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中国农业科技导报 2011年第4期13卷 127-127页

中国科协遴选并批准，由中国毒理学会和中国环境诱变剂学会联办的第十三届中国科协年会第五分会场“化学物的环境危害与健康风险评估国际研讨会”定于2011年9月20～23日在天津市举行。本次会议将分为大会特邀主旨报告，大会主题报告和... 详细信息

中国科协遴选并批准，由中国毒理学会和中国环境诱变剂学会联办的第十三届中国科协年会第五分会场“化学物的环境危害与健康风险评估国际研讨会”定于2011年9月20～23日在天津市举行。本次会议将分为大会特邀主旨报告，大会主题报告和壁报三部分，旨在对化学物的环境危害与健康风险评估这个交叉领域的最新研究成果进行交流，研讨新的研究方向。会议诚挚地欢迎并邀请广大的从事食品、药品、化妆品、工业和农业化学物、环境和日用化学物风险评估和管理，以及相关学科领域的研究人员、政府部门和企业研发与管理人员代表参加，

关键词：健康风险评估国际研讨会环境危害化学物中国科协管理人员环境诱变剂主题报告

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The Effects of Low-level Arsenic Exposure on Erythrocyte Membrane Proteins in Male Rats

The Effects of Low-level Arsenic Exposure on Erythrocyte Mem...

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第十三届中国科协年会第5分会场-化学物的环境危害与健康风险评估国际研讨会

作者： Jing ZHANG 1 , Zhifeng MA 1 , Yi GAO 1 , Fengjie TIAN 1 , Ning MA 2 , Qiuling PEI 1, * (1. Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China 2. Faculty of Health Science and Institute of Traditional Chinese Medicine, Suzuka University of Medical Science, Suzuka, Mie 510-0293, Japan)

The rats were exposed to arsenic in drinking water (10, 60, 360μg/L) for 30 days. As shown in SDS-PAGE, compared with the control group, ankyrin content was significantly decreased in 360μg/L dose group. With exposure levels rising, band 3 protein expression presented an increasing trend in the treated groups. Immunofluorescence analysis revealed that, in 60μg/L and 360μg/L arsenic treatment groups, band 3 and CD35 increased and clustered to the RBC membrane. The results for rat erythrocyte parameters revealed that the abnormal changes have not occurred in the exposed groups. This study suggests that the injuries in RBC membrane proteins occur earlier than the abnormal changes in RBC number and volume. Erythrocyte membrane proteins may be the early biomarkers of chronic arsenic poisoning.

关键词： low levels arsenic poisoning rat erythrocyte membrane proteins

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An NMR-spectroscopy-based Metabonomic Approach to the Analysis of Bay41-4109,A Novel Anti-HBV Compound,InducedHepatotoxicity in Rats

An NMR-spectroscopy-based Metabonomic Approach to the Analys...

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第十三届中国科协年会第5分会场-化学物的环境危害与健康风险评估国际研讨会

作者： Chang SHI 1 , Chunqi WU, Anmin CAO, Hezhang SHENG, Mingyang LIAO * (Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China)

An integrated metabonomics study using high-resolution 1 H NMR spectroscopy has been applied to investigate the biochemical composition of urine, serum, liver tissue aqueous extracts (acetonitrile/water) and liver tissue lipidic extracts (chloroform/methanol) obtained from Bay41-4109 treated rats (10, 50, 400mg/kg·d for 5 days, i.g.). Principal components analysis was used to visualize similarities and differences in biochemical profiles. The elevation of 3-HB, lactate, 2-hydroxy-acetol, hydroxymaleic acid and d-glucose was found in the urine, and the levels of VLDL/LDL(CH 2 )n, VLDL/LDL-CH 3 , 2-oxo-3-methyl-n-valerate, 3-HB, lactate, pyruvate, taurine, 3-amino-isovalerate, 2-hydroxy-isovalerate in serum were increased significantly in 400mg/kg·d group. The predominant changes identified in liver tissue aqueous extracts included an increase in the signal intensities of lactate, 3-amino-isovalerate, pyruvate, taurine, choline, TMAO and a reduction in the intensities of trytophan and d-glucose. In liver tissue chloroform/methanol extracts, there was a remarkably increase in many of the lipid signals including the triglyceride terminal methyl, methylene groups, and CH 2 CO, N + (CH 3 ) 3 , CH 2 OPO 2 , CH 2 OCOR. The results showed that fatty acid metabolism disorder and mitochondrial inability might contribute to the hepatotoxicity of Bay41-4109. The application of 1 H NMR spectroscopy to an array of biological samples comprising urine, serum and liver tissue extracts yields new insight into the hepatotoxicity of xenobiotics.

关键词： Bay41-4109 1 H NMR spectroscopy metabonomics pattern recognition hepatotoxicity

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The Toxicity Evaluation of Recombinant Replicating Vaccinia Virus Vaccine in BALB/c Mice

The Toxicity Evaluation of Recombinant Replicating Vaccinia ...

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第十三届中国科协年会第5分会场-化学物的环境危害与健康风险评估国际研讨会

作者： Sanlong WANG 1 , Limei CAO 1 , Yin LIU 2 , Danli DUAN 2 , Xiuwen WANG 1 , Bo LI 1 , Yiming SHAO 2 (1. National Center for Safety Evaluation of Drugs, National Institute for the Control of Pharmaceutical & Biological Products, Tianjin 300050, China 2. National Center for AIDS/STD Prevention and Control, China CDC, Beijing 100050, China)

To evaluate the preclinical safety of recombinant replicating vaccinia virus-based HIV vaccines (rVVV)in BALB/c mice. The study was composed of groups 1, 2, 3, 4, wherein the groups 1 and 2 received only one priming immunization and the groups 3, 4 received prime-boost immunizations at a 6-week interval. The dose given was 50μl/skin of back/2 dosing point by intradermal injection approximately 2.2×10 6 PFU. Cellular responses were evaluated in spleenocytes after restimulation on the following basis: detection of IFN-γ producing CD8 + -positive T cells, and CD4 + /CD8 + T cells ratio by FACS assay. Humoral responses were evaluated in serum samples on the basis of specific anti-rVVV antibodies. A real-time quantitative PCR was employed for detection of biodistribution of rVVV in tissues and organs. The results showed that there were no significant toxic effects and damages to major organs in control and rVVV-treated animals. The results of FACS analysis assay for the group 4 that received prime-boost immunization showed cellular immune responses, as indicated by high IFN-γ production by CD8 + -positive T cells. There was no significant change for the CD4 + /CD8 + T cells ratio in control and rVVV-treated animals. Immunogenicity of rVVV given with prime-boost doses was stronger than that of rVVV given with a single priming dose in BALB/c mice. Following intradermal injection of rVVV in mice, all tissues were Q-PCR-negative on Day 35 after dosing. The study showed that there were no significant toxic effects and the rVVV could induce both humoral and cellular immune responses in BALB/c mice.

关键词： Toxicity evaluation Recombinant replicating vaccinia virus Vaccine BALB/c Mice

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