Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid(ORM) suppression
会议名称：《首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会》
会议日期：2018年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
关 键 词：Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid suppression ORM
摘 要：Gender differences in fatigue manifest as females being more prone to feel exhaustion and having lower muscle ***,the mechanisms of these effects remain *** investigated whether orosomucoid,an endogenous anti-fatigue protein that enhances muscle endurance,is involved in this *** rats exhibited lower muscle endurance,and this gender difference disappeared in orosomucoid-1-deficient *** rats also exhibited weaker orosomucoid induction in serum,liver and muscle in response to fatigue compared with male *** elevated orosomucoid levels and increased swimming time,and estrogen replenishment reversed these *** estrogen treatment in male and female mice produced opposite *** decreased orosomucoid expression and its promoter activity in C2 C12 muscle and Chang liver cells in vitro,and estrogen receptor or p38 mitogen-activated protein kinase blockade abolished this ***,estrogen negatively regulates orosomucoid expression that is responsible for the weaker muscle endurance in females.