The Mechanism of Antimicrobial Peptide MPX against Enterohemorrhagic Escherichia coli in Vitro
作者单位：Sumy National Agrarian University College of Animal Science and Veterinary MedicineHenan Institute of Science and Technology College of Veterinary MedicineJiLin University
会议名称：《中国微生物学会兽医微生物学专业委员会暨中国畜牧兽医学会生物制品学分会2021年学术论坛》
会议日期：2021年
学科分类：090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学]
摘 要：Escherichia coli is a facultative anaerobic bacteria that exists in the gastrointestinal tract of humans and *** can cause diarrhea,enteritis,destruction of the host’s intestinal barrier,and intestinal microecological *** has a high lethality rate *** brings a huge threat to the development of animal husbandry and human *** recent years,due to the abuse of traditional antibiotics,a variety of drug-resistant strains and super bacteria have emerged in an endless ***,there is an urgent need to find new alternatives to *** peptides are a type of small peptides produced when organisms resist the invasion of foreign *** are an important part of the body’s innate immune system and have a variety of biological functions,such as anti-bacterial,anti-virus,anti-parasitic,promote wound healing and immune regulation and other *** with traditional antibiotics,antimicrobial peptides have the characteristics of small molecular weight,good water solubility,good thermal stability,unique antibacterial mechanism,broad-spectrum antibacterial activity against clinically resistant strains,and resistance to bacterial *** are considered to be the best alternative to antibiotics which has become a research hotspot in recent *** antimicrobial peptide MPX is extracted from wasp venom and has a good bactericidal effect on many *** the early stage of our research group,it has found that MPX has a good bactericidal effect on Actinobacillus pleuropneumoniae, with a minimum inhibitory concentration(MIC) of 16 ug/*** explore the effect of antimicrobial peptide MPX against *** function of antimicrobial peptide MPX against *** was detected by MIC,plate count,propidium iodide,NPN and DiSC(c5) permeability testing,immunofluorescence microscope observation,and the impact of MPX stability by temperature,pH,*** this study,the results of the antibacterial activity test