Clinical characteristics and risk factors in mixed-enterococcal bloodstream infections
会议名称：《第四届重症心脏全国学术大会暨第五届西湖重症医学大会、2019年浙江省重症医学学术大会（重症心脏-心与心外器官)》
会议日期：2019年
学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学]
关 键 词：Bloodstream infections Mixed-enterococcal bloodstream infections Monomicrobial enterococcal bloodstream infections Clinical characteristics Risk factors
摘 要：Objectives:Although the enterococcal bloodstream infections(EBSI) are often observed in clinic,the mixedEBSI were few *** aim of this study was to investigate the clinical characteristics and risk factors of mixedEBSI in comparison with monomicrobial EBSI(mono-EBSI).Methods:A single center retrospective observational study was performed between Jan 1,2013 and Dec 31,2018 in a tertiary *** patients with EBSI were enrolled,and their data were collected by reviewing electronic medical ***:A total of 451 patients with EBSI were enrolled including 157 cases(34.8%) with *** most common co-pathogens were Gram-negative bacteria(57.1%),followed by Gram-positive bacteria(38.3%) and fungi(4.6%).In multivariable analysis,burn injury(adjusted odds ratio [OR],0.136;95% confidence interval [CI],0.050-0.373),and length of prior hospital stay(aOR,1.009;95% CI,1.001-1.017) were associated with *** with mixed-EBSI developed with more proportion of septic shock(19% vs.31.8%,p=0.002),prolonged length of ICU stay [9(0,25) vs.15(2.5,36),p0.001] and hospital stay [29(16,49) vs.33(18.5,63),p=0.031].The mortality was not significantly different between mixed-EBSI and mono-EBSI(p=0.219).Conclusions:A high rate of mixed-EBSI was among EBSI,and the Gram-negative bacteria were the predominant co-existed *** injury and length of prior hospital stay were independent risk factors for *** the mortality was not different,patients with mixed-EBSI had poor outcomes in comparison with mono-EBSI,which merits more attention by physicians in the future.