双黄连注射液溶血性考察研究

黑龙江科技信息 2015年第18期 88-页

作者：吕鑫李慧玲张文娓闫静田明周庆华杨志欣张蕾杨德强黑龙江中医药大学黑龙江哈尔滨150040

为了研究双黄连注射液的溶血性,以家兔静脉血为样品,经肉眼观察法和红细胞计数法试验表明无体外溶血现象,双黄连注射液临床用药安全。

关键词：双黄连注射液肉眼观察法红细胞计数法

补肾益髓法治疗β-地中海贫血临床与基础研究

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中国中西医结合杂志 2007年第2期27卷 191-191页

作者：吴志奎张新华蔡辉国王荣新陈玉英柴立民李敏易杰刘咏梅李冀湘黄有文王蕾姜葆华刘凤云苑景春方素萍吕鑫霞张瑄陈佩贞刘文军黄世敬王文娟张冲中国中医科学院广安门医院北京100053 中国人民解放军302医院中国医学科学院血液学研究所

β-地中海贫血（简称β-地贫），属世界上发病高、危害最大的单基因遗传病。至今尚无有效治疗办法．我国南方是高发区。本课题根据中医肾生髓理论．用补肾益髓法在广西高发区治疗β-地贫，从理论基础、临床实践、调控珠蛋白基因表达机... 详细信息

β-地中海贫血（简称β-地贫），属世界上发病高、危害最大的单基因遗传病。至今尚无有效治疗办法．我国南方是高发区。本课题根据中医肾生髓理论．用补肾益髓法在广西高发区治疗β-地贫，从理论基础、临床实践、调控珠蛋白基因表达机制等方面，对中医药治疗本病进行了开创性研究。

关键词： β-地中海贫血补肾益髓法有效治疗临床实践中医药治疗单基因遗传病 β-地贫肾生髓理论

中医肾生髓理论分子基础研究的临床实践补肾益髓法治疗β-地中海贫血症临床与分子机理研究

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中西医结合心脑血管病杂志 2003年第10期1卷 607-607页

作者：吴志奎张新华方素萍蔡辉国王蕾陈玉英黄有文王荣新陈佩珍吕鑫霞中国中医研究院广安门医院分子生物学研究室解放军303医院中国医学科学院血液学研究所

目的β-地中海贫血症(以下简称β地贫)是一种遗传性溶血性贫血.该病发病的分子基础是β-基因缺陷,β-珠蛋白不能合成,导致早期造血障碍.对于它的治疗,迄今为止,仍是世界医学尚未解决的难题.本文研究了中药治疗β-地贫的理论基础、临床... 详细信息

目的β-地中海贫血症(以下简称β地贫)是一种遗传性溶血性贫血.该病发病的分子基础是β-基因缺陷,β-珠蛋白不能合成,导致早期造血障碍.对于它的治疗,迄今为止,仍是世界医学尚未解决的难题.本文研究了中药治疗β-地贫的理论基础、临床疗效及分子基础.

关键词：肾生髓理论分子基础临床实践补肾益髓法中医药治疗 β-地中海贫血症分子机理

Clinical Observation on Treatment of 78 Patients of B-Thalassemla with Bushen Ylsul (补肾益髓) Method and Study on Its Molecular Mechanism

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Chinese Journal of Integrated Traditional and Western Medicine 2003年第2期9卷 141-141页

作者：吴志奎蔡辉国方素萍张新华王蕾陈玉英吕鑫霞黄有文王荣新陈佩珍 Guanganmen Hospital of China Academy of TCM Beijing(100053) Institute of Hematology Chinese Academy of Medical Sciences Guanganment Hospital of China Academy of TCM Beijing(100053) The 303 Hospital of PLA

Objective: To study the treatment of B-Thalas-semia (ThE) with Chinese herbal medicine for Bushen Yisui (BSYS), its theoretical base and molecular mechanism. Methods: Seventy-eight patients with ThE were treated with BSYS recipe (consisted of 11 Chinese herbal drugs as Dogwood fruit, Fleeceflower root, prepared Rehmannia root and turtle shell, etc.) orally taken, 3 times per day, 10 g/time, 3 months as one therapeutic course. Hemoglobin (Hb), red blood cell (RBC), reticulocyte (Ret) and hemoglobin F (HbF) were checked every month. At the same time, PAGE, PVR, PCR-SSCP, RT-PCR, DNA series analysis, mRNA gene expression analysis techniques were used to conduct the systematic gene analysis in patients to study the molecular mechanism of TCM treatment from aspects of gene mutation, gene expression and control-regulation. Results: All the blood criteria in patients after BSYS treatment were improved significantly with clinical symptoms

关键词： of in gene Method and Study on Its Molecular Mechanism Clinical Observation on Treatment of 78 Patients of B-Thalassemla with Bushen Ylsul HbF on with