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In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31b magnesium alloy-hydroxyapatite composites

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bioactive Materials 2020年第4期5卷 891-901页

作者： Yee-Hsien Ho Kun Man Sameehan S.Joshi Mangesh V.Pantawane Tso-Chang Wu Yong Yang Narendra b.Dahotre Laboratory for Laser Aided Additive and Subtractive Manufacturing Department of Materials Science and EngineeringUniversity of North Texas1150 Union Circle 305310DentonTX76203-5017USA Department of biomedical Engineering University of North Texas1150 Union Circle 305310DentonTX76203-5017USA

The present study aims to evaluate effect of hydroxyapatite(HA,Ca10(PO4)6OH2),a ceramic similar to natural bone,into AZ31b Mg alloy matrix on biomineralization and *** novel friction stir processing additive manufacturing route was employed to fabricate Mg-HA *** HA contents(5,10,20 wt%)were incorporated into Mg *** observation and chemical composition analysis revealed that refined Mg grains and dispersion of HA particles at micro/nanoscales were achieved in Mg-HA composites after the friction stir *** biomineralization evaluation were carried out using immersion experiments in simulated body fluid followed by mineral morphology observation and chemical composition *** wettability measurements were conducted to correlate the biomineralization *** results showed improvement in wettability and bone-like Ca/P ratio in apatite deposit on the composites compared to as-received *** addition,the increase of blood compatibility,cell viability and spreading were found in the higher HA content composites,indicating the improved ***,friction stir processed Mg-20 wt%HA composite exhibited the highest wettability and better cell adhesion among other composites due to the effect of increased HA content within Mg matrix.

关键词： Friction stir processing Magnesium alloy Hydroxyapatite Additive manufacturing biomineralization Contact angle measurement blood compatibility Cell culture

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加拿大劳工史专家b.D.帕尔默访谈录

史学理论研究 2013年第2期 119-126页

作者： b.D.帕尔默刘军特伦特大学加拿大研究中心中国社会科学院世界历史研究所研究员100006

帕：欢迎您来特伦特大学加拿大研究中心做访问学者，我记得1992年去中国时，还访问过你们所。刘：那时我在加拿大萨斯卡彻温大学历史系读研究生，毕业论文是《E．P．汤普森的史学思想》，老师只介绍了一本入门参考书，就是您的《E．P．... 详细信息

帕：欢迎您来特伦特大学加拿大研究中心做访问学者，我记得1992年去中国时，还访问过你们所。刘：那时我在加拿大萨斯卡彻温大学历史系读研究生，毕业论文是《E．P．汤普森的史学思想》，老师只介绍了一本入门参考书，就是您的《E．P．汤普森的形成》（The Making of ***：Marxism，Humanism，and History，1981）。所以，虽未见面，我认识您很久了。这次来主要想了解加拿大劳工史研究状况。刚在图书馆看到，加拿大劳工史著述之多，给我印象很深。加拿大究竟有多少劳工史或工人阶级史学家？

关键词：加拿大劳工访谈录专家访问学者史学思想毕业论文工人阶级

Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers(Ⅰ):Tethered with a fused heterocyclic s-triazolo[2,1-b][1,3,4]thiadiazole

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Chinese Chemical Letters 2010年第6期 661-663页

作者： Guo Qiang Hu~(a,*),Zhong Quan Zhang~a,Song Qiang Xie~a,Wen Long Huang~b a Institute of Chemistry & biology,Henan University,Kaifeng 475001,China b China Pharmaceutical University,Nanjing 210009,China

Five C3/C3 fluoroquinolone dimers tethered with a fused heterocyclic ring of s-triazolo[2,1-b][1,3,4]thiadiazole derived from antibacterial quinoiones were synthesized and characterized,and their in vitro antitumor ac... 详细信息

关键词： Fluoroquinolone Dimer Antitumor evaluation

A bendamustine resistance gene signature in diffuse large b-cell lymphoma and multiple myeloma

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Cancer Drug Resistance 2021年第1期4卷 208-222页

作者： Issa Ismail Issa Rasmus Froberg brøndum Hanne Due Linnea Schmidt Martin bøgsted Karen Dybkær Department of Haematology Aalborg University HospitalAalborg 9000Denmark Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark.

Aim:bendamustine is primarily used for treatment of indolent lymphomas but has shown efficacy in some patients with diffuse large b-cell lymphoma(DLbCL)and multiple myeloma(MM).Molecular-based patient stratification for identification of resistant patients,who will benefit from alternative treatments,is *** aim of this study was to develop a resistance gene signature(REGS)from bendamustine dose-response assays in cultures of DLbCL and MM cell lines,enabling prediction of bendamustine response in DLbCL and MM ***:bendamustine response was determined in 14 DLbCL and 11 MM cell *** baseline gene expression profiles and degree of growth inhibition after bendamustine exposure,a bendamustine REGS was developed and examined for the risk stratification potential in DLbCL(n=971)and MM(n=1,126)patients divided into prognostic ***:bendamustine resistance significantly correlated with resistance to cyclophosphamide in DLbCL and melphalan in MM cell *** bendamustine REGS showed significantly lower bendamustine resistance probabilities in DLbCL patients with GCb subtype tumors and in tumors of the differentiation dependent centrocyte and plasmablast *** MM patients,pre-bII classified tumors displayed high bendamustine resistance probabilities and the plasma cell subtype had lower bendamustine resistance probability than memory ***,tumors belonging to the 4p14,MAF,and D2 TC subclasses consistently displayed high bendamustine resistance ***:Significant differences in predicted response to bendamustine were found in molecular subtypes of DLbCL and MM,encouraging validation in prospective bendamustine-treated cohorts with available gene expression profiles and follow-up data.

关键词： bendamustine diffuse large b-cell lymphoma multiple myeloma resistance gene signature

Estimation of radiative capture^(13)b(n,γ0+1)^(14)b reaction rate in the modified potential cluster model

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Chinese Physics C 2023年第10期47卷 130-142页

作者： A.S.Tkachenko N.A.burkova b.M.Yeleusheva S.b.Dubovichenko Fesenkov Astrophysical Institute 050020AlmatyKazakhstan al-Farabi Kazakh National University 050040AlmatyKazakhstan

We discuss current attempts to employ the modified potential cluster model to describe the available experimental data on the^(13)b(n,γ0+1)^(14)b total *** estimated results of the M1 and E1 transitions from the n^(13)b scattering states to the ground and first excited states of^(14)b are *** 1st resonance at Ex=1.275 MeV(1+)is revealed in both the cross-section and reaction *** the variation in the asymptotic constant,a thermal cross-section interval of 5.1-8.9 mb is *** on the theoretical total cross-sections at energies of 0.01 eV to 5 MeV,we calculate the reaction rate in the temperature range of 0.01 to *** ignition T9 values of the^(13)b(n,γ0+1)^(14)b reaction depending on a neutron number density n_(n)of~10^(22)cm^(−3)are *** radiative neutron capture reaction rates on the boron^(10-13)b and carbon^(12-14)Сisotopes are compared.

关键词： radiative neutron capture ^(14)b nucleus total cross-sections reaction rate potential cluster model r-process

ELECTRICAL TRANSPORT STUDIES IN 3Na_(2)O-6:5b_(2)O_(3) GLASSES

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Journal of Advanced Dielectrics 2011年第3期1卷 331-336页

作者： RAHUL VAISH KALIDHINDI b.R.VARMA Materials Research Centre Indian Institute of Science Bangalore 560012India

Transparent 3Na_(2)O-6:5b_(2)O_(3)(NbO)glasses were fabricated via the conventional melt-quenching technique.X-ray powder difraction(XRD)combined with Differential Scanning Calorimetric(DSC)studies carried out on the as-quenched samples confirmed their amorphous and glassy nature,*** frequency and temperature dependent of the dielectric constant,electric modulus and electrical conductivity of the transparent NbO glasses were investigated in the 100 Hz-10 MHz frequency *** electrical modulus and conductivity data have been rationalized using Jonscher's universal *** bulk dc conductivity at various temperatures was extracted from the electrical relaxation *** activation energy associated with dc conduc-tivity is 0.52±0.01 eV,which is ascribed to the motion of Na^(+)ions in the glass matrix.

关键词： Glass dielectric relaxation conductivity

The three dimcnsional structure of the core protein of hepatitis b virus

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The three dimcnsional structure of the core protein of hepat...

Interferon Gamma Restores breast Cancer Sensitivity to Fulvestrant by Regulating STAT1,IRF1,NFκb,Specific bCL2 Family Members,and Signaling to Caspase-dependent Apoptosis

Third Congress of the Asian-Pacific Organization for Cell biology

作者： R.A.Crowther b.bttcher S.A.Wynne A.G.W. Leslie Medical Research Council Laboratory of Molecular Biology Hills Road Cambridge CB2 2QH England Institut für Physikalische Chemie Universitt Freiburg Albertstrasse 23a D-79104 Freiburg Germany.

The core protein of human hepatitis b virus, when expressed in ***, assembles into spherical shells closely resembling the native core structure of the complete virus. We have used electron cryo-microscopy to solve the structure of the core protein to 7.4A resolution (Nature (1997) 386, 88-91). With cryo-microscopy the specimen is observed unstained and in a near-native environment, so that internal features can be imaged and a three dimensional map of the whole structure computed. We have studied shells containing 240 subunits.

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Interferon Gamma Restores Breast Cancer Sensitivity to Fulve...

Effects of annealing condition and Al content on novel Fe_(73.5)Si_(13.5)b_9Cu_1Nb_(3-x)Al_x alloys

中国病理生理学会受体、肿瘤和免疫专业委员会联合学术会议

作者： Rebecca b.Riggins Robert Clarke Lombardi Comprehensive Cancer Center and Department of Oncology Georgetown University School of Medicine

Antiestrogens are effective therapies for the management of estrogen receptor-alpha positive(ER+) breast ***,both de novo and acquired resistance occur and remain major problems in the clinical *** gamma(IFNγ) is an inflammatory cytokine that induces the expression and function of Interferon Regulatory Factor-1(IRF1),a tumor suppressor gene that can increase antiestrogen *** show that IFNγbut not IFNα,IFNβ,or ICI induces IRF1 expression in antiestrogen resistant MCF7/LCC9 and LY2 ***,IFNγrestores the responsiveness of these cells to Fulvestrant(ICI;ICI 182,780;Faslodex).Increased IRF1 activation suppresses NFκb p65(RELA) activity and inhibits the expression of prosurvival(bCL2,bCLW),and induces the expression of proapoptotic members(bAK,mitochondrial bAX) of the bCL2 *** molecular signaling is associated with activation of STAT1,and leads to increased mitochondrial membrane permeability,activation of CASP7,CASP8,and CASP9,and induction of apoptosis but not autophagy. While antiestrogen resistant cells are capable of inducing autophagy through IFN-mediated signaling,their ability to do so through antiestrogen-regulated signaling is *** abilities of IFNγto activate CASP8, induce apoptosis,and restore antiestrogen sensitivity,are prevented by siRNA targeting IRF1,while transient overexpression of IRF1 mimics the effects of IFNγ*** observations support the exploration of clinical trials combining antiestrogens and compounds that can induce IRF1,such as IFNγ, for the treatment of some ER-positive breast cancers.

关键词： apoptosis autophagy bCL2 breast neoplasms caspases cell death drug resistance estrogen receptor modulators Fulvestrant interferons Tamoxifen

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Rare Metals 2008年第5期27卷 545-549页

作者： LIU Haishun DU Youwei MIAO Xiexing HAN Kui SHEN Xiaopeng bU Wankui School of Sciences China University of Mining ＆ Technology Xuzhou 221008 China National Key Laboratory of Solid State Microstructure Nanjing University Nanjing 210093 China

The annealing condition, AI content, and field amplitude dependences of the complex permeability for Nb-poor Finemet type alloys, Fe73.5Si13.5b9Cu1Nba-xAlx （x = 0, 0.5, 1.5, 2.0, and 3.0）, were investigated using an impedance analyzer and X-ray diffraction. The results show that different AI contents lead to different optimum annealing conditions, and the A1 content exerts a distinct effect on microstructure thus resulting in a variety of real permeability value. For the samples annealed at 793 K for 0.5 h, the real permeability increases with an increase in A1 content when the AI content is below 2.0 at.%; as for those annealed at 793 K for 1 h and at 813 K for 0.5 h, an overall increase in real permeability can be obtained compared to those annealed at 793 K for 0.5 h. The permeability under different field amplitudes is also studied and it is found that the relaxation frequency in the lower frequency region tends to moving toward a higher frequency with an increase in field amplitude. All these might be because of the role of Nb in the annealing process and the solubility of AI in the amorphous matrix and nanocrystallized crystallites.

关键词： magnetism magnetic property impedance analysis Fe-based alloys