作者:
Xin ChenaJoost J.OppenheimbO.M.Zack HowardbFrom aBasic Research Program
SAIC-FrederickInc.National Cancer Institute-Frederick bLaboratory of Molecular ImmunoregulationCenter for Cancer ResearchNational Cancer Institute-FrederickNational Institute of HealthFrederickMaryland 21702-1201USA
Chemokines belong to a family of chemotactic cytokines that direct the migration of immune cells towards sites of *** mediate their biological effects by binding to cell surface receptors, which belong to the G protei...
Chemokines belong to a family of chemotactic cytokines that direct the migration of immune cells towards sites of *** mediate their biological effects by binding to cell surface receptors, which belong to the G protein - coupled receptor superfamily (GPCR). Study of this field was boosted by the discovery that chemokine receptors are HIV co - receptors, and more recently, that chemokinies can direct some tumor cell ***, numerous inflammatory human diseases have been closely associated with self- destructive activation of the chemokine network, including cardiovascular disease, allergic inflammatory disease, graft - vs- host diseases and *** chemokines/chemoattractants and their receptors provide an important target for pharmacological intervention and have spurred a global race to identify chemokine receptor antagonists by major pharmaceutical companies as well as biomedical research institutes.
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