Di-n-butyl phthalate(DBP) compromises human sperm functions by inhibiting sperm tyrosine phosphorylation
作者单位：丽水市人民医院
会议名称：《2018年浙江省男科学、泌尿外科学学术年会》
会议日期：1000年
学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学]
关 键 词：DBP Di-n-butyl phthalate compromises human sperm functions by inhibiting sperm tyrosine phosphorylation
摘 要：目的:In this study,we investigated the effects of DBP and MBP,on human sperm functions and elucidated the underlying mechanisms.方法:Human sperm were treated with DBP,MBP,and a mixture of DBP and MBP in ***-essential functions including vitality,motility,capacitation,and the acrosome reaction of human sperm were examined.结果:The results showed that DBP,MBP,and a mixture of DBP and MBP reduced total motility,progressive motility,and penetration ability dose-dependently.结论:In addition,these concentrations of phthalates suppressed tyrosine phosphorylation dose-dependently in human *** results indicated that DBP might compromise human sperm function by inhibiting sperm tyrosine phosphorylation.