Maresin1 Alleviates Metabolic Dysfunction in Septic Mice:A 1H NMR-based Metabolomics Analysis
会议名称：《第四届重症心脏全国学术大会暨第五届西湖重症医学大会、2019年浙江省重症医学学术大会（重症心脏-心与心外器官)》
会议日期：2019年
学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学]
关 键 词：sepsis inflammation resolution maresins NMR metabolomics
摘 要：Maresin1(MaR1),a new anti-inflammatory and pro-resolving lipid mediator,has been proven to exert organprotective effects in septic animal ***,the potential mechanisms are still not fully *** this study,we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and puncture(CLP) induced septic *** found that MaR1 significantly increased overall survival rate and attenuated lung and liver injuries in septic *** addition,MaR1 markedly reduced the levels of pro-inflammatory cytokines(TNF-α and IL-6) and alleviated mitochondrial *** on a 1 H NMR-based metabolomics analysis,CLP-induced septic mice had increased levels of acetate,pyruvate and lactate in serum and decreased levels of alanine,aspartate,glutamate and fumarate in ***,these metabolic disorders,mainly involving energy and amino acid metabolism,can be recovered by MaR1 ***,our results suggest that the protective effects of MaR1 on sepsis could be related to the recovery of metabolic dysfunction and the alleviation of inflammation and mitochondrial damage.